Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email: hengstler@ifado.de

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed


  • Albrecht, W.; Kappenberg, F.; Brecklinghaus, T.; Stoeber, R.; Marchan, R.; Cadenas, C.; Ghallab, A.; Hengstler, J. G.: Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
    Arch. Toxicol. 93: 1609-1637 (2019)
    I am interested in this work
  • Hengstler, J. G.; Albrecht, W.; Brecklinghaus, T.; Feuerborn, D.; Nell, P.; Cherianidou, A.; Edlund, K.; Sachinidis, A.: Der Mensch zum Selberbauen?: Möglichkeiten und Grenzen Stammzell-basierter Testverfahren in der Wirkstoffforschung
    LaborPraxis 2019: (August): 46-49 (2019)
    I am interested in this work
  • Sachinidis, A.; Albrecht, W.; Nell, P.; Cherianidou, A.; Hewitt, N. J.; Edlund, K.; Hengstler, J. G.: Road map for development of stem cell-based alternative test methods
    Trends Mol. Med. 25: 470-481 (2019)
    I am interested in this work
  • Golka, K.; Hengstler, J. G.: Toxikologie in der Arbeitsmedizin
    In: Toxikologie. 4., völlig neu bearb. Auflage (S. 1277-1283) / Marquardt/Schäfer/Barth (Hrsg.). Stuttgart: Wiss. Verl.ges., 2019.
    I am interested in this work
  • Wang, Y.; Tatham, M. H.; Schmidt-Heck, W.; Swann, C.; Singh-Dolt, K.; Hengstler, J. G.; Godoy, P.; Hay, D. C.: Multiomics analyses of HNF4? protein domain function during human pluripotent stem cell differentiation
    iScience XX: epub ahead of print (2019)
  • Damle-Vartak, A.; Begher-Tibbe, B.; Gunther, G.; Geisler, F.; Vartak, N.; Hengstler, J. G.: Pipe-3D: a pipeline based on immunofluorescence, 3D confocal imaging, reconstructions, and morphometry for biliary network analysis in cholestasis
    In: Experimental cholestasis research (S. 25-53) / edited by Mathieu Vinken. New York: Springer Science+Business, 2019.
    (Methods in molecular biology, 1981)
    I am interested in this work
  • Weisner, J.; Landel, I.; Reintjes, C.; Uhlenbrock, N.; Trajkovic-Arsic, M.; Günther, G.; Hengstler, J. G.; Rauh, D.: Preclinical efficacy of covalent-allosteric AKT inhibitor borussertib in combination with trametinib in KRAS-mutant pancreatic and colorectal cancer
    Cancer Res. 79: 2367-2378 (2019)
    I am interested in this work
  • Tietz, T.; Selinski, S.; Golka, K.; Hengstler, J. G.; Gripp, S.; Ickstadt, K.; Ruczinski, I.; Schwender, H.: Identification of interactions of binary variables associated with survival time using survivalFS
    Arch. Toxicol. 93: 585-602 (2019)
    I am interested in this work
  • Schmitz, C.; Welck, J.; Tavernaro, I.; Grinberg, M.; Rahnenführer, J.; van Thriel, C.; Hengstler, J. G.; Kraegeloh, A.: Mechanical strain mimicking breathing amplifies alterations in gene expression induced by SiO2 NPs in lung epithelial cells
    Nanotoxicology XX: Epub ahead of print (2019)
  • Cadenas, C.; Vosbeck, S.; Edlund, K.; Grgas, K.; Claus, M.; Watzl, C.; Marchan, R.; Hengstler, J. G.: LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
    Int. J. Cancer 145: 901-915 (2019)
    I am interested in this work
  • Edlund, K.; Madjar, K.; Mattsson, J. S. M.; Djureinovic, D.; Lindskog, C.; Rahnenführer, J.; Micke, P.; Hengstler, J. G.: Prognostic impact of tumor cell programmed death ligand 1 expression and immune cell infiltration in NSCLC
    J. Thorac. Oncol. 14: 628-640 (2019)
    I am interested in this work
  • Ghallab, A.; Vartak, N.; Hassan, R.; Zaza, A.; Godoy, P.; Drasdo, D.; Hengstler, J. G.; Reif, R.: Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood
    Hepatology 69: 666-683 (2019)
    I am interested in this work
  • Braeuning, A.; Oberemm, A.; Heise, T.; Gundert-Remy, U.; Hengstler, J. G.; Lampen, A.: In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism
    Arch. Toxicol. 93: 369-383 (2019)
    I am interested in this work
  • Ebmeyer, J.; Behrend, J.; Lorenz, M.; Günther, G.; Reif, R.; Hengstler, J. G.; Braeuning, A.; Hessel-Pras, S.: Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells
    Chem. Biol. Interact. 298: 104-111 (2019)
    I am interested in this work
  • Schmitz, Gernot; Watzl, C. [Referent]; Hengstler, J. G. [Koreferent]: Influence of the dopaminergic pathway on osteoclasts in arthritisSchmitz, Gernot; Watzl, C. [Referent]; Hengstler, J. G. [Koreferent]. Dortmund: Univ., 2019.
    Dortmund, Techn. Univ., Chem. Biol., Masterarbeit, 2019
    I am interested in this work
  • Hudert, C. A.; Selinski, S.; Rudolph, B.; Golka, K.; Cadenas, C.; Reinders, J.; Hengstler, J. G.; Wiegand, S.: Genetic determinants of steatosis and fibrosis progression in pediatric non-alcoholic fatty liver disease
    Liver Int. 39: 540-556 (2019)
    I am interested in this work
  • Gogiashvili, M.; Nowacki, J.; Hergenröder, R.; Hengstler, J. G.; Lambert, J.; Edlund, K.: HR-MAS NMR based quantitative metabolomics in breast cancer
    Metabolites 9: (2): E19 (27 pp) (2019)
    I am interested in this work
  • Gogiashvili, Mikheil; Hengstler, J. G. [2. Gutachter]: Quantitatives, nicht gezieltes metabolisches Profiling von Brustkrebsgewebe mittels HR-MAS NMR-Spektrometrie: analytische Aspekte und Zusammenhänge mit klinisch-pathologischen ParameternGogiashvili, Mikheil; Hengstler, J. G. [2. Gutachter]. Münster: Univ., 2018.
    Münster, Univ., Fachber. Chemie und Pharmazie der Math.-Naturwiss.Fak., Diss, 2018
    I am interested in this work
  • Hoehme, S.; Bertaux, F.; Weens, W.; Grasl-Kraupp, B.; Hengstler, J. G.; Drasdo, D.: Model prediction and validation of an order mechanism controlling the spatiotemporal phenotype of early hepatocellular carcinoma
    Bull. Math. Biol. 80: 1134-1171 (2018)
    I am interested in this work
  • Salhab, A.; Nordström, K.; Gasparoni, G.; Kattler, K.; Ebert, P.; Cadenas, C.; Hengstler, J. G.; Walter, J.: A comprehensive analysis of 195 DNA methylomes reveals shared and cell specific features of partially methylated domains
    Genome Biol. 19: 150 (13 pp) (2018)
    I am interested in this work