Head of department
Prof. Dr. Jan G. Hengstler
Ardeystr. 67
44139 Dortmund

Publications Toxicology

Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): Consideration of genotoxic potential for α,β-unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones. EFSA Journal 21 (4): e07967 (2023) (16 pp)
Flavouring Group Evaluation 76 Revision 2 (FGE.76Rev2): Consideration of sulfur-containing heterocyclic compounds, evaluated by JECFA, structurally related to thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev5. EFSA Journal 21 (2): e07784 (2023) (65 pp)
Classification of hepatotoxicity of compounds based on cytotoxicity assays is improved by additional interpretable summaries of high-dimensional gene expression data. Comput Toxicol 28: 100288 (2023) (8 pp)
Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice. Front Pharmacol 14: 1279357 (2023) (14 pp)
Radikale Zystektomie bei querschnittgelähmten Patienten. UroForum 14 (9): 22-26 (2023)
Acetaldehyde as a food flavoring substance: aspects of risk assessment. Mol Nutr Food Res 67: 2200661 (2023) (29 pp)
Cognitive functions, neurotransmitter alterations, and hippocampal microstructural changes in mice caused by feeding on western diet. Cells 12 (18): 2331 (2023) (20 pp)
PFASs-restriction proposal commentary on ECHA's Annex XV restriction report, proposal for a restriction, March 2023. (Guest editorial). Arch Toxicol 97: 3305-3312 (2023)
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC-MS/MS. Arch Toxicol 97: 3179-3196 (2023)
Guidance for statistical design and analysis of toxicological dose-response experiments, based on a comprehensive literature review. Arch Toxicol 97: 2741-2761 (2023)
Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells. Cell Death Discov 9 (1): 321 (2023) (12 pp)
Risk assessment of parabens in a transcriptomics-based in vitro test. Chem Biol Interact 384: 110699 (2023)
Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97: 3005-3017 (2023)
Vinpocetine protects against chloroquine-induced cardiotoxicity by mitigating oxidative stress. Arch Toxicol 97: 2763–2770 (2023)
Bladder cancer course, four genetic high-risk variants, and histopathological findings. EXCLI J 22: 867-879 (2023)