Head of Department
Immunology
Phone: +49 / 231 1084 233
Email: watzl@ifado.de
Curriculum Vitae:
- 2011 Full Professor for Immunology at Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund
- 2006 Extraordinary Professorship (apl. Prof.), University Heidelberg
- 2002-2011 Group Leader at the Institute for Immunology, University Heidelberg
- 2004 Habilitation in Immunology, Medical Faculty, University Heidelberg
- 1998-2002 PostDoc (University Heidelberg and NIAID-NIH, USA)
- 1998 PhD in biology at University Heidelberg
Research topics:
- Immunregulation
- NK Cells
- Signal Pathways
Key publications:
- Urlaub, D.; Wolfsdorff, N.; Hoffmann, J.-E.; Bröde, P.; Claus, M.; Wingert, S.; Renken, F.; Watzl, C.: Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination
Eur. J. Immunol. 52: 810-815 (2022)
https://doi.org/10.1002/eji.202149758
I am interested in this work - Siegler, J. J.; Correia, M. P.; Hofman, T.; Prager, I.; Birgin, E.; Rahbari, N. N.; Watzl, C.; Cerwenka, A.: Human ILC3 exert TRAIL-mediated cytotoxicity towards cancer cells
Front. Immunol. 13: 742571 (12 pp) (2022)
I am interested in this work
https://doi.org/10.3389/fimmu.2022.742571 - Jarahian, M.; Marstaller, K.; Banna, N.; Ahani, R.; Etemadzadeh, M. H.; Boller, L. K.; Azadmanesh, K.; Watzl, C.: Activating natural killer cell receptors, selectins, and inhibitory siglecs recognize Ebolavirus glycoprotein
J. Innate Immun. 14: 135-147 (2022)
https://doi.org/10.1159/000517628
I am interested in this work - Bröde, P.; Claus, M.; Gajewski, P.; Getzmann, S.; Golka, K.; Hengstler, J. G.; Wascher, E.; Watzl, C.: Immune age, but not chronological age, together with obesity and independently from sex predicts low physical working capacity
In: Technologie und Bildung in hybriden Arbeitswelten: 68. Kongress der Gesellschaft für Arbeitswissenschaft, Magdeburg, 02.-04.03.2022 (S. Beitrag A.1.2 (4 S)) / Gesellschaft für Arbeitswissenschaft (Hrsg.). St. Augustin: GfA-Press, 2022.
I am interested in this work - Blazquez-Navarro, A. ; Mittmann, L.; Thieme, C. J.; Anft, M.; Paniskaki, K.; Doevelaar, A.; Watzl, C.; Babel, N.: Impact of low eGFR on the immune response against COVID-19
J. Nephrol. XX: Epub ahead of print (2022)
https://doi.org/10.1007/s40620-022-01374-1 - Zhao, S.; Grieshaber-Bouyer, R.; Rao, D. A.; Kolb, P.; Chen, H.; Andreeva, I.; Watzl, C.; Merkt, W.: Effect of JAK inhibition on the induction of proinflammatory HLA-DR+CD90+ rheumatoid arthritis synovial fibroblasts by interferon-?
Arthritis Rheumatol. 74: 441-452 (2022)
https://doi.org/10.1002/art.41958
I am interested in this work - Picard, L. K.; Claus, M.; Fasbender, F.; Watzl, C.: Human NK cells responses are enhanced by CD56 engagement
Eur. J. Immunol. XX: epub ahead of print (2022)
https://doi.org/10.1002/eji.202249868 - Metzler, Sarah; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]: ¬The¬ role of innate lympoid cells 1 and natural killer cells during drug induced liver damageMetzler, Sarah; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]. Dortmund: Univ., 2022.
Dortmund, Tech. Univ., Faculty of Chemistry and Biological Chemistry, Diss., 2022
I am interested in this work - Peters, E. M. J.; Schedlowski, M.; Watzl, C.; Gimsa, U.: Stress und Covid-19: Ein narrativer Review über neuroendokrinimmune Mechanismen, die eine Abwehr von SARS-CoV-2 verbessern könnten. Can stress interact with SARS-CoV-2? A narrative review with a focus on stress-reducing interventions that may improve defence against COVID-19
Psychother. Psychosom. Med. Psychol. 71: 61-71 (2021)
https://dx.doi.org/10.1055/a-1322-3205
I am interested in this work - Peifer, C.; Hagemann, V.; Claus, M.; Larra, M. F.; Broede, P.; Watzl, C.; Wascher, E.; Capellino, S.: Low self-reported stress despite immune-physiological changes in paramedics during rescue operations
EXCLI J. 20: 792-811 (2021)
I am interested in this work
https://dx.doi.org/10.17179/excli2021-3617 - Guth, S.; Hüser, S.; Roth, A.; Nitsche, M. A.; van Thriel, C.; Wascher, E.; Watzl, C.; Hengstler, J. G.: Contribution to the ongoing discussion on fluoride toxicity
Arch. Toxicol. 95: 2571-2587 (2021)
https://dx.doi.org/10.1007/s00204-021-03072-6
I am interested in this work - Peters, E. M. J.; Schedlowski, M.; Watzl, C.; Gimsa, U.: To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2
Neurobiol. Stress 14: 100296 (2021)
I am interested in this work
https://dx.doi.org/10.1016/j.ynstr.2021.100296 - Wientjens, Chantal; Watzl, C. [1. Gutachter]: An in vitro system to connect MAIT cell metabolism to functionWientjens, Chantal; Watzl, C. [1. Gutachter]. Dortmund: Univ., 2021.
Dortmund, Univ., Department of Chemistry and Chemical Biology, Master thesis, 2021
I am interested in this work - Rekendt, Ann-Katrin; Watzl, C. [1. Gutachter]: Quantification of NK cell reactivity using carboxylate-modified latex beads to trigger combinations of activating, inhibitory and adhesion receptorsRekendt, Ann-Katrin; Watzl, C. [1. Gutachter]. Dortmund: Univ., 2021.
Dortmund, Univ., Department of Chemistry and Chemical Biology, Master thesis, 2021
I am interested in this work - Niemann, Jens; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]: Identification and characterization of serial killing human natural killer cellsNiemann, Jens; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]. Dortmund: Univ., 2021.
Dortmund, Techn. Univ., Fak. für Chemie und Chemische Biologie, Masterarbeit, 2021
I am interested in this work - Genc, E.; Gonzalez, D.; Keller, M.; Marchan, R.; Cadenas, C.; Watzl, C.; Nitsche, M. A.; Hengstler, J. G.: Spatio-temporal multiscale analysis of western diet-fed mice reveals a translationally relevant sequence of events during NAFLD progression
Cells 10: (10): 2516 (29 pp) (2021)
I am interested in this work
https://doi.org/10.3390/cells10102516 - Seidel, Florian; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Transcriptomics-based identification of teratogens in differentiating hiPSCs: A novel in vitro test systemSeidel, Florian; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2021.
Dortmund, Techn. Univ., Fak. f. Chemie und Chemische Biologie, Diss., 2021
I am interested in this work - Albrecht, Wiebke; Hengstler, J. G. [Erstgutachter]; Watzl, C. [Zweitgutachter]: Prediction of human drug-induced liver injury (DILI)in relation to oral doses and blood concentrationsAlbrecht, Wiebke; Hengstler, J. G. [Erstgutachter]; Watzl, C. [Zweitgutachter]. Dortmund: Univ., 2021.
enthält Supplements auf CD
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2021
I am interested in this work
http://hdl.handle.net/2003/40290
http://dx.doi.org/10.17877/DE290R-22163 - Holtdirk, F.; Mehnert, A.; Weiss, M.; Mayer, J.; Meyer, B.; Bröde, P.; Claus, M.; Watzl, C.: Results of the Optimune trial: A randomized controlled trial evaluating a novel Internet intervention for breast cancer survivors
PLoS ONE 16: (5): e0251276 (21 pp) (2021)
I am interested in this work
https://dx.doi.org/10.1371/journal.pone.0251276 - Urlaub, D.; Wolfsdorff, N.; Durak, D.; Renken, F.; Watzl, C.: SARS-CoV-2 infection shortly after BNT162b2 vaccination results in high anti-spike antibody levels in nursing home residents and staff
Immun. Inflamm. Dis. 9: 1702–1706 (2021)
https://doi.org/10.1002/iid3.525
I am interested in this work - Jashari, Adelina; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Alterations of the glyoxylate metabolism in hepatic steatosis – a risk factor for hyperoxaluriaJashari, Adelina; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2020.
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2020
I am interested in this work - Urlaub, D.; Watzl, C.: Coated latex beads as artificial cells for quantitative investigations of receptor/ligand interactions
Curr. Protoc. Immunol. 2020: e111 (12 pp) (131)
I am interested in this work
https://dx.doi.org/10.1002/cpim.111 - Fleige, Leonie; Watzl, C. [Erstgutachter]: Influence of sex on the dopaminergic pathway in human immune cellsFleige, Leonie; Watzl, C. [Erstgutachter]. Dortmund: Univ., 2020.
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Masterarbeit, 2020
- Thieme, C. J.; Anft, M.; Paniskaki, K.; Blazquez-Navarro, A. ; Doevelaar, A.; Seibert, F. S.; Watzl, C.; Babel, N.: Robust T cell response toward spike, membrane, and nucleocapsid SARS-CoV-2 proteins is not associated with recovery in critical COVID-19 patients
Cell Rep. Med. 1: (6): 100092 (20 pp) (2020)
I am interested in this work
https://dx.doi.org/10.1016/j.xcrm.2020.100092 - Anft, M.; Paniskaki, K.; Blazquez-Navarro, A. ; Doevelaar, A.; Seibert, F. S.; Hölzer, B.; Watzl, C.; Babel, N.: COVID-19-induced ARDS is associated with decreased frequency of activated memory/effector T cells expressing CD11a++
Mol. Therapy 28: 2691-2702 (2020)
https://doi.org/10.1016/j.ymthe.2020.10.001
I am interested in this work - Capellino, S.; Claus, M.; Watzl, C.: Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine
Cell. Mol. Immunol. 17: 705-711 (2020)
https://dx.doi.org/10.1038/s41423-020-0477-9
I am interested in this work - Prager, Isabel; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]: Regulation of natural killer cell cytotoxic pathways during serial killing activityPrager, Isabel; Watzl, C. [Erstgutachter]; Hengstler, J. G. [Zweitgutachter]. Dortmund: Univ., 2020.
Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2020
I am interested in this work - Anft, M.; Netter, P.; Urlaub, D.; Prager, I.; Schaffner, S.; Watzl, C.: NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production
Cell. Mol. Immunol. 17: 347-355 (2020)
https://dx.doi.org/10.1038/s41423-019-0277-2
I am interested in this work - Guth, S.; Hüser, S.; Roth, A.; Wascher, E.; Watzl, C.; Mühle, E.; Hengstler, J. G.: Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses
Arch. Toxicol. 94: 1375-1415 (2020)
I am interested in this work - Bönnemann, V.; Claus, M.; Butzeck, B.; Collette, D.; Bröde, P.; Golka, K.; Watzl, C.: Analysis of Natural Killer cell functions in patients with hereditary hemochromatosis
EXCLI J. 19: 430-441 (2020)
I am interested in this work
https://dx.doi.org/10.17179/excli2020-1116 - Fasbender, F.; Obholzer, M.; Metzler, S.; Stöber, R.; Hengstler, J. G.; Watzl, C.: Enhanced activation of human NK cells by drug-exposed hepatocytes
Arch. Toxicol. 94: 439–448 (2020)
https://dx.doi.org/10.1007/s00204-020-02668-8
I am interested in this work - Dorsch, M.; Urlaub, D.; Bönnemann, V.; Bröde, P.; Sandusky, M.; Watzl, C.: Quantitative analysis of human NK cell reactivity using latex beads coated with defined amounts of antibodies
Eur. J. Immunol. 50: 656-665 (2020)
https://dx.doi.org/10.1002/eji.201948344
I am interested in this work - Holtdirk, F.; Mehnert, A.; Weiss, M.; Meyer, B.; Watzl, C.: Protocol for the Optimune trial: a randomized controlled trial evaluating a novel Internet intervention for breast cancer survivors
Trials 21: 117 (11 pp) (2020)
https://dx.doi.org/10.1186/s13063-019-3987-y
I am interested in this work - Bruning, Nora; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]: Investigation on how granzyme B enters target cells via fluorescence localization reporterBruning, Nora; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]. Dortmund: Techn. Univ., 2020.
Dortmund, Techn. Univ., Faculty of Chemistry and Chemical Biology, Masterarbeit, 2020
I am interested in this work - González Leiva, Daniela Fernanda; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Role of WNT1-inducible signaling pathway protein-1 (WISP1) in liver injuryGonzález Leiva, Daniela Fernanda; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Techn. Univ., 2020.
Dortmund, Techn. Univ., Chem. Fak., Diss., 2020
I am interested in this work - Weklak, Denice; Watzl, C. [Erstprüfer]: Untersuchung der Wirkung von Dopamin auf natürliche Killerzellen der Zelllinien NKL und NK-92Weklak, Denice; Watzl, C. [Erstprüfer]. Dortmund: Univ., 2020.
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Studiengang Chemische Biologie, Masterarbeit, 2020
I am interested in this work - Fellmeth, Denise; Watzl, C. [Erstprüfer]; Hengstler, J. [Zweitprüfer]: Towards the characterization of a novel BMP type I receptor kinase inhibitorFellmeth, Denise; Watzl, C. [Erstprüfer]; Hengstler, J. [Zweitprüfer]. Dortmund: Univ., 2020.
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Masterarbeit, 2020
I am interested in this work - Urlaub, D.; Zhao, S.; Blank, N.; Bergner, R.; Claus, M.; Tretter, T.; Watzl, C.; Merkt, W.: Activation of natural killer cells by rituximab in granulomatosis with polyangiitis
Arthritis Res. Ther. 21: (1): 277 (11 pp) (2019)
I am interested in this work
https://dx.doi.org/10.1186/s13075-019-2054-0 - Mahmoud, Zhwan; Hengstler, J. G. [Erstgutachter]; Watzl, C. [Zweitgutachter]: ¬The¬ role of LIPG in cell adhesion in breast cancerMahmoud, Zhwan; Hengstler, J. G. [Erstgutachter]; Watzl, C. [Zweitgutachter]. Dortmund: Univ., 2019.
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Masterarbeit, 2019
I am interested in this work - Cossarizza, A.; Chang, H. D.; Radbruch, A.; Watzl, C.: Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition): Cossarizza A, Chang HD, Radbruch A
Eur. J. Immunol. 49: 1457-1973 (2019)
I am interested in this work
http://dx.doi.org/10.1002/eji.201970107 - Prager, I.; Liesche, C.; van Ooijen, H.; Urlaub, D.; Fasbender, F.; Claus, M.; Eils, R.; Watzl, C.: NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing
J. Exp. Med. 216: 2113-2127 (2019)
http://dx.doi.org/10.1084/jem.20181454
http://jem.rupress.org/content/jem/suppl/2019/07/02/jem.20181454.DC1/JEM_20181454_sm.pdf
I am interested in this work - Boller, Lea Katharina; Watzl, C. [1. Gutachter]: CD56 als aktivierender Rezeptor auf Natürlichen KillerzellenBoller, Lea Katharina; Watzl, C. [1. Gutachter]. Duisburg-Essen: Univ., 2019.
Duisburg-Essen, Univ., Studiengang Medizinische Biologie, Masterarbeit, 2019
I am interested in this work - Gilles, Markus; Watzl, C. [Referent]; Hengstler, J. G. [Korreferent]: Analyse der stimulationsabhängigen Expression von FasL und TRAIL auf NK-ZellenGilles, Markus; Watzl, C. [Referent]; Hengstler, J. G. [Korreferent]. Dortmund: Univ., 2019.
Dortmund, Techn. Univ., Fak. Chemie und Chemische Biologie, Masterarbeit, 2019
I am interested in this work - Prager, I.; Watzl, C.: Mechanisms of natural killer cell-mediated cellular cytotoxicity
J. Leukoc. Biol. 105: 1319-1329 (2019)
http://dx.doi.org/10.1002/JLB.MR0718-269R
I am interested in this work - Kleinertz, H.; Hepner-Schefczyk, M.; Ehnert, S.; Claus, M.; Halbgebauer, R.; Boller, L.; Watzl, C.; Flohé, S. B.: Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation
EBioMedicine 43: 380-391 (2019)
https://doi.org/10.1016/j.ebiom.2019.04.018
I am interested in this work - Cadenas, C.; Vosbeck, S.; Edlund, K.; Grgas, K.; Claus, M.; Watzl, C.; Marchan, R.; Hengstler, J. G.: LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
Int. J. Cancer 145: 901-915 (2019)
http://dx.doi.org/10.1002/ijc.32138
I am interested in this work - Schmitz, Gernot; Watzl, C. [Referent]; Hengstler, J. G. [Koreferent]: Influence of the dopaminergic pathway on osteoclasts in arthritisSchmitz, Gernot; Watzl, C. [Referent]; Hengstler, J. G. [Koreferent]. Dortmund: Univ., 2019.
Dortmund, Techn. Univ., Chem. Biol., Masterarbeit, 2019
I am interested in this work - Watzl, C.: Adaptive responses of innate lymphocytes
Nat. Immunol. 19: 426-427 (2018)
I am interested in this work
http://dx.doi.org/10.1038/s41590-018-0088-0 - Maydych, V.; Claus, M.; Watzl, C.; Kleinsorge, T.: Attention to emotional information is associated with cytokine responses to psychological stress
Front. Neurosci. 12: 687 (15 pp) (2018)
http://dx.doi.org/10.3389/fnins.2018.00687
I am interested in this work
https://www.frontiersin.org/articles/10.3389/fnins.2018.00687/full#supplementary-material - Bönnemann, Vivian; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]: Quantitative analysis of NK cell reactivity using latex beads as artificial targetsBönnemann, Vivian; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]. Dortmund: Techn. Univ., 2018.
Dortmund, TU, Leibniz Research Centre for Working Environment and Human Factors, Dept. of Immunology, Master thesis, 2018
I am interested in this work - Ewen, E.-M.; Pahl, J. H. W.; Miller, M.; Watzl, C.; Cerwenka, A.: KIR downregulation by IL-12/15/18 unleashes human NK cells from KIR/HLA-I inhibition and enhances killing of tumor cells
Eur. J. Immunol. 48: 355-365 (2018)
http://dx.doi.org/10.1002/eji.201747128
I am interested in this work - Watzl, C.: I wie Immunsystem: Bei Erwachsenen sind bis zu vier Infekte im Jahr normal
In: ¬Der¬ Gesundheit zuliebe: was uns die Signale des Körpers verraten ; Ärzte und Prominente berichten (S. 112-116) / Daniela Schaefer. Essen: Klartext-Verl., 2018.
I am interested in this work - Liesche, C.; Sauer, P.; Prager, I.; Urlaub, D.; Claus, M.; Eils, R.; Beaudouin, J.; Watzl, C.: Single-fluorescent protein reporters allow parallel quantification of natural killer cell-mediated granzyme and caspase activities in single target cells
Front. Immunol. 9: article 1840 (12 pp) (2018)
http://dx.doi.org/10.3389/fimmu.2018.01840
I am interested in this work - Gajewski, P. D.; Boden, S.; Freude, G.; Claus, M.; Bröde, P.; Watzl, C.; Getzmann, S.; Falkenstein, M.: Behaviorale, elektrophysiologische und immunologische Korrelate des subklinischen Burnouts und milder Depression bei Beschäftigten in emotional fordernden Jobs
In: 58. Wissenschaftliche Jahrestagung 2018: Dokumentation der Vorträge und Poster, München, 7.-9. März 2018 (S. 504-508) / Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. ; Herausgeber: Peter Angerer, Thomas Muth. [München]: DGAUM, 2018.
I am interested in this work - Fasbender, F.; Watzl, C.: Impedance-based analysis of Natural Killer cell stimulation
Sci. Rep. 8: (1): 4938 (9 pp) (2018)
I am interested in this work
http://dx.doi.org/10.1038/s41598-018-23368-5 - Kaszta, Darius; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Charkaterisierung der Rolle von mitochondrialen GPAT in OvarialkarzinomzellenKaszta, Darius; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2018.
Dortmund, Techn. Univ., Lehrstuhl für Chemische Biologie, Masterarbeit, 2018
I am interested in this work - Schlüter, Sarah; Hengstler, J. G. [Gutachter]; Watzl, C. [2. Gutachter]: Studying of the function of WISP1 in the liverSchlüter, Sarah; Hengstler, J. G. [Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2018.
Techn. Univ., Chemical Biology, Masterarbeit, 2018
I am interested in this work - Fasbender, Frank Oliver; Watzl, C. [Gutachter]; Hengstler, J. G. [Gutachter]: NK cell regulationFasbender, Frank Oliver; Watzl, C. [Gutachter]; Hengstler, J. G. [Gutachter]. Dortmund: Univ., 2017.
Dortmund, Techn. Univ., Fakultät für Chemie und Chemische Biologie, Diss., 2016 (2017)
I am interested in this work - Fasbender, F.; Claus, M.; Wingert, S.; Sandusky, M.; Watzl, C.: Differential requirements for Src-family kinases in SYK or ZAP70-mediated SLP-76 phosphorylation in lymphocytes
Front. Immunol. 8: article no. 789 (9 pp) (2017)
I am interested in this work
http://dx.doi.org/10.3389/fimmu.2017.00789 - Anft, Moritz; Watzl, C. [Gutachter]; Hengstler, J. G. [Gutachter]: ¬The¬ regulation of NK cell detachment from target cells as a key factor for serial killing and effector functionAnft, Moritz; Watzl, C. [Gutachter]; Hengstler, J. G. [Gutachter]. Dortmund: Univ., 2017.
Dortmund, Techn. Univ., Fak. f. Chemie und Chemische Biologie, Diss., 2017
I am interested in this work
http://hdl.handle.net/2003/35987
http://dx.doi.org/10.17877/DE290R-18005 - Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
Cancer Res. 77: 4589-4601 (2017)
I am interested in this work
http://dx.doi.org/10.1158/0008-5472.CAN-16-2065 - Urlaub, D.; Höfer, K.; Müller, M.-L.; Watzl, C.: LFA-1 activation in NK cells and their subsets: influence of receptors, maturation, and cytokine stimulation
J. Immunol. 198: 1944-1951 (2017)
I am interested in this work
http://dx.doi.org/10.4049/jimmunol.1601004 - Maydych, V.; Claus, M.; Dychus, N.; Ebel, M.; Damaschke, J.; Diestel, S.; Kleinsorge, T.; Watzl, C.: Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function
PLoS ONE 12: (11): e0188108 (19 pp) (2017)
I am interested in this work
https://doi.org/10.1371/journal.pone.0188108 - Cossarizza, A.; Chang, H.-D.; Radbruch, A.; Watzl, C.: Guidelines for the use of flow cytometry and cell sorting in immunological studies
Eur. J. Immunol. 47: 1584-1797 (2017)
I am interested in this work
http://dx.doi.org/10.1002/eji.201646632 - Rady, M.; Watzl, C.; Claus, M.; Khorshid, O.; Mahran, L.; Abou-Aisha, K.: Altered expression of miR-181a and miR-146a does not change the expression of surface NCRs in human NK cells
Sci. Rep. 7: 41381 (11 pp) (2017)
I am interested in this work
http://dx.doi.org/10.1038/srep41381 - Gajewski, P. D.; Boden, S.; Freude, G.; Claus, M.; Bröde, P.; Watzl, C.; Getzmann, S.; Falkenstein, M.: Executive control, ERP and pro-inflammatory activity in emotionally exhausted middle-aged employees: comparison between subclinical burnout and mild to moderate depression
Psychoneuroendocrinology 86: 176-186 (2017)
https://doi.org/10.1016/j.psyneuen.2017.09.017
I am interested in this work - Krawietz, Jasmin; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Signaling and transcriptional networks in liver damage and regenerationKrawietz, Jasmin; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2017.
Dortmund, Techn. Univ., Fak. Chemie und Chemische Biologie, Masterarbeit, 2017
I am interested in this work - Netter, P.; Anft, M.; Watzl, C.: Termination of the activating NK cell immunological synapse is an active and regulated process
J. Immunol. 199: 2528–2535 (2017)
I am interested in this work
http://dx.doi.org/10.4049/jimmunol.1700394 - Bagci, Mustafa; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Mechanismus der ErbB3 Rekrutierung an die Plasmamembran nach LigandenstimulationBagci, Mustafa; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2017.
Dortmund, Techn. Univ., Fak. Chemie und Chemische Biologie, Bachelorarbeit, 2017
I am interested in this work - Feuerborn, David; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]: Role of WISP1 on stress signaling in liver damageFeuerborn, David; Hengstler, J. G. [1. Gutachter]; Watzl, C. [2. Gutachter]. Dortmund: Univ., 2017.
Dortmund, Techn. Univ., Chemical Biology, Masterarbeit, 2017
I am interested in this work - Prescher, H.; Frank, M.; Gütgemann, S.; Kuhfeldt, E.; Schweizer, A.; Nitschke, L.; Watzl, C.; Brossmer, R.: Design, synthesis, and biological evaluation of small, high-affinity siglec-7 ligands: toward novel inhibitors of cancer immune evasion
J. Med. Chem. 60: 941-956 (2017)
I am interested in this work
http://dx.doi.org/10.1021/acs.jmedchem.6b01111 - Urlaub, D.; Bhat, R.; Messmer, B.; Watzl, C.: Co-activation of cultured human natural killer cells: enhanced function and decreased inhibition
J. Toxicol. Environ. Health 79A: 1078-1084 (2016)
I am interested in this work
http://dx.doi.org/10.1080/15287394.2016.1219587 - Dorsch, Madeleine; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]: Quantitative Untersuchungen zur Reaktivität von NK-Zellen mithilfe von Antikörper beladenen Latex BeadsDorsch, Madeleine; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]. Dortmund: Univ., 2016.
Dortmund, Techn. Univ., Fak. f. Chemie und Chemische Biologie, Masterarbeit, 2016
I am interested in this work - Erpenbach, Max Christian; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]: Stimulation von NK Zellen zur Umgehung des inhibitorischen Effekts durch regulatorische T Zellen in der ImmuntherapieErpenbach, Max Christian; Watzl, C. [1. Gutachter]; Hengstler, J. G. [2. Gutachter]. Dortmund: Univ., 2016.
Dortmund, Techn. Univ., Fak. f. Chemie und Chemische Biologie, Masterarbeit, 2016
I am interested in this work - Merkt, W.; Lorenz, H.-M.; Watzl, C.: Rituximab induces phenotypical and functional changes of NK cells in a non-malignant experimental setting
Arthritis Res. Ther. 18: 206 (11 pp) (2016)
I am interested in this work
http://dx.doi.org/10.1186/s13075-016-1101-3 - Merkt, W.; Claus, M.; Blank, N.; Hundemer, M.; Cerwenka, A.; Lorenz, H.-M.; Watzl, C.: Active but not inactive granulomatosis with polyangiitis is associated with decreased and phenotypically and functionally altered CD56(dim) natural killer cells
Arthritis Res. Ther. 18: 204 (12 pp.) (2016)
I am interested in this work
http://dx.doi.org/10.1186/s13075-016-1098-7 - Fasbender, F.; Widera, A.; Hengstler, J. G.; Watzl, C.: Natural killer cells and liver fibrosis
Front. Immunol. 7: article 19 (7 pp.) (2016)
I am interested in this work
http://dx.doi.org/10.3389/fimmu.2016.00019 - Claus, M.; Dychus, N.; Ebel, M.; Damaschke, J.; Maydych, V.; Wolf, O. T.; Kleinsorge, T.; Watzl, C.: Measuring the immune system: a comprehensive approach for the analysis of immune functions in humans
Arch. Toxicol. 90: 2481-2495 (2016)
http://dx.doi.org/10.1007/s00204-016-1809-5
I am interested in this work
http://rdcu.be/kC87 - Garrecht, R.; Meyer, R.; Duppach, J.; Reipschläger, S.; Watzl, C.; Niemeyer, C. M.: Designed DNA surfaces for in vitro modulation of natural killer cells
ChemBioChem 17: 486-492 (2016)
I am interested in this work
http://dx.doi.org/10.1002/cbic.201500629 - Claus, M.; Wingert, S.; Watzl, C.: Modulation of natural killer cell functions by interactions between 2B4 and CD48 in cis and in trans
Open Biol. 6: article 160010 (11 pp) (2016)
I am interested in this work
http://dx.doi.org/10.1098/rsob.160010 - Merkt, W.; Urlaub, D.; Meinke, S.; Kammerer, R.; Watzl, C.: Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors
Eur. J. Immunol. 45: 2134-2142 (2015)
I am interested in this work
http://dx.doi.org/10.1002/eji.201445151 - Prescher, H.; Gütgemann, S.; Frank, M.; Kuhfeldt, E.; Watzl, C.; Brossmer, R.: Synthesis and biological evaluation of 9-N-oxamyl sialosides as Siglec-7 ligands
Bioorg. Med. Chem. 23: 5915-5921 (2015)
I am interested in this work
http://dx.doi.org/10.1016/j.bmc.2015.06.069 - Gütgemann, S. A.; Sandusky, M. M.; Watzl, C.; Wingert, S.; Claus, M.: Recruitment of activating NK-cell receptors 2B4 and NKG2D to membrane microdomains in mammalian cells is dependent on their transmembrane regions
Eur. J. Immunol. 45: 1258-1269 (2015)
I am interested in this work
http://dx.doi.org/10.1002/eji.201444741 - Merkt, W.; Sturm, P.; Lasitschka, F.; Tretter, T.; Watzl, C.; Saure, D.; Hundemer, M.; Schwenger, V.: Peripheral blood natural killer cell percentages in granulomatosis with polyangiitis correlate with disease inactivity and stage
Arthritis Res. Ther. 17: 337 (11 pp) (2015)
I am interested in this work
http://dx.doi.org/10.1186/s13075-015-0851-7 - Watzl, C.: How to trigger a killer: modulation of natural killer cell reactivity on many levels
Adv. Immunol. 124: 137-170 (2014)
I am interested in this work
http://dx.doi.org/10.1016/B978-0-12-800147-9.00005-4 - Claus, M.; Urlaub, D.; Watzl, C.: NK cell activation
In: Encyclopedia of medical immunology (S. pp 795-805) / Ian R. Mackay ... (eds.). New York [u.a.]: Springer, 2014.
I am interested in this work
http://dx.doi.org/10.1007/978-0-387-84828-0_43 - Watzl, C.; Claus, M.: WhatSAP - 2B4 sends mixed messages in the absence of SAP
Eur. J. Immunol. 44: 1281-1284 (2014)
I am interested in this work
http://dx.doi.org/10.1002/eji.201444562 - Watzl, C.; Urlaub, D.; Fasbender, F.; Claus, M.: Natural killer cell regulation - beyond the receptors
F1000Prime Rep. 6: 87 (10 pp) (2014)
I am interested in this work
http://dx.doi.org/10.12703/P6-87 - Balzarolo, M.; Watzl, C.; Medema, J. P.; Wolkers, M. C.: NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells
Immunol. Lett. 151: 61-67 (2013)
I am interested in this work
http://dx.doi.org/10.1016/j.imlet.2013.02.001 - Momburg, F.; Watzl, C.; Cerwenka, A.: NK cells - versatile tools for viral defense and cancer treatment
Eur. J. Immunol. 43: 860-863 (2013)
I am interested in this work
http://dx.doi.org/10.1002/eji.201370047 - Meinke, S.; Watzl, C.: NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation
Front. Immunol. 4: article 3 (6 pp) (2013)
I am interested in this work
http://dx.doi.org/10.3389/fimmu.2013.00003 - Koch, J.; Steinle, A.; Watzl, C.; Mandelboim, O.: Activating natural cytotoxicity receptors of natural killer cells in cancer and infection
Trends Immunol. 34: 182-191 (2013)
I am interested in this work
http://dx.doi.org/10.1016/j.it.2013.01.003 - Windheim, M.; Southcombe, J. H.; Kremmer, E.; Chaplin, L.; Urlaub, D.; Falk, C. S.; Claus, M.; Watzl, C.: ¬A¬ unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions
Proc. Natl. Acad. Sci. USA 110: E4884-E4893 (2013)
I am interested in this work
http://dx.doi.org/10.1073/pnas.1312420110 - Cohnen, A.; Chiang, S. C.; Stojanovic, A.; Schmidt, H.; Claus, M.; Saftig, P.; Janßen, O.; Watzl, C.: Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage
Blood 122: 1411-1418 (2013)
I am interested in this work
http://dx.doi.org/10.1182/blood-2012-07-441832 - Watzl, C.; Urlaub, D.: Molecular mechanisms of natural killer cell regulation
Front. Biosci. Landmark ed. 17: 1418-1432 (2012)
I am interested in this work
http://dx.doi.org/10.2741/3995 - Hassold, N.; Seystahl, K.; Kempf, K.; Urlaub, D.; Zekl, M.; Einsele, H.; Watzl, C.; Wischhusen, J.: Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib
Int. J. Cancer 131: E916-E927 (2012)
I am interested in this work - Urlaub, D.; Watzl, C.: Töten oder leben lassen?: Mathematische Modelle ermöglichen Einblicke in die Regulationsmechanismen von Immunzellen
Systembiologie.de 2012: (5): 8-11 (2012)
I am interested in this work
http://www.systembiologie.de - Sommaggio, R.; Cohnen, A.; Watzl, C.; Costa, C.: Multiple receptors trigger human NK-cell-mediated cytotoxicity against porcine chondrocytes
J. Immunol. 188: 2075-2083 (2012)
I am interested in this work
http://dx.doi.org/10.4049/jimmunol.1100433 - Watzl, C.; Sternberg-Simon, M.; Urlaub, D.; Mehr, R.: Understanding natural killer cell regulation by mathematical approaches
Front. Immunol. 3: article 359 (6 pp.) (2012)
I am interested in this work
http://dx.doi.org/10.3389/fimmu.2012.00359 - Hartmann, J.; Tran, T. V.; Kaudeer, J.; Oberle, K.; Herrmann, J.; Quagliano, I.; Abel, T.; Watzl, C.: ¬The¬ stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding
J. Biol. Chem. 287: 31527-31539 (2012)
I am interested in this work
I am interested in this work
http://dx.doi.org/10.1074/jbc.M111.304238 - Colonna, M.; Jonjic, S.; Watzl, C.: Natural killer cells: fighting viruses and much more
Nat. Immunol. 12: 107-110 (2011)
I am interested in this work - Hoffmann, S. C.; Cohnen, A.; Ludwig, T.; Watzl, C.: 2B4 Engagement Mediates Rapid LFA-1 and Actin-Dependent NK Cell Adhesion to Tumor Cells as Measured by Single Cell Force Spectroscopy
J. Immunol. 186: 2757-2764 (2011)
I am interested in this work
http://dx.doi.org/10.4049/jimmunol.1002867 - Kühne, L.; Konstandin, M.; Samstag, Y.; Meuer, S.; Giese, T.; Watzl, C.: WF10 stimulates NK cell cytotoxicity by increasing LFA-1-mediated adhesion to tumor cells
J. Biomed. Biotechnol. 2011: article ID 436587 (6 pp.) (2011)
I am interested in this work
http://dx.doi.org/10.1155/2011/436587 - Mesecke, S.; Urlaub, D.; Busch, H.; Eils, R.; Watzl, C.: Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells
Sci. Signal. 4: (175): ra36 (9 pp.) (2011)
I am interested in this work
http://dx.doi.org/10.1126/scisignal.2001325 - Jarahian, M.; Fiedler, M.; Cohnen, A.; Djandji, D.; Hämmerling, G. J.; Gati, C.; Cerwenka, A.; Watzl, C.: Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin
PLoS Pathog. 7: (8): e1002195 (18 pp.) (2011)
I am interested in this work
http://dx.doi.org/10.1371/journal.ppat.1002195 - Margraf-Schönfeld, S.; Böhm, C.; Watzl, C.: Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein
J. Biol. Chem. 286: 24142-24149 (2011)
I am interested in this work
http://dx.doi.org/10.1074/jbc.M111.225334 - Claus, M.; Watzl, C.: Evaluation of Human Natural Killer Cell Activities in Whole Blood
Curr. Protoc. Immunol. Suppl. 91: Chapter 7; Unit 7.39 (17 pp.) (2010)
I am interested in this work
http://dx.doi.org/10.1002/0471142735.im0739s91 - Meinke, S.; Böhm, C.; Durlanik, S.; Watzl, C.: ¬The¬ activating receptors 2B4 and NTB-A, but not CRACC are subject to ligand-induced down-regulation on human natural killer cells
Nature Precedings : 7 pp. (2010)
I am interested in this work
http://dx.doi.org/10.1038/npre.2010.4917.1 - Watzl, C.; Long, E. O. : Signal Transduction During Activation and Inhibition of Natural Killer Cells
Curr. Protoc. Immunol. Suppl. 90: Chapter 11; Unit 11.9B (17 pp.) (2010)
I am interested in this work
http://dx.doi.org/10.1002/0471142735.im1109bs90 - Jarahian, M.; Watzl, C.; Fournier, P. A.; Arnold, A.; Djandji, D.; Zahedi, S.; Cerwenka, A.; Paschen, A.: Activation of natural killer cells by Newcastle disease virus hemagglutinin-neuraminidase
J. Virol. 83: 8108-8121 (2009)
I am interested in this work - Raemer, P.; Kohl, K.; Watzl, C.: Statins inhibit NK cell cytotoxicity by interfering with LFA-1-mediated conjugate formation
Eur. J. Immunol. 39: 1456-1465 (2009)
I am interested in this work
http://dx.doi.org/10.1002/eji.200838863 - Oberlies, J.; Watzl, C.; Giese, T.; Luckner, C.; Kropf, P.; Müller, I.; Ho, A.D.: Regulation of NK cell function by human granulocyte arginase
J. Immunol. 182: 5259-5267 (2009)
I am interested in this work
http://dx.doi.org/10.4049/jimmunol.0803523 - Claus, M.; Greil, J.; Watzl, C.: Comprehensive analysis of NK cell function in whole blood samples
J. Immunol. Methods 341: 154-164 (2009)
I am interested in this work
http://dx.doi.org/10.1016/j.jim.2008.11.006 - Mehrle, S.; Watzl, C.; von Lilienfeld-Toal, M.; Amoroso, A.; Schmidt, J.; Märten, A.: Comparison of phenotype of gamma delta T cells generated using various cultivation methods
Immunol. Lett. 125: 53-58 (2009)
I am interested in this work
http://dx.doi.org/10.1016/j.imlet.2009.05.009 - Jacobi, C.; Claus, M.; Wildemann, B.; Wingert, S.; Korporal, M.; Römisch, J.; Meuer, S.; Watzl, C.: Exposure of NK cells to intravenous immunoglobulin induces IFNgamma release and degranulation but inhibits their cytotoxic activity
Clin. Immunol. 133: 393-401 (2009)
I am interested in this work
http://dx.doi.org/10.1016/j.clim.2009.09.006 - Textor, S.; Dürst, M.; Jansen, L.; Accardi, R.; Tommasino, M.; Trunk, M. J.; Porgador, A.; Watzl, C.: Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer
Int. J. Cancer 123: 2343-2353 (2008)
I am interested in this work
http://dx.doi.org/10.1002/ijc.23733 - Schmidt, H.; Gelhaus, C.; Nebendahl, M.; Lettau, M.; Watzl, C.; Kabelitz, D.; Leippe, M.; Janssen, O.: 2D-DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells
Proteomics 8: 2911-2925 (2008)
I am interested in this work
http://dx.doi.org/10.1002/pmic.200800170 - Mehrle, S.; Schmidt, J.; Büchler, M. W.; Watzl, C.; Märten, A.: Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP
Mol. Immunol. 45: 796-804 (2008)
I am interested in this work
http://dx.doi.org/10.1016/j.molimm.2007.06.361 - Claus, M.; Meinke, S.; Bhat, R.; Watzl, C.: Regulation of NK cell activity by 2B4, NTB-A and CRACC
Front. Biosci. 13: 956-965 (2008)
I am interested in this work - Hershkovitz, O.; Jarahian, M.; Bar-Ilan, A.; Zilka, A.; Jivov, S.; Tekoah, Y.; Watzl, C.: Altered glycosylation of recombinant NKp30 hampers the binding to heparan sulfate: a lesson for the use of recombinant immuno-receptors as an immunological tool
J. Glycobiol. 18: 28-41 (2008)
I am interested in this work
http://dx.doi.org/10.1093/glycob/cwm125 - Watzl, C.: Natural Killer Cells, Probiotics and Cancer
Int. J. Probiotics Prebiotics 3: 141-146 (2008)
I am interested in this work - Endt, J.; Eissmann, P.; Hoffmann, S. C.; Meinke, S.; Giese, T.; Watzl, C.: Modulation of 2B4 (CD244) activity and regulated SAP expression in human NK cells
Eur. J. Immunol. 37: 193-198 (2007)
I am interested in this work
http://dx.doi.org/10.1002/eji.200636341 - Jarahian, M.; Watzl, C.; Jasmin, I.; Altevogt, P.; Momburg, F.: Blockade of natural killer cell-mediated lysis by NCAM140 expressed on tumor cells
Int. J. Cancer 120: 2625-2634 (2006/2007)
I am interested in this work
http://dx.doi.org/10.1002/ijc.22579 - Endt, J.; McCann, F. E.; Almeida, C. R.; Urlaub, D.; Leung, R.; Pende, D.; Davis, D. M.; Watzl, C.: Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse
J. Immunol. 178: 5606-5611 (2007)
I am interested in this work - Bhat, R.; Watzl, C.: Serial killing of tumor cells by human natural killer cells: enhancement by therapeutic antibodies
PLoS ONE 2: e326 (7 pp) (2007)
I am interested in this work
http://dx.doi.org/10.1371/journal.pone.0000326 - Byrd, A.; Hoffmann, S. C.; Jarahian, M.; Momburg, F.; Watzl, C.: Expression Analysis of the Ligands for the Natural Killer Cell Receptors NKp30 and NKp44
PLoS ONE 2: e1339 (9 pp) (2007)
I am interested in this work
http://dx.doi.org/10.1371/journal.pone.0001339 - Hoffmann, S. C.; Schellack, C.; Textor, S.; Konold, S.; Schmitz, D.; Cerwenka, A.; Pflanz, S.; Watzl, C.: Identification of CLEC12B, an inhibitory receptor on myeloid cells
J. Biol. Chem. 282: 22370-22375 (2007)
I am interested in this work - Cerwenka, A.; Falk, C. S.; Watzl, C.: Natural Killer Cells: from basic research to cancer therapy
Eur. J. Immunol. 37: 1161-1164 (2007)
I am interested in this work - Bhat, R.; Eissmann, P.; Endt, J.; Hoffmann, S.; Watzl, C.: Fine-tuning of immune responses by SLAM-related receptors
J. Leukocyte Biol. 79: 417 - 427 (2006)
I am interested in this work
http://dx.doi.org/10.1189/jlb.0905537 - Stark, S.; Watzl, C.: 2B4 (CD244), NTB-A and CRACC (CS1) Stimulate Cytotoxicity but no Proliferation in Human NK Cells
18: 241-247 (2006)
I am interested in this work
http://dx.doi.org/10.1093/intimm/dxh358 - Sandusky, M. M.; Messmer, B.; Watzl, C.: Regulation of 2B4 (CD244)-mediated NK cell activation by ligand-induced receptor modulation
Eur. J. Immunol. 36: 3268-3276 (2006)
I am interested in this work
http://dx.doi.org/10.1002/eji.200636146 - Eissmann, P.; Watzl, C.: Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A mediated activation of human NK cells
J. Immunol. 177: 3170 -3177 (2006)
I am interested in this work - Golks, A.; Brenner, D.; Schmitz, I.; Watzl, C.; Krüger, A.; Krammer, P. H.; Lavrik, I. N. : ¬The¬ role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation
Cell Death Differ. 13: 489 -498 (2006)
I am interested in this work - Messmer, B.; Eissmann, P.; Stark, S.; Watzl, C.: CD48 Stimulation by 2B4 (CD244) Expressing Targets Activates Human Natural Killer Cells
J. Immunol. 176: 4646 - 4650 (2006)
I am interested in this work - Watzl, C.: Production and use of trimeric isoleucine zipper fusion proteins to study surface receptor ligand interactions
Curr. Prot. Protein Sci. 43 Suppl.: Unit 19.11, 13 pp. (2006)
I am interested in this work - Eissmann, P.; Endt, J.; Flaig, R. M.; Watzl, C.: Regulation of Natural Killer Cells by SLAM-Related Receptors (SRR)
Recent Devel. Cell Res. 2: 1-18 (2005)
I am interested in this work - Eissmann, P.; Beauchamp, L.; Wooters, J.; Tilton, J. C.; Long, E. O. ; Watzl, C.: Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)
Blood 105: 4722-4729 (2005)
I am interested in this work
http://dx.doi.org/10.1182/blood-2004-09-3796 - Stark, S.; Flaig, R. M.; Sandusky, M. M.; Watzl, C.: ¬The¬ use of trimeric isoleucine-zipper fusion proteins to study surface-receptor ligand interactions in natural killer cells
J. Immunol. Methods 296: 149-158 (2005)
I am interested in this work
http://dx.doi.org/10.1016/j.jim.2004.11.010 - Möller, M. J.; Soofi, A.; Braun, G. S.; Li, X.; Watzl, C.; Kriz, W.; Holzman, L. B.: Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization
EMBO J. 23: 3769-3779 (2004)
I am interested in this work - Flaig, R. M.; Stark, S.; Watzl, C.: NTB-A activates Natural Killer cells via homophilic interaction
J. Immunol. 172: 6524-6527 (2004)
I am interested in this work - Stebbins, C. C.; Watzl, C.; Billadeau, D. D.; Leibson, P. J.; Burshtyn, D. N.; Long, E. O. : Vav1 dephosphorylation by the phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity
Mol. Cell. Biol. 253: 6291-6299 (2003)
I am interested in this work - Watzl, C.; Long, E. O. : Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts
J. Exp. Med. 197: 77-85 (2003)
I am interested in this work
http://dx.doi.org/10.1084/jem.20020427 - Watzl, C.: ¬The¬ NKG2D receptor and its ligands : recognition beyond the "missing self"?
Microbes Infect. 5: 31-37 (2003)
I am interested in this work - Long, E. O. ; Burshtyn, D. N.; Stebbins, C. C.; Watzl, C.: How do killer cell Ig-like receptors inhibit natural killer cells?
In: Activating and inhibitory immunoglobulin-like receptors: [CREST International Symposium on Immunoglobulin-like Receptors; September 18-19, 2000, Sendai City] (S. 235-241) / M. D. Cooper, T. Takai, J. V. Ravetch (Eds.). Tokio: Springer, 2001.
I am interested in this work - Long, E. O. ; Barber, D. F.; Burshtyn, D. N.; Faure, M.; Peterson, M.; Rajagopalan, S.; Sandusky, M.; Watzl, C.: Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)
Immunol. Rev. 181: 223-233 (2001)
I am interested in this work - Scaffidi, C.; Long, E. O. : Exposing tumor cells to killer cell attack
Nat. Medicine 6: 867-868 (2000)
I am interested in this work - Watzl, C.; Stebbins, C. C.; Long, E. O. : NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)
J. Immunol. 165: 3545-3548 (2000)
I am interested in this work - Scaffidi, C.; Peterson, M.; Long, E. O. : Homogenous expression of killer cell immunoglobulin-like receptors (KIR) on polyclonal natural killer cells detected by a monoclonal antibody to KIR2D
Tissue Antigens 2000: 240-247 (56)
I am interested in this work - Scaffidi, C.; Kischkel, F. C.; Krammer, P. H.; Peter, M. E.: Analysis of the CD95 (APO-1/Fas) death-inducing signaling complex by high-resolution two-dimensional gel electrophoresis
Methods Enzymol. 2000: 363-373 (322)
I am interested in this work - Willems, F.; Amraoui, Z.; Vanderheyde, N.; Verhasselt, V.; Aksoy, E.; Scaffidi, C.; Peter, M. E.; Krammer, P. H.: Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide
Blood 95: 3478-3482 (2000)
I am interested in this work - Scaffidi, C.; Volkland, J.; Blomberg, I.; Hoffmann, I.; Krammer, P. H.; Peter, M. E.: Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase
J. Immunol. 164: 1236-1242 (2000)
I am interested in this work - Scaffidi, C.; Krammer, P. H.; Peter, M. E.: Isolation and analysis of components of CD95 (APO-1/Fas) death-inducing signaling complex
Methods 17: 287-291 (1999)
I am interested in this work - Scaffidi, C.; Schmitz, I.; Zha, J.; Korsmeyer, S. J.; Krammer, P. H.; Peter, M. E.: Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
J. Biol. Chem. 274: 22532-22538 (1999)
I am interested in this work - Scaffidi, C.; Schmitz, I.; Krammer, P. H.; Peter, M. E.: ¬The¬ role of c-FLIP in modulation of CD95-induced apoptosis
J. Biol. Chem. 274: 1541-1548 (1999)
I am interested in this work - Peter, M. E.; Scaffidi, C.; Medema, J. P.; Kischkel, F. C.; Krammer, P. H.: ¬The¬ death receptors
Results Probl Cell Differ 23: 25-63 (1999)
I am interested in this work - Scaffidi, C.; Kirchhoff, S.; Krammer, P. H.; Peter, M. E.: Apoptosis signaling in lymphocytes
Curr Opin Immunol 1999: 277-285 (11)
I am interested in this work
http://biomednet.com/elecref/0952791501100277 - Scaffidi, C.; Fulda, S.; Srinivasan, A.; Friesen, C.; Li, F.; Tomaselli, K. J.; Debatin, K. M. ; Krammer, P. H.: Two CD95 (APO-1/Fas) signaling pathways
EMBO J. 17: 1675-1687 (1998)
I am interested in this work - Fulda, S.; Scaffidi, C.; Susin, S. A.; Krammer, P. H.; Kroemer, G.; Peter, M. E.; Debatin, K. M. : Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
J. Biol. Chem. 273: 33942-33948 (1998)
I am interested in this work - Medema, J. P.; Scaffidi, C.; Krammer, P. H.; Peter, M. E.: Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex
J. Biol. Chem. 273: 3388-3393 (1998)
I am interested in this work - Stegh, A. H.; Schickling, O.; Ehret, A.; Scaffidi, C.; Peterhansel, C.; Hofmann, T. G.; Grummt, I.; Krammer, P. H.: DEDD, a novel death effector domain-containing protein, targeted to the nucleolus
EMBO J. 17: 5974-5986 (1998)
I am interested in this work - Muller, M.; Scaffidi, C.; Galle, P. R.; Stremmel, W.; Krammer, P. H.: ¬The¬ role of p53 and the CD95 (APO-1/Fas) death system in chemotherapy-induced apoptosis
Eur. Cytokine Netw. 9: 685-686 (1998)
I am interested in this work - Chlichlia, K.; Peter, M. E.; Rocha, M.; Scaffidi, C.; Bucur, M.; Krammer, P. H.; Schirrmacher, V.; Umansky, V.: Caspase activation is required for nitric oxide-mediated, CD95(APO-1/Fas)-dependent and independent apoptosis in human neoplastic lymphoid cells
Blood 91: 4311-4320 (1998)
I am interested in this work - Fulda, S.; Scaffidi, C.; Pietsch, T.; Krammer, P. H.; Peter, M. E.; Debatin, K. M. : Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells
Cell Death Differ. 5: 884-893 (1998)
I am interested in this work - Medema, J. P.; Scaffidi, C.; Kischkel, F. C.; Shevchenko, A.; Mann, M.; Krammer, P. H.; Peter, M. E.: FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
EMBO J. 16: 2794-2804 (1997)
I am interested in this work - Thome, M.; Schneider, P.; Scaffidi, C.; Hofmann, K.; Fickenscher, H.; Meinl, E.; Neipel, F.; Mattmann, C.: Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Nature 386: 517-521 (1997)
I am interested in this work - Fulda, S.; Friesen, C.; Los, M.; Scaffidi, C.; Mier, W.; Benedict, M.; Nunez, G.; Krammer, P. H.: Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
Cancer Res. 57: 4956-4964 (1997)
I am interested in this work - Medema, J. P.; Toes, R. E.; Scaffidi, C.; Zheng, T. S.; Flavell, R. A.; Melief, C. J.; Peter, M. E.; Offringa, R.: Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis
Eur. J. Immunol. 27: 3492-3498 (1997)
I am interested in this work - Scaffidi, C.; Medema, J. P.; Krammer, P. H.; Peter, M. E.: FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
J. Biol. Chem. 272: 26953-26958 (1997)
I am interested in this work - Muzio, M.; Chinnaiyan, A. M.; Kischkel, F. C.; O'Rourke, K.; Shevchenko, A.; Ni, J.; Scaffidi, C.; Bretz, J. D.: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
Cell 84: 817-827 (1996)
I am interested in this work
