Prof. Dr. Jan G. Hengstler

Head of Department

Head of department

Prof. Dr. Jan G. Hengstler

hengstler@ifado.de

+49 231 1084-348

Secretariat

Monika Turajski

turajski@ifado.de

+49 231 1084-349

Address

Ardeystr. 67
44139 Dortmund

since 03/2007
Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
03/2006 – 02/2007
Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
04/2003 - 02/2007
Professor of Molecular Pharmacology and Toxicology, University of Leipzig
11/1990 - 03/2003
Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
11/1998
“Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
06/1997
Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
08/1992
License to practice medicine
12/1991
Thesis (MD): DNA damage in patients treated with alkylating agents
10/1984 – 10/1990
Study of Medicine, University of Mainz, Germany

Here you will find the Key publications from 2010 onwards that were produced at IfADo. For all other publications of our scientific staff, please look at the links to other databases such as Pubmed.

Schneider KM, Candels LS, Hov JR, Myllys M, Hassan R, Schneider CV, Wahlström A, Mohs A, Zühlke S, Liao L, Elfers C, Kilic K, Henricsson M, Molinaro A, Hatting M, Zaza A, Drasdo D, Frissen M, Devlin AS, Gálvez EJC, Strowig T, Karlsen TH, Hengstler JG, Marschall HU, Ghallab A, Trautwein C:

Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling. Nat Metab 3 (9):1228-1241 (2021)

Remetic J, Ghallab A, Hobloss Z, Brackhagen L, Hassan R, Myllys M, Radun R, Mlitz V, Zhu C, Baumgartner M, Schrottmaier WC, Mussbacher M, Timelthaler G, Scharnagl H, Stojakovic T, Assinger A, Fuchs CD, Hengstler JG, Trauner M:

Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology 75: 1095-1109 (2022)

Nell P, Kattler K, Feuerborn D, Hellwig B, Rieck A, Salhab A, Lepikhov K, Gasparoni G, Thomitzek A, Belgasmi K, Blüthgen N, Morkel M, Küppers-Munther B, Godoy P, Hay DC, Cadenas C, Marchan R, Vartak N, Edlund K, Rahnenführer J, Walter J, Hengstler JG:

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. J Hepatol 77: 1386-1398 (2022)

Mohs A, Otto T, Schneider KM, Peltzer M, Boekschoten M, Holland CH, Hudert CA, Kalveram L, Wiegand S, Saez-Rodriguez J, Longerich T, Hengstler JG, Trautwein C:

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. J Hepatol 74: 638-648 (2021)

Gui W, Hole MJ, Molinaro A, Edlund K, Jørgensen KK, Su H, Begher-Tibbe B, Gaßler N, Schneider CV, Muthukumarasamy U, Mohs A, Liao L, Jaeger J, Mertens CJ, Bergheim I, Strowig T, Hengstler JG, Hov JR, Marschall HU, Trautwein C, Schneider KM:

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis. Nat Commun 14 (1): 3304 (2023) (17 pp)

Edlund K, Madjar K, Lebrecht A, Aktas B, Pilch H, Hoffmann G, Hofmann M, Kolberg HC, Boehm D, Battista MJ, Seehase M, Stewen K, Gebhard S, Cadenas C, Marchan R, Brenner W, Hasenburg A, Koelbl H, Solbach C, Gehrmann M, Tanner B, Weber K, Loibl S, Sachinidis A, Rahnenführer J, Schmidt M, Hengstler JG:

Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial. Clin Cancer Res 27: 2148-2158 (2021)

Bloch D, Diel P, Epe B, Hellwig M, Lampen A, Mally A, Marko D, Villar Fernández MA, Guth S, Roth A, Marchan R, Ghallab A, Cadenas C, Nell P, Vartak N, van Thriel C, Luch A, Schmeisser S, Herzler M, Landsiedel R, Leist M, Marx-Stoelting P, Tralau T, Hengstler JG:

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97: 3005-3017 (2023)

Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG:

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93: 1609-1637 (2019)

Vartak N, Drasdo D, Geisler F, Itoh T, Oude Elferink RPJ, van de Graaf SFJ, Chiang J, Keitel V, Trauner M, Jansen P, Hengstler JG:

On the mechanisms of biliary flux. Hepatology 74: 3497-3512 (2021)

Marchan R, Büttner B, Lambert J, Edlund K, Glaeser I, Blaszkewicz M, Leonhardt G, Marienhoff L, Kaszta D, Anft M, Watzl C, Madjar K, Grinberg M, Rempel E, Hergenröder R, Selinski S, Rahnenführer J, Lesjak MS, Stewart JD, Cadenas C, Hengstler JG:

Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma. Cancer Res 77: 4589-4601 (2017)

Jansen PL, Ghallab A, Vartak N, Reif R, Schaap FG, Hampe J, Hengstler JG:

The ascending pathophysiology of cholestatic liver disease. Hepatology 65: 722-738 (2017)

Guth S, Hüser S, Roth A, Degen G, Diel P, Edlund K, Eisenbrand G, Engel K-H, Epe B, Grune T, Heinz V, Henle T, Humpf H-U, Jäger H, Joost H-G, Kulling SE, Lampen A, Mally A, Marchan R, Marko D, Mühle E, Nitsche MA, Röhrdanz E, Stadler R, van Thriel C, Vieths S, Vogel RF, Wascher E, Watzl C, Nöthlings U, Hengstler JG:

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol 94: 1375-1415 (2020)

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R:

Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood. Hepatology 69: 666-683 (2019)

Here you will find the Publications from 2010 onwards that were produced at IfADo. For all other publications of our scientific staff, please look at the links to other databases such as Pubmed.

Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Mattsson J, Marschall HU, Hoehme S, Stirnimann G, Schwab M, Boor P, Amann K, Schmitz J, Bräsen JH, Rahnenführer J, Edlund K, Karpen SJ, Simbrunner B, Reiberger T, Mandorfer M, Trauner M, Dawson PA, Lindström E, Hengstler JG:

Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol 80: 268-281 (2024)

Getzmann S, Golka K, Bröde P, Reinders J, Kadhum T, Hengstler JG, Wascher E, Gajewski PD:

Chronic Toxoplasma gondii infection modulates hearing ability across the adult life span. Life 14 (2): 194 (2024) (10 pp)

Zhao J, Ghallab A, Hassan R, Dooley S, Hengstler JG, Drasdo D:

A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage. iScience 27 (2): 108077 (2024) (26 pp)

Jaeger JW, Brandt A, Gui W, Yergaliyev T, Hernández-Arriaga A, Muthu MM, Edlund K, Elashy A, Molinaro A, Möckel D, Sarges J, Halibasic E, Trauner M, Kahles F, Rolle-Kampczyk U, Hengstler J, Schneider CV, Lammers T, Marschall HU, von Bergen M, Camarinha-Silva A, Bergheim I, Trautwein C, Schneider KM:

Microbiota modulation by dietary oat beta-glucan prevents steatotic liver disease progression. JHEP Rep 6 (3): 100987 (2024) (14 pp)

Hassan R, Gerdemann A, Cramer B, Hobloss Z, Myllys M, González D, Albrecht W, Veerkamp J, Friebel A, Hoehme S, Esselen M, Degen GH, Humpf HU, Hengstler JG, Ghallab A:

Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats. Arch Toxicol. 2024 Mar 4. Epub ahead of print.

Kadhum T, Selinski S, Blaszkewicz M, Reinders J, Roth E, Volkert F, Ovsiannikov D, Moormann O, Gerullis H, Barski D, Otto T, Höhne S, Hengstler JG, Golka K:

Bladder cancer course, four genetic high-risk variants, and histopathological findings. EXCLI J 22: 867-879 (2023)

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97: 3005-3017 (2023)

Seidel F, Kappenberg F, Fayyaz S, Scholtz-Illigens A, Cherianidou A, Derksen K, Nell P, Marchan R, Edlund K, Leist M, Sachinidis A, Rahnenführer J, Kreiling R, Hengstler JG:

Risk assessment of parabens in a transcriptomics-based in vitro test. Chem Biol Interact 384: 110699 (2023)

Cherianidou A, Kappenberg F, Seidel F, Acharya A, Papazoglou P, Srinivasan SP, Hescheler J, Peng L, Leist M, Hengstler JG, Rahnenführer J, Sachinidis A:

Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells. Cell Death Discov 9 (1): 321 (2023) (12 pp)

Kappenberg F, Duda JC, Schürmeyer L, Gül O, Brecklinghaus T, Hengstler JG, Schorning K, Rahnenführer J:

Guidance for statistical design and analysis of toxicological dose-response experiments, based on a comprehensive literature review. Arch Toxicol 97: 2741-2761 (2023)

Gerdemann A, Cramer B, Degen GH, Veerkamp J, Günther G, Albrecht W, Behrens M, Esselen M, Ghallab A, Hengstler JG, Humpf HU:

Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC-MS/MS. Arch Toxicol 97: 3179-3196 (2023)

Cartus AT, Lachenmeier DW, Guth S, Roth A, Baum M, Diel P, Eisenbrand G, Engeli B, Hellwig M, Humpf HU, Joost HG, Kulling SE, Lampen A, Marko D, Steinberg P, Wätjen W, Hengstler JG, Mally A:

Acetaldehyde as a food flavoring substance: aspects of risk assessment. Mol Nutr Food Res 67: 2200661 (2023) (29 pp)

Wollin KM, Batke M, Damm G, Freyberger A, Gundert-Remy U, Mangerich A, Hengstler JG, Partosch F, Schupp T, Sonnenburg A, Foth H:

PFASs-restriction proposal commentary on ECHA's Annex XV restriction report, proposal for a restriction, March 2023. (Guest editorial). Arch Toxicol 97: 3305-3312 (2023)

Custodio RJP, Hobloss Z, Myllys M, Hassan R, González D, Reinders J, Bornhorst J, Weishaupt AK, Seddek AL, Abbas T, Friebel A, Hoehme S, Getzmann S, Hengstler JG, van Thriel C, Ghallab A:

Cognitive functions, neurotransmitter alterations, and hippocampal microstructural changes in mice caused by feeding on western diet. Cells 12 (18): 2331 (2023) (20 pp)

Fendt R, Ghallab A, Myllys M, Hofmann U, Hassan R, Hobloss Z, González D, Brackhagen L, Marchan R, Edlund K, Seddek AL, Abdelmageed N, Blank LM, Schlender JF, Holland CH, Hengstler JG, Kuepfer L:

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice. Front Pharmacol 14: 1279357 (2023) (14 pp)