Dr. rer. nat. Cristina Cadenas

cadenas_4 Head of the junior research group

Interorgan Toxicology

Phone: +49 / 231 1084 392
Email: cadenas@ifado.de

Curriculum Vitae:

  • since 08/2010: Junior group leader at Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Department Systems Toxicology - Prof. Dr. Jan G. Hengstler
  • 01/2008-07/2010: Postdoc , Institute for Analytical Sciences – ISAS - e.V., Dortmund, Department Metabolomics - PD. Dr. J.I. Baumbach, Line of research: "Metabolome analysis of cancer cell lines"
  • 03/2003-12/2007: Family break, Teaching at the public school (Volkshochschule) Dortmund.
  • 05/2000-02/2003: Postdoc, Max Planck Institute for experimental Endocrinology, Hannover. Laboratory Prof. Dr. Gregor Eichele, Line of research: "Molecular basis of circadian rhythms"
  • 06/1994-03/2000: Ph.D. Thesis, Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold, Thesis: "Identification of new genes involved in embryonic development by Gene-trap insertional mutagenesis in mouse embryonic stem cells"
  • 09/1988-09/1994: Academic Studies, Biology Study with specialization in Biochemistry and Molecular Biology, Universidad Autónoma, Madrid (Spanien) and Université Paul Sabatier, Toulouse (France), Final Thesis: Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold

Research topics:

  • Oncogene-mediated tumor metabolome
  • Cell survival mechanisms and Prognostic factors in breast cancer
  • Metabolic alterations in non-alcoholic fatty liver disease (NAFLD)

Key publications:

  • Godoy, P.; Marchan, R.; Cadenas, C.; Grgas, K.; Ghallab, A.; Reinders, J.; Edlund, K.; Hengstler, J. G.: Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria
    Cell Rep. 36: (8): 109526 (28 pp) (2021)
    I am interested in this work
  • Holland, C. H.; Ramirez-Flores, R. O.; Myllys, M.; Hassan, R.; Edlund, K.; Marchan, R.; Cadenas, C.; Reinders, J.: Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice
    Hepatol. Commun. XX: epub ahead of print (2021)
  • Genc, E.; Gonzalez, D.; Keller, M.; Marchan, R.; Cadenas, C.; Watzl, C.; Nitsche, M. A.; Hengstler, J. G.: Spatio-temporal multiscale analysis of western diet-fed mice reveals a translationally relevant sequence of events during nafld progression
    Cells 10: (10): 2516 (29 pp) (2021)
    I am interested in this work
  • Edlund, K.; Madjar, K.; Lebrecht, A.; Cadenas, C.; Marchan, R.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.: Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial
    Clin. Cancer Res. 27: 2148-2158 (2021)
    I am interested in this work
  • Garner, Melissa; Capellino, S. [1. Gutachter]; Cadenas, C. [Betreuer]: Expression and signal transmission of adrenoceptors in the non-alcoholic fatty liverGarner, Melissa; Capellino, S. [1. Gutachter]; Cadenas, C. [Betreuer]. Köln: Univ., 2020.
    Köln, Rheinische Fachhochschule, Bachelorarbeit, 2020
    I am interested in this work
  • Campos, G.; Ghallab, A.; Pütter, L.; Edlund, K.; Cadenas, C.; Marchan, R.; Hengstler, J. G.; Godoy, P.: Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
    Arch. Toxicol. 94: 205-217 (2020)
    I am interested in this work
  • Ramisch, A.; Heinrich, V.; Glaser, L. V.; Fuchs, A.; Yang, X.; Cadenas, C.; Hengstler, J. G.; Vingron, M.: CRUP: a comprehensive framework to predict condition-specific regulatory units
    Genome Biol. 20: (1): 227 (23 pp) (2019)
    I am interested in this work
  • Brockmann, Jessica; Capellino, S. [Betreuer]; Cadenas, C. [Betreuer]: Sympathische Innervation in der nicht-alkoholischen Fettleber in Maus und MenschBrockmann, Jessica; Capellino, S. [Betreuer]; Cadenas, C. [Betreuer]. Recklinghausen: Hochsch., 2019.
    Recklinghausen, Westfälische Hochschule, Bachelorarbeit, 2019
    I am interested in this work
  • Albrecht, W.; Kappenberg, F.; Brecklinghaus, T.; Stoeber, R.; Marchan, R.; Cadenas, C.; Ghallab, A.; Hengstler, J. G.: Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
    Arch. Toxicol. 93: 1609-1637 (2019)
    I am interested in this work
  • Cadenas, C.; Vosbeck, S.; Edlund, K.; Grgas, K.; Claus, M.; Watzl, C.; Marchan, R.; Hengstler, J. G.: LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
    Int. J. Cancer 145: 901-915 (2019)
    I am interested in this work