Prof. Dr. Jan G. Hengstler

Leitung Forschungsbereich

seit 03/2007
Leitung der Projektgruppe Systemtoxikologie
03/2006 - 02/2007
Kommissarischer Leiter des Instituts für Rechtsmedizin und der Forensischen Toxikologie, Universität Leipzig
04/2003 - 02/2007
Professor für Molekulare Toxikologie, Universität Leipzig
11/1990 - 03/2003
Forschung am Institut für Toxikologie, Universität Mainz (Direktor: Prof. Dr. Franz Oesch)
11/1998
Habilitation, venia legendi für Pharmakologie und Toxikologie
06/1997
Facharzt für Pharmakologie und Toxikologie
08/1992
Approbation als Arzt
12/1991
Promotion zum Dr. med.
10/1984 – 10/1990
Studium Humanmedizin, Universität Mainz

Hier finden Sie Schlüsselpublikationen ab 2010. Für alle anderen Veröffentlichungen unserer wissenschaftlichen Mitarbeiter beachten Sie bitte die Links zu anderen Datenbanken wie Pubmed.

Schneider KM, Candels LS, Hov JR, Myllys M, Hassan R, Schneider CV, Wahlström A, Mohs A, Zühlke S, Liao L, Elfers C, Kilic K, Henricsson M, Molinaro A, Hatting M, Zaza A, Drasdo D, Frissen M, Devlin AS, Gálvez EJC, Strowig T, Karlsen TH, Hengstler JG, Marschall HU, Ghallab A, Trautwein C:

Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling. Nat Metab 3 (9):1228-1241 (2021)

Remetic J, Ghallab A, Hobloss Z, Brackhagen L, Hassan R, Myllys M, Radun R, Mlitz V, Zhu C, Baumgartner M, Schrottmaier WC, Mussbacher M, Timelthaler G, Scharnagl H, Stojakovic T, Assinger A, Fuchs CD, Hengstler JG, Trauner M:

Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology 75: 1095-1109 (2022)

Nell P, Kattler K, Feuerborn D, Hellwig B, Rieck A, Salhab A, Lepikhov K, Gasparoni G, Thomitzek A, Belgasmi K, Blüthgen N, Morkel M, Küppers-Munther B, Godoy P, Hay DC, Cadenas C, Marchan R, Vartak N, Edlund K, Rahnenführer J, Walter J, Hengstler JG:

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. J Hepatol 77: 1386-1398 (2022)

Mohs A, Otto T, Schneider KM, Peltzer M, Boekschoten M, Holland CH, Hudert CA, Kalveram L, Wiegand S, Saez-Rodriguez J, Longerich T, Hengstler JG, Trautwein C:

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. J Hepatol 74: 638-648 (2021)

Gui W, Hole MJ, Molinaro A, Edlund K, Jørgensen KK, Su H, Begher-Tibbe B, Gaßler N, Schneider CV, Muthukumarasamy U, Mohs A, Liao L, Jaeger J, Mertens CJ, Bergheim I, Strowig T, Hengstler JG, Hov JR, Marschall HU, Trautwein C, Schneider KM:

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis. Nat Commun 14 (1): 3304 (2023) (17 pp)

Edlund K, Madjar K, Lebrecht A, Aktas B, Pilch H, Hoffmann G, Hofmann M, Kolberg HC, Boehm D, Battista MJ, Seehase M, Stewen K, Gebhard S, Cadenas C, Marchan R, Brenner W, Hasenburg A, Koelbl H, Solbach C, Gehrmann M, Tanner B, Weber K, Loibl S, Sachinidis A, Rahnenführer J, Schmidt M, Hengstler JG:

Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial. Clin Cancer Res 27: 2148-2158 (2021)

Bloch D, Diel P, Epe B, Hellwig M, Lampen A, Mally A, Marko D, Villar Fernández MA, Guth S, Roth A, Marchan R, Ghallab A, Cadenas C, Nell P, Vartak N, van Thriel C, Luch A, Schmeisser S, Herzler M, Landsiedel R, Leist M, Marx-Stoelting P, Tralau T, Hengstler JG:

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97: 3005-3017 (2023)

Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG:

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93: 1609-1637 (2019)

Vartak N, Drasdo D, Geisler F, Itoh T, Oude Elferink RPJ, van de Graaf SFJ, Chiang J, Keitel V, Trauner M, Jansen P, Hengstler JG:

On the mechanisms of biliary flux. Hepatology 74: 3497-3512 (2021)

Marchan R, Büttner B, Lambert J, Edlund K, Glaeser I, Blaszkewicz M, Leonhardt G, Marienhoff L, Kaszta D, Anft M, Watzl C, Madjar K, Grinberg M, Rempel E, Hergenröder R, Selinski S, Rahnenführer J, Lesjak MS, Stewart JD, Cadenas C, Hengstler JG:

Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma. Cancer Res 77: 4589-4601 (2017)

Jansen PL, Ghallab A, Vartak N, Reif R, Schaap FG, Hampe J, Hengstler JG:

The ascending pathophysiology of cholestatic liver disease. Hepatology 65: 722-738 (2017)

Guth S, Hüser S, Roth A, Degen G, Diel P, Edlund K, Eisenbrand G, Engel K-H, Epe B, Grune T, Heinz V, Henle T, Humpf H-U, Jäger H, Joost H-G, Kulling SE, Lampen A, Mally A, Marchan R, Marko D, Mühle E, Nitsche MA, Röhrdanz E, Stadler R, van Thriel C, Vieths S, Vogel RF, Wascher E, Watzl C, Nöthlings U, Hengstler JG:

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol 94: 1375-1415 (2020)

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R:

Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood. Hepatology 69: 666-683 (2019)

Hier finden Sie Publikationen ab 2010. Für alle anderen Veröffentlichungen unserer wissenschaftlichen Mitarbeiter beachten Sie bitte die Links zu anderen Datenbanken wie Pubmed.

Stewart JD, Marchan R, Lesjak MS, Lambert J, Hergenroeder R, Ellis JK, Lau C-H, Keun HC, Schmitz G, Schiller J, Eibisch M, Hedberg C, Waldmann H, Lausch E, Tanner B, Sehouli J, Sagemueller J, Staude H, Steiner E, Hengstler JG:

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci U S A 109: 8155-8160 (2012)

Heise T, Schug M, Storm D, Ellinger-Ziegelbauer H, Ahr HJ, Hellwig B, Rahnenfuhrer J, Ghallab A, Guenther G, Sisnaiske J, Reif R, Godoy P, Mielke H, Gundert-Remy U, Lampen A, Oberemm A, Hengstler JG:

In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens. Curr Med Chem 19: 1721-1730 (2012)

Selinski S, Lehmann M-L, Blaszkewicz M, Ovsiannikov D, Moormann O, Guballa C, Kress A, Truß MC, Gerullis H, Otto T, Barski D, Niegisch G, Albers P, Frees S, Brenner W, Thüroff JW, Angeli-Greaves M, Seidel T, Roth G, Volkert F, Ebbinghaus R, Prager H-M, Lukas C, Bolt HM, Falkenstein M, Zimmermann A, Klein T, Reckwitz T, Roemer HC, Hartel M, Weistenhöfer W, Schöps W, Rizvi SAH, Aslam M, Bánfi G, Romics I, Ickstadt K, Hengstler JG, Golka K:

Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene. Arch Toxicol 86: 195-203 (2012)

Selinski S, Lehmann ML, Blaszkewicz M, Ovsiannikov D, Moormann O, Guballa C, Kress A, Truß MC, Gerullis H, Otto T, Barski D, Niegisch G, Albers P, Frees S, Brenner W, Thüroff JW, Angeli-Greaves M, Seidel T, Roth G, Volkert F, Ebbinghaus R, Prager HM, Bolt HM, Falkenstein M, Zimmermann A, Klein T, Reckwitz T, Roemer HC, Hartel M, Weistenhöfer W, Schöps W, Rizvi SA, Aslam M, Bánfi G, Romics I, Ickstadt K, Hengstler JG, Golka K:

Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk. Arch Toxicol 86: 1369–1378 (2012)

Bolt HM, Marchan R, Hengstler JG:

Nanotoxicology and oxidative stress control: cutting-edge topics in toxicology. (Editorial). Arch Toxicol 86: 1629-1635 (2012)

Hengstler JG, Marchan R, Leist M:

Highlight report: towards the replacement of in vivo repated dose systemic toxicity testing. (Editorial). Arch Toxicol 86: 13-15 (2012)

Kadereit S, Zimmer B, van Thriel C, Hengstler JG, Leist M:

Compound selection for in vitro modeling of developmental neurotoxicity. Front Biosci (Landmark ed.) 17: 2442-2460 (2012)

van Thriel C, Hengstler JG, Marchan R:

Pyrethroid insecticide neurotoxicity. (Editorial). Arch Toxicol 86: 341-342 (2012)

Hengstler JG, Godoy P, Reif R, Stewart J, Schug M, Heise T, Oberemm A, Braeuning A, Zellmer S, Böttger J, Gebhardt R, Hoehme S, Drasdo D, Schwarz M:

The virtual liver. Spatial-temporal modelling of tissue damage & regeneration. In: Seidle T, Spielmann H (Eds.): Alternative testing strategies. Progress report 2011 & AXLR8-2 Workshop report on a ‚Roadmap to innnovative toxicity testing‘ (pp 218-225). Berlin: AXLR8 Consortium, 2011

Stewart JD, Hengstler JG, Bolt HM:

Contrast agent-induced nephrotoxicity: role of oxidative stress and apoptosis through the mitochondrial pathway. (Editorial). Arch Toxicol 85: 163-164 (2011)