Publications Toxicology

Volkert I, Grube J, Woitok MM, Mohamed MR, Edlund K, Duda JC, Dietrich J, Schneider U, Yin G, Lin C, Erschfeld S, Berger H, Candels L, Davis RJ, Bartneck M, Kühnel MP, Guillot A, Schneider KM, Schneider CV, Jonigk D, Rahnenführer J, Tacke F, Hengstler J, Trautwein C:

Selective genetic inactivation of Caspase 8 in hepatocytes ameliorates progression of MASH following Jnk deficiency. Hepatology (2025) doi: 10.1097/HEP.0000000000001286. Epub ahead of print.

Kauth F, Bertolini A, Wendel EM, Koukou G, Naggar IE, Chung J, Baumann M, Schödl C, Lechner C, Bigi S, Blaschek A, Hengstler JG, Schimmel M, Nosadini M, Sartori S, Puthenparampil M, Van's Gravesande KS, Drenckhahn A, Nikolaus M, Kauffmann B, Thiels C, Häusler MG, Eckenweiler M, Karenfort M, Marina AD, Selek A, Öncel I, Kornek B, Reindl M, Rostásy K:

Characterization of children with early onset pediatric multiple sclerosis. Eur J Paediatr Neurol 54: 113-120 (2025) doi: 10.1016/j.ejpn.2025.01.006

Schneider AT, Koppe C, Crouchet E, Papargyriou A, Singer MT, Büttner V, Keysberg L, Szydlowska M, Jühling F, Moehlin J, Chen MC, Leone V, Mueller S, Neuß T, Castoldi M, Lesina M, Bergmann F, Hackert T, Steiger K, Knoefel WT, Zaufel A, Kather JN, Esposito I, Gaida MM, Ghallab A, Hengstler JG, Einwächter H, Unger K, Algül H, Gassler N, Schmid RM, Rad R, Baumert TF, Reichert M, Heikenwalder M, Kondylis V, Vucur M, Luedde T:

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development. Nat Commun 16: 1765 (2025) doi: 10.1038/s41467-025-56493-7

Engeli BE, Lachenmeier DW, Diel P, Guth S, Villar Fernandez MA, Roth A, Lampen A, Cartus AT, Wätjen W, Hengstler JG, Mally A:

Cannabidiol in Foods and Food Supplements: Evaluation of Health Risks and Health Claims. Nutrients 17(3): 489 (2025) doi: 10.3390/nu17030489

Albrecht W, Brecklinghaus T, Stolte M, Kappenberg F, Gründler L, Chen P, Cadenas C, Damm G, Edlund K, Ghallab A, Marchan R, Nell P, Reinders J, Seehofer D, Behr AC, Braeuning A, van Thriel C, Gardner I, Rahnenführer J, Hengstler JG:

Improved identification of human hepatotoxic potential by summary variables of gene expression. ALTEX 42(3): 397-412 (2025) doi: 10.14573/altex.2403272

Kurze I, Jakisch E, Jakisch M, Werner F, Kowald B, Golka K, Böthig R:

Indications, feasibility safety and efficacy of dorsal rhizotomy at the level of the conus medullaris (conus deafferentation) in individuals with spinal cord injury. J Spinal Cord Med 1-9 (2025) doi: 10.1080/10790268.2024.2442151. Epub ahead of print.

Link F, Li Y, Zhao J, Munker S, Fan W, Nwosu ZC, Yao Y, Wang S, Huang C, Liebe R, Hammad S, Liu H, Shao C, Gao C, Sun B, Török NJ, Ding H, Ebert MP, Weng H, Ten Dijke P, Drasdo D, Dooley S, Wang S:

ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation. Gut 74(3): 424-439 (2025) doi: 10.1136/gutjnl-2024-333213

Schürmeyer L, Peng C, Albrecht W, Brecklinghaus T, Baur P, Hengstler JG, Schorning K:

Design of optimal concentrations for in vitro cytotoxicity experiments. Arch Toxicol 99(1): 357-376 (2025) doi: 10.1007/s00204-024-03893-1

Fromme M, Payancé A, Mandorfer M, Thorhauge KH, Pons M, Miravitlles M, Stolk J, van Hoek B, Stirnimann G, Frankova S, Sperl J, Kremer AE, Burbaum B, Schrader C, Kadioglu A, Walkenhaus M, Schneider CV, Klebingat F, Balcar L, Kappe NN, Schaefer B, Chorostowska-Wynimko J, Aigner E, Gensluckner S, Striedl P, Roger P, Ryan J, Roche S, Vögelin M, Ala A, Bantel H, Verbeek J, Mariño Z, Praktiknjo M, Gevers TJG, Reuken PA, Berg T, George J, Demir M, Bruns T, Trautwein C, Zoller H, Trauner M, Genesca J, Griffiths WJ, Clark V, Krag A, Turner AM, McElvaney NG, Strnad P:

Longitudinal evaluation of individuals with severe alpha-1 antitrypsin deficiency (Pi∗ZZ Genotype). Gastroenterology 168(2): 367-381 (2025) doi: 10.1053/j.gastro.2024.10.010

Lin C, Kuzmanović A, Wang N, Liao L, Ernst S, Penners C, Jans A, Hammoor T, Stach PB, Peltzer M, Volkert I, Zechendorf E, Hassan R, Myllys M, Liedtke C, Herrmann A, Chakraborty G, Trautwein C, Hengstler J, Müller-Newen G, Wang J, Ghallab A, Bartneck M:

Exceptional uptake, limited protein expression: liver macrophages lost in translation of synthetic mRNA. Adv Sci (Weinh) 12(9):e2409729 (2025) doi: 10.1002/advs.202409729