Prof. Dr. Jan G. Hengstler
Head of Department
- since 03/2007Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
- 03/2006 – 02/2007Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
- 04/2003 - 02/2007Professor of Molecular Pharmacology and Toxicology, University of Leipzig
- 11/1990 - 03/2003Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
- 11/1998“Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
- 06/1997Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
- 08/1992License to practice medicine
- 12/1991Thesis (MD): DNA damage in patients treated with alkylating agents
- 10/1984 – 10/1990Study of Medicine, University of Mainz, Germany
- Liver physiology
- Liver pathology
- Imaging of the functions of the liver
Here you will find the Key publications from 2010 onwards. For all other publications of our scientific staff, please look at the links to other databases such as Pubmed.
Schneider KM, Candels LS, Hov JR, Myllys M, Hassan R, Schneider CV, Wahlström A, Mohs A, Zühlke S, Liao L, Elfers C, Kilic K, Henricsson M, Molinaro A, Hatting M, Zaza A, Drasdo D, Frissen M, Devlin AS, Gálvez EJC, Strowig T, Karlsen TH, Hengstler JG, Marschall HU, Ghallab A, Trautwein C:
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling. Nat Metab 3 (9):1228-1241 (2021)
Remetic J, Ghallab A, Hobloss Z, Brackhagen L, Hassan R, Myllys M, Radun R, Mlitz V, Zhu C, Baumgartner M, Schrottmaier WC, Mussbacher M, Timelthaler G, Scharnagl H, Stojakovic T, Assinger A, Fuchs CD, Hengstler JG, Trauner M:
Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology 75: 1095-1109 (2022)
Nell P, Kattler K, Feuerborn D, Hellwig B, Rieck A, Salhab A, Lepikhov K, Gasparoni G, Thomitzek A, Belgasmi K, Blüthgen N, Morkel M, Küppers-Munther B, Godoy P, Hay DC, Cadenas C, Marchan R, Vartak N, Edlund K, Rahnenführer J, Walter J, Hengstler JG:
Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. J Hepatol 77: 1386-1398 (2022)
Mohs A, Otto T, Schneider KM, Peltzer M, Boekschoten M, Holland CH, Hudert CA, Kalveram L, Wiegand S, Saez-Rodriguez J, Longerich T, Hengstler JG, Trautwein C:
Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. J Hepatol 74: 638-648 (2021)
Gui W, Hole MJ, Molinaro A, Edlund K, Jørgensen KK, Su H, Begher-Tibbe B, Gaßler N, Schneider CV, Muthukumarasamy U, Mohs A, Liao L, Jaeger J, Mertens CJ, Bergheim I, Strowig T, Hengstler JG, Hov JR, Marschall HU, Trautwein C, Schneider KM:
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis. Nat Commun 14 (1): 3304 (2023) (17 pp)
Edlund K, Madjar K, Lebrecht A, Aktas B, Pilch H, Hoffmann G, Hofmann M, Kolberg HC, Boehm D, Battista MJ, Seehase M, Stewen K, Gebhard S, Cadenas C, Marchan R, Brenner W, Hasenburg A, Koelbl H, Solbach C, Gehrmann M, Tanner B, Weber K, Loibl S, Sachinidis A, Rahnenführer J, Schmidt M, Hengstler JG:
Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial. Clin Cancer Res 27: 2148-2158 (2021)
Bloch D, Diel P, Epe B, Hellwig M, Lampen A, Mally A, Marko D, Villar Fernández MA, Guth S, Roth A, Marchan R, Ghallab A, Cadenas C, Nell P, Vartak N, van Thriel C, Luch A, Schmeisser S, Herzler M, Landsiedel R, Leist M, Marx-Stoelting P, Tralau T, Hengstler JG:
Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97: 3005-3017 (2023)
Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG:
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93: 1609-1637 (2019)
Vartak N, Drasdo D, Geisler F, Itoh T, Oude Elferink RPJ, van de Graaf SFJ, Chiang J, Keitel V, Trauner M, Jansen P, Hengstler JG:
On the mechanisms of biliary flux. Hepatology 74: 3497-3512 (2021)
Marchan R, Büttner B, Lambert J, Edlund K, Glaeser I, Blaszkewicz M, Leonhardt G, Marienhoff L, Kaszta D, Anft M, Watzl C, Madjar K, Grinberg M, Rempel E, Hergenröder R, Selinski S, Rahnenführer J, Lesjak MS, Stewart JD, Cadenas C, Hengstler JG:
Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma. Cancer Res 77: 4589-4601 (2017)
Jansen PL, Ghallab A, Vartak N, Reif R, Schaap FG, Hampe J, Hengstler JG:
The ascending pathophysiology of cholestatic liver disease. Hepatology 65: 722-738 (2017)
Guth S, Hüser S, Roth A, Degen G, Diel P, Edlund K, Eisenbrand G, Engel K-H, Epe B, Grune T, Heinz V, Henle T, Humpf H-U, Jäger H, Joost H-G, Kulling SE, Lampen A, Mally A, Marchan R, Marko D, Mühle E, Nitsche MA, Röhrdanz E, Stadler R, van Thriel C, Vieths S, Vogel RF, Wascher E, Watzl C, Nöthlings U, Hengstler JG:
Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol 94: 1375-1415 (2020)
Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R:
Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood. Hepatology 69: 666-683 (2019)
Here you will find the Publications from 2010 onwards. For all other publications of our scientific staff, please look at the links to other databases such as Pubmed.
Smets L, Viola MF, Boesch M, Raman J, Van Melkebeke L, Nobis M, Flint E, Pajk N, Brescia P, Silvestri A, Feio-Azevedo R, Modave E, De Herdt L, Sanga A, Pop OT, Govaere O, Verbeek J, Denadai-Souza A, Cassiman D, Vandamme N, Boeckx B, Lambrechts D, Rescigno M, Bernsmeier C, Jones EAV, Hengstler JG, Ghallab A, Scheele CLGJ, Nevens F, Korf H, Boeckxstaens G, Van der Merwe SW:
Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis. Gut (2026) doi: 10.1136/gutjnl-2025-335745. Epub ahead of print.
Bröde P, Claus M, Getzmann S, Golka K, Hengstler JG, Reinders J, Wascher E, Watzl C, Gajewski PD:
Latent Toxoplasma gondii Infection Does Not Modulate Immune Aging in a Cross-Sectional Working-Age Population Study. Biomolecules 16(1): 55 (2026) doi: 10.3390/biom16010055
Dignus P, Albert J, Hengstler JG, Trautwein C:
Die primär sklerosierende Cholangitis als cholestatische Lebererkrankung und Modellerkrankung einer gestörten Darm-Leber-Achse. Gastroenterologie (2026) doi: 10.1007/s11377-025-00953-5. Epub ahead of print.
Zhou P, Hammour MM, Aspera-Werz RH, Ehnert S, Myllys M, Hobloss Z, Hassan R, González D, Hendawi R, Edlund K, Hans S, Laschke MW, Ghallab A, Hengstler JG, Nüssler AK, Maisenbacher TC:
Long-term Western diet feeding impairs hepatic vitamin D metabolism and promotes bone loss in mice. EXCLI J 25: 290-309 (2026) doi: 10.17179/excli2025-9085
Heij L, Hayat S, Reichel K, Maryam S, O'Rourke CJ, Tan X, van den Braber M, Verhoeff J, Halder M, Peisker F, Wiltberger G, Bednarsch J, Heise D, Deierl JC, Lang SA, Ulmer F, Luedde T, Dahl E, Jonigk D, Nolting J, Sivakumar S, Siveke J, Vondran F, Rocha FG, Baba HA, Hartmann S, Andersen JB, Hobloss Z, Ghallab A, Hengstler JG, Vallejo JJG, Kramann R, Neumann U:
Multimodal single-cell profiling reveals crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients. NPJ Precis Oncol (2026) doi: 10.1038/s41698-026-01292-6. Epub ahead of print.
Volkert I, Grube J, Woitok MM, Mohamed MR, Edlund K, Duda JC, Dietrich J, Schneider U, Yin G, Lin C, Erschfeld S, Berger H, Candels L, Davis RJ, Bartneck M, Kühnel MP, Guillot A, Schneider KM, Schneider CV, Jonigk D, Rahnenführer J, Tacke F, Hengstler J, Trautwein C:
Selective genetic inactivation of Caspase 8 in hepatocytes ameliorates progression of MASH following Jnk deficiency. Hepatology 83(2): 344-361 (2026) doi: 10.1097/HEP.0000000000001286
Hazari Y, Habbouche L, Garcia Lopez VA, Urra H, Diaz J, Tamburini G, Milani M, Durand S, Aprahamian F, Baxter R, Huang M, Dong XC, Gonzalez-Rojas L, Francisco SJ, Tapia-Dufey I, Vihinen H, Ratziu V, Foufelle F, Hengstler JG, Jokitalo E, Maiers JL, Plate L, Kroemer G, Bailly-Maitre B, Hetz C:
Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. Hepatology 83(1): 75-93 (2026) doi: 10.1097/HEP.0000000000001335
Bozkurt S, Selinski S, Blaszkewicz M, Reinders J, Hengstler JG, Niggemann L, Golka K:
Follow-up of GSTM1, GSTT1, and NAT2 genotyped patients with knee or hip replacement. EXCLI J 24: 677-689 (2025) doi: 10.17179/excli2025-8565
Gerdemann A, Behrens M, Günther G, Ghallab A, Hengstler JG, Humpf HU, Esselen M:
A simplified LC-MS-based method for sensitive analysis of DNA adducts utilizing accessible in vitro metabolism models. Arch Toxicol 99(10): 4021-4034 (2025) doi: 10.1007/s00204-025-04125-w
Mohamed MR, Zhao G, Volkert I, Molinaro A, Schneider CV, Strnad P, Hengstler JG, Xu C, Davis RJ, Schneider KM, Cubero FJ, Trautwein C:
Differential protective roles of c-Jun N-terminal kinase-2 in non-parenchymal liver cells and hepatocytes during cholestasis. Cell Mol Gastroenterol Hepatol 19(11): 101588 (2025) doi: 10.1016/j.jcmgh.2025.101588