Univ.-Prof. Dr. med. Jan G. Hengstler

0521103J_G_Hengstler Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email: hengstler@ifado.de

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed

Key publications:

  • Vartak, N.; Drasdo, D.; Geisler, F.; Itoh, T.; Oude Elferink, R. P. J.; van de Graaf, S. F. J.; Jansen, P.; Hengstler, J. G.: On the mechanisms of biliary flux
    Hepatology XX: epub ahead of print (2021)
    https://dx.doi.org/10.1002/hep.32027
  • Godoy, P.; Marchan, R.; Cadenas, C.; Grgas, K.; Ghallab, A.; Reinders, J.; Edlund, K.; Hengstler, J. G.: Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria
    Cell Rep. 36: (8): 109526 (28 pp) (2021)
    I am interested in this work
    https://dx.doi.org/10.1016/j.celrep.2021.109526
  • Guth, S.; Hüser, S.; Roth, A.; Degen, G.; Edlund, K.; Marchan, R.; Mühle, E.; Hengstler, J. G.: Contribution to the ongoing discussion on fluoride toxicity
    Arch. Toxicol. 95: 2571-2587 (2021)
    https://dx.doi.org/10.1007/s00204-021-03072-6
    I am interested in this work
  • Koeppert, S.; Ghallab, A.; Peglow, S.; Winkler, C. F.; Graeber, S.; Büscher, A.; Hengstler, J. G.; Jahnen-Dechent, W.: Live imaging of calciprotein particle clearance and receptor mediated uptake: Role of calciprotein monomers
    Front. Cell Dev. Biol. 9: 633925 (14 pp) (2021)
    I am interested in this work
    https://dx.doi.org/10.3389/fcell.2021.633925
  • Myllys, Maiju Karoliina; Hengstler, J. G. [Erstgutachter]: Identification of a novel mechanism driving NAFLD progression and therapeutic strategiesMyllys, Maiju Karoliina; Hengstler, J. G. [Erstgutachter]. Dortmund: Univ., 2021.
    Dortmund, Techn. Univ., Fak. für Chemie und chemische Biologie, Diss., 2021
    I am interested in this work
  • Oesch, F.; Fruth, D.; Hengstler, J. G.; Fabian, E.; Berger, F. I.; Landsiedel, R.: Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat
    Arch. Toxicol. 95: 3717–3744 (2021)
    https://doi.org/10.1007/s00204-021-03151-8
    I am interested in this work
  • Schneider, K. M.; Candels, L. S.; Hov, J. R.; Myllys, M.; Hassan, R.; Zaza, A.; Hengstler, J. G.; Ghallab, A.: Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
    Nat. Metab. 3: 1228-1241 (2021)
    https://doi.org/10.1038/s42255-021-00452-1
  • Holland, C. H.; Ramirez-Flores, R. O.; Myllys, M.; Reinders, J.; Godoy, P.; Begher-Tibbe, B.; Hengstler, J. G.; Ghallab, A.: Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice
    Hepatol. Commun. XX: epub ahead of print (2021)
    https://doi.org/10.1002/hep4.1797
  • Guth, S.; Hüser, S.; Roth, A.; Nitsche, M. A.; van Thriel, C.; Wascher, E.; Watzl, C.; Hengstler, J. G.: Contribution to the ongoing discussion on fluoride toxicity
    Arch. Toxicol. 95: 2571-2587 (2021)
    https://dx.doi.org/10.1007/s00204-021-03072-6
    I am interested in this work
  • Buchmueller, J.; Sprenger, H.; Ebmeyer, J.; Rasinger, J. D.; Hengstler, J. G.; Guenther, G.; Braeuning, A.; Hessel-Pras, S.: Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study
    Arch. Toxicol. 95: 2785–2796 (2021)
    https://dx.doi.org/10.1007/s00204-021-03108-x
    I am interested in this work
  • Kappenberg, F.; Grinberg, M.; Jiang, X.; Kopp-Schneider, A. ; Hengstler, J. G.; Rahnenführer, J.: Comparison of observation-based and model-based identification of alert concentrations from concentration-expression data
    Bioinformatics 37: 1990–1996 (2021)
    https://dx.doi.org/10.1093/bioinformatics/btab043
    I am interested in this work
  • Niemann, Jens; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]: Identification and characterization of serial killing human natural killer cellsNiemann, Jens; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]. Dortmund: Univ., 2021.
    Dortmund, Techn. Univ., Fak. für Chemie und Chemische Biologie, Masterarbeit, 2021
    I am interested in this work
  • Genc, E.; Gonzalez, D.; Keller, M.; Marchan, R.; Cadenas, C.; Watzl, C.; Nitsche, M. A.; Hengstler, J. G.: Spatio-temporal multiscale analysis of western diet-fed mice reveals a translationally relevant sequence of events during nafld progression
    Cells 10: (10): 2516 (29 pp) (2021)
    I am interested in this work
    https://doi.org/10.3390/cells10102516
  • Edlund, K.; Madjar, K.; Lebrecht, A.; Cadenas, C.; Marchan, R.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.: Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial
    Clin. Cancer Res. 27: 2148-2158 (2021)
    https://dx.doi.org/10.1158/1078-0432.CCR-20-2662
    I am interested in this work
  • Albrecht, Wiebke; Hengstler, J. G. [Erstgutachter]; Watzl, C. [Zweitgutachter]: Prediction of human drug-induced liver injury (DILI)in relation to oral doses and blood concentrationsAlbrecht, Wiebke; Hengstler, J. G. [Erstgutachter]; Watzl, C. [Zweitgutachter]. Dortmund: Univ., 2021.
    Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2021
    I am interested in this work
    http://hdl.handle.net/2003/40290
    http://dx.doi.org/10.17877/DE290R-22163
  • Gianmoena, K.; Jashari, A.; Gabrys, P.; Grgas, K.; Ghallab, A.; Reinders, J.; Edlund, K.; Hengstler, J. G.: Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria
    Cell Rep. 36: (8): 109526 (28 pp) (2021)
    I am interested in this work
    https://dx.doi.org/10.1016/j.celrep.2021.109526
  • Seidel, Florian; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Transcriptomics-based identification of teratogens in differentiating hiPSCs: A novel in vitro test systemSeidel, Florian; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2021.
    Dortmund, Techn. Univ., Fak. f. Chemie und Chemische Biologie, Diss., 2021
    I am interested in this work
  • Schmidt, M.; Edlund, K.; Hengstler, J. G.; Heimes, A.-S.; Almstedt, K.; Lebrecht, A.; Rahnenführer, J.; Joensuu, H.: Prognostic impact of immunoglobulin kappa C (IGKC) in early breast cancer
    Cancers ( Basel) 13: (14): 3626 (13 pp) (2021)
    I am interested in this work
    https://doi.org/10.3390/cancers13143626
  • Mattonet, K.; Nowack-Weyers, N.; Vogel, V.; Moser, D.; Tierling, S.; Kasper-Sonnenberg, M.; Hengstler, J. G.; Kumsta, R.: Prenatal exposure to endocrine disrupting chemicals is associated with altered DNA methylation in cord blood
    Epigenetics XX: epub ahead of print (2021)
    https://doi.org/10.1080/15592294.2021.1975917
  • Wijaya, L. S.; Rau, C.; Braun, T. S.; Albrecht, W.; Brecklinghaus, T.; Hengstler, J. G.; Leist, M.; Schildknecht, S.: Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
    Cell Biol. Toxicol. XX: epub ahead of print (2021)
    https://dx.doi.org/10.1007/s10565-021-09610-3