Publikationen Toxikologie

Arechederra M, Bik E, Rojo C, Elurbide J, Elizalde M, Kruk B, Krasnodębski M, Pertkiewicz J, Kozieł S, Grąt M, Raszeja-Wyszomirska J, Rullan M, Alkorta-Aranburu G, Oyón D, Fernández-Barrena MG, Candels LS, Białek A, Krupa Ł, Schneider KM, Urman J, Strnad P, Trautwein C, Milkiewicz P, Krawczyk M, Ávila MA, Berasain C:

Mutational Analysis of Bile Cell-Free DNA in Primary Sclerosing Cholangitis: A Pilot Study. Liver Int. 2025; 45(11):e70049. doi: 10.1111/liv.70049

Kerbert AJC, Engelmann C, Habtesion A, Kumar P, Hassan M, Qi T, Volkert I, Otto T, Hall A, Khetan VU, Olde Damink S, Aguilar F, Chollet C, Brunet L, Clària J, Moreau R, Arroyo V, Coenraad MJ, Mehta G, Castelli F, Trautwein C, Fenaille F, Andreola F, Jalan R:

Hyperammonemia induces programmed liver cell death. Sci Adv. 2025; 11(10):eado1648. doi: 10.1126/sciadv.ado1648

Volkert I, Grube J, Woitok MM, Mohamed MR, Edlund K, Duda JC, Dietrich J, Schneider U, Yin G, Lin C, Erschfeld S, Berger H, Candels L, Davis RJ, Bartneck M, Kühnel MP, Guillot A, Schneider KM, Schneider CV, Jonigk D, Rahnenführer J, Tacke F, Hengstler J, Trautwein C:

Selective genetic inactivation of Caspase 8 in hepatocytes ameliorates progression of MASH following Jnk deficiency. Hepatology. 2025. doi: 10.1097/HEP.0000000000001286. Epub ahead of print.

Kauth F, Bertolini A, Wendel EM, Koukou G, Naggar IE, Chung J, Baumann M, Schödl C, Lechner C, Bigi S, Blaschek A, Hengstler JG, Schimmel M, Nosadini M, Sartori S, Puthenparampil M, Van's Gravesande KS, Drenckhahn A, Nikolaus M, Kauffmann B, Thiels C, Häusler MG, Eckenweiler M, Karenfort M, Marina AD, Selek A, Öncel I, Kornek B, Reindl M, Rostásy K:

Characterization of children with early onset pediatric multiple sclerosis. Eur J Paediatr Neurol. 2025; 54:113-120. doi: 10.1016/j.ejpn.2025.01.006

Schneider AT, Koppe C, Crouchet E, Papargyriou A, Singer MT, Büttner V, Keysberg L, Szydlowska M, Jühling F, Moehlin J, Chen MC, Leone V, Mueller S, Neuß T, Castoldi M, Lesina M, Bergmann F, Hackert T, Steiger K, Knoefel WT, Zaufel A, Kather JN, Esposito I, Gaida MM, Ghallab A, Hengstler JG, Einwächter H, Unger K, Algül H, Gassler N, Schmid RM, Rad R, Baumert TF, Reichert M, Heikenwalder M, Kondylis V, Vucur M, Luedde T:

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development. Nat Commun. 2025; 16:1765. doi: 10.1038/s41467-025-56493-7

Engeli BE, Lachenmeier DW, Diel P, Guth S, Villar Fernandez MA, Roth A, Lampen A, Cartus AT, Wätjen W, Hengstler JG, Mally A:

Cannabidiol in Foods and Food Supplements: Evaluation of Health Risks and Health Claims. Nutrients. 2025; 17(3):489. doi: 10.3390/nu17030489

Albrecht W, Brecklinghaus T, Stolte M, Kappenberg F, Gründler L, Chen P, Cadenas C, Damm G, Edlund K, Ghallab A, Marchan R, Nell P, Reinders J, Seehofer D, Behr AC, Braeuning A, van Thriel C, Gardner I, Rahnenführer J, Hengstler JG:

Improved identification of human hepatotoxic potential by summary variables of gene expression. ALTEX. 2025. doi: 10.14573/altex.2403272. Epub ahead of print.

Kurze I, Jakisch E, Jakisch M, Werner F, Kowald B, Golka K, Böthig R:

Indications, feasibility safety and efficacy of dorsal rhizotomy at the level of the conus medullaris (conus deafferentation) in individuals with spinal cord injury. J Spinal Cord Med. 2025; 1-9. doi: 10.1080/10790268.2024.2442151. Epub ahead of print.

Link F, Li Y, Zhao J, Munker S, Fan W, Nwosu ZC, Yao Y, Wang S, Huang C, Liebe R, Hammad S, Liu H, Shao C, Gao C, Sun B, Török NJ, Ding H, Ebert MP, Weng H, Ten Dijke P, Drasdo D, Dooley S, Wang S:

ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation. Gut. 2025; 74(3):424-439. doi: 10.1136/gutjnl-2024-333213

Schürmeyer L, Peng C, Albrecht W, Brecklinghaus T, Baur P, Hengstler JG, Schorning K:

Design of optimal concentrations for in vitro cytotoxicity experiments. Arch Toxicol. 2025; 99(1):357-376. doi: 10.1007/s00204-024-03893-1

Fromme M, Payancé A, Mandorfer M, Thorhauge KH, Pons M, Miravitlles M, Stolk J, van Hoek B, Stirnimann G, Frankova S, Sperl J, Kremer AE, Burbaum B, Schrader C, Kadioglu A, Walkenhaus M, Schneider CV, Klebingat F, Balcar L, Kappe NN, Schaefer B, Chorostowska-Wynimko J, Aigner E, Gensluckner S, Striedl P, Roger P, Ryan J, Roche S, Vögelin M, Ala A, Bantel H, Verbeek J, Mariño Z, Praktiknjo M, Gevers TJG, Reuken PA, Berg T, George J, Demir M, Bruns T, Trautwein C, Zoller H, Trauner M, Genesca J, Griffiths WJ, Clark V, Krag A, Turner AM, McElvaney NG, Strnad P:

Longitudinal evaluation of individuals with severe alpha-1 antitrypsin deficiency (Pi∗ZZ Genotype). Gastroenterology. 2025; 168(2):367-381. doi: 10.1053/j.gastro.2024.10.010

Lin C, Kuzmanović A, Wang N, Liao L, Ernst S, Penners C, Jans A, Hammoor T, Stach PB, Peltzer M, Volkert I, Zechendorf E, Hassan R, Myllys M, Liedtke C, Herrmann A, Chakraborty G, Trautwein C, Hengstler J, Müller-Newen G, Wang J, Ghallab A, Bartneck M:

Exceptional uptake, limited protein expression: liver macrophages lost in translation of synthetic mRNA. Adv Sci (Weinh). 2025; 12(9):e2409729. doi: 10.1002/advs.202409729

Blum J, Brüll M, Hengstler JG, Dietrich DR, Gruber AJ, Dipalo M, Kraushaar U, Mangas I, Terron A, Fritsche E, Marx-Stoelting P, Hardy B, Schepky A, Escher S, Hartung T, Landsiedel R, Odermatt A, Sachana M, Koch K, Dönmez A, Masjosthusmann S, Bothe K, Schildknecht S, Beilmann M, Beltman JB, Fitzpatrick S, Mangerich A, Rehm M, Tangianu S, Zickgraf FM, Kamp H, Burger G, van de Water B, Kleinstreuer N, White A, Leist M:

The long way from raw data to NAM-based information: Overview on data layers and processing steps. ALTEX. 2025; 42(1):167-180. doi: 10.14573/altex.2412171

Gajewski PD, Bröde P, Claus M, Golka K, Hengstler JG, Watzl C, Wascher E, Getzmann S:

The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers. Brain Behav Immun Health. 2025; 43:100909. doi: 10.1016/j.bbih.2024.100909

Elurbide J, Colyn L, Latasa MU, Uriarte I, Mariani S, Lopez-Pascual A, Valbuena E, Castello-Uribe B, Arnes-Benito R, Adan-Villaescusa E, Martinez-Perez LA, Azkargorta M, Elortza F, Wu H, Krawczyk M, Schneider KM, Sangro B, Aldrighetti L, Ratti F, Casadei Gardini A, Marin JJG, Amat I, Urman JM, Arechederra M, Martinez-Chantar ML, Trautwein C, Huch M, Cubero FJ, Berasain C, G Fernandez-Barrena M, Avila MA:

Identification of PRMT5 as a therapeutic target in cholangiocarcinoma. Gut. 2024; 74(1):116-127. doi: 10.1136/gutjnl-2024-332998