Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email:

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2002: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed

Publications:

  • Han, D.; Gao, J.; Gu, X.; Hengstler, J. G.; Zhang, L.; Shahid, M.; Ali, T.; Han, B.: P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway
    Arch. Toxicol. XX: epub ahead of print (2017)
    http://dx.doi.org/10.1007/s00204-017-2070-2
  • Chaudhari, U.; Nemade, H.; Sureshkumar, P.; Vinken, M.; Ates, G.; Rogiers, V.; Hengstler, J. G.; Sachinidis, A.: Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
    Arch. Toxicol. XX: epub ahead of print (2017)
    http://dx.doi.org/10.1007/s00204-017-2065-z
  • Engel, J.; Smith, S.; Lategahn, J.; Tumbrink, H. L.; Goebel, L.; Günther, G.; Hengstler, J. G.; Rauh, D.: Structure-guided development of covalent and mutant-selective pyrazolopyrimidines to target T790M drug resistance in epidermal growth factor receptor
    J. Med. Chem. 60: 7725-7744 (2017)
    http://dx.doi.org/10.1021/acs.jmedchem.7b00515
    I am interested in this work
  • Vinken, M.; Knapen, D.; Vergauwen, L.; Hengstler, J. G.; Angrish, M.; Whelan, M.: Adverse outcome pathways: a concise introduction for toxicologists
    Arch. Toxicol. 91: 3697-3707 (2017)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-017-2020-z
  • Hammad, S.; Braeuning, A.; Meyer, C.; Mohamed, F. E. Z. A.; Hengstler, J. G.; Dooley, S.: A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein
    Arch. Toxicol. 91: 3689-3692 (2017)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-017-2040-8
  • Jabs, V.; Edlund, K.; König, H.; Grinberg, M.; Madjar, K.; Rahnenführer, J.; Hengstler, J. G.; Micke, P.: Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.
    PLoS ONE 12: (11): e0187246 (2017)
    I am interested in this work
    http://dx.doi.org/10.1371/journal.pone.0187246
  • Leist, M.; Ghallab, A.; Marchan, R.; Godoy, P.; Reif, R.; van Thriel, C.; Cadenas, C.; Hengstler, J. G.: Adverse outcome pathways: opportunities, limitations and open questions
    Arch. Toxicol. 91: 3477-3505 (2017)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-017-2045-3
  • Golka, K.; Ickstadt, K.; Selinski, S.; Hengstler, J. G.; Wilhelm, M.: Third symposium on Environmental Toxicology in North Rhine-Westphalia, Germany: Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine: Meeting report on a symposium held in Dortmund May 7-8, 2015
    Arch. Toxicol. 91: 3711-3715 (2017)
    http://dx.doi.org/10.1007/s00204-017-2093-8
    I am interested in this work
  • Selinski, S.; Blaszkewicz, M.; Ickstadt, K.; Gerullis, H.; Otto, T.; Roth, E.; Hengstler, J. G.; Golka, K.: Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer
    Carcinogenesis 38: 1167-1179 (2017)
    I am interested in this work
    I am interested in this work
    http://dx.doi.org/10.1093/carcin/bgx102
  • Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
    Cancer Res. 77: 4589-4601 (2017)
    http://dx.doi.org/10.1158/0008-5472.CAN-16-2065
    I am interested in this work
  • Kuhn, C.; Lehmann, M.-L.; Kress, A.; Truß, M. C.; Hermes, M.; Blaszkewicz, M.; Hengstler, J. G.; Golka, K.: Micro-brushing-based technique to gain fresh urothelial cells for gene expression analysis
    J. Toxicol. Environ. Health 80A: 411-416 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304723
  • Lukas, C.; Selinski, S.; Prager, H.-M.; Blaszkewicz, M.; Hengstler, J. G.; Golka, K.: Occupational bladder cancer: polymorphisms of xenobiotic metabolizing enzymes, exposures, and prognosis
    J. Toxicol. Environ. Health 80A: 439-452 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304731
  • Krech, E.; Selinski, S.; Blaszkewicz, M.; Bürger, H.; Kadhum, T.; Hengstler, J. G.; Truß, M. C.; Golka, K.: Urinary bladder cancer risk factors in an area of former coal, iron, and steel industries in Germany
    J. Toxicol. Environ. Health 80A: 430-438 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304719
  • Ebbinghaus, D.; Banfi, G.; Selinski, S.; Blaszkewicz, M.; Bürger, H.; Hengstler, J. G.; Nyirady, P.; Golka, K.: Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary
    J. Toxicol. Environ. Health 80A: 423-429 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304736
  • Höhne, S.; Gerullis, H.; Blaszkewicz, M.; Selinski, S.; Hengstler, J. G.; Otto, T.; Golka, K.: N-acetyltransferase 1*10 genotype in bladder cancer patients
    J. Toxicol. Environ. Health 80A: 417-422 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304727
  • Isermann, J.; Prager, H.-M.; Ebbinghaus, R.; Janasik, B.; Widera, A.; Selinski, S.; Hengstler, J. G.; Golka, K.: Urinary cadmium levels in active and retired coal miners
    J. Toxicol. Environ. Health 80A: 405-410 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304710
  • Golka, K.; Ickstadt, K.; Selinski, S.; Hengstler, J. G.; Wilhelm, M.: Third Symposium on Interdisciplinary Activities in Environmental Toxicology in North Rhine-Westphalia, Germany
    J. Toxicol. Environ. Health 80A: 395 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304744
  • Heimes, A.-S.; Madjar, K.; Edlund, K.; Battista, M. J.; Almstedt, K.; Rahnenführer, J.; Hengstler, J. G.; Schmidt, M.: Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer
    Breast Cancer Res. Treat. 165: 293-300 (2017)
    http://dx.doi.org/10.1007/s10549-017-4327-0
    I am interested in this work
  • Colaianna, M.; Ilmjärv, S.; Peterson, H.; Kern, I.; Julien, S.; Hengstler, J. G.; Leist, M.; Krause, K. H.: Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
    Arch. Toxicol. 91: 365-391 (2017)
    http://dx.doi.org/10.1007/s00204-016-1690-2
    I am interested in this work
  • Golka, K.; Ovsiannikov, D.; Blaszkewicz, M.; Moormann, O.; Haenel, M. W.; Hengstler, J. G.; Selinski, S.: Urinary bladder cancer in a former area of underground hard coal mining
    In: Progress in medical geology (S. 214-228) / ed. by Motomu Ibaraki and Hiroko Mori. Newcastle upon Tyne: Cambridge Scholars Publ., 2017.
    I am interested in this work