Apl. Prof. Dr. rer. nat. Dr. med. Gisela Degen

Leitung der ehemaligen Forschungsgruppe

Chemikalienrisiken

Tel.: +49 / 231 1084 465
E-Mail: degen@ifado.de

Vita:

  • 1997 apl. Prof. an der Ruhr-Universität Bochum (seit 2016 im Ruhestand, weiterhin als Senior Fellow Scientist tätig)
  • 1993 Umhabilitation an die Ruhr-Universität Bochum
  • seit 1992 Leiterin der Projektgruppe "Chemikalienrisiken" am IfADo
  • 1990 Habilitation (Dr. med. habil.) für Biochemische Pharmakologie und Toxikologie; Priv.-Doz. an der Universität Würzburg
  • 1983–1992 Wiss. Mitarb./Akad. Rätin a. Z. am Institut für Toxikologie, Universität Würzburg und Teilprojektleiterin im Sonderforschungsbereich 172
  • 1979–1983 Postdoctoral Fellow am NIEHS, Research Triangle Park, N.C., USA
  • 1978 Promotion (Dr. rer. nat.; Universität Würzburg)
  • 1972 Staatsexamen in Lebensmittelchemie (Universität Würzburg)

Arbeitsgebiete:

  • Biochemische Toxikologie (Bioaktivierung und Detoxifizierung von Fremdstoffen)
  • Genotoxizität von Chemikalien (Mykotoxine, Steroide u. a.)
  • Humanbiomotoring (Biomarker of Exposure)
  • Toxikokinetik und Toxikodynamik hormonell aktiver Stoffe
  • Risikobewertung von Chemikalien
Keine weitere Betreuung von Doktor- oder Masterarbeiten mehr möglich.

Schlüsselpublikationen:

  • Ali, N.; Degen, G. H.: Biological monitoring for ochratoxin A and citrinin and their metabolites in urine samples of infants and children in Bangladesh
    Mycotoxin Res. 36: 409-417 (2020)
    https://doi.org/10.1007/s12550-020-00407-7
    Ich bin an dieser Arbeit interessiert
  • Ali, N.; Manirujjaman, M.; Rana, S.; Degen, G. H.: Determination of aflatoxin M1 and deoxynivalenol biomarkers in infants and children urines from Bangladesh
    Arch. Toxicol. 94: 3775–3786 (2020)
    https://doi.org/10.1007/s00204-020-02857-5
    Ich bin an dieser Arbeit interessiert
  • Guth, S.; Hüser, S.; Roth, A.; Degen, G.; Edlund, K.; Marchan, R.; Nitsche, M. A.; van Thriel, C.: Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses
    Arch. Toxicol. 94: 1375-1415 (2020)
    https://dx.doi.org/10.1007/s00204-020-02725-2
    Ich bin an dieser Arbeit interessiert
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, a,b-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3
    EFSA Journal 18: 5924 (44 pp) (2020)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2020.5924
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 61 Revision 2 (FGE.61Rev2): Consideration of aliphatic acetals evaluated by JECFA (57th, 63rd and 68th meetings) structurally related to acetals evaluated by EFSA in FGE.03Rev2
    EFSA Journal 18: 5923 (23 pp) (2020)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2020.5923
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): Consideration of genotoxicity data on alicyclic aldehydes with a,ß-unsaturation in ring/side-chain and precursors from chemical subgroup 2.2 of FGE.19
    EFSA Journal 17: 5569 (50 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5569
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 217, Revision 2 (FGE.217Rev2): Consideration of genotoxic potential for a,ß-unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones
    EFSA Journal 17: 5568 (45 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5568
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 210 Revision 3 (FGE.210Rev3): Consideration of genotoxic potential for a,ß-unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 of FGE.19
    EFSA Journal 17: 5676 (42 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5676
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable)
    EFSA Journal 17: 5675 (57 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5675
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 70, Revision 1 (FGE.70Rev1): Consideration of aliphatic, linear, a,ß-unsaturated, di- and trienals and related alcohols, acids and esters evaluated by JECFA (61st-68th-69th meeting)
    EFSA Journal 17: 5749 (41 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5749
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): Consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, a,ß-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19
    EFSA Journal 17: 5750 (26 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5750
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 5, Revision 3 (FGE.05Rev3): Branched- and straight-chain unsaturated aldehydes, dienals, unsaturated and saturated carboxylic acids and related esters with saturated and unsaturated aliphatic alcohol and a phenylacetic acid related ester from chemical groups 1, 2, 3, 5 and 15
    EFSA Journal 17: 5761 (69 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5761
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on the safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: Rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract
    EFSA Journal 17: 5867 (19 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5867
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 215 Revision 1 (FGE.215Rev1): seven a,ß-unsaturated cinnamyl ketones from subgroup 3.2 of FGE.19
    EFSA Journal 17: 5875 (34 pp) (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.2903/j.efsa.2019.5875
  • Ali, N.; Degen, G. H.: Citrinin biomarkers: a review of recent data and application to human exposure assessment
    Arch. Toxicol. 93: 3057-3066 (2019)
    https://doi.org/10.1007/s00204-019-02570-y
    Ich bin an dieser Arbeit interessiert
  • Malir, F.; Louda, M.; Ostry, V.; Toman, J.; Ali, N.; Grosse, Y.; Pfohl-Leszkowicz, A.; Degen, G. H.: Analyses of biomarkers of exposure to nephrotoxic mycotoxins in a cohort of patients with renal tumours
    Mycotoxin Res. 35: 391-403 (2019)
    https://doi.org/10.1007/s12550-019-00365-9
    Ich bin an dieser Arbeit interessiert
  • Ali, N.; Degen, G. H.: Biomonitoring of zearalenone and its main metabolites in urines of Bangladeshi adults
    Food Chem. Toxicol. 130: 276-283 (2019)
    Ich bin an dieser Arbeit interessiert
    https://doi.org/10.1016/j.fct.2019.05.036
  • Degen, G. H.; Ali, N.; Gundert-Remy, U.: Preliminary data on citrinin kinetics in humans and their use to estimate citrinin exposure based on biomarkers
    Toxicol. Lett. 282: 43-48 (2018)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1016/j.toxlet.2017.10.006
  • Ali, N.; Hossain, K.; Degen, G. H.: Blood plasma biomarkers of citrinin and ochratoxin A exposure in young adults in Bangladesh
    Mycotoxin Res. 34: 59-67 (2018)
    https://doi.org/10.1007/s12550-017-0299-5
    Ich bin an dieser Arbeit interessiert
  • Ali, N.; Degen, G. H.: Urinary biomarkers of exposure to the mycoestrogen zearalenone and its modified forms in German adults
    Arch. Toxicol. 92: 2691-2700 (2018)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1007/s00204-018-2261-5