Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email: hengstler@ifado.de

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed

Publications:

  • Frach, L.; Tierling, S.; Schwaiger, M.; Moser, D.; Heinrichs, M.; Hengstler, J. G.; Walter, J.; Kumsta, R.: ¬The¬ mediating role of KITLG DNA methylation in the association between childhood adversity and cortisol stress reactivity does not replicate in monocytes
    Psychoneuroendocrinology 116: 104653 (2020)
    https://doi.org/10.1016/j.psyneuen.2020.104653
    I am interested in this work
  • Schupp, T.; Damm, G.; Foth, H.; Gebel, T.; Gundert-Remy, U.; Hengstler, J. G.; Mangerich, A.; Wollin, K.-M.: Long-term simulation of lead concentrations in agricultural soils in relation to human adverse health effects
    Arch. Toxicol. 94: 2319-2329 (2020)
    I am interested in this work
    https://dx.doi.org/10.1007/s00204-020-02762-x
  • Autrup, H.; Barile, F. A.; Berry, S. C.; Blaauboer, B. J.; Boobis, A.; Bolt, H.; Hengstler, J.; Vermeulen, N. P.: Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs? (Guest editorial)
    Arch. Toxicol. 94: 2549–2557 (2020)
    I am interested in this work
    https://doi.org/10.1007/s00204-020-02800-8
  • Autrup, H.; Barile, F. A.; Berry, S. C.; Blaauboer, B. J.; Boobis, A.; Bolt, H.; Hengstler, J.; Vermeulen, N. P.: Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs? (Editorial)
    Environ. Toxicol. Pharmacol. 78: 103396 (6 pp) (2020)
    https://dx.doi.org/10.1016/j.cbi.2020.109099
    I am interested in this work
    https://dx.doi.org/10.1016/j.etap.2020.103396
  • Autrup, H.; Barile, F. A.; Berry, S. C.; Blaauboer, B. J.; Boobis, A.; Bolt, H.; Hengstler, J.; Vermeulen, N. P.: Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs? (Editorial)
    J. Toxicol. Environ. Health 83A: 485-494 (2020)
    https://dx.doi.org/10.1016/j.cbi.2020.109099
    I am interested in this work
    https://dx.doi.org/10.1080/15287394.2020.1756592
  • Autrup, H.; Barile, F. A.; Berry, S. C.; Blaauboer, B. J.; Boobis, A.; Bolt, H.; Hengstler, J.; Vermeulen, N. P.: Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs? (Editorial)
    Comput. Toxicol. 14: 100124 (6 pp) (2020)
    https://dx.doi.org/10.1016/j.toxlet.2020.04.008
    I am interested in this work
    https://doi.org/10.1016/j.comtox.2020.100124
  • Krebs, A.; van Vugt-Lussenburg, B. M. A.; Waldmann, T.; Albrecht, W.; Brecklinghaus, T.; Hengstler, J. G.; Stöber, R.; Leist, M.: ¬The¬ EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
    Arch. Toxicol. 94: 2435-2461 (2020)
    I am interested in this work
    https://dx.doi.org/10.1007/s00204-020-02802-6
  • Ebmeyer, J.; Rasinger, J. D.; Hengstler, J. G.; Schaudien, D.; Creutzenberg, O.; Lampen, A.; Braeuning, A.; Hessel-Pras, S.: Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study
    Arch. Toxicol. 94: 1739-1751 (2020)
    I am interested in this work
    https://doi.org/10.1007/s00204-020-02779-2
  • Autrup, H.; Barile, F. A.; Berry, S. C.; Blaauboer, B. J.; Boobis, A.; Bolt, H.; Hengstler, J.; Vermeulen, N. P.: Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs? (Editorial)
    Toxicol. in Vitro 67: 104861 (6 pp) (2020)
    https://dx.doi.org/10.1016/j.tiv.2020.104861
    I am interested in this work
  • Autrup, H.; Barile, F. A.; Berry, S. C.; Blaauboer, B. J.; Boobis, A.; Bolt, H.; Hengstler, J.; Vermeulen, N. P.: Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs? (Editorial)
    Toxicol. Lett. 331: 259-264 (6 pp) (2020)
    https://dx.doi.org/10.1016/j.toxlet.2020.04.008
    I am interested in this work
  • Autrup, H.; Barile, F. A.; Berry, S. C.; Blaauboer, B. J.; Boobis, A.; Bolt, H.; Hengstler, J.; Vermeulen, N. P.: Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs? (Guest editorial)
    Food Chem. Toxicol. 142: 111349 (6 pp) (2020)
    https://dx.doi.org/10.1016/j.fct.2020.111349
    I am interested in this work
  • Autrup, H.; Barile, F. A.; Berry, S. C.; Blaauboer, B. J.; Boobis, A.; Bolt, H.; Hengstler, J.; Vermeulen, N. P.: Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs? (Editorial)
    Chem. Biol. Interact. 326: 109099 (2020)
    https://dx.doi.org/10.1016/j.cbi.2020.109099
    I am interested in this work
  • Wollin, K.-M.; Damm, G.; Foth, H.; Freyberger, A.; Gebel, T.; Mangerich, A.; Gundert-Remy, U.; Hengstler, J. G.: Critical evaluation of human health risks due to hydraulic fracturing in natural gas and petroleum production
    Arch. Toxicol. 94: 967-1016 (2020)
    https://dx.doi.org/10.1007/s00204-020-02758-7
    I am interested in this work
  • Guth, S.; Hüser, S.; Roth, A.; Wascher, E.; Watzl, C.; Mühle, E.; Hengstler, J. G.: Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses
    Arch. Toxicol. 94: 1375-1415 (2020)
    I am interested in this work
  • Tomasovic, A.; Brand, T.; Schanbacher, C.; Kramer, S.; Hümmert, M. W.; Godoy, P.; Hengstler, J. G.; Lorenz, K.: Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
    Nat. Commun. 11: (1): 1733 (16 pp) (2020)
    I am interested in this work
    https://dx.doi.org/10.1038/s41467-020-15505-4
  • Fasbender, F.; Obholzer, M.; Metzler, S.; Stöber, R.; Hengstler, J. G.; Watzl, C.: Enhanced activation of human NK cells by drug-exposed hepatocytes
    Arch. Toxicol. 94: 439–448 (2020)
    https://dx.doi.org/10.1007/s00204-020-02668-8
    I am interested in this work
  • Ruoß, M.; Vosough, M.; Königsrainer, A.; Nadalin, S.; Wagner, S.; Sajadian, S.; Hengstler, J. G.; Nussler, A. K.: Towards improved hepatocyte cultures: Progress and limitatios
    Food Chem. Toxicol. 138: article no. 111188 (2020)
    https://dx.doi.org/10.1016/j.fct.2020.111188
    I am interested in this work
  • Campos, G.; Ghallab, A.; Pütter, L.; Edlund, K.; Cadenas, C.; Marchan, R.; Hengstler, J. G.; Godoy, P.: Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
    Arch. Toxicol. 94: 205-217 (2020)
    http://dx.doi.org/10.1007/s00204-019-02630-3
    I am interested in this work
  • Winkler, I.; Bitter, C.; Winkler, S.; Thavamani, A.; Hengstler, J. G.; Borkham-Kamphorst, E.; Kohlbacher, O.; Nordheim, A.: Identification of Ppargamma-modulated miRNA hubs that target the fibrotic tumor microenvironment
    Proc. Natl. Acad. Sci. USA 117: 454-463 (2020)
    http://dx.doi.org/10.1073/pnas.1909145117
    I am interested in this work
  • Dreser, N.; Madjar, K.; Holzer, A. K.; van Thriel, C.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.; Leist, M.: Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances
    Arch. Toxicol. 94: 151-171 (2020)
    https://doi.org/10.1007/s00204-019-02612-5
    I am interested in this work