Dr. Patrick Nell

Group Leader Regulatory Networks of Stem Cell Differentiation

Head of department

Prof. Dr. Jan G. Hengstler

hengstler@ifado.de

+49 231 1084-348

Secretariat

Monika Turajski

turajski@ifado.de

+49 231 1084-349

Address

Ardeystr. 67
44139 Dortmund

Since 2022
Junior group leader: “Regulatory Networks of Stem Cell Differentiation”, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Germany
2016-2021
Doctoral studies in Stem Cell Technology, Liver Physiology and Transcriptional Regulatory Networks, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Germany
2014-2016
M.Sc. Molecular and Developmental Stem Cell Biology, Ruhr Universität Bochum, Germany (2014-2016)/ Tongji University Shanghai, China (2016)
2009-2014
B.Sc. Biology (medical minor), Radboud University Nijmegen, Netherlands

Here you will find the Publications from 2010 onwards that were produced at IfADo.

Albrecht W, Brecklinghaus T, Stolte M, Kappenberg F, Gründler L, Chen P, Cadenas C, Damm G, Edlund K, Ghallab A, Marchan R, Nell P, Reinders J, Seehofer D, Behr AC, Braeuning A, van Thriel C, Gardner I, Rahnenführer J, Hengstler JG:

Improved identification of human hepatotoxic potential by summary variables of gene expression. ALTEX. 2025. doi: 10.14573/altex.2403272. Epub ahead of print.

Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Mattsson J, Marschall HU, Hoehme S, Stirnimann G, Schwab M, Boor P, Amann K, Schmitz J, Bräsen JH, Rahnenführer J, Edlund K, Karpen SJ, Simbrunner B, Reiberger T, Mandorfer M, Trauner M, Dawson PA, Lindström E, Hengstler JG:

Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol 80: 268-281 (2024)

Bloch D, Diel P, Epe B, Hellwig M, Lampen A, Mally A, Marko D, Villar Fernández MA, Guth S, Roth A, Marchan R, Ghallab A, Cadenas C, Nell P, Vartak N, van Thriel C, Luch A, Schmeisser S, Herzler M, Landsiedel R, Leist M, Marx-Stoelting P, Tralau T, Hengstler JG:

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97: 3005-3017 (2023)

Seidel F, Kappenberg F, Fayyaz S, Scholtz-Illigens A, Cherianidou A, Derksen K, Nell P, Marchan R, Edlund K, Leist M, Sachinidis A, Rahnenführer J, Kreiling R, Hengstler JG:

Risk assessment of parabens in a transcriptomics-based in vitro test. Chem Biol Interact 384: 110699 (2023)

Nell P, Kattler K, Feuerborn D, Hellwig B, Rieck A, Salhab A, Lepikhov K, Gasparoni G, Thomitzek A, Belgasmi K, Blüthgen N, Morkel M, Küppers-Munther B, Godoy P, Hay DC, Cadenas C, Marchan R, Vartak N, Edlund K, Rahnenführer J, Walter J, Hengstler JG:

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. J Hepatol 77: 1386-1398 (2022)

Nell P:

Highlight report: Hepatobiliary differentiation from human induced pluripotent stem cells. (Letter to the editor). EXCLI J 19: 167-169 (2020)

Lucendo-Villarin B, Nell P, Hellwig B, Filis P, Feuerborn D, O’Shaughnessy PJ, Godoy P, Rahnenführer J, Hengstler JG, Cherianidou A, Sachinidis A, Fowler PA, Hay DC:

Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells. EXCLI J 19: 1459-1476 (2020)

Behjati Ardakani F, Kattler K, Heinen T, Schmidt F, Feuerborn D, Gasparoni G, Lepikhov K, Nell P, Hengstler J, Walter J, Schulz MH:

Prediction of single-cell gene expression for transcription factor analysis. GigaScience 9(11): giaa113 (2020)

Nell P:

Highlight report: Liver regeneration by a subset of hepatocytes with high expression of telomerase. Arch Toxicol 93: 3633-3634 (2019)

Sachinidis A, Albrecht W, Nell P, Cherianidou A, Hewitt NJ, Edlund K, Hengstler JG:

Road map for development of stem cell-based alternative test methods. Trends Mol Med 25: 470-481 (2019)