Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email: hengstler@ifado.de

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed


  • Damle-Vartak, A.; Begher-Tibbe, B.; Gunther, G.; Geisler, F.; Vartak, N.; Hengstler, J. G.: Pipe-3D: a pipeline based on immunofluorescence, 3D confocal imaging, reconstructions, and morphometry for biliary network analysis in cholestasis
    In: Experimental cholestasis research (S. 25-53) / Mathieu Vinken (Editor). New York: Springer Science+Business, 2019.
    (Methods in molecular biology, 1981)
    I am interested in this work
  • Edlund, K.; Madjar, K.; Mattsson, J. S. M.; Djureinovic, D.; Lindskog, C.; Rahnenführer, J.; Micke, P.; Hengstler, J. G.: Prognostic impact of tumor cell programmed death ligand 1 expression and immune cell infiltration in NSCLC
    J. Thorac. Oncol. 14: 628-640 (2019)
    I am interested in this work
  • Gogiashvili, M.; Nowacki, J.; Hergenröder, R.; Hengstler, J. G.; Lambert, J.; Edlund, K.: HR-MAS NMR based quantitative metabolomics in breast cancer
    Metabolites 9: (2): E19 (27 pp) (2019)
    I am interested in this work
  • Tietz, T.; Selinski, S.; Golka, K.; Hengstler, J. G.; Gripp, S.; Ickstadt, K.; Ruczinski, I.; Schwender, H.: Identification of interactions of binary variables associated with survival time using survivalFS
    Arch. Toxicol. XX: epub ahead of print (2019)
  • Ghallab, A.; Vartak, N.; Hassan, R.; Zaza, A.; Godoy, P.; Drasdo, D.; Hengstler, J. G.; Reif, R.: Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood
    Hepatology 69: 666-683 (2019)
    I am interested in this work
  • Schmitz, Gernot; Watzl, C. [Referent]; Hengstler, J. G. [Koreferent]: Influence of the dopaminergic pathway on osteoclasts in arthritisSchmitz, Gernot; Watzl, C. [Referent]; Hengstler, J. G. [Koreferent]. Dortmund: Univ., 2019.
    Dortmund, Techn. Univ., Chem. Biol., Masterarbeit, 2019
    I am interested in this work
  • Hudert, C. A.; Selinski, S.; Rudolph, B.; Golka, K.; Cadenas, C.; Reinders, J.; Hengstler, J. G.; Wiegand, S.: Genetic determinants of steatosis and fibrosis progression in pediatric non-alcoholic fatty liver disease
    Liver Int. 39: 540-556 (2019)
    I am interested in this work
  • Ebmeyer, J.; Behrend, J.; Lorenz, M.; Günther, G.; Reif, R.; Hengstler, J. G.; Braeuning, A.; Hessel-Pras, S.: Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells
    Chem. Biol. Interact. 298: 104-111 (2019)
    I am interested in this work
  • Braeuning, A.; Oberemm, A.; Heise, T.; Gundert-Remy, U.; Hengstler, J. G.; Lampen, A.: In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism
    Arch. Toxicol. 93: 369-383 (2019)
    I am interested in this work
  • Cadenas, C.; Vosbeck, S.; Edlund, K.; Grgas, K.; Claus, M.; Watzl, C.; Marchan, R.; Hengstler, J. G.: LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
    Int. J. Cancer XX: epub ahead of print (2019)
  • Weisner, J.; Landel, I.; Reintjes, C.; Uhlenbrock, N.; Trajkovic-Arsic, M.; Günther, G.; Hengstler, J. G.; Rauh, D.: Preclinical efficacy of covalent-allosteric AKT inhibitor borussertib in combination with trametinib in KRAS-mutant pancreatic and colorectal cancer.
    Cancer Res. XX: epub ahead of print (2019)
  • Godoy, P.; Schmidt-Heck, W.; Hellwig, B.; Nell, P.; Feuerborn, D.; Rahnenführer, J.; Kattler, K.; Hengstler, J. G.: Assessment of stem cell differentiation based on genome-wide expression profiles
    Philos. Trans. R. Soc. London B. Biol. Sci. 373: (1750): 20170221 (2018)
    I am interested in this work
  • Knaack, H.; Lenk, L.; Philipp, L. M.; Miarka, L.; Rahn, S.; Hengstler, J. G.; Sebens, S.: Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells
    Oncotarget 9: 31771-31786 (2018)
    I am interested in this work
  • Hammad, S.; Othman, A.; Meyer, C.; Telfah, A.; Lambert, J.; Dewidar, B.; Hengstler, J. G.; Dooley, S.: Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation
    Arch. Toxicol. 92: 2549-2561 (2018)
    I am interested in this work
  • Leist, M.; Hengstler, J. G.: Essential components of methods papers
    ALTEX 35: 429-432 (2018)
    I am interested in this work
  • Hengstler, J. G.: The liver
    In: Toxicology and risk assessment: a comprehensive introduction. 2nd ed. (S. 231-248) / ed. by Helmut Greim, Robert Snyder. Hoboken, NJ: Wiley, 2018.
    I am interested in this work
  • Kappenberg, Franziska; Rahnenführer, Jörg [Betreuer]; Hengstler, J. G. [2. Gutachter]: Vorhersage von Lebertoxizität aus GenexpressionsdatenKappenberg, Franziska; Rahnenführer, Jörg [Betreuer]; Hengstler, J. G. [2. Gutachter]. Dortmund: Techn. Univ., 2018.
    Dortmund, Techn. Univ., Fakultät Statistik, Masterarbeit, 2018
    I am interested in this work
  • Rodrigues, R. M.; Kollipara, L.; Chaudhari, U.; Sachinidis, A.; Zahedi, R. P.; Sickmann, A.; Hengstler, J. G.; Vinken, M.: Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
    Arch. Toxicol. 92: 1939-1952 (2018)
    I am interested in this work
  • Nemade, H.; Chaudhari, U.; Acharya, A.; Hescheler, J.; Hengstler, J. G.; Papadopoulos, S.; Sachinidis, A.: Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells
    Arch. Toxicol. 92: 1507-1524 (2018)
    I am interested in this work
  • Schmidt, M.; Weyer-Elberich, V.; Hengstler, J. G.; Heimes, A.-S.; Almstedt, K.; Gerhold-Ay, A.; Lebrecht, A.; Joensuu, H.: Prognostic impact of CD4-positive T cell subsets in early breast cancer: a study based on the FinHer trial patient population
    Breast Cancer Res. 20: article 15 (10 pp) (2018)
    I am interested in this work