Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email: hengstler@ifado.de

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed

Key publications:

  • Guth, S.; Hüser, S.; Roth, A.; Nitsche, M. A.; van Thriel, C.; Wascher, E.; Watzl, C.; Hengstler, J. G.: Contribution to the ongoing discussion on fluoride toxicity
    Arch. Toxicol. 95: 2571-2587 (2021)
    https://dx.doi.org/10.1007/s00204-021-03072-6
    I am interested in this work
  • Vartak, N.; Drasdo, D.; Geisler, F.; Itoh, T.; Oude Elferink, R. P. J.; van de Graaf, S. F. J.; Jansen, P.; Hengstler, J. G.: On the mechanisms of biliary flux
    Hepatology XX: epub ahead of print (2021)
    https://dx.doi.org/10.1002/hep.32027
  • Guth, S.; Hüser, S.; Roth, A.; Degen, G.; Edlund, K.; Marchan, R.; Mühle, E.; Hengstler, J. G.: Contribution to the ongoing discussion on fluoride toxicity
    Arch. Toxicol. 95: 2571-2587 (2021)
    https://dx.doi.org/10.1007/s00204-021-03072-6
    I am interested in this work
  • Koeppert, S.; Ghallab, A.; Peglow, S.; Winkler, C. F.; Graeber, S.; Büscher, A.; Hengstler, J. G.; Jahnen-Dechent, W.: Live imaging of calciprotein particle clearance and receptor mediated uptake: Role of calciprotein monomers
    Front. Cell Dev. Biol. 9: 633925 (14 pp) (2021)
    I am interested in this work
    https://dx.doi.org/10.3389/fcell.2021.633925
  • Buchmueller, J.; Sprenger, H.; Ebmeyer, J.; Rasinger, J. D.; Hengstler, J. G.; Guenther, G.; Braeuning, A.; Hessel-Pras, S.: Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study
    Arch. Toxicol. XX: epub ahead of print (2021)
    https://dx.doi.org/10.1007/s00204-021-03108-x
  • Kappenberg, F.; Grinberg, M.; Jiang, X.; Kopp-Schneider, A. ; Hengstler, J. G.; Rahnenführer, J.: Comparison of observation-based and model-based identification of alert concentrations from concentration-expression data
    Bioinformatics XX: epub ahead of print (2021)
    https://dx.doi.org/10.1093/bioinformatics/btab043
  • Edlund, K.; Madjar, K.; Lebrecht, A.; Cadenas, C.; Marchan, R.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.: Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial
    Clin. Cancer Res. 27: 2148-2158 (2021)
    https://dx.doi.org/10.1158/1078-0432.CCR-20-2662
    I am interested in this work
  • Ghallab, A.; Hassan, R.; Myllys, M.; Albrecht, W.; Hoehme, S.; Braeuning, A.; Degen, G. H.; Hengstler, J. G.: Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney
    Arch. Toxicol. 95: 2163-2177 (2021)
    I am interested in this work
    https://dx.doi.org/10.1007/s00204-021-03073-5
  • Vartak, N.; Guenther, G.; Joly, F.; Damle-Vartak, A.; Begher-Tibbe, B.; Ghallab, A.; Drasdo, D.; Hengstler, J. G.: Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux
    Hepatology 73: 1531-1550 (2021)
    https://doi.org/10.1002/hep.31422
    I am interested in this work
  • Wijaya, L. S.; Rau, C.; Braun, T. S.; Albrecht, W.; Brecklinghaus, T.; Hengstler, J. G.; Leist, M.; Schildknecht, S.: Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
    Cell Biol. Toxicol. XX: epub ahead of print (2021)
    https://dx.doi.org/10.1007/s10565-021-09610-3
  • Mohs, A.; Otto, T.; Schneider, K. M.; Peltzer, M.; Boekschoten, M.; Holland, C. H.; Hengstler, J. G.; Trautwein, C.: Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis
    J. Hepatol. 74: 638-648 (2021)
    https://dx.doi.org/10.1016/j.jhep.2020.09.037
    I am interested in this work
  • Kadhum, T.; Kopps, S.; Bolt, H. M.; Blaszkewicz, M.; Reinders, J.; Hengstler, J. G.; Selinski, S.; Golka, K.: Harnblasenkrebs durch Rissprüfsprays auf Azofarbstoff-Basis
    Zbl. Arbeitsmed. 71: 1-7 (2021)
    https://doi.org/10.1007/s40664-020-00406-6
    I am interested in this work
  • Gupta, R.; Schrooders, Y.; Hauser, D.; Albrecht, W.; Brecklinghaus, T.; Hengstler, J. G.; Ghallab, A.; Caiment, F.: Comparing in vitro human liver models to in vivo human liver using RNA-Seq
    Arch. Toxicol. 95: 573–589 (2021)
    https://doi.org/10.1007/s00204-020-02937-6
    I am interested in this work
  • Schneider, K. M.; Elfers, C.; Ghallab, A.; Schneider, C. V.; Galvez, E. J. C.; Myllys, M.; Hengstler, J. G.; Trautwein, C.: Intestinal dysbiosis amplifies acetaminophen-inducedaAcute liver injury
    Cell. Mol. Gastroenterol. Hepatol. 11: 909-933 (2021)
    https://dx.doi.org/10.1016/j.jcmgh.2020.11.002
    I am interested in this work
  • Kube, I.; Tardio, L. B.; Hofmann, U.; Ghallab, A.; Hengstler, J. G.; Fuehrer, D.; Zwanziger, D.: Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.
    Thyroid 31: 973–984 (2021)
    I am interested in this work
    https://dx.doi.org/10.1089/thy.2020.0636
  • Seidel, Florian; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Transcriptomics-based identification of teratogens in differentiating hiPSCs: A novel in vitro test systemSeidel, Florian; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2021.
    Dortmund, Techn. Univ., Fak. f. Chemie und Chemische Biologie, Diss., 2021
    I am interested in this work
  • Wijaya, L. S.; Trairatphisan, P.; Gabor, A.; Stevens, J. L.; Hengstler, J.; Leist, M.; Saez-Rodriguez, J.; van de Water, B.: Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury
    Biochem. Pharmacol. 190: 114591 (17 pp) (2021)
    I am interested in this work
    https://dx.doi.org/10.1016/j.bcp.2021.114591
  • Albrecht, Wiebke; Hengstler, J. G. [Erstgutachter]; Watzl, C. [Zweitgutachter]: Prediction of human drug-induced liver injury (DILI)in relation to oral doses and blood concentrationsAlbrecht, Wiebke; Hengstler, J. G. [Erstgutachter]; Watzl, C. [Zweitgutachter]. Dortmund: Univ., 2021.
    Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2021
    I am interested in this work
    http://hdl.handle.net/2003/40290
    http://dx.doi.org/10.17877/DE290R-22163
  • Rohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]: Regulation of the glycerophosphodiesterase, EDI3 via HER2 signaling in breast cancerRohlf, Katharina; Marchan, Rosemarie [Betreuerin]; Hengstler, J. G. [Erstgutachter]. Dortmund: Univ., 2020.
    Dortmund, Techn. Univ., Faculty of Chemistry and Chemical Biology, Masterarbeit, 2020
    I am interested in this work
  • Prager, Isabel; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]: Regulation of natural killer cell cytotoxic pathways during serial killing activityPrager, Isabel; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]. Dortmund: Univ., 2020.
    Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2020
    I am interested in this work