Dr. Rosemarie Marchan

Marchen_web Leitung der Nachwuchsgruppe

Zelluläre Toxikologie

Tel.: +49 / 231 1084 213
E-Mail: marchan@ifado.de

Vita:

  • Seit 2013 Leitung der Juniorgruppe am IfADo
  • 05/2008 – 12/2012 Post-doctoral fellow am IfADo (Dortmund) – Abteilung System Toxikologie, Advisor: Jan Hengstler
  • 08/2002 – 12/2007 Studium der Toxikologie, Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Advisor: Ned Ballatori
  • PhD, Toxicology (Department of Environmental Medicine), May 2008
  • M.Sc., Toxicology (Department of Environmental Medicine), May 2005
  • North Carolina Central University, Durham, NC, USA (dual degree)
  • B.Sc., Environmental Sciences (Department of Environmental Science), May 2002
  • B.Sc., Biology (Department Biology), May 2002

Schlüsselpublikationen:

  • Godoy, P.; Marchan, R.; Cadenas, C.; Grgas, K.; Ghallab, A.; Reinders, J.; Edlund, K.; Hengstler, J. G.: Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria
    Cell Rep. 36: (8): 109526 (28 pp) (2021)
    Ich bin an dieser Arbeit interessiert
    https://dx.doi.org/10.1016/j.celrep.2021.109526
  • Guth, S.; Hüser, S.; Roth, A.; Degen, G.; Edlund, K.; Marchan, R.; Mühle, E.; Hengstler, J. G.: Contribution to the ongoing discussion on fluoride toxicity
    Arch. Toxicol. 95: 2571-2587 (2021)
    https://dx.doi.org/10.1007/s00204-021-03072-6
    Ich bin an dieser Arbeit interessiert
  • Holland, C. H.; Ramirez-Flores, R. O.; Myllys, M.; Hassan, R.; Edlund, K.; Marchan, R.; Cadenas, C.; Reinders, J.: Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice
    Hepatol. Commun. XX: epub ahead of print (2021)
    https://doi.org/10.1002/hep4.1797
  • Genc, E.; Gonzalez, D.; Keller, M.; Marchan, R.; Cadenas, C.; Watzl, C.; Nitsche, M. A.; Hengstler, J. G.: Spatio-temporal multiscale analysis of western diet-fed mice reveals a translationally relevant sequence of events during nafld progression
    Cells 10: (10): 2516 (29 pp) (2021)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.3390/cells10102516
  • Edlund, K.; Madjar, K.; Lebrecht, A.; Cadenas, C.; Marchan, R.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.: Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial
    Clin. Cancer Res. 27: 2148-2158 (2021)
    https://dx.doi.org/10.1158/1078-0432.CCR-20-2662
    Ich bin an dieser Arbeit interessiert
  • Rohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]: Regulation of the glycerophosphodiesterase, EDI3 via HER2 signaling in breast cancerRohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]. Dortmund: Univ., 2020.
    Dortmund, Techn. Univ., Faculty of Chemistry and Chemical Biology, Masterarbeit, 2020
    Ich bin an dieser Arbeit interessiert
  • Guth, S.; Hüser, S.; Roth, A.; Degen, G.; Edlund, K.; Marchan, R.; Nitsche, M. A.; van Thriel, C.: Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses
    Arch. Toxicol. 94: 1375-1415 (2020)
    https://dx.doi.org/10.1007/s00204-020-02725-2
    Ich bin an dieser Arbeit interessiert
  • Campos, G.; Ghallab, A.; Pütter, L.; Edlund, K.; Cadenas, C.; Marchan, R.; Hengstler, J. G.; Godoy, P.: Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
    Arch. Toxicol. 94: 205-217 (2020)
    http://dx.doi.org/10.1007/s00204-019-02630-3
    Ich bin an dieser Arbeit interessiert
  • Albrecht, W.; Kappenberg, F.; Brecklinghaus, T.; Stoeber, R.; Marchan, R.; Cadenas, C.; Ghallab, A.; Hengstler, J. G.: Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
    Arch. Toxicol. 93: 1609-1637 (2019)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1007/s00204-019-02492-9
  • Oprisko, Anastasia; Marchan, R. [Betreuerin]: Characterization of lysophosphatidic acid producing enzymes in ovarian cancer: Focus on acylglycerol kinaseOprisko, Anastasia; Marchan, R. [Betreuerin]. Bochum: Univ., 2019.
    Bochum, Ruhr-Universität, Fakultät für Chemie und Biochemie, Masterarbeit, 2019
    Ich bin an dieser Arbeit interessiert
  • Cadenas, C.; Vosbeck, S.; Edlund, K.; Grgas, K.; Claus, M.; Watzl, C.; Marchan, R.; Hengstler, J. G.: LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
    Int. J. Cancer 145: 901-915 (2019)
    http://dx.doi.org/10.1002/ijc.32138
    Ich bin an dieser Arbeit interessiert
  • Gu, X.; Albrecht, W.; Edlund, K.; Cadenas, C.; Marchan, R.; Brecklinghaus, T.; Hengstler, J. G.; Stoeber, R.: Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes
    Arch. Toxicol. 92: 3505-3515 (2018)
    http://dx.doi.org/10.1007/s00204-018-2302-0
    Ich bin an dieser Arbeit interessiert
  • Grinberg, M.; Stöber, R. M.; Albrecht, W.; Edlund, K.; Godoy, P.; Cadenas, C.; Marchan, R.; Hengstler, J. G.: Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes
    Arch. Toxicol. 92: 3517-3533 (2018)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.1007/s00204-018-2352-3
  • Gogiashvili, M.; Horsch, S.; Marchan, R.; Gianmoena, K.; Cadenas, C.; Tanner, B.; Hengstler, J. G.; Edlund, K.: Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy
    NMR Biomed. 31: e3862 (2018)
    http://dx.doi.org//10.1002/nbm.3862
    Ich bin an dieser Arbeit interessiert
  • Marchan, R.; Büttner, B.; Lambert, J.; Edlund, K.; Glaeser, I.; Blaszkewicz, M.; Leonhardt, G.; Marienhoff, L.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
    Cancer Res. 77: 4589-4601 (2017)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1158/0008-5472.CAN-16-2065
  • Leist, M.; Ghallab, A.; Marchan, R.; Godoy, P.; Reif, R.; van Thriel, C.; Cadenas, C.; Hengstler, J. G.: Adverse outcome pathways: opportunities, limitations and open questions
    Arch. Toxicol. 91: 3477-3505 (2017)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1007/s00204-017-2045-3
  • Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
    Cancer Res. 77: 4589-4601 (2017)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1158/0008-5472.CAN-16-2065
  • Gogiashvili, M.; Edlund, K.; Gianmoena, K.; Marchan, R.; Brik, A.; Andersson, J. T.; Hengstler, J. G.; Cadenas, C.: Metabolic profiling of ob/ob mouse fatty liver using HR-MAS (1)H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway:
    Anal. Bioanal. Chem. 409: 1591-1606 (2017)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1007/s00216-016-0100-1
  • Godoy, P.; Widera, A.; Schmidt-Heck, W.; Campos, G.; Cadenas, C.; Reif, R.; Marchan, R.; Hengstler, J. G.: Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue
    Arch. Toxicol. 90: 2513-2529 (2016)
    http://dx.doi.org/10.1007/s00204-016-1761-4
    Ich bin an dieser Arbeit interessiert
  • Hellwig, B.; Madjar, K.; Edlund, K.; Marchan, R.; Cadenas, C.; Heimes, A.-S.; Hengstler, J. G.; Rahnenführer, J.: Epsin family member 3 and ribosome-related genes are associated with late metastasis in estrogen receptor-positive breast cancer and long-term survival in non-small cell lung cancer using a genome-wide identification and validation strategy
    PLoS ONE 11: (12): e0167585 (18 pp.) (2016)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1371/journal.pone.0167585