Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2003: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed


  • Hoehme, S.; Bertaux, F.; Weens, W.; Grasl-Kraupp, B.; Hengstler, J. G.; Drasdo, D.: Model prediction and validation of an order mechanism controlling the spatiotemporal phenotype of early hepatocellular carcinoma
    Bull. Math. Biol. XX: epub ahead of print (2018)
  • Gogiashvili, M.; Horsch, S.; Marchan, R.; Gianmoena, K.; Cadenas, C.; Tanner, B.; Hengstler, J. G.; Edlund, K.: Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy
    NMR Biomed. 31: e3862 (2018)
    I am interested in this work
  • Han, D.; Gao, J.; Gu, X.; Hengstler, J. G.; Zhang, L.; Shahid, M.; Ali, T.; Han, B.: P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway
    Arch. Toxicol. 92: 679-692 (2018)
    I am interested in this work
  • Chaudhari, U.; Nemade, H.; Sureshkumar, P.; Vinken, M.; Ates, G.; Rogiers, V.; Hengstler, J. G.; Sachinidis, A.: Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
    Arch. Toxicol. 92: 371-381 (2018)
    I am interested in this work
  • Waldmann, T.; Grinberg, M.; König, A.; Rempel, E.; Schildknecht, S.; Henry, M.; Hengstler, J. G.; Leist, M.: Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity
    Chem. Res. Toxicol. 30: 905-922 (2017)
    I am interested in this work
  • Hengstler, J. G.: Leber
    In: Das Toxikologiebuch: Grundlagen, Verfahren, Bewertung (S. 251-274) / herausgegeben von Helmut Greim. Weinheim: Wiley-VCH Verlag, 2017.
    I am interested in this work
  • Hengstler, J. G.; van Thriel, C.: Gesundheitsrisiken durch Aluminium
    Pädiatr. Praxis 87: 719-725 (2017)
    I am interested in this work
  • Selinski, S.; Blaszkewicz, M.; Ickstadt, K.; Gerullis, H.; Otto, T.; Roth, E.; Hengstler, J. G.; Golka, K.: Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer
    Carcinogenesis 38: 1167-1179 (2017)
    I am interested in this work
    I am interested in this work
  • Golka, K.; Ovsiannikov, D.; Blaszkewicz, M.; Moormann, O.; Haenel, M. W.; Hengstler, J. G.; Selinski, S.: Urinary bladder cancer in a former area of underground hard coal mining
    In: Progress in medical geology (S. 214-228) / ed. by Motomu Ibaraki and Hiroko Mori. Newcastle upon Tyne: Cambridge Scholars Publ., 2017.
    I am interested in this work
  • Heimes, A.-S.; Madjar, K.; Edlund, K.; Battista, M. J.; Almstedt, K.; Gebhard, S.; Hengstler, J. G.; Schmidt, M.: Prognostic significance of interferon regulating factor 4 (IRF4) in node-negative breast cancer
    J. Cancer Res. Clin. Oncol. 143: 1123-1131 (2017)
    I am interested in this work
  • Bucur, P. O.; Bekheit, M.; Audebert, C.; Othman, A.; Hammad, S.; Sebagh, M.; Hengstler, J. G.; Vibert, E.: Modulating portal hemodynamics with vascular ring allows efficient regeneration after partial hepatectomy in a porcine model
    Ann. Surg. XX: epub ahead of print (2017)
  • Ehnert, S.; Sreekumar, V.; Aspera-Werz, R. H.; Sajadian, S. O.; Wintermeyer, E.; Hengstler, J. G.; Godoy, P.; Nussler, A. K.: TGF-ß1 impairs mechanosensation of human osteoblasts via HDAC6-mediated shortening and distortion of primary cilia
    J. Mol. Med. 95: 653-663 (2017)
    I am interested in this work
  • Grinberg, M.; Djureinovic, D.; Brunnström, H. R.; Mattsson, J. S.; Edlund, K.; Hengstler, J. G.; la Fleur, L.; Micke, P.: Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters
    Mod. Pathol. 30: 964-977 (2017)
    I am interested in this work
  • Hoehme, S.; Friebel, A.; Hammad, S.; Drasdo, D.; Hengstler, J. G.: Creation of three-dimensional liver tissue models from experimental images for systems medicine
    Methods Mol. Biol. 1506: 319-362 (2017)
    I am interested in this work
  • Reif, R.; Ghallab, A.; Beattie, L.; Günther, G.; Kuepfer, L.; Kaye, P. M.; Hengstler, J. G.: In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
    Arch. Toxicol. 91: 1335-1352 (2017)
    I am interested in this work
  • Golka, K.; Ickstadt, K.; Selinski, S.; Hengstler, J. G.; Wilhelm, M.: Third symposium on Environmental Toxicology in North Rhine-Westphalia, Germany: Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine: Meeting report on a symposium held in Dortmund May 7-8, 2015
    Arch. Toxicol. 91: 3711-3715 (2017)
    I am interested in this work
  • Heimes, A.-S.; Madjar, K.; Edlund, K.; Battista, M. J.; Almstedt, K.; Rahnenführer, J.; Hengstler, J. G.; Schmidt, M.: Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer
    Breast Cancer Res. Treat. 165: 293-300 (2017)
    I am interested in this work
  • Jabs, V.; Edlund, K.; König, H.; Grinberg, M.; Madjar, K.; Rahnenführer, J.; Hengstler, J. G.; Micke, P.: Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.
    PLoS ONE 12: (11): e0187246 (2017)
    I am interested in this work
  • Hammad, S.; Braeuning, A.; Meyer, C.; Mohamed, F. E. Z. A.; Hengstler, J. G.; Dooley, S.: A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein
    Arch. Toxicol. 91: 3689-3692 (2017)
    I am interested in this work
  • Vinken, M.; Knapen, D.; Vergauwen, L.; Hengstler, J. G.; Angrish, M.; Whelan, M.: Adverse outcome pathways: a concise introduction for toxicologists
    Arch. Toxicol. 91: 3697-3707 (2017)
    I am interested in this work