Dr. Karolina Edlund

Scientific staff

Systems Toxicology

+49 231 1084-467

edlund@ifado.de

Head of department

Prof. Dr. Jan G. Hengstler

hengstler@ifado.de

+49 231 1084-348

Secretariat

Monika Turajski

turajski@ifado.de

+49 231 1084-349

Address

Ardeystr. 67
44139 Dortmund

Publications

Here you will find the Publications from 2010 onwards.

Zhou P, Hammour MM, Aspera-Werz RH, Ehnert S, Myllys M, Hobloss Z, Hassan R, González D, Hendawi R, Edlund K, Hans S, Laschke MW, Ghallab A, Hengstler JG, Nüssler AK, Maisenbacher TC:

Long-term Western diet feeding impairs hepatic vitamin D metabolism and promotes bone loss in mice. EXCLI J 25: 290-309 (2026) doi: 10.17179/excli2025-9085

Volkert I, Grube J, Woitok MM, Mohamed MR, Edlund K, Duda JC, Dietrich J, Schneider U, Yin G, Lin C, Erschfeld S, Berger H, Candels L, Davis RJ, Bartneck M, Kühnel MP, Guillot A, Schneider KM, Schneider CV, Jonigk D, Rahnenführer J, Tacke F, Hengstler J, Trautwein C:

Selective genetic inactivation of Caspase 8 in hepatocytes ameliorates progression of MASH following Jnk deficiency. Hepatology (2025) doi: 10.1097/HEP.0000000000001286. Epub ahead of print.

Colyn L, Grube J, Wang C, Dietrich J, Kühnel M, Reinders J, Edlund K, Jonigk D, Gaßler N, Hengstler J, Trautwein C:

Keap1 Deletion Rescues Cell Death Associated With Gpx4 Loss in Hepatocytes During Acute Liver Injury. Liver Int 45(9): e70210 (2025) doi: 10.1111/liv.70210.

Nell P, Thomitzek A, Feuerborn D, Scholtz-Illigens A, Seidel SM, Derksen K, Chilinski LM, Kattler-Lackes K, Blüthgen N, Morkel M, Walter J, Edlund K, Rahnenführer J, Hengstler JG:

Elimination of CDX2 restricts intestinal hybrid differentiation signatures in stem cell-derived hepatocyte-like cells. Stem Cell Res Ther 16(1): 543 (2025) doi: 10.1186/s13287-025-04696-6

Ghallab A, Myllys M, González D, Friebel A, Hobloss Z, Hassan R, Schmidt H, Siddiqui Q, Zhipeng D, Hendawi R, Begher-Tibbe B, Reinders J, Derksen K, Hofmann U, Duda JC, Ameis L, Möllenhoff K, Seddek A, Abdelmageed N, Strängberg E, Åkerblad P, Vucur M, Luedde T, Stirnimann G, Schwab M, Abbas T, Hild B, Schmidt H, Karpen SJ, Simbrunner B, Mandorfer M, Rahnenführer J, Edlund K, Hoehme S, Trauner M, Dawson PA, Lindström E, Hengstler JG:

Stage-dependent effects of systemic ASBT inhibition in a cholestasis-induced cholemic nephropathy mouse model. JHEP Rep 7(12): 101599 (2025) doi: 10.1016/j.jhepr.2025.101599

Albrecht W, Brecklinghaus T, Stolte M, Kappenberg F, Gründler L, Chen P, Cadenas C, Damm G, Edlund K, Ghallab A, Marchan R, Nell P, Reinders J, Seehofer D, Behr AC, Braeuning A, van Thriel C, Gardner I, Rahnenführer J, Hengstler JG:

Improved identification of human hepatotoxic potential by summary variables of gene expression. ALTEX 42(3): 397-412 (2025) doi: 10.14573/altex.2403272

Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Mattsson J, Marschall HU, Hoehme S, Stirnimann G, Schwab M, Boor P, Amann K, Schmitz J, Bräsen JH, Rahnenführer J, Edlund K, Karpen SJ, Simbrunner B, Reiberger T, Mandorfer M, Trauner M, Dawson PA, Lindström E, Hengstler JG:

Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol 80: 268-281 (2024)

Jaeger JW, Brandt A, Gui W, Yergaliyev T, Hernández-Arriaga A, Muthu MM, Edlund K, Elashy A, Molinaro A, Möckel D, Sarges J, Halibasic E, Trauner M, Kahles F, Rolle-Kampczyk U, Hengstler J, Schneider CV, Lammers T, Marschall HU, von Bergen M, Camarinha-Silva A, Bergheim I, Trautwein C, Schneider KM:

Microbiota modulation by dietary oat beta-glucan prevents steatotic liver disease progression. JHEP Rep 6 (3): 100987 (2024) (14 pp)

Glotzbach A, Rohlf K, Gonscharow A, Lüke S, Demirci Ö, Begher-Tibbe B, Overbeck N, Reinders J, Cadenas C, Hengstler JG, Edlund K, Marchan R:

EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis. Breast Cancer Res 26(1): 87 (2024) (20 pp)

Seidel F, Kappenberg F, Fayyaz S, Scholtz-Illigens A, Cherianidou A, Derksen K, Nell P, Marchan R, Edlund K, Leist M, Sachinidis A, Rahnenführer J, Kreiling R, Hengstler JG:

Risk assessment of parabens in a transcriptomics-based in vitro test. Chem Biol Interact 384: 110699 (2023)