Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email: hengstler@ifado.de

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed

Key publications:

  • Kadhum, T.; Kopps, S.; Bolt, H. M.; Blaszkewicz, M.; Reinders, J.; Hengstler, J. G.; Selinski, S.; Golka, K.: Harnblasenkrebs durch Rissprüfsprays auf Azofarbstoff-Basis
    Zbl. Arbeitsmed. 71: 1-7 (2021)
    https://doi.org/10.1007/s40664-020-00406-6
  • Frach, L.; Tierling, S.; Schwaiger, M.; Moser, D.; Heinrichs, M.; Hengstler, J. G.; Walter, J.; Kumsta, R.: ¬The¬ mediating role of KITLG DNA methylation in the association between childhood adversity and cortisol stress reactivity does not replicate in monocytes
    Psychoneuroendocrinology 116: 104653 (2020)
    https://doi.org/10.1016/j.psyneuen.2020.104653
    I am interested in this work
  • Meisig, J.; Dreser, N.; Kapitza, M.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.; Leist, M.; Blüthgen, N.: Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
    Nucleic Acids Res. 48: 12577-12592 (2020)
    I am interested in this work
    https://dx.doi.org/10.1093/nar/gkaa1089
  • Schneider, K. M.; Elfers, C.; Ghallab, A.; Schneider, C. V.; Galvez, E. J. C.; Myllys, M.; Hengstler, J. G.; Trautwein, C.: Intestinal dysbiosis amplifies acetaminophen-inducedaAcute liver injury
    Cell. Mol. Gastroenterol. Hepatol. XX: epub ahead of proof (2020)
    https://dx.doi.org/10.1016/j.jcmgh.2020.11.002
  • Kube, I.; Tardio, L. B.; Hofmann, U.; Ghallab, A.; Hengstler, J. G.; Fuehrer, D.; Zwanziger, D.: Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.
    Thyroid XX: epub ahead of print (2020)
    https://dx.doi.org/10.1089/thy.2020.0636
  • Brackhagen, Lisa; Hengstler, J. G. [2. Gutachter]: Bile acids as mediators of acetaminophen induced hepatotocixityBrackhagen, Lisa; Hengstler, J. G. [2. Gutachter]. Hamm-Lippstadt: Univ., 2020.
    Hamm-Lippstadt, Hochsch., Studiengang „Umwelt- und Gefahrstoffanalytik“, Masterarbeit, 2020
    I am interested in this work
  • Bruning, Nora; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]: Investigation on how granzyme B enters target cells via fluorescence localization reporterBruning, Nora; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]. Dortmund: Techn. Univ., 2020.
    Dortmund, Techn. Univ., Faculty of Chemistry and Chemical Biology, Masterarbeit, 2020
    I am interested in this work
  • González Leiva, Daniela Fernanda; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Role of WNT1-inducible signaling pathway protein-1 (WISP1) in liver injuryGonzález Leiva, Daniela Fernanda; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Techn. Univ., 2020.
    Dortmund, Techn. Univ., Chem. Fak., Diss., 2020
    I am interested in this work
  • Rohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]: Regulation of the glycerophosphodiesterase, EDI3 via HER2 signaling in breast cancerRohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]. Dortmund: Univ., 2020.
    Dortmund, Techn. Univ., Faculty of Chemistry and Chemical Biology, Masterarbeit, 2020
    I am interested in this work
  • Prager, Isabel; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]: Regulation of natural killer cell cytotoxic pathways during serial killing activityPrager, Isabel; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]. Dortmund: Univ., 2020.
    Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2020
    I am interested in this work
  • Guth, A.; Roth, A.; Engeli, B.; Lachenmeier, D. W.; Hüser, S.; Hengstler, J. G.; Steinberg, P.; Zarn, J. A.: Comparison of points of departure between subchronic and chronic toxicity studies on food additives, food contaminants and natural food constituents
    Food Chem. Toxicol. 146: 111784 (11 pp) (2020)
    I am interested in this work
    https://dxc.doi.org/10.1016/j.fct.2020.111784
  • Heimes, A.-S.; Härtner, F.; Almstedt, K.; Krajnak, S.; Lebrecht, A.; Edlund, K.; Hengstler, J. G.; Schmidt, M.: Prognostic significance of interferon-? and its signaling pathway in early breast cancer depends on the molecular subtypes
    Int. J. Mol. Sci. 21: 7178 (13 pp) (2020)
    I am interested in this work
    https://dx.doi.org/10.3390/ijms21197178
  • Behjati Ardakani, F. ; Kattler, K.; Heinen, T.; Schmidt, F.; Feuerborn, D.; Nell, P.; Hengstler, J. G.; Schulz, M. H.: Prediction of single-cell gene expression for transcription factor analysis
    GigaScience 9: (11): giaa113 (2020)
    I am interested in this work
    https://dx.doi.org/10.1093/gigascience/giaa113
  • Kampf, Tatjana; Brecklinghaus, T. [Betr.]; Albrecht, W. [Betr.]; Hengstler, J. G. [Erstgutachter]: Zytotoxizitätsprüfung von Lebensmittelzusatzstoffen anhand von Cell-Titer-Blue-Viabilitäts-AssaysKampf, Tatjana; Brecklinghaus, T. [Betr.]; Albrecht, W. [Betr.]; Hengstler, J. G. [Erstgutachter]. Dortmund: Univ., 2020.
    Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Bachelorarbeit, 2020
    I am interested in this work
  • Lucendo-Villarin, B.; Nell, P.; Hellwig, B.; Filis, P.; Feuerborn, D.; Godoy, P.; Hengstler, J. G.; Hay, D. C.: Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells
    EXCLI J. 19: 1459-1476 (2020)
    I am interested in this work
    https://www.excli.de/index.php/excli/article/view/2934
  • Jashari, Adelina; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Alterations of the glyoxylate metabolism in hepatic steatosis – a risk factor for hyperoxaluriaJashari, Adelina; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2020.
    Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2020
    I am interested in this work
  • Mohs, A.; Otto, T.; Schneider, K. M.; Peltzer, M.; Boekschoten, M.; Holland, C. H.; Hengstler, J. G.; Trautwein, C.: Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis
    J. Hepatol. XX: epub ahead of print (2020)
    https://dx.doi.org/10.1016/j.jhep.2020.09.037
  • Kappenberg, F.; Brecklinghaus, T.; Albrecht, W.; Blum, J.; van der Wurp, C.; Leist, M.; Hengstler, J. G.; Rahnenführer, J.: Handling deviating control values in concentration-response curves
    Arch. Toxicol. 94: 3787–3798 (2020)
    https://doi.org/10.1007/s00204-020-02913-0
    I am interested in this work
  • Bierbrauer, A.; Kunz, L.; Gomes, C. A.; Getzmann, S.; Wascher, E.; Gajewski, P. D.; Hengstler, J. G.; Axmacher, N.: Unmasking selective path integration deficits in Alzheimer’s disease risk carriers
    Sci. Adv. 6: (35): eaba1394 (2020)
    I am interested in this work
    https://dx.doi.org/10.1126/sciadv.aba1394
    https://advances.sciencemag.org/content/suppl/2020/08/24/6.35.eaba1394.DC1
  • Vartak, N.; Guenther, G.; Joly, F.; Damle-Vartak, A.; Begher-Tibbe, B.; Ghallab, A.; Drasdo, D.; Hengstler, J. G.: Intravital dynamic and correlative imaging reveals diffusion?dominated canalicular and flow?augmented ductular bile flux
    Hepatology XX: accepted ms. (2020)
    https://doi.org/10.1002/hep.31422