Dr. rer. nat. Cristina Cadenas

cadenas_4 Head of the junior research group

Interorgan Toxicology

Phone: +49 / 231 1084 392
Email: cadenas@ifado.de

Curriculum Vitae:

  • since 08/2010: Junior group leader at Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Department Systems Toxicology - Prof. Dr. Jan G. Hengstler
  • 01/2008-07/2010: Postdoc , Institute for Analytical Sciences – ISAS - e.V., Dortmund, Department Metabolomics - PD. Dr. J.I. Baumbach, Line of research: "Metabolome analysis of cancer cell lines"
  • 03/2003-12/2007: Family break, Teaching at the public school (Volkshochschule) Dortmund.
  • 05/2000-02/2003: Postdoc, Max Planck Institute for experimental Endocrinology, Hannover. Laboratory Prof. Dr. Gregor Eichele, Line of research: "Molecular basis of circadian rhythms"
  • 06/1994-03/2000: Ph.D. Thesis, Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold, Thesis: "Identification of new genes involved in embryonic development by Gene-trap insertional mutagenesis in mouse embryonic stem cells"
  • 09/1988-09/1994: Academic Studies, Biology Study with specialization in Biochemistry and Molecular Biology, Universidad Autónoma, Madrid (Spanien) and Université Paul Sabatier, Toulouse (France), Final Thesis: Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold

Research topics:

  • Oncogene-mediated tumor metabolome
  • Cell survival mechanisms and Prognostic factors in breast cancer
  • Metabolic alterations in non-alcoholic fatty liver disease (NAFLD)

Key publications:

  • Edlund, K.; Madjar, K.; Lebrecht, A.; Cadenas, C.; Marchan, R.; Sachinidis, A.; Rahnenführer, J.; Hengstler, J. G.: Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial
    Clin. Cancer Res. XX: epub ahead of print (2021)
    https://dx.doi.org/10.1158/1078-0432.CCR-20-2662
  • Garner, Melissa; Capellino, S. [1. Gutachter]; Cadenas, C. [Betreuer]: Expression and signal transmission of adrenoceptors in the non-alcoholic fatty liverGarner, Melissa; Capellino, S. [1. Gutachter]; Cadenas, C. [Betreuer]. Köln: Univ., 2020.
    Köln, Rheinische Fachhochschule, Bachelorarbeit, 2020
    I am interested in this work
  • Campos, G.; Ghallab, A.; Pütter, L.; Edlund, K.; Cadenas, C.; Marchan, R.; Hengstler, J. G.; Godoy, P.: Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
    Arch. Toxicol. 94: 205-217 (2020)
    http://dx.doi.org/10.1007/s00204-019-02630-3
    I am interested in this work
  • Brockmann, Jessica; Capellino, S. [Betreuer]; Cadenas, C. [Betreuer]: Sympathische Innervation in der nicht-alkoholischen Fettleber in Maus und MenschBrockmann, Jessica; Capellino, S. [Betreuer]; Cadenas, C. [Betreuer]. Recklinghausen: Hochsch., 2019.
    Recklinghausen, Westfälische Hochschule, Bachelorarbeit, 2019
    I am interested in this work
  • Ramisch, A.; Heinrich, V.; Glaser, L. V.; Fuchs, A.; Yang, X.; Cadenas, C.; Hengstler, J. G.; Vingron, M.: CRUP: a comprehensive framework to predict condition-specific regulatory units
    Genome Biol. 20: (1): 227 (23 pp) (2019)
    I am interested in this work
    https://doi.org/10.1186/s13059-019-1860-7
  • Czepukojc, B.; Abuhaliema, A.; Barghash, A.; Tierling, S.; Cadenas, C.; Sachinidis, A.; Hengstler, J. G.; Kessler, S. M.: IGF2 mRNA binding protein 2 transgenic mice are more prone to develop a ductular reaction and to progress toward cirrhosis
    Front. Med. 6: 179 (16 pp) (2019)
    I am interested in this work
    https://doi.org/10.3389/fmed.2019.00179
  • Albrecht, W.; Kappenberg, F.; Brecklinghaus, T.; Stoeber, R.; Marchan, R.; Cadenas, C.; Ghallab, A.; Hengstler, J. G.: Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
    Arch. Toxicol. 93: 1609-1637 (2019)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-019-02492-9
  • Cadenas, C.; Vosbeck, S.; Edlund, K.; Grgas, K.; Claus, M.; Watzl, C.; Marchan, R.; Hengstler, J. G.: LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
    Int. J. Cancer 145: 901-915 (2019)
    http://dx.doi.org/10.1002/ijc.32138
    I am interested in this work
  • Hudert, C. A.; Selinski, S.; Rudolph, B.; Golka, K.; Cadenas, C.; Reinders, J.; Hengstler, J. G.; Wiegand, S.: Genetic determinants of steatosis and fibrosis progression in pediatric non-alcoholic fatty liver disease
    Liver Int. 39: 540-556 (2019)
    http://dx.doi.org/10.1111/liv.14006
    I am interested in this work
  • Salhab, A.; Nordström, K.; Gasparoni, G.; Kattler, K.; Ebert, P.; Cadenas, C.; Hengstler, J. G.; Walter, J.: ¬A¬ comprehensive analysis of 195 DNA methylomes reveals shared and cell specific features of partially methylated domains
    Genome Biol. 19: 150 (13 pp) (2018)
    I am interested in this work
    http://dx.doi.org/10.1186/s13059-018-1510-5