Prof. Dr. Silvia Capellino
Group Leader Neuroimmunology
- 2020Conferment of the title "Associate Professor" by the University Duisburg-Essen, Germany
- Since 2017Member of the faculty council at the medical faculty of the University of Duisburg-Essen, Germany
- Since 2016Leader of the Junior Research Group „Neuroimmunology“ at the Leibniz Research Centre for Working Environment and Human Factors(IfADo)
- 2016-2019Marie Skłodowska-Curie scholarship holder at Leibniz Research Centre for Working Environment and Human Factors (IfADo)
- 2015-2016PostDoc (University of Giessen and Kerckhoff Clinic, Bad Nauheim, Germany)
- 2014Maternity leave
- 2012-2013PostDoc (The Johns Hopkins University, School of Medicine, Baltimore MD, USA)
- 2012Habilitation (University of Regensburg, Germany)
- 2007-2012PostDoc (University of Regensburg, Germany)
- 2007Ph.D. on Clinical and Experimental Immunology (University of Genoa, Italy and University of Regensburg, Germany)
- 2003Diploma in Biology (University of Genoa, Italy)
Here you will find the Key publications from 2010 onwards that were produced at IfADo.
Fleige L, Capellino S:
Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women. Biol Sex Differ 16(1): 8 (2025) doi: 10.1186/s13293-025-00689-5
Fleige L, Fillatreau S, Claus M, Capellino S:
Additional use of α-IgM antibodies potentiates CpG ODN2006-induced B cell activation by targeting mainly naïve and marginal zone-like B cells. Cell Immunol 403-404: 104846 (2024) (12 pp)
Jürgens M, Claus M, Wingert S, Niemann JA, Picard LK, Hennes E, Haasler I, Hellwig B, Overbeck N, Reinders J, Rahnenführer J, Schedel M, Capellino S, Watzl C:
Chronic stimulation desensitizes β2-adrenergic receptor responses in natural killer cells. Eur J Immunol 54 (12): e2451299 (2024)
Fleige L, Capellino S:
Simultaneous stimulation of peripheral blood mononuclear cells with CpG ODN2006 and α-IgM antibodies leads to strong immune responses in monocytes independent of B cell activation. Cells 13 (22): 1822 (2024) (14 pp)
Claus M, Capellino S:
Catecholamines and immunomodulation. In: Konsman JP, Reyes TM (eds): Neuroendocrine-immune system interactions (pp 105-133). Cham: Springer, 2023 (Masterclass in Neuroendocrinology, Vol. 13)
Larra M, Capellino S, Schwendich E, von Haugwitz L, Reinders J, Wascher E:
Immediate and delayed salivary cytokine responses during repeated exposures to Cold Pressor stress. Neuroimmunomodulation 30: 81–92 (2023)
Schwendich E, Salinas Tejedor L, Schmitz G, Rickert M, Steinmeyer J, Rehart S, Tsiami S, Braun J, Baraliakos X, Reinders J, Neumann E, Müller-Ladner U, Capellino S:
Modulation of dopamine receptors on osteoblasts as a possible therapeutic strategy for inducing bone formation in arthritis. Cells 11 (10): 1609 (2022) (20 pp)
Capellino S, Engler H, Rohleder N (eds):
14th Conference of the German Endocrine-Brain-Immune-Network (GEBIN), Erlangen, March 30 – April 1, 2022. Abstracts. Basel: Karger, 2022 (Neuroimmunomodulation, Vol. 29, Suppl. 1)
Gajewski PD, Getzmann S, Bröde P, Burke M, Cadenas C, Capellino S, Claus M, Genç E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E:
Impact of biological and lifestyle factors on cognitive aging and work ability in the Dortmund Vital Study: Protocol of an interdisciplinary, cross-sectional, and longitudinal study. JMIR Res Protoc 11 (3): e32352 (2022) (18 pp)
Wieber K, Fleige L, Tsiami S, Reinders J, Braun J, Baraliakos X, Capellino S:
Dopamine receptor 1 expressing B cells exert a proinflammatory role in female patients with rheumatoid arthritis. Sci Re17 (1): 5985 (2022) (15 pp)
Peifer C, Hagemann V, Claus M, Larra MF, Aust F, Kühn M, Owczarek M, Broede P, Pacharra M, Steffens H, Watzl C, Wascher E, Capellino S:
Low self-reported stress despite immune-physiological changes in paramedics during rescue operations. EXCLI J 20: 792-811 (2021)
Van Nie L, Salinas-Tejedor L, Dychus N, Fasbender F, Hülser M-L, Cutolo M, Rehart S, Neumann E, Müller-Ladner U, Capellino S:
Dopamine induces in vitro migration of synovial fibroblast from patients with rheumatoid arthritis. Sci Rep 10: 11928 (2020) (13 pp)
Capellino S, Claus M, Watzl C:
Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine. Cell Mol Immunol 17: 705-711 (2020)
Novaira HJ, Negron AL, Graceli JB, Capellino S, Schoeffield A, Hoffman GE, Levine JE, Wolfe A, Wondisford FE, Radovick S:
Impairments in the reproductive axis of female mice lacking estrogen receptor β in GnRH neurons. Am J Physiol Endocrinol Metab 315: E1019–E1033 (2018)
Böhm M, Apel M, Lowin T, Lorenz J, Jenei-Lanzl Z, Capellino S, Dosoki H, Luger TA, Straub RH, Grässel S:
α-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients. Biochem Pharmacol 116: 89-99 (2016)
Novaira HJ, Graceli JB, Capellino S, Schoeffield A, Hoffman GE, Wolfe A, Wondisford F, Radovick S:
Development and Characterization of Novel Rat Anti-mERβ Sera. Endocrinology 157: 2844-2852 (2016)
Jenei-Lanzl Z, Capellino S, Kees F, Fleck M, Lowin T, Straub RH:
Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis. Ann Rheum Dis 74: 444-451 (2015)
van der Goes MC, Straub RH, Wenting MJ, Capellino S, Jacobs JW, Jahangier ZN, Rauch L, Bijlsma JW, Lafeber FP:
Intra-articular glucocorticoid injections decrease the number of steroid hormone receptor positive cells in synovial tissue of patients with persistent knee arthritis. Ann Rheum Dis 71: 1552-1558 (2015)
Capellino S, Cosentino M, Luini A, Bombelli R, Lowin T, Cutolo M, Marino F, Straub RH:
Increased expression of dopamine receptors in synovial fibroblasts from patients with rheumatoid arthritis: inhibitory effects of dopamine on interleukin-8 and interleukin-6. Arthritis Rheumatol 66: 2685-2693 (2014)
Capellino S, Straub RH, Cutolo M:
Aromatase and regulation of the estrogen-to-androgen ratio in synovial tissue inflammation: common pathway in both sexes. Ann N Y Acad Sci 1317: 24-31 (2014)
Lowin T, Weidler C, Jenei-Lanzl Z, Capellino S, Baerwald CG, Buttgereit F, Straub RH:
Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis. Arthritis Rheum 64: 1799-1808 (2012)
Capellino S, Weber K, Gelder M, Härle P, Straub RH:
First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy. Arthritis Rheum 64: 1110-1118 (2012)
Graf N, McLean M, Capellino S, Schölmerich J, Murray GI, El-Omar EM, Straub RH:
Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps--a putative role of semaphorins 3F and 3A. Neurogastroenterol Motil 24: 120-128, e83 (2012)
Probst C, Pongratz G, Capellino S, Szeimies RM, Schölmerich J, Fleck M, Salzberger B, Ehrenstein B:
Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report. BMC Infect Dis 10: 239 (2010)
Capellino S, Cosentino M, Wolff C, Schmidt M, Grifka J, Straub RH:
Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target. Ann Rheum Dis 69: 1853-1860 (2010)
Haas S, Capellino S, Phan NQ, Böhm M, Luger TA, Straub RH, Ständer S:
Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis. J Dermatol Sci. 58: 193-197 (2010)
Cutolo M, Brizzolara R, Atzeni F, Capellino S, Straub RH, Puttini PC:
The immunomodulatory effects of estrogens: clinical relevance in immune-mediated rheumatic diseases. Ann N Y Acad Sci 1193: 36-42 (2010)
Ferrero S, Haas S, Remorgida V, Camerini G, Fulcheri E, Ragni N, Straub RH, Capellino S:
Loss of sympathetic nerve fibers in intestinal endometriosis. Fertil Steril 94: 2817-2819 (2010)
Schmidt M, Hartung R, Capellino S, Cutolo M, Pfeifer-Leeg A, Straub RH:
Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis. Arthritis Rheum 60: 2913-2922 (2009)
Here you will find the Publications from 2010 onwards that were produced at IfADo.
Fleige L, Capellino S:
Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women. Biol Sex Differ 16(1): 8 (2025) doi: 10.1186/s13293-025-00689-5
Fleige L, Fillatreau S, Claus M, Capellino S:
Additional use of α-IgM antibodies potentiates CpG ODN2006-induced B cell activation by targeting mainly naïve and marginal zone-like B cells. Cell Immunol 403-404: 104846 (2024) (12 pp)
Jürgens M, Claus M, Wingert S, Niemann JA, Picard LK, Hennes E, Haasler I, Hellwig B, Overbeck N, Reinders J, Rahnenführer J, Schedel M, Capellino S, Watzl C:
Chronic stimulation desensitizes β2-adrenergic receptor responses in natural killer cells. Eur J Immunol 54 (12): e2451299 (2024)
Fleige L, Capellino S:
Simultaneous stimulation of peripheral blood mononuclear cells with CpG ODN2006 and α-IgM antibodies leads to strong immune responses in monocytes independent of B cell activation. Cells 13 (22): 1822 (2024) (14 pp)
Claus M, Capellino S:
Catecholamines and immunomodulation. In: Konsman JP, Reyes TM (eds): Neuroendocrine-immune system interactions (pp 105-133). Cham: Springer, 2023 (Masterclass in Neuroendocrinology, Vol. 13)
Larra M, Capellino S, Schwendich E, von Haugwitz L, Reinders J, Wascher E:
Immediate and delayed salivary cytokine responses during repeated exposures to Cold Pressor stress. Neuroimmunomodulation 30: 81–92 (2023)
Schwendich E, Salinas Tejedor L, Schmitz G, Rickert M, Steinmeyer J, Rehart S, Tsiami S, Braun J, Baraliakos X, Reinders J, Neumann E, Müller-Ladner U, Capellino S:
Modulation of dopamine receptors on osteoblasts as a possible therapeutic strategy for inducing bone formation in arthritis. Cells 11 (10): 1609 (2022) (20 pp)
Capellino S, Engler H, Rohleder N (eds):
14th Conference of the German Endocrine-Brain-Immune-Network (GEBIN), Erlangen, March 30 – April 1, 2022. Abstracts. Basel: Karger, 2022 (Neuroimmunomodulation, Vol. 29, Suppl. 1)
Gajewski PD, Getzmann S, Bröde P, Burke M, Cadenas C, Capellino S, Claus M, Genç E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E:
Impact of biological and lifestyle factors on cognitive aging and work ability in the Dortmund Vital Study: Protocol of an interdisciplinary, cross-sectional, and longitudinal study. JMIR Res Protoc 11 (3): e32352 (2022) (18 pp)