Dr. Raymond Reif

Head of the junior research group

Visualizing Toxicology

Phone: +49 / 231 1084 275
Email:

Curriculum Vitae:

  • since 2009 scientific fellow at IfADo
  • 2014 guest stay at Jefferson University Philadelphia (Prof. Jan Hoek and Prof. György Hajnóczky)
  • 2008 Institute for Pharmaceutics and Toxicology, University Zürich
  • 2007 PhD at the Institute for Biochemie, University Zürich
  • 2001 licensure as pharmacist
  • study of pharmaceutics, University Marburg

Research topics:

  • intravitale microscopy
  • molecular mechanism of drug detoxification metabolism
  • intracellular protein transport

Publications:

  • Reif, R.; Ghallab, A.; Beattie, L.; Günther, G.; Kuepfer, L.; Kaye, P. M.; Hengstler, J. G.: In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
    Arch. Toxicol. 91: 1335-1352 (2017)
    http://dx.doi.org/10.1007/s00204-016-1906-5
    I am interested in this work
  • Jansen, P. L.; Ghallab, A.; Vartak, N.; Reif, R.; Schaap, F. G.; Hampe, J.; Hengstler, J. G.: The ascending pathophysiology of cholestatic liver disease
    Hepatology 65: 722-738 (2017)
    http://dx.doi.org/10.1002/hep.28965
    I am interested in this work
  • Godoy, P.; Widera, A.; Schmidt-Heck, W.; Campos, G.; Cadenas, C.; Reif, R.; Marchan, R.; Hengstler, J. G.: Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue
    Arch. Toxicol. 90: 2513-2529 (2016)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-016-1761-4
  • Arbo, M. D.; Melega, S.; Stöber, R.; Schug, M.; Godoy, P.; Reif, R.; Cadenas, C.; Hengstler, J. G.: Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis
    Arch. Toxicol. 90: 3045-3060 (2016)
    http://dx.doi.org/10.1007/s00204-016-1665-3
    I am interested in this work
  • Ghallab, A.; Celliere, G.; Henkel, S. G.; Godoy, P.; Blaszkewicz, M.; Reif, R.; Marchan, R.; Hengstler, J. G.: Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases
    J. Hepatol. 64: 860-871 (2016)
    http://dx.doi.org/10.1016/j.jhep.2015.11.018
    I am interested in this work
  • Reif, R.; Adawy, A.; Vartak, N.; Schröder, J.; Günther, G.; Ghallab, A.; Schmidt, M.; Hengstler, J. G.: Activated ErbB3 translocates to the nucleus via clathrin-independent endocytosis, which is associated with proliferating cells
    J. Biol. Chem. 291: 3837-3847 (2016)
    http://dx.doi.org/10.1074/jbc.M115.686782
    I am interested in this work
  • Reif, R.; Karlsson, J.; Günther, G.; Wrangborg, D.; Hammad, S.; Begher-Tibbe, B.; Vartak, A.; Hengstler, J. G.: Bile canalicular dynamics in hepatocyte sandwich cultures
    Arch. Toxicol. 89: 1861-1870 (2015)
    http://dx.doi.org/10.1007/s00204-015-1575-9
    I am interested in this work
  • Grinberg, M.; Stöber, R. M.; Edlund, K.; Rempel, E.; Godoy, P.; Reif, R.; Widera, A.; Hengstler, J. G.: Toxicogenomics directory of chemically exposed human hepatocytes
    Arch. Toxicol. 88: 2261-2287 (2014)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-014-1400-x
  • Hammad, S.; von Recklinghausen, I.; Begher-Tibbe, B.; Reif, R.; Godoy, P.; Golka, K.; Marchan, R.; Hengstler, J. G.: Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis
    Arch. Toxicol. 88: 1161-1183 (2014)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-014-1243-5
  • Hengstler, J. G.; Hammad, S.; Ghallab, A.; Reif, R.; Godoy, P.: In vitro systems for hepatoxicity testing
    In: In vitro toxicology systems (S. 27-44) / ed. by Anna Bal-Price .... New York, NY: Springer Science+Business Media, 2014.
    (Methods in Pharmacology and Toxicology, )
    I am interested in this work
    http://dx.doi.org/10.1007/978-1-4939-0521-8_2