Dr. rer. nat. Cristina Cadenas

cadenas Head of the junior research group

Interorgan Toxicology

Phone: +49 / 231 1084 392
Email: cadenas@ifado.de

Curriculum Vitae:

  • since 08/2010: Junior group leader at Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Department Systems Toxicology - Prof. Dr. Jan G. Hengstler
  • 01/2008-07/2010: Postdoc , Institute for Analytical Sciences – ISAS - e.V., Dortmund, Department Metabolomics - PD. Dr. J.I. Baumbach, Line of research: "Metabolome analysis of cancer cell lines"
  • 03/2003-12/2007: Family break, Teaching at the public school (Volkshochschule) Dortmund.
  • 05/2000-02/2003: Postdoc, Max Planck Institute for experimental Endocrinology, Hannover. Laboratory Prof. Dr. Gregor Eichele, Line of research: "Molecular basis of circadian rhythms"
  • 06/1994-03/2000: Ph.D. Thesis, Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold, Thesis: "Identification of new genes involved in embryonic development by Gene-trap insertional mutagenesis in mouse embryonic stem cells"
  • 09/1988-09/1994: Academic Studies, Biology Study with specialization in Biochemistry and Molecular Biology, Universidad Autónoma, Madrid (Spanien) and Université Paul Sabatier, Toulouse (France), Final Thesis: Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold

Research topics:

  • Oncogene-mediated tumor metabolome
  • Cell survival mechanisms and Prognostic factors in breast cancer
  • Metabolic alterations in non-alcoholic fatty liver disease (NAFLD)


  • Cadenas, C.; Vosbeck, S.; Edlund, K.; Grgas, K.; Claus, M.; Watzl, C.; Marchan, R.; Hengstler, J. G.: LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
    Int. J. Cancer XX: epub ahead of print (2019)
  • Hudert, C. A.; Selinski, S.; Rudolph, B.; Golka, K.; Cadenas, C.; Reinders, J.; Hengstler, J. G.; Wiegand, S.: Genetic determinants of steatosis and fibrosis progression in pediatric non-alcoholic fatty liver disease
    Liver Int. 39: 540-556 (2019)
    I am interested in this work
  • Salhab, A.; Nordström, K.; Gasparoni, G.; Kattler, K.; Ebert, P.; Cadenas, C.; Hengstler, J. G.; Walter, J.: A comprehensive analysis of 195 DNA methylomes reveals shared and cell specific features of partially methylated domains
    Genome Biol. 19: 150 (13 pp) (2018)
    I am interested in this work
  • Grinberg, M.; Stöber, R. M.; Albrecht, W.; Edlund, K.; Godoy, P.; Cadenas, C.; Marchan, R.; Hengstler, J. G.: Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes
    Arch. Toxicol. 92: 3517-3533 (2018)
    I am interested in this work
  • Vosse, C.; Wienken, C.; Cadenas, C.; Hayen, H.: Separation and identification of phospholipids by hydrophilic interaction liquid chromatography coupled to tandem high resolution mass spectrometry with focus on isomeric phosphatidylglycerol and bis(monoacylglycero)phosphate
    J. Chromatogr. A 1565: 105-113 (2018)
    I am interested in this work
  • Gu, X.; Albrecht, W.; Edlund, K.; Cadenas, C.; Marchan, R.; Brecklinghaus, T.; Hengstler, J. G.; Stoeber, R.: Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes
    Arch. Toxicol. 92: 3505-3515 (2018)
    I am interested in this work
  • Gogiashvili, M.; Horsch, S.; Marchan, R.; Gianmoena, K.; Cadenas, C.; Tanner, B.; Hengstler, J. G.; Edlund, K.: Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy
    NMR Biomed. 31: e3862 (2018)
    I am interested in this work
  • Schriewer, A.; Cadenas, C.; Hayen, H.: Hydrophilic interaction liquid chromatography tandem mass spectrometry analysis of malonyl-coenzyme A in breast cancer cell cultures applying online solid-phase extraction
    J. Sep. Sci. 40: 4303-4310 (2017)
    I am interested in this work
  • Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
    Cancer Res. 77: 4589-4601 (2017)
    I am interested in this work
  • Leist, M.; Ghallab, A.; Marchan, R.; Godoy, P.; Reif, R.; van Thriel, C.; Cadenas, C.; Hengstler, J. G.: Adverse outcome pathways: opportunities, limitations and open questions
    Arch. Toxicol. 91: 3477-3505 (2017)
    I am interested in this work