Dr. Tim Brecklinghaus

Scientific staff

Head of department
Prof. Dr. Jan G. Hengstler
Secretariat
Monika Turajski
Address
Ardeystr. 67
44139 Dortmund

Here you will find the Publications from 2010 onwards that were produced at IfADo.

Guidance for statistical design and analysis of toxicological dose-response experiments, based on a comprehensive literature review. Arch Toxicol 97: 2741-2761 (2023)
Classification of hepatotoxicity of compounds based on cytotoxicity assays is improved by additional interpretable summaries of high-dimensional gene expression data. Comput Toxicol 28: 100288 (2023) (8 pp)
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. Chem Biol Interact 351: 109728 (2022) (16 pp)
Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes. Toxicol In Vitro 81: 105344 (2022)
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes. Cell Biol Toxicol 38: 847-864 (2022)
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. J Hepatol 77: 71-83 (2022)
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay. Toxicol Lett 368: 33-46 (2022)
Comparing in vitro human liver models to in vivo human liver using RNA-Seq. Arch Toxicol 95: 573–589 (2021)
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods. Arch Toxicol 94: 2435-2461 (2020)
Highlight report: Mechanisms of nephrotoxicity and available in vitro systems. Arch Toxicol 94: 347-348 (2020)
Handling deviating control values in concentration-response curves. Arch Toxicol 94: 3787–3798 (2020)
Roadmap for the development of alternative test methods. (Letter to the editor). Arch Toxicol 94: 3597-3598 (2020)
Role of autophagy in drug induced liver injury. (Letter to the editor). Arch Toxicol 94: 3599-3600 (2020)
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93: 1609-1637 (2019)
Der Mensch zum Selberbauen? Möglichkeiten und Grenzen Stammzell-basierter Testverfahren in der Wirkstoffforschung. Laborpraxis 2019 (August): 46-49