Dr. rer. nat. Cristina Cadenas

cadenas Leitung der Nachwuchsgruppe

Zelluläre Toxikologie

Tel.: +49 / 231 1084 392
E-Mail:

Vita:

  • 09/1988-09/1994: Academic Studies, Biology Study with specialization in Biochemistry and Molecular Biology, Universidad Autónoma, Madrid (Spanien) and Université Paul Sabatier, Toulouse (France), Final Thesis: Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold
  • 06/1994-03/2000: Ph.D. Thesis, Technical University Braunschweig (Germany), Department of Cell and Molecular Biology - Prof. Dr. H.-H. Arnold, Thesis: "Identification of new genes involved in embryonic development by Gene-trap insertional mutagenesis in mouse embryonic stem cells"
  • 05/2000-02/2003: Postdoc, Max Planck Institute for experimental Endocrinology, Hannover. Laboratory Prof. Dr. Gregor Eichele, Line of research: "Molecular basis of circadian rhythms"
  • 03/2003-12/2007: Family break, Teaching at the public school (Volkshochschule) Dortmund.
  • 01/2008-07/2010: Postdoc , Institute for Analytical Sciences – ISAS - e.V., Dortmund, Department Metabolomics - PD. Dr. J.I. Baumbach, Line of research: "Metabolome analysis of cancer cell lines"
  • since 08/2010: Junior group leader at Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Department Systems Toxicology - Prof. Dr. Jan G. Hengstler

Arbeitsgebiete:

  • Oncogene-mediated tumor metabolome
  • Cell survival mechanisms and Prognostic factors in breast cancer
  • Metabolic alterations in non-alcoholic fatty liver disease (NAFLD)

Publikationen:

  • Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
    Cancer Res. 77: 4589-4601 (2017)
    http://dx.doi.org/10.1158/0008-5472.CAN-16-2065
    Ich bin an dieser Arbeit interessiert
  • Schmidt, F.; Gasparoni, N.; Gianmoena, K.; Cadenas, C.; Polansky, J. K.; Ebert, P.; Hengstler, J. G.; Schulz, M. H.: Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction
    Nucleic Acids Res. 45: 54-66 (2017)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1093/nar/gkw1061
  • Gogiashvili, M.; Edlund, K.; Gianmoena, K.; Marchan, R.; Brik, A.; Andersson, J. T.; Hengstler, J. G.; Cadenas, C.: Metabolic profiling of ob/ob mouse fatty liver using HR-MAS (1)H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway:
    Anal. Bioanal. Chem. 409: 1591-1606 (2017)
    http://dx.doi.org/10.1007/s00216-016-0100-1
    Ich bin an dieser Arbeit interessiert
  • Hellwig, B.; Madjar, K.; Edlund, K.; Marchan, R.; Cadenas, C.; Heimes, A.-S.; Hengstler, J. G.; Rahnenführer, J.: Epsin family member 3 and ribosome-related genes are associated with late metastasis in estrogen receptor-positive breast cancer and long-term survival in non-small cell lung cancer using a genome-wide identification and validation strategy
    PLoS ONE 11: (12): e0167585 (18 pp.) (2016)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1371/journal.pone.0167585
  • Pink, M.; Ratsch, B. A.; Mardahl, M.; Durek, P.; Polanksy, J. K.; Cadenas, C.; Gianmoena, K.; Syrbe, U.: Imprinting of skin/inflammation homing in CD4+ T cells is controlled by DNA methylation within the fucosyltransferase 7 gene
    J. Immunol. 197: 3406-3414 (2016)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.4049/jimmunol.1502434
  • Godoy, P.; Widera, A.; Schmidt-Heck, W.; Campos, G.; Cadenas, C.; Reif, R.; Marchan, R.; Hengstler, J. G.: Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue
    Arch. Toxicol. 90: 2513-2529 (2016)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1007/s00204-016-1761-4
  • Arbo, M. D.; Melega, S.; Stöber, R.; Schug, M.; Godoy, P.; Reif, R.; Cadenas, C.; Hengstler, J. G.: Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis
    Arch. Toxicol. 90: 3045-3060 (2016)
    http://dx.doi.org/10.1007/s00204-016-1665-3
    Ich bin an dieser Arbeit interessiert
  • Stock, A.-M.; Klee, F.; Edlund, K.; Hammad, S.; Marchan, R.; Cadenas, C.; Hengstler, J. G.; Entschladen, F.: Gelsolin is associated with longer metastasis-free survival and reduced cell migration in estrogen receptor-positive breast cance
    Anticancer Res. 35: 5277-5286 (2015)
    Ich bin an dieser Arbeit interessiert
  • Cadenas, C.; van de Sandt, L.; Edlund, K.; Lohr, M.; Hellwig, B.; Marchan, R.; Schmidt, M.; Hengstler, J. G.: Loss of circadian clock gene expression is associated with tumor progression in breast cancer
    Cell Cycle 13: 3282-3291 (2014)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.4161/15384101.2014.954454
  • Gaspar, J. A.; Doss, M. X.; Hengstler, J. G.; Cadenas, C.; Hescheler, J.; Sachinidis, A.: Unique metabolic features of stem cells, cardiomyocytes, and their progenitors
    Circ. Res. 114: 1346-1360 (2014)
    Ich bin an dieser Arbeit interessiert
    http://dx.doi.org/10.1161/CIRCRESAHA.113.302021