Ph.D. Raly James Perez Custodio

Custodio Scientific Staff

Phone: +49 / 231 1084-267
Email: custodio@ifado.de

Curriculum Vitae:

  • Since June 2022: Post-doctoral Researcher, Ergonomics Department, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany
  • September 2021 – May 2022: Post-doctoral Researcher, Institute for New Drug Development, College of Pharmacy, Jeonbuk National University, Jeonju, South Korea
  • August 2021: Doctor of Philosophy (Ph.D.) in Pharmacy (major in Pharmacology), Graduate School of Pharmacy, Sahmyook University, Seoul, South Korea
  • August 2018: Master of Science (M.Sc.) in Pharmacy (major in Pharmacology), Graduate School of Pharmacy, Sahmyook University, Seoul, South Korea
  • August 2016 – August 2021: Graduate Researcher, Uimyung Research Institute for Neuroscience, Laboratory of Pharmacology, Sahmyook University, Seoul, South Korea
  • October 2015: Master of Arts (M.A.) in Nursing major in Clinical Supervision at the School of Healthcare Professions, Department of Nursing, University of San Carlos, Cebu City, Philippines
  • March 2014 – July 2016: Clinical Instructor (General and Psychiatric Nursing), College of Nursing, Colegio de Sta. Lourdes of Leyte foundation, Inc., Tabontabon, Leyte, Philippines
  • January 2014: Registered Nurse (R.N.) in the Philippines
  • May 2013: Bachelor of Science (B.Sc.) in Nursing, College of Nursing, Colegio de Sta. Lourdes of Leyte Foundation, Inc., Tabontabon, Leyte, Philippines

Research topics:

  • Behavioral phenotyping in rodent models of attention-deficit/hyperactivity disorder (ADHD), autism, addiction, aging and aging-related cognitive changes (Alzheimer’s disease), and depression.
  • Pharmacological evaluation of existing psychoactive drugs and the novel psychoactive compounds: their potential for abuse and use as a psychiatric treatment modality.

Key publications:

  • Custodio, R. J.P., Ortiz, D. M., Lee, H. J., Sayson, L. V., Buctot, D., Kim, M., Lee, Y. S., Kim, K-M., Cheong, J. H., & Kim, H. J. 5-HT2CR Is as Important as 5-HT2AR in Inducing Hallucinogenic Effects in Serotonergic Compounds. Available at SSRN 4121838.
  • Custodio, R. J. P., Kim, M., Sayson, L. V., Ortiz, D. M., Buctot, D., Lee, H. J., Cheong, J. H., & Kim, H. J. (2022). Regulation of clock and clock-controlled genes during morphine reward and reinforcement: Involvement of the period 2 circadian clock. Journal of Psychopharmacology, 02698811221089040.
  • Custodio, R. J. P., Kim, M., Sayson, L. V., Lee, H. J., Ortiz, D. M., Kim, B. N., Kim, H.J., & Cheong, J. H. (2021). Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein. Communications biology, 4(1), 1-14.
  • Custodio, R. J. P., Sayson, L. V., Botanas, C. J., Abiero, A., You, K. Y., Kim, M., Lee, H. J., Yoo, S. Y., Lee, K. W., Lee, Y. S., Seo, J-W., Ryu, I. S., Kim, H. J., & Cheong, J. H. (2020). 25B‐NBOMe, a novel N‐2‐methoxybenzyl‐phenethylamine (NBOMe) derivative, may induce rewarding and reinforcing effects via a dopaminergic mechanism: evidence of abuse potential. Addiction Biology, 25(6), e12850.
  • Custodio, R. J. P., Sayson, L. V., Botanas, C. J., Abiero, A., Kim, M., Lee, H. J., Ryu, H. W., Lee, Y. S., Kim, H. J., & Cheong, J. H. (2020). Two newly-emerging substituted phenethylamines MAL and BOD induce differential psychopharmacological effects in rodents. Journal of Psychopharmacology, 34(9), 1056-1067.
  • Custodio, R. J. P., Botanas, C. J., de la Peña, J. B., dela Peña, I. J., Kim, M., Sayson, L. V., Abiero, A., Ryoo, Z. Y., Kim, B-N., Kim, H. J., & Cheong, J. H. (2018). Overexpression of the thyroid hormone-responsive (THRSP) gene in the striatum leads to the development of inattentive-like phenotype in mice. Neuroscience, 390, 141-150.
  • Custodio, R. J. P., Botanas, C. J., Yoon, S. S., De La Pena, J. B., dela Peña, I. J., Kim, M., Woo, T., Seo, J-W., Jang, C-G., Kwon, Y. H., Kim, N. Y., Lee, Y. S., Kim, H. J., & Cheong, J. H. (2017). Evaluation of the abuse potential of novel amphetamine derivatives with modifications on the amine (NBNA) and phenyl (EDA, PMEA, 2-APN) sites. Biomolecules & therapeutics, 25(6), 578.
  • Kim, M., Custodio, R. J., Lee, H. J., Sayson, L. V., Ortiz, D. M., Kim, B. N., Kim, H. J., & Cheong, J. H. (2022). Per2 Expression Regulates the Spatial Working Memory of Mice through DRD1-PKA-CREB Signaling. Molecular Neurobiology, 59(7), 4292-4303.
  • Sayson, L. V., Kim, M., Jeon, S. J., Custodio, R. J. P., Lee, H. J., Ortiz, D. M., Cheong, J. H., & Kim, H. J. (2022). Differentially Expressed Genes in Period 2-Overexpressing Mice Striatum May Underlie Their Lower Sensitivity to Methamphetamine Addiction-Like Behavior. Biomolecules & Therapeutics, 30(3), 238.
  • Kim, T. H., Bormate, K. J., Custodio, R. J. P., Cheong, J. H., Lee, B. K., Kim, H. J., & Jung, Y. S. (2022). Involvement of the adenosine A1 receptor in the hypnotic effect of rosmarinic acid. Biomedicine & Pharmacotherapy, 146, 112483.
  • Botanas, C. J., Custodio, R. J. P., Kim, H. J., de la Pena, J. B., Sayson, L. V., Ortiz, D. M., Kim, M., Lee, H. J., Acharya, S., Kim, K-Y., Lee, C. J., Ryu, J. H., Lee, Y. S., & Cheong, J. H. (2021). R (−)-methoxetamine exerts rapid and sustained antidepressant effects and fewer behavioral side effects relative to S (+)-methoxetamine. Neuropharmacology, 193, 108619.
  • Kim, T. H., Custodio, R. J., Cheong, J. H., Kim, H. J., & Jung, Y. S. (2019). Sleep promoting effect of luteolin in mice via adenosine A1 and A2A receptors. Biomolecules & therapeutics, 27(6), 584.