Apl. Prof. Dr. rer. nat. Dr. med. Gisela Degen

Head of the Senior Group

Chemical Risks

Phone: +49 / 231 1084 465
Email: degen@ifado.de

Curriculum Vitae:

  • 1997 apl. Prof. at the Ruhr-University of Bochum (retired in 2016; continues as Senior Fellow Scientist)
  • since 1992 head of the research group "Chemical toxicity" (since 2007 "Chemical risks")
  • 1990 habilitation (Dr. med. habil.) for Biochemical Pharmacology and Toxicology; Priv. Doz. at the University of Würzburg, Germany
  • 1983-1992 research associate at the Institute of Toxicology, Univ. of Würzburg and project leader in Special Center Grant (Sonderforschungsbereich 172)
  • 1979-1983 postdoctoral fellow at the NIEHS, Research Triangle Park, NC/USA
  • 1978 dissertation (Dr. rer. nat.; University of Würzburg, Germany)
  • 1972 state examen completing the academic training in food chemistry (University of Würzburg)

Research topics:

  • biochemical toxicology (bioactivation and detoxication of xenobiotics)
  • genotoxicity of chemicals (mycotoxins, steroids, metals, others)
  • Human biomotoring (Biomarker of Exposure)
  • toxicokinetics and toxicodynamics of hormonally active compounds
  • risk assessment of chemicals
  • Boards and committees:
  • editorial board member (since 2009) of Mycotoxin Research (Springer)
  • vice president (2008-2010) of the Society for Mycotoxin Research (since 2008)
  • member of the Scientific Committee for Consumer Products (SCCP since 2004), now Scientific Committee for Consumer Safety (SCCS), European Commission, Health and Consumer Protection Directorate-General
  • member of the Ausschuss für Gefahrstoffe (AGS) of the BMAS (German Federal Ministry of Labour and Social Affairs)
  • chair of the AK "Grenzwerte und Einstufungen für CM Stoffe" of the UAIII in AGS
  • 2003-2005 member of the International Peer Review Panel for the Uterotrophic Bioassay of the OECD
  • 2000-2003 member of the (German) Risikokommision (gemeinsame ad hoc Kommission von BMG und BMU zur "Neuordnung der Verfahren und Strukturen der Risikobewertung und Standardsetzung im gesundheitlichen Umweltschutz der Bundesrepublik Deutschland")
No supervision of master theses or dissrtations possible any longer.

Key publications:

  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Safety of a proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: to expand the list of steviol glycosides to all those identified in the leaves of Stevia Rebaudiana Bertoni.
    EFSA Journal 18: 6106 (33 pp) (2020)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2020.6106
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Safety of use of oat lecithin as a food additive
    EFSA Journal 18: 5969 (22 pp) (2020)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2020.5969
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 72, Revision 2 (FGE.72Rev2): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids and related esters evaluated by JECFA (61st, 68th and 69th meetings) and structurally related to flavouring substances in FGE.05Rev3
    EFSA Journal 18: 6029 (36 pp) (2020)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2020.6029
  • Ali, N.; Degen, G. H.: Biological monitoring for ochratoxin A and citrinin and their metabolites in urine samples of infants and children in Bangladesh
    Mycotoxin Res. 36: 409-417 (2020)
    https://doi.org/10.1007/s12550-020-00407-7
    I am interested in this work
  • Ali, N.; Manirujjaman, M.; Rana, S.; Degen, G. H.: Determination of aflatoxin M1 and deoxynivalenol biomarkers in infants and children urines from Bangladesh
    Arch. Toxicol. 94: 3775–3786 (2020)
    https://doi.org/10.1007/s00204-020-02857-5
    I am interested in this work
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 73, Revision 5 (FGE.73Rev5): consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th, 63rd and 86th meeting) and structurally related to substances evaluated in FGE.12Rev5
    EFSA Journal 18: 5970 (31 pp) (2020)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2020.5970
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 91, Revision 3 (FGE.91Rev3): consideration of aliphatic, aromatic and a,ß-unsaturated sulfides and thiols evaluated by JECFA (53rd, 61st, 68th and 76th meetings), structurally related to substances in FGE.08Rev5
    EFSA Journal 18: 6154 (49 pp) (2020)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2020.6154
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 69, Revision 1 (FGE.69Rev1): consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting), structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16Rev2
    EFSA Journal 18: 6265 (35 pp) (2020)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2020.6265
  • Guth, S.; Hüser, S.; Roth, A.; Degen, G.; Edlund, K.; Marchan, R.; Nitsche, M. A.; van Thriel, C.: Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses
    Arch. Toxicol. 94: 1375-1415 (2020)
    https://dx.doi.org/10.1007/s00204-020-02725-2
    I am interested in this work
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, a,b-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3
    EFSA Journal 18: 5924 (44 pp) (2020)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2020.5924
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 61 Revision 2 (FGE.61Rev2): Consideration of aliphatic acetals evaluated by JECFA (57th, 63rd and 68th meetings) structurally related to acetals evaluated by EFSA in FGE.03Rev2
    EFSA Journal 18: 5923 (23 pp) (2020)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2020.5923
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): Consideration of genotoxicity data on alicyclic aldehydes with a,ß-unsaturation in ring/side-chain and precursors from chemical subgroup 2.2 of FGE.19
    EFSA Journal 17: 5569 (50 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5569
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 217, Revision 2 (FGE.217Rev2): Consideration of genotoxic potential for a,ß-unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones
    EFSA Journal 17: 5568 (45 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5568
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 210 Revision 3 (FGE.210Rev3): Consideration of genotoxic potential for a,ß-unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 of FGE.19
    EFSA Journal 17: 5676 (42 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5676
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable)
    EFSA Journal 17: 5675 (57 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5675
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 70, Revision 1 (FGE.70Rev1): Consideration of aliphatic, linear, a,ß-unsaturated, di- and trienals and related alcohols, acids and esters evaluated by JECFA (61st-68th-69th meeting)
    EFSA Journal 17: 5749 (41 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5749
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): Consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, a,ß-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19
    EFSA Journal 17: 5750 (26 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5750
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 5, Revision 3 (FGE.05Rev3): Branched- and straight-chain unsaturated aldehydes, dienals, unsaturated and saturated carboxylic acids and related esters with saturated and unsaturated aliphatic alcohol and a phenylacetic acid related ester from chemical groups 1, 2, 3, 5 and 15
    EFSA Journal 17: 5761 (69 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5761
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on the safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: Rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract
    EFSA Journal 17: 5867 (19 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5867
  • EFSA Panel on Food Additives and Flavourings; Degen, G. H.: Scientific Opinion on Flavouring Group Evaluation 215 Revision 1 (FGE.215Rev1): seven a,ß-unsaturated cinnamyl ketones from subgroup 3.2 of FGE.19
    EFSA Journal 17: 5875 (34 pp) (2019)
    I am interested in this work
    https://doi.org/10.2903/j.efsa.2019.5875