Karolina Edlund receives funding for spatial resolution of tissue samples

The European Association for Cancer Research (EACR) regularly awards funding to researchers to be able to analyse spatial biomarkers in cancer research more precisely (European Whole Transcription Atlas Grant). This year, Karolina Edlund from the IfADo research area Toxicology is one of the winners. The scientist wants to perform spatially resolved sequencing of tissue to better understand the early forms of liver cancer (hepatocellular carcinoma).

Scientific Contact: 
Dr. Karolina Edlund
Research Associate
Phone: +49 231 1084-354
Email: edlund@ifado.de

Press Contact:
Anne Rommel
Press Officer
Phone: +49 231 1084-239
Email: rommel@ifado.de

New research project analyses different disease stages of non-alcoholic fatty liver disease for therapeutic steps

In a new research project, the Leibniz Research Centre for Working Environment and Human Factors in Dortmund (IfADo) and partner institutions are analysing the different stages of non-alcoholic fatty liver disease, from benign steatosis to cancer development. The aim is to identify the mechanisms that initiate the different stages of the disease. Based on this, suitable time windows for therapeutic measures are to be developed. The project is funded by the Deutsche Forschungsgemeinschaft (German Research Foundation).

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New insights into the functioning of the liver

In Germany, as many as five million people suffer from liver diseases. The liver is a resilient and complex organ which we do not understand enough even in its basic functioning. A team at the Leibniz Research Centre for Working Environment and Human Factors (IfADo) is now providing fundamentally new insights into the function of the liver to produce bile and transport it through ‘canaliculi’: According to the study, there is a stagnant liquid in these canaliculi and the constituents of bile move in this standing liquid primarily by diffusion. These findings overturn long-standing assumptions about how the liver secretes bile. They are published in the journal “Hepatology”.

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