Publications Toxicology

Dignus P, Albert J, Hengstler JG, Trautwein C:

Die primär sklerosierende Cholangitis als cholestatische Lebererkrankung und Modellerkrankung einer gestörten Darm-Leber-Achse. Gastroenterologie 21: 14-24 (2026) doi: 10.1007/s11377-025-00953-5

EFSA Panel on Food Additives and Flavourings (FAF), u.a. Degen G:

Safety evaluation of the modification of the food additive enzymatically produced steviol glycosides (E 960c). EFSA J 24(1): e9779 (2026) doi: 10.2903/j.efsa.2026.9779

Bröde P, Claus M, Getzmann S, Golka K, Hengstler JG, Reinders J, Wascher E, Watzl C, Gajewski PD:

Latent Toxoplasma gondii Infection Does Not Modulate Immune Aging in a Cross-Sectional Working-Age Population Study. Biomolecules 16(1): 55 (2026) doi: 10.3390/biom16010055

Herta T, Franke A, Müller T, Stein K, Bantel H, Günther R, Denk G, Reuken PA, Schattenberg JM, Naumann U, Böttler T, Weber A, Zeuzem S, Hinz M, Greinert R, Berg C, Wissniowski TT, Simon KG, Trebicka J, Behrens R, Grümmer H, Hofmann WP, Dikopoulos N, Sarrazin C, Roeb E, Muche M, Ringelhan M, Teufel A, Merle U, Keitel V, Marquardt JU, Kautz A, Tacke F, Piotrowski K, Köppe-Bauernfeind N, Trautwein C, Berg T, Wiegand J, Kremer AE:

Pruritus in primary biliary cholangitis: insights from the German PBC registry across secondary and tertiary care. Ann Hepatol 31(1): 102140 (2026) doi: 10.1016/j.aohep.2025.102140

Smets L, Viola MF, Boesch M, Raman J, Van Melkebeke L, Nobis M, Flint E, Pajk N, Brescia P, Silvestri A, Feio-Azevedo R, Modave E, De Herdt L, Sanga A, Pop OT, Govaere O, Verbeek J, Denadai-Souza A, Cassiman D, Vandamme N, Boeckx B, Lambrechts D, Rescigno M, Bernsmeier C, Jones EAV, Hengstler JG, Ghallab A, Scheele CLGJ, Nevens F, Korf H, Boeckxstaens G, Van der Merwe SW:

Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis. Gut (2026) doi: 10.1136/gutjnl-2025-335745

Goldring CE, Russomanno G, Pin C, Trairatphisan P, Beattie KA, Fisher CP, Piñero J, Brennan RJ, Clausznitzer D, Copple IM, de Kok TM, Duckworth CA, Furlong LI, Füzi B, Gabor A, Gall L, Hengstler J, Hermjakob H, Hunter F, Jennen D, Koskinen M, Kunnen SJ, Lammens L, Lobentanzer S, Mohr M, Passini E, Pritchard DM, Malik-Sheriff RS, Rodríguez B, Rossman EI, Saez-Rodríguez J, Schmidt F, Sison-Young R, Soininen I, Turner S, van de Water B, van Hasselt JGC, Venezia F, Willy JA, Leishman DJ, Stevens JL, Laplanche L:

Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety. Nat Rev Drug Discov 25: 138–153 (2026) doi: 10.1038/s41573-025-01308-z

Wu W, Liu J, Chen X, Zhu P, Xu J, Yue J, Liu X, Fang J, Chen X, Pi J, Zheng L, Zhang Q, Zhang L, Schneider CV, Schneider KM, Trautwein C, Gao P, Reilly MP, Zhang Y, Zheng X, Liu J:

Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure. Eur Heart J 47(14): 1721–1737 (2026) doi: 10.1093/eurheartj/ehaf742

Alimba CG, Adesida SO, Owonikoko WM, Oteyola AO:

Micro (Nano)plastics Vitiation of Genetic Material: Systematic Review of Genotoxic Biomarkers and Model Bioindicators. J Appl Toxicol 46(1): 110-140 (2026) doi: 10.1002/jat.4928

Temprano AG, Romero MR, Ghallab A, Llera L, Macias RIR, van Eijk HM, Rullán M, Urman J, Ay Ü, Lenicek M, Hengstler JG, Neumann UP, Berasain C, Avila MA, Olde Damink SWM, Monte MJ, Marin JJG, Schaap FG:

Gut-to-Bile transfer of microbially amidated minor bile acids in patients with hepatopancreatobiliary disorders. Hepatology 83(5): 1158-1173 (2026) doi: 10.1097/HEP.0000000000001441

Hazari Y, Habbouche L, Garcia Lopez VA, Urra H, Diaz J, Tamburini G, Milani M, Durand S, Aprahamian F, Baxter R, Huang M, Dong XC, Gonzalez-Rojas L, Francisco SJ, Tapia-Dufey I, Vihinen H, Ratziu V, Foufelle F, Hengstler JG, Jokitalo E, Maiers JL, Plate L, Kroemer G, Bailly-Maitre B, Hetz C:

Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. Hepatology 83(1): 75-93 (2026) doi: 10.1097/HEP.0000000000001335