Publikationen

  • Brecklinghaus, T.; Albrecht, W.; Kappenberg, F.; Duda, J.; Marchan, R.; Ghallab, A.; Rahnenführer, J.; Hengstler, J. G.: Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes
    Toxicol. in Vitro 81: 105344 (2022)
    https://doi.org/10.1016/j.tiv.2022.105344
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  • Budelmann, D.; Laue, H.; Weiss, N.; Ghallab, A.; Hassan, R.; Begher-Tibbe, B.; Hengstler, J. G.; Schwen, L. O.: Automated detection of portal fields and central veins in whole-slide images of liver tissue
    J. Pathol. Inform. 13: 100001 (11 pp) (2022)
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    https://doi.org/10.1016/j.jpi.2022.100001
  • Brecklinghaus, T.; Albrecht, W.; Kappenberg, F.; Duda, J.; Vartak, N.; Edlund, K.; Marchan, R.; Ghallab, A.: ¬The¬ hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds
    Chem. Biol. Interact. 351: 109728 (16 pp) (2022)
    https://doi.org/10.1016/j.cbi.2021.109728
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  • Ghallab, A.; Hassan, R.; Myllys, M.; Reinders, J.; Overbeck, N.; Brecklinghaus, T.; Marchan, R.; Hengstler, J. G.: Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
    J. Hepatol. XX: epub ahead of print (2022)
    https://doi.org/10.1016/j.jhep.2022.01.020
  • Remetic, J.; Ghallab, A.; Hobloss, Z.; Brackhagen, L.; Hassan, R.; Myllys, M.; Hengstler, J. G.; Trauner, M.: Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance
    Hepatology 75: 1095-1109 (2022)
    https://doi.org/10.1002/hep.32289
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  • Schnabl, B.; Arteel, G. E.; Stickel, F.; Hengstler, J. G.; Vartak, N.; Ghallab, A.; Dooley, S.; Schwabe, R. F.: Liver specific, systemic and genetic contributors to alcohol-related liver disease progression
    Z. Gastroenterol. 60: 36-44 (2022)
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    https://doi.org/10.1055/a-1714-9330
  • Holland, C. H.; Ramirez-Flores, R. O.; Myllys, M.; Reinders, J.; Godoy, P.; Begher-Tibbe, B.; Hengstler, J. G.; Ghallab, A.: Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice
    Hepatol. Commun. 6: 161-177 (2022)
    https://doi.org/10.1002/hep4.1797
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  • Koeppert, S.; Ghallab, A.; Peglow, S.; Winkler, C. F.; Graeber, S.; Büscher, A.; Hengstler, J. G.; Jahnen-Dechent, W.: Live imaging of calciprotein particle clearance and receptor mediated uptake: Role of calciprotein monomers
    Front. Cell Dev. Biol. 9: 633925 (14 pp) (2021)
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    https://dx.doi.org/10.3389/fcell.2021.633925
  • Schneider, K. M.; Candels, L. S.; Hov, J. R.; Myllys, M.; Hassan, R.; Zaza, A.; Hengstler, J. G.; Ghallab, A.: Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
    Nat. Metab. 3: 1228-1241 (2021)
    https://doi.org/10.1038/s42255-021-00452-1
  • Ghallab, A.; Myllys, M.; Edlund, K.; Hobloss, Z.; Brackhagen, L.; Begher-Tibbe, B.; Hassan, R.; Burke, M.: Spatio-temporal multiscale analysis of western diet-fed mice reveals a translationally relevant sequence of events during NAFLD progression
    Cells 10: (10): 2516 (29 pp) (2021)
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    https://doi.org/10.3390/cells10102516
  • Gianmoena, K.; Jashari, A.; Gabrys, P.; Grgas, K.; Ghallab, A.; Reinders, J.; Edlund, K.; Hengstler, J. G.: Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria
    Cell Rep. 36: (8): 109526 (28 pp) (2021)
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    https://dx.doi.org/10.1016/j.celrep.2021.109526
  • Schneider, K. M.; Elfers, C.; Ghallab, A.; Schneider, C. V.; Galvez, E. J. C.; Myllys, M.; Hengstler, J. G.; Trautwein, C.: Intestinal dysbiosis amplifies acetaminophen-inducedaAcute liver injury
    Cell. Mol. Gastroenterol. Hepatol. 11: 909-933 (2021)
    https://dx.doi.org/10.1016/j.jcmgh.2020.11.002
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  • Kube, I.; Tardio, L. B.; Hofmann, U.; Ghallab, A.; Hengstler, J. G.; Fuehrer, D.; Zwanziger, D.: Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.
    Thyroid 31: 973–984 (2021)
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    https://dx.doi.org/10.1089/thy.2020.0636
  • Ghallab, A.; Hassan, R.; Myllys, M.; Albrecht, W.; Hoehme, S.; Braeuning, A.; Degen, G. H.; Hengstler, J. G.: Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney
    Arch. Toxicol. 95: 2163-2177 (2021)
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    https://dx.doi.org/10.1007/s00204-021-03073-5
  • Vartak, N.; Guenther, G.; Joly, F.; Damle-Vartak, A.; Begher-Tibbe, B.; Ghallab, A.; Drasdo, D.; Hengstler, J. G.: Intravital dynamic and correlative imaging of mouse livers reveals diffusion-dominated canalicular and flow-augmented ductular bile flux
    Hepatology 73: 1531-1550 (2021)
    https://doi.org/10.1002/hep.31422
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  • Schuran, F. A.; Lommetz, C.; Steudter, A.; Ghallab, A.; Wieschendorf, B.; Schwinge, D.; Reinders, J.; Carambia, A.: Aryl hydrocarbon receptor activity in hepatocytes sensitizes to hyperacute acetaminophen-induced hepatotoxicity in mice
    Cell. Mol. Gastroenterol. Hepatol. 11: 371-388 (2021)
    https://doi.org/10.1016/j.jcmgh.2020.09.002
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  • Gupta, R.; Schrooders, Y.; Hauser, D.; Albrecht, W.; Brecklinghaus, T.; Hengstler, J. G.; Ghallab, A.; Caiment, F.: Comparing in vitro human liver models to in vivo human liver using RNA-Seq
    Arch. Toxicol. 95: 573–589 (2021)
    https://doi.org/10.1007/s00204-020-02937-6
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  • Campos, G.; Ghallab, A.; Pütter, L.; Edlund, K.; Cadenas, C.; Marchan, R.; Hengstler, J. G.; Godoy, P.: Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
    Arch. Toxicol. 94: 205-217 (2020)
    http://dx.doi.org/10.1007/s00204-019-02630-3
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  • Ghallab, A.; Myllys, M.; Holland, C. H.; Zaza, A.; Hassan, R.; Reinders, J.; Drasdo, D.; Hengstler, J. G.: Influence of liver fibrosis on lobular zonation
    Cells 8: (12): 1556 (24 pp) (2019)
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    https://doi.org/10.3390/cells8121556
  • Albrecht, W.; Kappenberg, F.; Brecklinghaus, T.; Stoeber, R.; Marchan, R.; Cadenas, C.; Ghallab, A.; Hengstler, J. G.: Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
    Arch. Toxicol. 93: 1609-1637 (2019)
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    http://dx.doi.org/10.1007/s00204-019-02492-9
  • Ghallab, A.; Vartak, N.; Hassan, R.; Zaza, A.; Godoy, P.; Drasdo, D.; Hengstler, J. G.; Reif, R.: Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood
    Hepatology 69: 666-683 (2019)
    http://dx.doi.org/10.1002/hep.30213
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  • Sezgin, S.; Hassan, R.; Zühlke, S.; Kuepfer, L.; Hengstler, J. G.; Spiteller, M.; Ghallab, A.: Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI
    Arch. Toxicol. 92: 2963-2977 (2018)
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    http://dx.doi.org/10.1007/s00204-018-2271-3
  • Köppert, S.; Büscher, A.; Babler, A.; Ghallab, A.; Buhl, E. M.; Latz, E.; Hengstler, J. G.; Jahnen-Dechent, W.: Cellular clearance and biological activity of calciprotein particles depend on their maturation state and crystallinity
    Front. Immunol. 9: 1991 (17 pp) (2018)
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    https://doi.org/10.3389/fimmu.2018.01991
  • Ahmed, Y. A.; Ali, S.; Ghallab, A.: Hair histology as a tool for forensic identification of some domestic animal species
    EXCLI J. 17: 663-670 (2018)
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    http://dx.doi.org/10.17179/excli2018-1478
  • Schenk, A.; Ghallab, A.; Hofmann, U.; Hassan, R.; Schwarz, M.; Schuppert, A.; Hengstler, J. G.; Kuepfer, L.: Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage
    Sci. Rep. 7: 6224 (13 pp) (2017)
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    http://dx.doi.org/10.1038/s41598-017-04574-z
  • Reif, R.; Ghallab, A.; Beattie, L.; Günther, G.; Kuepfer, L.; Kaye, P. M.; Hengstler, J. G.: In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
    Arch. Toxicol. 91: 1335-1352 (2017)
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    http://dx.doi.org/10.1007/s00204-016-1906-5
  • Leist, M.; Ghallab, A.; Marchan, R.; Godoy, P.; Reif, R.; van Thriel, C.; Cadenas, C.; Hengstler, J. G.: Adverse outcome pathways: opportunities, limitations and open questions
    Arch. Toxicol. 91: 3477-3505 (2017)
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    http://dx.doi.org/10.1007/s00204-017-2045-3
  • Jansen, P. L.; Ghallab, A.; Vartak, N.; Reif, R.; Schaap, F. G.; Hampe, J.; Hengstler, J. G.: ¬The¬ ascending pathophysiology of cholestatic liver disease
    Hepatology 65: 722-738 (2017)
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    http://dx.doi.org/10.1002/hep.28965