Dr. Cristina Cadenas

Group Leader Interorgan Toxicology

Head of department

Prof. Dr. Jan G. Hengstler

hengstler@ifado.de

+49 231 1084-348

Secretariat

Monika Turajski

turajski@ifado.de

+49 231 1084-349

Address

Ardeystr. 67
44139 Dortmund

since 01/2018
Group leader, Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Department of Toxicology - Prof. Dr. Jan G. Hengstler
07/2013-12/2017
Junior group leader, Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Department of Toxicology - Prof. Dr. Jan G. Hengstler
08/2010-06/2013
Postdoc, Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Department of Toxicology - Prof. Dr. Jan G. Hengstler
01/2008-07/2010
Postdoc, Leibniz-Institute for Analytical Sciences – ISAS - e.V., Dortmund, Department Metabolomics - PD. Dr. J.I. Baumbach, Line of research: "Metabolome analysis of cancer cell lines"
01/2003-12/2007
Family break, Teaching at the public school (Volkshochschule) Dortmund
05/2000-12/2002
Postdoc, Max Planck Institute for experimental Endocrinology, Hannover. Laboratory Prof. Dr. Gregor Eichele, Line of research: "Molecular basis of circadian rhythms"
06/1994-03/2000
Ph.D. Thesis, Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold, Thesis: "Identification of new genes involved in embryonic development by Gene-trap insertional mutagenesis in mouse embryonic stem cells"
09/1988-09/1994
Academic Studies, Biology Study with specialization in Biochemistry and Molecular Biology, Universidad Autónoma, Madrid (Spanien) and Université Paul Sabatier, Toulouse (France), Final Thesis: Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold

Here you will find the Key publications from 2010 onwards. For all other publications of our scientific staff, please look at the links to other databases such as Pubmed.

Nell P, Kattler K, Feuerborn D, Hellwig B, Rieck A, Salhab A, Lepikhov K, Gasparoni G, Thomitzek A, Belgasmi K, Blüthgen N, Morkel M, Küppers-Munther B, Godoy P, Hay DC, Cadenas C, Marchan R, Vartak N, Edlund K, Rahnenführer J, Walter J, Hengstler JG:

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. J Hepatol 77: 1386-1398 (2022)

Ghallab A, Myllys M, Friebel A, Duda J, Edlund K, Halilbasic E, Vucur M, Hobloss Z, Brackhagen L, Begher-Tibbe B, Hassan R, Burke M, Genc E, Frohwein LJ, Hofmann U, Holland CH, González D, Keller M, Seddek A-l, Abbas T, Mohammed ESI, Teufel A, Itzel T, Metzler S, Marchan R, Cadenas C, Watzl C, Nitsche MA, Kappenberg F, Luedde T, Longerich T, Rahnenführer J, Hoehme S, Trauner M, Hengstler JG:

Spatio-temporal multiscale analysis of western diet-fed mice reveals a translationally relevant sequence of events during NAFLD progression. Cells 10 (10): 2516 (2021) (29 pp)

Gianmoena K, Gasparoni N, Jashari A, Gabrys P, Grgas K, Ghallab A, Nordström K, Gasparoni G, Reinders J, Edlund K, Godoy P, Schriewer A, Hayen H, Hudert CA, Damm G, Seehofer D, Weiss TS, Boor P, Anders HJ, Motrapu M, Jansen P, Schiergens TS, Falk-Paulsen M, Rosenstiel P, Lisowski C, Salido E, Marchan R, Walter J, Hengstler JG, Cadenas C:

Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria. Cell Rep 36 (8):109526 (2021) (28 pp)

Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Ponten F, Mardinoglu A, Zhang C, Käfferlein H, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG:

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer. Int J Cancer 145: 901-915 (2019)

Gogiashvili M, Edlund K, Gianmoena K, Marchan R, Brik A, Andersson JT, Lambert J, Madjar K, Hellwig B, Rahnenführer J, Hengstler JG, Hergenröder R, Cadenas C:

Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway. Anal Bioanal Chem 409: 1591-1606 (2017)

Cadenas C, van de Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, Schmidt M, Rahnenführer J, Oster H, Hengstler JG:

Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle 13: 3282-3291 (2014)

Cadenas C, Vosbeck S, Hein EM, Hellwig B, Langer A, Hayen H, Franckenstein D, Büttner B, Hammad S, Marchan R, Hermes M, Selinski S, Rahnenführer J, Peksel B, Török Z, Vígh L, Hengstler JG:

Glycerophospholipid profile in oncogene-induced senescence. Biochim Biophys Acta 1821: 1256-1268 (2012)

Cadenas C, Franckenstein D, Schmidt M, Gehrmann M, Hermes M, Geppert B, Schormann W, Maccoux LJ, Schug M, Schumann A, Wilhelm C, Freis E, Ickstadt K, Rahnenfuhrer J, Baumbach JI, Sickmann A, Hengstler JG:

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer. Breast Cancer Res 12: R44 (2010)

Here you will find the Publications from 2010 onwards. For all other publications of our scientific staff, please look at the links to other databases such as Pubmed.

Kwon Y, Gottmann P, Wang S, Tissink J, Motzler K, Sekar R, Albrecht W, Cadenas C, Hengstler JG, Schürmann A, Zeigerer A:

Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease. J Hepatol 82(1): 18-27 (2025) doi: 10.1016/j.jhep.2024.06.040

Albrecht W, Brecklinghaus T, Stolte M, Kappenberg F, Gründler L, Chen P, Cadenas C, Damm G, Edlund K, Ghallab A, Marchan R, Nell P, Reinders J, Seehofer D, Behr AC, Braeuning A, van Thriel C, Gardner I, Rahnenführer J, Hengstler JG:

Improved identification of human hepatotoxic potential by summary variables of gene expression. ALTEX 42(3): 397-412 (2025) doi: 10.14573/altex.2403272

Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Mattsson J, Marschall HU, Hoehme S, Stirnimann G, Schwab M, Boor P, Amann K, Schmitz J, Bräsen JH, Rahnenführer J, Edlund K, Karpen SJ, Simbrunner B, Reiberger T, Mandorfer M, Trauner M, Dawson PA, Lindström E, Hengstler JG:

Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol 80: 268-281 (2024)

Glotzbach A, Rohlf K, Gonscharow A, Lüke S, Demirci Ö, Begher-Tibbe B, Overbeck N, Reinders J, Cadenas C, Hengstler JG, Edlund K, Marchan R:

EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis. Breast Cancer Res 26(1): 87 (2024) (20 pp)

Maji RK, Czepukojc B, Scherer M, Tierling S, Cadenas C, Gianmoena K, Gasparoni N, Nordström K, Gasparoni G, Laggai S, Yang X, Sinha A, Ebert P, Falk-Paulsen M, Kinkley S, Hoppstädter J, Chung HR, Rosenstiel P, Hengstler JG, Walter J, Schulz MH, Kessler SM, Kiemer AK:

Alterations in the hepatocyte epigenetic landscape in steatosis. Epigenetics Chromatin 16 (1): 30 (2023) (14 pp)

Bloch D, Diel P, Epe B, Hellwig M, Lampen A, Mally A, Marko D, Villar Fernández MA, Guth S, Roth A, Marchan R, Ghallab A, Cadenas C, Nell P, Vartak N, van Thriel C, Luch A, Schmeisser S, Herzler M, Landsiedel R, Leist M, Marx-Stoelting P, Tralau T, Hengstler JG:

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97: 3005-3017 (2023)

Keller M, Rohlf K, Glotzbach A, Leonhardt G, Lüke S, Derksen K, Demirci Ö, Göçener D, AlWahsh M, Lambert J, Lindskog C, Schmidt M, Brenner W, Baumann M, Zent E, Zischinsky M-L, Hellwig B, Madjar K, Rahnenführer J, Overbeck N, Reinders J, Cadenas C, Hengstler JG, Edlund K, Marchan R:

Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth. J Exp Clin Cancer Res 42 (1): 25 (2023) (18 pp)

Holland CH, Ramirez Flores RO, Myllys M, Hassan R, Edlund K, Hofmann U, Marchan R, Cadenas C, Reinders J, Hoehme S, Seddek AL, Dooley S, Keitel V, Godoy P, Begher-Tibbe B, Trautwein C, Rupp C, Mueller S, Longerich T, Hengstler JG, Saez-Rodriguez J, Ghallab A:

Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice. Hepatol Commun 6: 161-177 (2022)

Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Vartak N, Edlund K, Marchan R, Ghallab A, Cadenas C, Günther G, Leist M, Zhang M, Gardner I, Reinders J, Russel FGM, Foster AJ, Williams DP, Damle-Vartak A, Grandits M, Ecker G, Kittana N, Rahnenführer J, Hengstler JG:

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. Chem Biol Interact 351: 109728 (2022) (16 pp)

Gajewski PD, Getzmann S, Bröde P, Burke M, Cadenas C, Capellino S, Claus M, Genç E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E:

Impact of biological and lifestyle factors on cognitive aging and work ability in the Dortmund Vital Study: Protocol of an interdisciplinary, cross-sectional, and longitudinal study. JMIR Res Protoc 11 (3): e32352 (2022) (18 pp)