Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email: hengstler@ifado.de

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed


  • Hammad, S.; Othman, A.; Meyer, C.; Telfah, A.; Lambert, J.; Dewidar, B.; Hengstler, J. G.; Dooley, S.: Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation
    Arch. Toxicol. 92: 2549-2561 (2018)
    I am interested in this work
  • Leist, M.; Hengstler, J. G.: Essential components of methods papers
    ALTEX 35: 429-432 (2018)
    I am interested in this work
  • Rodrigues, R. M.; Kollipara, L.; Chaudhari, U.; Sachinidis, A.; Zahedi, R. P.; Sickmann, A.; Hengstler, J. G.; Vinken, M.: Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
    Arch. Toxicol. 92: 1939-1952 (2018)
    I am interested in this work
  • Nemade, H.; Chaudhari, U.; Acharya, A.; Hescheler, J.; Hengstler, J. G.; Papadopoulos, S.; Sachinidis, A.: Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells
    Arch. Toxicol. 92: 1507-1524 (2018)
    I am interested in this work
  • Schmidt, M.; Weyer-Elberich, V.; Hengstler, J. G.; Heimes, A.-S.; Almstedt, K.; Gerhold-Ay, A.; Lebrecht, A.; Joensuu, H.: Prognostic impact of CD4-positive T cell subsets in early breast cancer: a study based on the FinHer trial patient population
    Breast Cancer Res. 20: article 15 (10 pp) (2018)
    I am interested in this work
  • Godoy, P.; Schmidt-Heck, W.; Hellwig, B.; Nell, P.; Feuerborn, D.; Rahnenführer, J.; Kattler, K.; Hengstler, J. G.: Assessment of stem cell differentiation based on genome-wide expression profiles
    Philos. Trans. R. Soc. London B. Biol. Sci. 373: (1750): 20170221 (2018)
    I am interested in this work
  • Bucur, P. O.; Bekheit, M.; Audebert, C.; Othman, A.; Hammad, S.; Sebagh, M.; Hengstler, J. G.; Vibert, E.: Modulating portal hemodynamics with vascular ring allows efficient regeneration after partial hepatectomy in a porcine model
    Ann. Surg. 268: 134-142 (2018)
    I am interested in this work
  • Hoehme, S.; Bertaux, F.; Weens, W.; Grasl-Kraupp, B.; Hengstler, J. G.; Drasdo, D.: Model prediction and validation of an order mechanism controlling the spatiotemporal phenotype of early hepatocellular carcinoma
    Bull. Math. Biol. 80: 1134-1171 (2018)
    I am interested in this work
  • Gogiashvili, M.; Horsch, S.; Marchan, R.; Gianmoena, K.; Cadenas, C.; Tanner, B.; Hengstler, J. G.; Edlund, K.: Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy
    NMR Biomed. 31: e3862 (2018)
    I am interested in this work
  • Chaudhari, U.; Nemade, H.; Sureshkumar, P.; Vinken, M.; Ates, G.; Rogiers, V.; Hengstler, J. G.; Sachinidis, A.: Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
    Arch. Toxicol. 92: 371-381 (2018)
    I am interested in this work
  • Han, D.; Gao, J.; Gu, X.; Hengstler, J. G.; Zhang, L.; Shahid, M.; Ali, T.; Han, B.: P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway
    Arch. Toxicol. 92: 679-692 (2018)
    I am interested in this work
  • Engel, J.; Smith, S.; Lategahn, J.; Tumbrink, H. L.; Goebel, L.; Günther, G.; Hengstler, J. G.; Rauh, D.: Structure-guided development of covalent and mutant-selective pyrazolopyrimidines to target T790M drug resistance in epidermal growth factor receptor
    J. Med. Chem. 60: 7725-7744 (2017)
    I am interested in this work
  • Vinken, M.; Knapen, D.; Vergauwen, L.; Hengstler, J. G.; Angrish, M.; Whelan, M.: Adverse outcome pathways: a concise introduction for toxicologists
    Arch. Toxicol. 91: 3697-3707 (2017)
    I am interested in this work
  • Hammad, S.; Braeuning, A.; Meyer, C.; Mohamed, F. E. Z. A.; Hengstler, J. G.; Dooley, S.: A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein
    Arch. Toxicol. 91: 3689-3692 (2017)
    I am interested in this work
  • Jabs, V.; Edlund, K.; König, H.; Grinberg, M.; Madjar, K.; Rahnenführer, J.; Hengstler, J. G.; Micke, P.: Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.
    PLoS ONE 12: (11): e0187246 (2017)
    I am interested in this work
  • Leist, M.; Ghallab, A.; Marchan, R.; Godoy, P.; Reif, R.; van Thriel, C.; Cadenas, C.; Hengstler, J. G.: Adverse outcome pathways: opportunities, limitations and open questions
    Arch. Toxicol. 91: 3477-3505 (2017)
    I am interested in this work
  • Golka, K.; Ickstadt, K.; Selinski, S.; Hengstler, J. G.; Wilhelm, M.: Third symposium on Environmental Toxicology in North Rhine-Westphalia, Germany: Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine: Meeting report on a symposium held in Dortmund May 7-8, 2015
    Arch. Toxicol. 91: 3711-3715 (2017)
    I am interested in this work
  • Schenk, A.; Ghallab, A.; Hofmann, U.; Hassan, R.; Schwarz, M.; Schuppert, A.; Hengstler, J. G.; Kuepfer, L.: Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage
    Sci. Rep. 7: 6224 (13 pp) (2017)
    I am interested in this work
  • Selinski, S.; Blaszkewicz, M.; Ickstadt, K.; Gerullis, H.; Otto, T.; Roth, E.; Hengstler, J. G.; Golka, K.: Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer
    Carcinogenesis 38: 1167-1179 (2017)
    I am interested in this work
    I am interested in this work
  • Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
    Cancer Res. 77: 4589-4601 (2017)
    I am interested in this work