Here you will find the Key publications from 2010 onwards.
Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG:
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93: 1609-1637 (2019)
Here you will find the Publications from 2010 onwards.
Kappenberg F, Brecklinghaus T, Schürmeyer L, Albrecht W, Schorning K, Hengstler JG, Rahnenführer J:
Adjustment for day-to-day variability in the estimation of effective concentrations for the assessment of mixture toxicity. Arch Toxicol 99(11): 4439-4454 (2025) doi: 10.1007/s00204-025-04141-w
Kwon Y, Gottmann P, Wang S, Tissink J, Motzler K, Sekar R, Albrecht W, Cadenas C, Hengstler JG, Schürmann A, Zeigerer A:
Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease. J Hepatol 82(1): 18-27 (2025) doi: 10.1016/j.jhep.2024.06.040
Schürmeyer L, Peng C, Albrecht W, Brecklinghaus T, Baur P, Hengstler JG, Schorning K:
Design of optimal concentrations for in vitro cytotoxicity experiments. Arch Toxicol 99(1): 357-376 (2025) doi: 10.1007/s00204-024-03893-1
Albrecht W, Brecklinghaus T, Stolte M, Kappenberg F, Gründler L, Chen P, Cadenas C, Damm G, Edlund K, Ghallab A, Marchan R, Nell P, Reinders J, Seehofer D, Behr AC, Braeuning A, van Thriel C, Gardner I, Rahnenführer J, Hengstler JG:
Improved identification of human hepatotoxic potential by summary variables of gene expression. ALTEX 42(3): 397-412 (2025) doi: 10.14573/altex.2403272
Castoldi M, Roy S, Angendohr C, Pellegrino R, Vucur M, Singer MT, Buettner V, Dille MA, Wolf SD, Heij LR, Ghallab A, Albrecht W, Hengstler JG, Flügen G, Knoefel WT, Bode JG, Zender L, Neumann UP, Heikenwälder M, Longerich T, Roderburg C, Luedde T:
Regulation of KIF23 by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma. J Hepatol 82(3): 499-511 (2025) doi: 10.1016/j.jhep.2024.08.025
Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Mattsson J, Marschall HU, Hoehme S, Stirnimann G, Schwab M, Boor P, Amann K, Schmitz J, Bräsen JH, Rahnenführer J, Edlund K, Karpen SJ, Simbrunner B, Reiberger T, Mandorfer M, Trauner M, Dawson PA, Lindström E, Hengstler JG:
Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol 80: 268-281 (2024)
Hassan R, Gerdemann A, Cramer B, Hobloss Z, Myllys M, González D, Albrecht W, Veerkamp J, Friebel A, Hoehme S, Esselen M, Degen GH, Humpf HU, Hengstler JG, Ghallab A:
Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats. Arch Toxicol 98: 1081-1093 (2024)
Gerdemann A, Cramer B, Degen GH, Veerkamp J, Günther G, Albrecht W, Behrens M, Esselen M, Ghallab A, Hengstler JG, Humpf HU:
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC-MS/MS. Arch Toxicol 97: 3179-3196 (2023)
Stolte M, Albrecht W, Brecklinghaus T, Gründler L, Chen P, Hengstler JG, Kappenberg F, Rahnenführer J:
Classification of hepatotoxicity of compounds based on cytotoxicity assays is improved by additional interpretable summaries of high-dimensional gene expression data. Comput Toxicol 28: 100288 (2023) (8 pp)