Prof. Dr. rer. nat. Silvia Capellino

silvia-capellino_neu-600x453-cut8 Group Leader

Neuroimmunology

Phone: +49 231 1084 420
Email: capellino@ifado.de

Curriculum Vitae:

  • 2020: Conferment of the title "Associate Professor" by the University Duisburg-Essen, Germany.
  • Since 2017: Member of the faculty council at the medical faculty of the University of Duisburg-Essen, Germany.
  • Since 2016: Leader of the Junior Research Group „Neuroimmunology“ at the Leibniz Research Centre for Working Environment and Human Factors(IfADo).
  • 2016-2019: Marie Skłodowska-Curie scholarship holder at Leibniz Research Centre for Working Environment and Human Factors (IfADo).
  • 2015-2016: PostDoc (University of Giessen and Kerckhoff Clinic, Bad Nauheim, Germany).
  • 2014: Maternity leave
  • 2012-2013: PostDoc (The Johns Hopkins University, School of Medicine, Baltimore MD, USA).
  • 2012: Habilitation (University of Regensburg, Germany)
  • 2007-2012: PostDoc (University of Regensburg, Germany)
  • 2007: Ph.D. on Clinical and Experimental Immunology (University of Genoa, Italy and University of Regensburg, Germany)
  • 2003: Diploma in Biology (University of Genoa, Italy)

Research topics:

  • NeuroEndocrine Immunology
  • Rheumatology

Key publications:

  • Peifer, C.; Hagemann, V.; Claus, M.; Larra, M. F.; Broede, P.; Watzl, C.; Wascher, E.; Capellino, S.: Low self-reported stress despite immune-physiological changes in paramedics during rescue operations
    EXCLI J. 20: 792-811 (2021)
    I am interested in this work
    https://dx.doi.org/10.17179/excli2021-3617
  • Wieber, Karolin Stephanie; Capellino, S. [Betreuer]: ¬The¬ dopaminergic pathway: A potential approach to target specific leukocyte subpopulations in chronic inflammatory joint diseasesWieber, Karolin Stephanie; Capellino, S. [Betreuer]. Duisburg-Essen: Univ., 2020.
    Diss. ist noch gesperrt Link in Bibliotheca noch setzen, wenn Arbeit durch den Prüfungsausschuss ist, Stand. 26.08.2020 Die Arbeit wurde in Englisch verfasst und ist zunächst bis zum 31.05.2021 gesperrt. Die Online-Version findet sich dann auf der Seite DuEPublico der Uni Duisburg-Essen.CD im Kern vorhanden
    Duisburg-Essen, Univ., Fakultät für Biologie, Diss., 2020
  • Flegel, Anke; Capellino, S. [Betreuer]: Phänotypische Charakterisierung primärer humaner Osteoblasten zur Evaluierung verschiedener Zellkulturbedingungen: Phenotypic characterization of primary human osteoblasts to evaluate different cell culture conditionsFlegel, Anke; Capellino, S. [Betreuer]. Bochum: Univ., 2020.
    Bochum, Univ., Fakultät für Biologie und Biotechnologie, Bachelorarbeit, 2020
    I am interested in this work
  • van Nie, L.; Salinas-Tejedor, L.; Dychus, N.; Fasbender, Frank; Hülser, M.-L.; Cutolo, M.; Rehart, S.; Capellino, S.: Dopamine induces in vitro migration of synovial fibroblast from patients with rheumatoid arthritis
    Sci. Rep. 10: 11928 (13 pp) (2020)
    I am interested in this work
    https://doi.org/10.1038/s41598-020-68836-z
  • Capellino, S.; Claus, M.; Watzl, C.: Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine
    Cell. Mol. Immunol. 17: 705-711 (2020)
    https://dx.doi.org/10.1038/s41423-020-0477-9
    I am interested in this work
  • Capellino, S.: Dopaminergic agents in rheumatoid arthritis
    J. Neuroimmune Pharmacol. 15: 48–56 (2020)
    https://doi.org/10.1007/s11481-019-09850-5
    I am interested in this work
  • Garner, Melissa; Capellino, S. [1. Gutachter]; Cadenas, C. [Betreuer]: Expression and signal transmission of adrenoceptors in the non-alcoholic fatty liverGarner, Melissa; Capellino, S. [1. Gutachter]; Cadenas, C. [Betreuer]. Köln: Univ., 2020.
    Köln, Rheinische Fachhochschule, Bachelorarbeit, 2020
    I am interested in this work
  • Brockmann, Jessica; Capellino, S. [Betreuer]; Cadenas, C. [Betreuer]: Sympathische Innervation in der nicht-alkoholischen Fettleber in Maus und MenschBrockmann, Jessica; Capellino, S. [Betreuer]; Cadenas, C. [Betreuer]. Recklinghausen: Hochsch., 2019.
    Recklinghausen, Westfälische Hochschule, Bachelorarbeit, 2019
    I am interested in this work
  • Novaira, H. J.; Negron, A. L.; Graceli, J. B.; Capellino, S.; Schoeffield, A.; Hoffman, G. E.; Levine, J. E.; Radovick, S.: Impairments in the reproductive axis of female mice lacking estrogen receptor ß in GnRH neurons
    Am. J. Physiol. 315: E1019-E1033 (2018)
    http://dx.doi.org/10.1152/ajpendo.00173.2018
    I am interested in this work
  • Novaira, H. J.; Graceli, J. B.; Capellino, S.; Schoeffield, A.; Hoffman, G. E.; Wolfe, A.; Wondisford, F.; Radovick, S.: Development and characterization of novel rat anti-mERbeta sera
    Endocrinology 157: 2844-2852 (2016)
    http://dx.doi.org/10.1210/en.2016-1122
    I am interested in this work
  • Böhm, M.; Apel, M.; Lowin, T.; Lorenz, J.; Jenei-Lanzl, Z.; Capellino, S.; Dosoki, H.; Grässel, S.: alpha-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients
    Biochem. Pharmacol. 116: 89-99 (2016)
    http://dx.doi.org/10.1016/j.bcp.2016.07.003
    I am interested in this work
  • Jenei-Lanzl, Z.; Capellino, S.; Kees, F.; Fleck, M.; Lowin, T.; Straub, R. H.: Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis
    Ann. Rheum. Dis. 74: 444-451 (2015)
    I am interested in this work
    http://dx.doi.org/10.1136/annrheumdis-2013-203925
  • Capellino, S.; Straub, R. H.; Cutolo, M.: Aromatase and regulation of the estrogen-to-androgen ratio in synovial tissue inflammation: common pathway in both sexes
    Ann. N. Y. Acad. Sci. 1317: 24-31 (2014)
    http://dx.doi.org/10.1111/nyas.12398
    I am interested in this work
  • Capellino, S.; Cosentino, M.; Luini, A.; Bombelli, R.; Lowin, T.; Cutolo, M.; Marino, F.; Straub, R. H.: Increased expression of dopamine receptors in synovial fibroblasts from patients with rheumatoid arthritis: inhibitory effects of dopamine on interleukin-8 and interleukin-6
    Arthritis Rheumatol. 66: 2685-2693 (2014)
    http://dx.doi.org/10.1002/art.38746
    I am interested in this work
  • Graf, N.; McLean, M.; Capellino, S.; Schölmerich, J.; Murray, G. I.; El-Omar, E. M.; Straub, R. H.: Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps: a putative role of semaphorins 3F and 3A
    Neurogastroenterol. Motil. 24: 120-128 (2012)
    http://dx.doi.org/10.1111/j.1365-2982.2011.01818.x
    I am interested in this work
  • Capellino, Silvia: Funktion von Tyrosin-Hydroxylase (TH)-positiven Zellen im Rahmen des Entzündungsgeschehens bei Arthritis: (kumulative Habilitationsschrift)Capellino, Silvia. Regensburg: Univ., 2012.
    Regensburg, Univ., Med. Fak., Habil.-Schr., 2012
    I am interested in this work
  • Capellino, S.; Weber, K.; Gelder, M.; Härle, P.; Straub, R. H.: First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy
    Arthritis Rheumatol 64: 1110-1118 (2012)
    I am interested in this work
    http://dx.doi.org/10.1002/art.33431
  • van der Goes, M. C.; Straub, R. H.; Wenting, M. J.; Capellino, S.; Jacobs, J. W.; Jahangier, Z. N.; Rauch, L.; Lafeber, F. P.: Intra-articular glucocorticoid injections decrease the number of steroid hormone receptor positive cells in synovial tissue of patients with persistent knee arthritis
    Ann. Rheum. Dis. 71: 1552-1558 (2012)
    http://dx.doi.org/10.1136/annrheumdis-2011-201019
    I am interested in this work
  • Lowin, T.; Weidler, C.; Jenei-Lanzl, Z.; Capellino, S.; Baerwald, C. G.; Buttgereit, F.; Straub, R. H.: Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis
    Arthritis Rheumatol 64: 1799-1808 (2012)
    I am interested in this work
    http://dx.doi.org/10.1002/art.34338
  • Probst, C.; Pongratz, G.; Capellino, S.; Szeimies, R. M.; Schölmerich, J.; Fleck, M.; Salzberger, B.; Ehrenstein, B.: Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis : a case report
    BMC Infect. Dis. 10: article 239 (5 pp) (2010)
    http://dx.doi.org/10.1186/1471-2334-10-239
    I am interested in this work
  • Capellino, S.; Cosentino, M.; Wolff, C.; Schmidt, M.; Grifka, J.; Straub, R. H.: Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target
    Ann. Rheum. Dis. 69: 1853-1860 (2010)
    I am interested in this work
  • Haas, S.; Capellino, S.; Phan, N. Q.; Böhm, M.; Luger, T. A.; Straub, R. H.; Ständer, S.: Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis
    J. Derm. Sci. 58: 193-197 (2010)
    I am interested in this work
    http://dx.doi.org/10.1016/j.jdermsci.2010.03.020
  • Cutolo, M.; Brizzolara, R.; Atzeni, F.; Capellino, S.; Straub, R. H.; Puttini, P. C.: ¬The¬ immunomodulatory effects of estrogens: clinical relevance in immune-mediated rheumatic diseases
    Ann. N. Y. Acad. Sci. 1193: 36-42 (2010)
    I am interested in this work
    http://dx.doi.org/10.1111/j.1749-6632.2009.05383.x
  • Ferrero, S.; Haas, S.; Remorgida, V.; Camerini, G.; Fulcheri, E.; Ragni, N.; Straub, R. H.; Capellino, S.: Loss of sympathetic nerve fibers in intestinal endometriosis
    Fertil. Steril. 94: 2817-2819 (2010)
    I am interested in this work
    http://dx.doi.org/10.1016/j.fertnstert.2010.06.069
  • Schmidt, M.; Hartung, R.; Capellino, S.; Cutolo, M.; Pfeifer-Leeg, A.; Straub, R. H.: Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis
    Arthritis Rheumatol. 60: 2913-2922 (2009)
    I am interested in this work
    http://dx.doi.org/10.1002/art.24859
  • Capellino, S.; Montagna, P.; Villaggio, B.; Soldano, S.; Straub, R. H.; Cutolo, M.: Hydroxylated estrogen metabolites influence the proliferation of cultured human monocytes: possible role in synovial tissue hyperplasia
    Clin. Exp. Rheumatol. 26: 903-909 (2008)
    I am interested in this work
  • Cutolo, M.; Capellino, S.; Straub, R. H.: Oestrogens in rheumatic diseases: friend or foe?
    Rheumatology 47: Suppl. 3 :iii2-iii5 (2008)
    I am interested in this work
    http://dx.doi.org/10.1093/rheumatology/ken150
  • Capellino, S.; Straub, R. H.: Neuroendocrine immune pathways in chronic arthritis
    Best. Pract. Res. Clin. Rheumatol. 22: 285-297 (2008)
    I am interested in this work
    http://dx.doi.org/10.1016/j.berh.2008.01.010
  • Dirmeier, M.; Capellino, S.; Schubert, T.; Angele, P.; Anders, S.; Straub, R. H.: Lower density of synovial nerve fibres positive for calcitonin gene-related peptide relative to substance P in rheumatoid arthritis but not in osteoarthritis
    Rheumatology 47: 36-40 (2008)
    I am interested in this work
    http://dx.doi.org/10.1093/rheumatology/kem301
  • Lehner, B.; Koeck, F. X.; Capellino, S.; Schubert, T. E.; Hofbauer, R.; Straub, R. H.: Preponderance of sensory versus sympathetic nerve fibers and increased cellularity in the infrapatellar fat pad in anterior knee pain patients after primary arthroplasty
    J. Orthop. Res. 26: 342-350 (2008)
    I am interested in this work
    http://dx.doi.org/10.1002/jor.20498
  • Straub, R. H.; Grum, F.; Strauch, U.; Capellino, S.; Battaille, F.; Bleich, A.; Falk, W.; Obermeier, F.: Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation
    Gut. 57: 977-921 (2008)
    I am interested in this work
    http://dx.doi.org/10.1136/gut.2007.125401
  • Capellino, S.; Lowin, T.; Angele, P.; Falk, W.; Grifka, J.; Straub, R. H.: Increased chromogranin A levels indicate sympathetic hyperactivity in patients with rheumatoid arthritis and systemic lupus erythematosus
    J. Rheumatol. 35: 91-99 (2008)
    I am interested in this work
  • Montagna, P.; Capellino, S.; Villaggio, B.; Remorgida, V.; Ragni, N.; Cutolo, M.; Ferrero, S.: Peritoneal fluid macrophages in endometriosis: correlation between the expression of estrogen receptors and inflammation
    Fertil. Steril. 90: 156-164 (2008)
    I am interested in this work
  • Capellino, S.; Riepl, B.; Rauch, L.; Angele, P.; Cutolo, M.; Straub, R. H.: Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation?
    Ann. Rheum. Dis. 66: 53-58 (2007)
    I am interested in this work
    http://dx.doi.org/10.1136/ard.2006.055483
  • Janele, D.; Lang, T.; Capellino, S.; Cutolo, M.; da Silva, J. A.; Straub, R. H.: Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol
    Ann. NY Acad. Sci. 1069: 168-182 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1351.015
  • Cutolo, M.; Montecucco, C. M.; Cavagna, L.; Caporali, R.; Capellino, S.; Montagna, P.; Fazzuoli, L.; Sulli, A.: Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis
    Ann. Rheum. Dis. 65: 1438-1443 (2006)
    I am interested in this work
    http://dx.doi.org/10.1136/ard.2006.051979
  • Cutolo, M.; Capellino, S.; Sulli, A.; Serioli, B.; Sechhi, M. E.; Villaggio, B.; Straub, R. H.: Estrogens and autoimmune diseases
    Ann. N. Y. Acad. Sci. 1089: 538-547 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1386.043
  • Sulli, A.; Montecucco, C. M.; Caporali, R.; Cavagna, L.; Montagna, P.; Capellino, S.; Fazzuoli, L.; Cutolo, M.: Glucocorticoid effects on adrenal steroids and cytokine responsiveness in polymyalgia rheumatica and elderly onset rheumatoid arthritis
    Ann. NY Acad. Sci. 1069: 307-314 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1351.029
  • Cutolo, M.; Sulli, A.; Capellino, S.; Villaggio, B.; Montagna, P.; Pizzorni, C.; Paolino, S.; Seriolo, B.: Anti-TNF and sex hormones
    Ann. NY Acad. Sci. 1069: 391-400 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1351.037
  • Capellino, S.; Montagna, P.; Villaggio, B.; Sulli, A.; Soldano, S.; Ferrero, S.; Remorgida, V.; Cutolo, M.: Role of estrogens in inflammatory response: expression of estrogen receptors in peritoneal fluid macrophages from endometriosis
    Ann. NY Acad. Sci. 1069: 263-267 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1351.024
  • Cutolo, M.; Capellino, S.; Montagna, P.; Sulli, A.; Seriolo, B.; Villaggio, B.: Anti-inflammatory effects of leflunomide in combination with methotrexate on co-culture of T lymphocytes and synovial macrophages from rheumatoid arthritis patients
    Ann. Rheum. Dis. 65: 728-735 (2006)
    I am interested in this work
    http://dx.doi.org/10.1136/ard.2005.045641
  • Capellino, S.; Villaggio, V.; Montagna, P.; Sulli, A.; Craviotto, C.; Cutolo, M.: 17beta-Estradiol and testosterone influence the mRNA expression and the time course of inflammatory cytokines in activated human monocytic cell line (THP-1)
    Reumatismo 57: 193-196 (2005)
    I am interested in this work
    http://dx.doi.org/10.4081/reumatismo.2005.193
  • Cutolo, M.; Maestroni, G. J.; Otsa, K.; Aakre, O.; Villaggio, B.; Capellino, S.; Montagna, P.; Sulli, A.: Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison
    Ann. Rheum. Dis. 64: 212-216 (2005)
    I am interested in this work
    http://dx.doi.org/10.1136/ard.2004.023416
  • Capellino, S.; Montagna, P.; Villaggio, B.; Cutolo, M.: [Effects of estrogen peripheral metabolism in rheumatoid arthritis]: [Article in Italian]
    Rheumatismo 57: 78-82 (2005)
    I am interested in this work
  • Cutolo, M.; Capellino, S.; Montagna, P.; Ghiorzo, P.; Sulli, A.; Villaggio, B.: Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line
    Arthritis Res. Ther. 7: R1124-R1132 (2005)
    I am interested in this work
    http://dx.doi.org/10.1186/ar179
  • Cutolo, M.; Villaggio, B.; Seriolo, B.; Montagna, P.; Capellino, S.; Straub, R. H.; Sulli, A.: Synovial fluid estrogens in rheumatoid arthritis
    Autoimmun. Rev. 3: 193-198 (2004)
    I am interested in this work
    https://doi.org/10.1016/j.autrev.2003.08.003
  • Cutolo, M.; Villaggio, B.; Seriolo, B.; Montagna, P.; Capellino, S.; Straub, R. H.; Sulli, A.: Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity
    Lupus 13: 635-638 (2004)
    I am interested in this work
    http://dx.doi.org/10.1191/0961203304lu1094oa
  • Cutolo, M.; Capellino, S.; Montagna, P.; Villaggio, B.; Sulli, A.; Seriolo, B.; Straub, R. H.: New roles for estrogens in rheumatoid arthritis
    Clin. Exp. Rheumatol. 21: 687-690 (2003)
    I am interested in this work