Head of Department
Toxicology / Systems Toxicology
Phone: +49 / 231 1084 348
Email: hengstler@ifado.de
Curriculum Vitae:
- March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
- March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
- April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
- November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
- November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
- June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
- August 05, 1992: License to practice medicine
- December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
- October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
- Awards and honours:
- March 2002: Aventis Poster Award
- July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
- November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)
Research topics:
- toxicogenomics
- oncogenes and carcinogenesis
- liver and hepatocytes
Key publications:
- Edlund, K.; Madjar, K.; Lebrecht, A.; Cadenas, C.; Marchan, R.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.: Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial
Clin. Cancer Res. XX: epub ahead of print (2021)
https://dx.doi.org/10.1158/1078-0432.CCR-20-2662 - Kadhum, T.; Kopps, S.; Bolt, H. M.; Blaszkewicz, M.; Reinders, J.; Hengstler, J. G.; Selinski, S.; Golka, K.: Harnblasenkrebs durch Rissprüfsprays auf Azofarbstoff-Basis
Zbl. Arbeitsmed. 71: 1-7 (2021)
https://doi.org/10.1007/s40664-020-00406-6 - Brackhagen, Lisa; Hengstler, J. G. [2. Gutachter]: Bile acids as mediators of acetaminophen induced hepatotocixityBrackhagen, Lisa; Hengstler, J. G. [2. Gutachter]. Hamm-Lippstadt: Univ., 2020.
Hamm-Lippstadt, Hochsch., Studiengang „Umwelt- und Gefahrstoffanalytik“, Masterarbeit, 2020
I am interested in this work - Meisig, J.; Dreser, N.; Kapitza, M.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.; Leist, M.; Blüthgen, N.: Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
Nucleic Acids Res. 48: 12577-12592 (2020)
I am interested in this work
https://dx.doi.org/10.1093/nar/gkaa1089 - Schneider, K. M.; Elfers, C.; Ghallab, A.; Schneider, C. V.; Galvez, E. J. C.; Myllys, M.; Hengstler, J. G.; Trautwein, C.: Intestinal dysbiosis amplifies acetaminophen-inducedaAcute liver injury
Cell. Mol. Gastroenterol. Hepatol. XX: epub ahead of proof (2020)
https://dx.doi.org/10.1016/j.jcmgh.2020.11.002 - Kube, I.; Tardio, L. B.; Hofmann, U.; Ghallab, A.; Hengstler, J. G.; Fuehrer, D.; Zwanziger, D.: Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.
Thyroid XX: epub ahead of print (2020)
https://dx.doi.org/10.1089/thy.2020.0636 - Bruning, Nora; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]: Investigation on how granzyme B enters target cells via fluorescence localization reporterBruning, Nora; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]. Dortmund: Techn. Univ., 2020.
Dortmund, Techn. Univ., Faculty of Chemistry and Chemical Biology, Masterarbeit, 2020
I am interested in this work - González Leiva, Daniela Fernanda; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Role of WNT1-inducible signaling pathway protein-1 (WISP1) in liver injuryGonzález Leiva, Daniela Fernanda; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Techn. Univ., 2020.
Dortmund, Techn. Univ., Chem. Fak., Diss., 2020
I am interested in this work - Rohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]: Regulation of the glycerophosphodiesterase, EDI3 via HER2 signaling in breast cancerRohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]. Dortmund: Univ., 2020.
Dortmund, Techn. Univ., Faculty of Chemistry and Chemical Biology, Masterarbeit, 2020
I am interested in this work - Prager, Isabel; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]: Regulation of natural killer cell cytotoxic pathways during serial killing activityPrager, Isabel; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]. Dortmund: Univ., 2020.
Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2020
I am interested in this work - Guth, A.; Roth, A.; Engeli, B.; Lachenmeier, D. W.; Hüser, S.; Hengstler, J. G.; Steinberg, P.; Zarn, J. A.: Comparison of points of departure between subchronic and chronic toxicity studies on food additives, food contaminants and natural food constituents
Food Chem. Toxicol. 146: 111784 (11 pp) (2020)
I am interested in this work
https://dxc.doi.org/10.1016/j.fct.2020.111784 - Gupta, R.; Schrooders, Y.; Hauser, D.; Albrecht, W.; Brecklinghaus, T.; Hengstler, J. G.; Ghallab, A.; Caiment, F.: Comparing in vitro human liver models to in vivo human liver using RNA-Seq
Arch. Toxicol. XX: epub ahead of print (2020)
https://doi.org/10.1007/s00204-020-02937-6 - Heimes, A.-S.; Härtner, F.; Almstedt, K.; Krajnak, S.; Lebrecht, A.; Edlund, K.; Hengstler, J. G.; Schmidt, M.: Prognostic significance of interferon-? and its signaling pathway in early breast cancer depends on the molecular subtypes
Int. J. Mol. Sci. 21: 7178 (13 pp) (2020)
I am interested in this work
https://dx.doi.org/10.3390/ijms21197178 - Behjati Ardakani, F. ; Kattler, K.; Heinen, T.; Schmidt, F.; Feuerborn, D.; Nell, P.; Hengstler, J. G.; Schulz, M. H.: Prediction of single-cell gene expression for transcription factor analysis
GigaScience 9: (11): giaa113 (2020)
I am interested in this work
https://dx.doi.org/10.1093/gigascience/giaa113 - Kampf, Tatjana; Brecklinghaus, T. [Betr.]; Albrecht, W. [Betr.]; Hengstler, J. G. [Erstgutachter]: Zytotoxizitätsprüfung von Lebensmittelzusatzstoffen anhand von Cell-Titer-Blue-Viabilitäts-AssaysKampf, Tatjana; Brecklinghaus, T. [Betr.]; Albrecht, W. [Betr.]; Hengstler, J. G. [Erstgutachter]. Dortmund: Univ., 2020.
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Bachelorarbeit, 2020
I am interested in this work - Lucendo-Villarin, B.; Nell, P.; Hellwig, B.; Filis, P.; Feuerborn, D.; Godoy, P.; Hengstler, J. G.; Hay, D. C.: Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells
EXCLI J. 19: 1459-1476 (2020)
I am interested in this work
https://www.excli.de/index.php/excli/article/view/2934 - Jashari, Adelina; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Alterations of the glyoxylate metabolism in hepatic steatosis – a risk factor for hyperoxaluriaJashari, Adelina; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2020.
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2020
I am interested in this work - Frach, L.; Tierling, S.; Schwaiger, M.; Moser, D.; Heinrichs, M.; Hengstler, J. G.; Walter, J.; Kumsta, R.: ¬The¬ mediating role of KITLG DNA methylation in the association between childhood adversity and cortisol stress reactivity does not replicate in monocytes
Psychoneuroendocrinology 116: 104653 (2020)
https://doi.org/10.1016/j.psyneuen.2020.104653
I am interested in this work - Mohs, A.; Otto, T.; Schneider, K. M.; Peltzer, M.; Boekschoten, M.; Holland, C. H.; Hengstler, J. G.; Trautwein, C.: Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis
J. Hepatol. XX: epub ahead of print (2020)
https://dx.doi.org/10.1016/j.jhep.2020.09.037 - Kappenberg, F.; Brecklinghaus, T.; Albrecht, W.; Blum, J.; van der Wurp, C.; Leist, M.; Hengstler, J. G.; Rahnenführer, J.: Handling deviating control values in concentration-response curves
Arch. Toxicol. 94: 3787–3798 (2020)
https://doi.org/10.1007/s00204-020-02913-0
I am interested in this work
