Publikationen Toxikologie

Heij L, Hayat S, Reichel K, Maryam S, O'Rourke CJ, Tan X, van den Braber M, Verhoeff J, Halder M, Peisker F, Wiltberger G, Bednarsch J, Heise D, Deierl JC, Lang SA, Ulmer F, Luedde T, Dahl E, Jonigk D, Nolting J, Sivakumar S, Siveke J, Vondran F, Rocha FG, Baba HA, Hartmann S, Andersen JB, Hobloss Z, Ghallab A, Hengstler JG, Vallejo JJG, Kramann R, Neumann U:

Multimodal single-cell profiling reveals crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients. NPJ Precis Oncol 10: 105 (2026) doi: 10.1038/s41698-026-01292-6

Zhou P, Hammour MM, Aspera-Werz RH, Ehnert S, Myllys M, Hobloss Z, Hassan R, González D, Hendawi R, Edlund K, Hans S, Laschke MW, Ghallab A, Hengstler JG, Nüssler AK, Maisenbacher TC:

Long-term Western diet feeding impairs hepatic vitamin D metabolism and promotes bone loss in mice. EXCLI J 25: 290-309 (2026) doi: 10.17179/excli2025-9085

Roth A, Franz CMAP, Hertwig S, Holzhauser T, Hertel C, Humpf HU, Engel KH, Schwarzenbolz U, Schlüter O, Jäger H, Aganovic K, Heinz V:

Limitations and safety aspects related to the use of bacteriophages in food production. FEMS Microbiol Rev 50: fuag002 (2026) doi: 10.1093/femsre/fuag002

Dignus P, Albert J, Hengstler JG, Trautwein C:

Die primär sklerosierende Cholangitis als cholestatische Lebererkrankung und Modellerkrankung einer gestörten Darm-Leber-Achse. Gastroenterologie 21: 14-24 (2026) doi: 10.1007/s11377-025-00953-5

EFSA Panel on Food Additives and Flavourings (FAF), u.a. Degen G:

Safety evaluation of the modification of the food additive enzymatically produced steviol glycosides (E 960c). EFSA J 24(1): e9779 (2026) doi: 10.2903/j.efsa.2026.9779

Bröde P, Claus M, Getzmann S, Golka K, Hengstler JG, Reinders J, Wascher E, Watzl C, Gajewski PD:

Latent Toxoplasma gondii Infection Does Not Modulate Immune Aging in a Cross-Sectional Working-Age Population Study. Biomolecules 16(1): 55 (2026) doi: 10.3390/biom16010055

Herta T, Franke A, Müller T, Stein K, Bantel H, Günther R, Denk G, Reuken PA, Schattenberg JM, Naumann U, Böttler T, Weber A, Zeuzem S, Hinz M, Greinert R, Berg C, Wissniowski TT, Simon KG, Trebicka J, Behrens R, Grümmer H, Hofmann WP, Dikopoulos N, Sarrazin C, Roeb E, Muche M, Ringelhan M, Teufel A, Merle U, Keitel V, Marquardt JU, Kautz A, Tacke F, Piotrowski K, Köppe-Bauernfeind N, Trautwein C, Berg T, Wiegand J, Kremer AE:

Pruritus in primary biliary cholangitis: insights from the German PBC registry across secondary and tertiary care. Ann Hepatol 31(1): 102140 (2026) doi: 10.1016/j.aohep.2025.102140

Smets L, Viola MF, Boesch M, Raman J, Van Melkebeke L, Nobis M, Flint E, Pajk N, Brescia P, Silvestri A, Feio-Azevedo R, Modave E, De Herdt L, Sanga A, Pop OT, Govaere O, Verbeek J, Denadai-Souza A, Cassiman D, Vandamme N, Boeckx B, Lambrechts D, Rescigno M, Bernsmeier C, Jones EAV, Hengstler JG, Ghallab A, Scheele CLGJ, Nevens F, Korf H, Boeckxstaens G, Van der Merwe SW:

Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis. Gut (2026) doi: 10.1136/gutjnl-2025-335745

Goldring CE, Russomanno G, Pin C, Trairatphisan P, Beattie KA, Fisher CP, Piñero J, Brennan RJ, Clausznitzer D, Copple IM, de Kok TM, Duckworth CA, Furlong LI, Füzi B, Gabor A, Gall L, Hengstler J, Hermjakob H, Hunter F, Jennen D, Koskinen M, Kunnen SJ, Lammens L, Lobentanzer S, Mohr M, Passini E, Pritchard DM, Malik-Sheriff RS, Rodríguez B, Rossman EI, Saez-Rodríguez J, Schmidt F, Sison-Young R, Soininen I, Turner S, van de Water B, van Hasselt JGC, Venezia F, Willy JA, Leishman DJ, Stevens JL, Laplanche L:

Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety. Nat Rev Drug Discov 25: 138–153 (2026) doi: 10.1038/s41573-025-01308-z

Wu W, Liu J, Chen X, Zhu P, Xu J, Yue J, Liu X, Fang J, Chen X, Pi J, Zheng L, Zhang Q, Zhang L, Schneider CV, Schneider KM, Trautwein C, Gao P, Reilly MP, Zhang Y, Zheng X, Liu J:

Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure. Eur Heart J 47(14): 1721–1737 (2026) doi: 10.1093/eurheartj/ehaf742