Dr. Nachiket Vartak

Leitung Forschungsgruppe Bioimaging

seit 2022
Gruppenleitung "Bioimaging", Abteilung für Toxikologie, Leibniz-Institut für Arbeitsforschung an der TU Dortmund (IfADo)
2016-2022
Juniorgruppenleitung am Leibniz-Institut für Arbeitsforschung, Abteilung Toxikologie - Prof. Dr. Jan G. Hengstler
2014-2016
Postdoc am Leibniz-Institut für Arbeitsforschung, Abteilung Toxikologie - Prof. Dr. Jan G. Hengstler
2011-2014
Postdoc am Max-Planck-Institut (MPI-MOPH), Dortmund
2007-2011
Doktorarbeit am Max-Planck-Institut (MPI-MOPH), Dortmund
2004-2006
Masterstudium (Biotechnologie) am Indian Institute of Technology (IITB), Mumbai, Indien
2001-2004
Bachelorstudium (Life Sciences und Biochemie) am St. Xavier's College, University of Mumbai, Indien

Hier finden Sie die Publikationen ab 2010, die am IfADo entstanden sind. Für alle anderen Veröffentlichungen unserer wissenschaftlichen Mitarbeiter beachten Sie bitte die Links zu anderen Datenbanken wie Pubmed.

Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Mattsson J, Marschall HU, Hoehme S, Stirnimann G, Schwab M, Boor P, Amann K, Schmitz J, Bräsen JH, Rahnenführer J, Edlund K, Karpen SJ, Simbrunner B, Reiberger T, Mandorfer M, Trauner M, Dawson PA, Lindström E, Hengstler JG:

Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol 80: 268-281 (2024)

Bloch D, Diel P, Epe B, Hellwig M, Lampen A, Mally A, Marko D, Villar Fernández MA, Guth S, Roth A, Marchan R, Ghallab A, Cadenas C, Nell P, Vartak N, van Thriel C, Luch A, Schmeisser S, Herzler M, Landsiedel R, Leist M, Marx-Stoelting P, Tralau T, Hengstler JG:

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol 97: 3005-3017 (2023)

Schnabl B, Arteel GE, Stickel F, Hengstler JG, Vartak N, Ghallab A, Dooley S, Li Y, Schwabe RF:

Liver specific, systemic and genetic contributors to alcohol-related liver disease progression. Z Gastroenterol 60: 36-44 (2022)

Nell P, Kattler K, Feuerborn D, Hellwig B, Rieck A, Salhab A, Lepikhov K, Gasparoni G, Thomitzek A, Belgasmi K, Blüthgen N, Morkel M, Küppers-Munther B, Godoy P, Hay DC, Cadenas C, Marchan R, Vartak N, Edlund K, Rahnenführer J, Walter J, Hengstler JG:

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. J Hepatol 77: 1386-1398 (2022)

Brecklinghaus T, Albrecht W, Duda J, Kappenberg F, Gründler L, Edlund K, Marchan R, Ghallab A, Cadenas C, Rieck A, Vartak N, Tolosa L, Castell JV, Gardner I, Halilbasic E, Trauner M, Ullrich A, Zeigerer A, Demirci Turgunbayer Ö, Damm G, Seehofer D, Rahnenführer J, Hengstler JG:

In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay. Toxicol Lett 368: 33-46 (2022)

Vartak N, Hengstler JG:

Reply to 21-1766: Challenging the dogma of canalicular bile flow. (Correspondence). Hepatology 75: 493-494 (2022)

Vartak N, Elferink RO, van de Graaf S, Drasdo D, Hengstler J:

Reply (to: Javitt NB: Intravital Dynamic and Correlative Imaging Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux (Letter to the editor). https://doi.org/10.1002/hep.31746). Hepatology 76 (3): E58 (2022)

Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Vartak N, Edlund K, Marchan R, Ghallab A, Cadenas C, Günther G, Leist M, Zhang M, Gardner I, Reinders J, Russel FGM, Foster AJ, Williams DP, Damle-Vartak A, Grandits M, Ecker G, Kittana N, Rahnenführer J, Hengstler JG:

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. Chem Biol Interact 351: 109728 (2022) (16 pp)

Vartak N, Hengstler J:

Reply (To the editor). (Correspondence). Hepatology 74: 1133 (2021)

Vartak N, Guenther G, Joly F, Damle‐Vartak A, Wibbelt G, Fickel J, Jörs S, Begher‐Tibbe B, Friebel A, Wansing K, Ghallab A, Rosselin R, Boissier N, Vignon‐Clementel I, Hedberg C, Geisler F, Hofer H, Hoehme S, Drasdo D, Hengstler JG:

Intravital dynamic and correlative imaging of mouse livers reveals diffusion-dominated canalicular and flow-augmented ductular bile flux. Hepatology 73: 1531-1550 (2021)

Vartak N, Drasdo D, Geisler F, Itoh T, Oude Elferink RPJ, van de Graaf SFJ, Chiang J, Keitel V, Trauner M, Jansen P, Hengstler JG:

On the mechanisms of biliary flux. Hepatology 74: 3497-3512 (2021)

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R:

Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood. Hepatology 69: 666-683 (2019)

Damle-Vartak A, Begher-Tibbe B, Günther G, Geisler F, Vartak N, Hengstler JG:

Pipe-3D: A pipeline based on immunofluorescence, 3D confocal imaging, reconstructions, and morphometry for biliary network analysis in cholestasis. In: Vinken M (ed): Experimental cholestasis research (pp 25-53). New York, NY: Humana Press, 2019 (Methods in Molecular Biology, Vol 1981)

Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG:

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93: 1609-1637 (2019)

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M:

Single cell polarity in liquid phase facilitates tumour metastasis. Nat Commun 9: 887 (20 pp) (2018)