Head of Department
Toxicology / Systems Toxicology
Phone: +49 / 231 1084 348
Email: hengstler@ifado.de
Curriculum Vitae:
- March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
- March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
- April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
- November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
- November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
- June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
- August 05, 1992: License to practice medicine
- December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
- October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
- Awards and honours:
- March 2002: Aventis Poster Award
- July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
- November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)
Research topics:
- toxicogenomics
- oncogenes and carcinogenesis
- liver and hepatocytes
Publications:
- Hammad, S.; Othman, A.; Meyer, C.; Telfah, A.; Lambert, J.; Dewidar, B.; Hengstler, J. G.; Dooley, S.: Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation
Arch. Toxicol. 92: 2549-2561 (2018)
http://dx.doi.org/10.1007/s00204-018-2254-4
I am interested in this work - Leist, M.; Hengstler, J. G.: Essential components of methods papers
ALTEX 35: 429-432 (2018)
I am interested in this work
http://dx.doi.org/10.14573/altex.1807031 - Rodrigues, R. M.; Kollipara, L.; Chaudhari, U.; Sachinidis, A.; Zahedi, R. P.; Sickmann, A.; Hengstler, J. G.; Vinken, M.: Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
Arch. Toxicol. 92: 1939-1952 (2018)
I am interested in this work
http://dx.doi.org/10.1007/s00204-018-2214-z
https://link.springer.com/article/10.1007%2Fs00204-018-2214-z#SupplementaryMaterial - Nemade, H.; Chaudhari, U.; Acharya, A.; Hescheler, J.; Hengstler, J. G.; Papadopoulos, S.; Sachinidis, A.: Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells
Arch. Toxicol. 92: 1507-1524 (2018)
https://link.springer.com/article/10.1007%2Fs00204-018-2170-7#SupplementaryMaterial
https://doi.org/10.1007/s00204-018-2170-7
I am interested in this work - Schmidt, M.; Weyer-Elberich, V.; Hengstler, J. G.; Heimes, A.-S.; Almstedt, K.; Gerhold-Ay, A.; Lebrecht, A.; Joensuu, H.: Prognostic impact of CD4-positive T cell subsets in early breast cancer: a study based on the FinHer trial patient population
Breast Cancer Res. 20: article 15 (10 pp) (2018)
I am interested in this work
https://doi.org/10.1186/s13058-018-0942-x - Godoy, P.; Schmidt-Heck, W.; Hellwig, B.; Nell, P.; Feuerborn, D.; Rahnenführer, J.; Kattler, K.; Hengstler, J. G.: Assessment of stem cell differentiation based on genome-wide expression profiles
Philos. Trans. R. Soc. London B. Biol. Sci. 373: (1750): 20170221 (2018)
I am interested in this work
http://dx.doi.org/10.1098/rstb.2017.0221 - Bucur, P. O.; Bekheit, M.; Audebert, C.; Othman, A.; Hammad, S.; Sebagh, M.; Hengstler, J. G.; Vibert, E.: Modulating portal hemodynamics with vascular ring allows efficient regeneration after partial hepatectomy in a porcine model
Ann. Surg. 268: 134-142 (2018)
http://dx.doi.org/10.1097/SLA.0000000000002146
I am interested in this work - Hoehme, S.; Bertaux, F.; Weens, W.; Grasl-Kraupp, B.; Hengstler, J. G.; Drasdo, D.: Model prediction and validation of an order mechanism controlling the spatiotemporal phenotype of early hepatocellular carcinoma
Bull. Math. Biol. 80: 1134-1171 (2018)
I am interested in this work
https://doi.org/10.1007/s11538-017-0375-1 - Gogiashvili, M.; Horsch, S.; Marchan, R.; Gianmoena, K.; Cadenas, C.; Tanner, B.; Hengstler, J. G.; Edlund, K.: Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy
NMR Biomed. 31: e3862 (2018)
http://dx.doi.org//10.1002/nbm.3862
I am interested in this work - Chaudhari, U.; Nemade, H.; Sureshkumar, P.; Vinken, M.; Ates, G.; Rogiers, V.; Hengstler, J. G.; Sachinidis, A.: Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
Arch. Toxicol. 92: 371-381 (2018)
http://dx.doi.org/10.1007/s00204-017-2065-z
I am interested in this work - Han, D.; Gao, J.; Gu, X.; Hengstler, J. G.; Zhang, L.; Shahid, M.; Ali, T.; Han, B.: P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway
Arch. Toxicol. 92: 679-692 (2018)
http://dx.doi.org/10.1007/s00204-017-2070-2
I am interested in this work - Engel, J.; Smith, S.; Lategahn, J.; Tumbrink, H. L.; Goebel, L.; Günther, G.; Hengstler, J. G.; Rauh, D.: Structure-guided development of covalent and mutant-selective pyrazolopyrimidines to target T790M drug resistance in epidermal growth factor receptor
J. Med. Chem. 60: 7725-7744 (2017)
http://dx.doi.org/10.1021/acs.jmedchem.7b00515
I am interested in this work - Vinken, M.; Knapen, D.; Vergauwen, L.; Hengstler, J. G.; Angrish, M.; Whelan, M.: Adverse outcome pathways: a concise introduction for toxicologists
Arch. Toxicol. 91: 3697-3707 (2017)
I am interested in this work
http://dx.doi.org/10.1007/s00204-017-2020-z - Hammad, S.; Braeuning, A.; Meyer, C.; Mohamed, F. E. Z. A.; Hengstler, J. G.; Dooley, S.: A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein
Arch. Toxicol. 91: 3689-3692 (2017)
I am interested in this work
http://dx.doi.org/10.1007/s00204-017-2040-8 - Jabs, V.; Edlund, K.; König, H.; Grinberg, M.; Madjar, K.; Rahnenführer, J.; Hengstler, J. G.; Micke, P.: Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.
PLoS ONE 12: (11): e0187246 (2017)
I am interested in this work
http://dx.doi.org/10.1371/journal.pone.0187246 - Leist, M.; Ghallab, A.; Marchan, R.; Godoy, P.; Reif, R.; van Thriel, C.; Cadenas, C.; Hengstler, J. G.: Adverse outcome pathways: opportunities, limitations and open questions
Arch. Toxicol. 91: 3477-3505 (2017)
I am interested in this work
http://dx.doi.org/10.1007/s00204-017-2045-3 - Golka, K.; Ickstadt, K.; Selinski, S.; Hengstler, J. G.; Wilhelm, M.: Third symposium on Environmental Toxicology in North Rhine-Westphalia, Germany: Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine: Meeting report on a symposium held in Dortmund May 7-8, 2015
Arch. Toxicol. 91: 3711-3715 (2017)
http://dx.doi.org/10.1007/s00204-017-2093-8
I am interested in this work - Schenk, A.; Ghallab, A.; Hofmann, U.; Hassan, R.; Schwarz, M.; Schuppert, A.; Hengstler, J. G.; Kuepfer, L.: Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage
Sci. Rep. 7: 6224 (13 pp) (2017)
I am interested in this work
http://dx.doi.org/10.1038/s41598-017-04574-z - Selinski, S.; Blaszkewicz, M.; Ickstadt, K.; Gerullis, H.; Otto, T.; Roth, E.; Hengstler, J. G.; Golka, K.: Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer
Carcinogenesis 38: 1167-1179 (2017)
I am interested in this work
I am interested in this work
http://dx.doi.org/10.1093/carcin/bgx102 - Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
Cancer Res. 77: 4589-4601 (2017)
http://dx.doi.org/10.1158/0008-5472.CAN-16-2065
I am interested in this work
