Dr. Rosemarie Marchan

Marchen_web Head of the junior research group

Cellular Toxicology

Phone: +49 / 231 1084 213
Email: marchan@ifado.de

Curriculum Vitae:

  • Since 2013 Junior Group Leader at Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany – Department Toxicology
  • 05/2008 – 12/2012 Post-doctoral fellow at Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany – Department Systems Toxicology, Advisor: Jan Hengstler
  • University of Rochester Medical Center, Rochester, NY, USA
  • PhD, Toxicology (Department of Environmental Medicine), May 2008
  • M.Sc., Toxicology (Department of Environmental Medicine), May 2005
  • North Carolina Central University, Durham, NC, USA (dual degree)
  • B.Sc., Environmental Sciences (Department of Environmental Science), May 2002
  • B.Sc., Biology (Department Biology), May 2002

Key publications:

  • Godoy, P.; Marchan, R.; Cadenas, C.; Grgas, K.; Ghallab, A.; Reinders, J.; Edlund, K.; Hengstler, J. G.: Epigenetic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria
    Cell Rep. 36: (8): 109526 (28 pp) (2021)
    I am interested in this work
    https://dx.doi.org/10.1016/j.celrep.2021.109526
  • Guth, S.; Hüser, S.; Roth, A.; Degen, G.; Edlund, K.; Marchan, R.; Mühle, E.; Hengstler, J. G.: Contribution to the ongoing discussion on fluoride toxicity
    Arch. Toxicol. 95: 2571-2587 (2021)
    https://dx.doi.org/10.1007/s00204-021-03072-6
    I am interested in this work
  • Edlund, K.; Madjar, K.; Lebrecht, A.; Cadenas, C.; Marchan, R.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.: Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial
    Clin. Cancer Res. 27: 2148-2158 (2021)
    https://dx.doi.org/10.1158/1078-0432.CCR-20-2662
    I am interested in this work
  • Rohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]: Regulation of the glycerophosphodiesterase, EDI3 via HER2 signaling in breast cancerRohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]. Dortmund: Univ., 2020.
    Dortmund, Techn. Univ., Faculty of Chemistry and Chemical Biology, Masterarbeit, 2020
    I am interested in this work
  • Guth, S.; Hüser, S.; Roth, A.; Degen, G.; Edlund, K.; Marchan, R.; Nitsche, M. A.; van Thriel, C.: Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses
    Arch. Toxicol. 94: 1375-1415 (2020)
    https://dx.doi.org/10.1007/s00204-020-02725-2
    I am interested in this work
  • Campos, G.; Ghallab, A.; Pütter, L.; Edlund, K.; Cadenas, C.; Marchan, R.; Hengstler, J. G.; Godoy, P.: Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
    Arch. Toxicol. 94: 205-217 (2020)
    http://dx.doi.org/10.1007/s00204-019-02630-3
    I am interested in this work
  • Albrecht, W.; Kappenberg, F.; Brecklinghaus, T.; Stoeber, R.; Marchan, R.; Cadenas, C.; Ghallab, A.; Hengstler, J. G.: Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
    Arch. Toxicol. 93: 1609-1637 (2019)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-019-02492-9
  • Oprisko, Anastasia; Marchan, R. [Betreuerin]: Characterization of lysophosphatidic acid producing enzymes in ovarian cancer: Focus on acylglycerol kinaseOprisko, Anastasia; Marchan, R. [Betreuerin]. Bochum: Univ., 2019.
    Bochum, Ruhr-Universität, Fakultät für Chemie und Biochemie, Masterarbeit, 2019
    I am interested in this work
  • Cadenas, C.; Vosbeck, S.; Edlund, K.; Grgas, K.; Claus, M.; Watzl, C.; Marchan, R.; Hengstler, J. G.: LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
    Int. J. Cancer 145: 901-915 (2019)
    http://dx.doi.org/10.1002/ijc.32138
    I am interested in this work
  • Gu, X.; Albrecht, W.; Edlund, K.; Cadenas, C.; Marchan, R.; Brecklinghaus, T.; Hengstler, J. G.; Stoeber, R.: Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes
    Arch. Toxicol. 92: 3505-3515 (2018)
    http://dx.doi.org/10.1007/s00204-018-2302-0
    I am interested in this work