Dr. Rosemarie Marchan

Leitung Forschungsgruppe Zellmetabolismus

seit 01/2018
Gruppenleitung am Leibniz-Institut für Arbeitsforschung, Abteilung Toxikologie - Prof. Dr. Jan G. Hengstler
08/2010-12/2017
Juniorgruppenleitung am Leibniz-Institut für Arbeitsforschung, Abteilung Toxikologie - Prof. Dr. Jan G. Hengstler
01/2008-07/2010:
Postdoc, Institut für Analytische Wissenschaften ISAS e.V., Dortmund, Abt. Metabolomics, PD Dr. J.I. Baumbach, Line of research: 'Metabolome analysis of cancer cell lines'
05/2008
PhD, Toxicology, University of Rochester Medical Centre, Rochester, USA, Titel der Doktorarbeit: Mechanism of cellular glutathione (GSH) export in apoptosis
05/2005
M.Sc., Toxicology, University of Rochester Medical Centre, Rochester, USA
05/2002
B.Sc., Environmental Sciences, North Carolina Central University, Durham, USA
05/2002
B.Sc., Biology, North Carolina Central University, Durham, USA

Hier finden Sie die Publikationen ab 2010, die am IfADo entstanden sind. Für alle anderen Veröffentlichungen unserer wissenschaftlichen Mitarbeiter beachten Sie bitte die Links zu anderen Datenbanken wie Pubmed.

Bloch D, Diel P, Epe B, Hellwig M, Lampen A, Mally A, Marko D, Villar Fernández MA, Guth S, Roth A, Marchan R, Ghallab A, Cadenas C, Nell P, Vartak N, van Thriel C, Luch A, Schmeisser S, Herzler M, Landsiedel R, Leist M, Marx-Stoelting P, Tralau T, Hengstler JG. Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97:

3005-3017 (2023)

Seidel F, Kappenberg F, Fayyaz S, Scholtz-Illigens A, Cherianidou A, Derksen K, Nell P, Marchan R, Edlund K, Leist M, Sachinidis A, Rahnenführer J, Kreiling R, Hengstler JG:

Risk assessment of parabens in a transcriptomics-based in vitro test. Chem Biol Interact 384: 110699 (2023)

Keller M, Rohlf K, Glotzbach A, Leonhardt G, Lüke S, Derksen K, Demirci Ö, Göçener D, AlWahsh M, Lambert J, Lindskog C, Schmidt M, Brenner W, Baumann M, Zent E, Zischinsky M-L, Hellwig B, Madjar K, Rahnenführer J, Overbeck N, Reinders J, Cadenas C, Hengstler JG, Edlund K, Marchan R:

Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth. J Exp Clin Cancer Res 42 (1): 25 (2023) (18 pp)

Holland CH, Ramirez Flores RO, Myllys M, Hassan R, Edlund K, Hofmann U, Marchan R, Cadenas C, Reinders J, Hoehme S, Seddek AL, Dooley S, Keitel V, Godoy P, Begher-Tibbe B, Trautwein C, Rupp C, Mueller S, Longerich T, Hengstler JG, Saez-Rodriguez J, Ghallab A:

Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice. Hepatol Commun 6: 161-177 (2022)

Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Vartak N, Edlund K, Marchan R, Ghallab A, Cadenas C, Günther G, Leist M, Zhang M, Gardner I, Reinders J, Russel FGM, Foster AJ, Williams DP, Damle-Vartak A, Grandits M, Ecker G, Kittana N, Rahnenführer J, Hengstler JG:

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. Chem Biol Interact 351: 109728 (2022) (16 pp)

Gajewski PD, Getzmann S, Bröde P, Burke M, Cadenas C, Capellino S, Claus M, Genç E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E:

Impact of biological and lifestyle factors on cognitive aging and work ability in the Dortmund Vital Study: Protocol of an interdisciplinary, cross-sectional, and longitudinal study. JMIR Res Protoc 11 (3): e32352 (2022) (18 pp)

Alwahsh M, Knitsch R, Marchan R, Lambert J, Hoerner C, Zhang X, Schalke B, Lee DH, Bulut E, Graeter T, Ott G, Kurz KS, Preissler G, Schölch S, Farhat J, Yao Z, Sticht C, Ströbel P, Hergenröder R, Marx A, Belharazem D:

Metabolic profiling of thymic epithelial tumors hints to a strong Warburg effect, glutaminolysis and precarious redox homeostasis as potential therapeutic targets. Cancers (Basel) 14 (6): 1564 (2022) (22 pp)

Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Zhang M, Gardner I, Marchan R, Ghallab A, Turgunbayer ÖD, Rahnenführer J, Hengstler JG:

Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes. Toxicol In Vitro 81: 105344 (2022)

Ghallab A, Hassan R, Hofmann U, Friebel A, Hobloss Z, Brackhagen L, Begher-Tibbe B, Myllys M, Reinders J, Overbeck N, Sezgin S, Zühlke S, Seddek AL, Murad W, Brecklinghaus T, Kappenberg F, Rahnenführer J, González D, Goldring C, Copple IM, Marchan R, Longerich T, Vucur M, Luedde T, Urban S, Canbay A, Schreiter T, Trauner M, Akakpo JY, Olyaee M, Curry SC, Sowa JP, Jaeschke H, Hoehme S, Hengstler JG:

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. J Hepatol 77: 71-83 (2022)

Nell P, Kattler K, Feuerborn D, Hellwig B, Rieck A, Salhab A, Lepikhov K, Gasparoni G, Thomitzek A, Belgasmi K, Blüthgen N, Morkel M, Küppers-Munther B, Godoy P, Hay DC, Cadenas C, Marchan R, Vartak N, Edlund K, Rahnenführer J, Walter J, Hengstler JG:

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. J Hepatol 77: 1386-1398 (2022)

Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG:

Classification of developmental toxicants in a human iPSC transcriptomics-based test. Chem Res Toxicol 35: 760–773 (2022)

Brecklinghaus T, Albrecht W, Duda J, Kappenberg F, Gründler L, Edlund K, Marchan R, Ghallab A, Cadenas C, Rieck A, Vartak N, Tolosa L, Castell JV, Gardner I, Halilbasic E, Trauner M, Ullrich A, Zeigerer A, Demirci Turgunbayer Ö, Damm G, Seehofer D, Rahnenführer J, Hengstler JG:

In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay. Toxicol Lett 368: 33-46 (2022)

Hassan R, Friebel A, Brackhagen L, Hobloss Z, Myllys M, González D, Albrecht W, Mohammed ESI, Seddek A-L, Marchan R, Cadenas C, Cramer B, Humpf H-U, Hartl L, Simbrunner B, Reiberger T, Trauner M, Hoehme S, Degen GH, Hengstler JG, Ghallab A:

Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity. Arch Toxicol 96: 2967–2981 (2022)

Hassan R, González D, Hobloss Z, Brackhagen L, Myllys M, Friebel A, Seddek A-l, Marchan R, Cramer B, Humpf H-U, Hoehme S, Degen GH, Hengstler JG, Ghallab A:

Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A. Arch Toxicol 96: 3349–3361 (2022)

Hassan R, Myllys M, Brackhagen L, Hobloss Z, González D, Seddek A-L, Friebel A, Hoehme S, Marchan R, Trauner M, Hengstler JG, Ghallab A:

Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins. Arch Toxicol 96: 3067-3076 (2022)