Univ.-Prof. Dr. med. Jan G. Hengstler

Hengstler_web Head of Department

Toxicology / Systems Toxicology

Phone: +49 / 231 1084 348
Email:

Curriculum Vitae:

  • March 2007 - present: Head of the research group "Systemtoxicology", Leibniz Research Centre for Working Environment and Human Factors, Dortmund
  • March 2006 – Feb 2007: Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, University of Leipzig
  • April 2003 - Feb 2007: Professor of Molecular Pharmacology and Toxicology, University of Leipzig
  • November 1990 - March 2002: Research scientist at the Institute of Toxicology, University of Mainz (Director of Institute: Prof. Dr. Franz Oesch)
  • November 11, 1998: “Habilitation“ (German university lecturing qualification) in Pharmacology and Toxicology
  • June 04, 1997: Physician specialized in Pharmacology and Toxicology (Ph.D. equivalent according to World Education Services, New York, NY)
  • August 05, 1992: License to practice medicine
  • December 19, 1991: Thesis (MD): DNA damage in patients treated with alkylating agents
  • October 1984 – October 1990: Study of Medicine, University of Mainz, Germany
  • Awards and honours:
  • March 2002: Aventis Poster Award
  • July 2001: Rudolf-Buchheim-Award (awarded by the German Society for Pharmacology and Toxicology – DGPT)
  • November 1999: Innovation Award (awarded by the State of Rhineland-Palatinae)

Research topics:

  • toxicogenomics
  • oncogenes and carcinogenesis
  • liver and hepatocytes
Publications in Pubmed

Publications:

  • Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma
    Cancer Res. 77: 4589-4601 (2017)
    http://dx.doi.org/10.1158/0008-5472.CAN-16-2065
    I am interested in this work
  • Kuhn, C.; Lehmann, M.-L.; Kress, A.; Truß, M. C.; Hermes, M.; Blaszkewicz, M.; Hengstler, J. G.; Golka, K.: Micro-brushing-based technique to gain fresh urothelial cells for gene expression analysis
    J. Toxicol. Environ. Health 80A: 411-416 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304723
  • Lukas, C.; Selinski, S.; Prager, H.-M.; Blaszkewicz, M.; Hengstler, J. G.; Golka, K.: Occupational bladder cancer: polymorphisms of xenobiotic metabolizing enzymes, exposures, and prognosis
    J. Toxicol. Environ. Health 80A: 439-452 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304731
  • Krech, E.; Selinski, S.; Blaszkewicz, M.; Bürger, H.; Kadhum, T.; Hengstler, J. G.; Truß, M. C.; Golka, K.: Urinary bladder cancer risk factors in an area of former coal, iron, and steel industries in Germany
    J. Toxicol. Environ. Health 80A: 430-438 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304719
  • Ebbinghaus, D.; Banfi, G.; Selinski, S.; Blaszkewicz, M.; Bürger, H.; Hengstler, J. G.; Nyirady, P.; Golka, K.: Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary
    J. Toxicol. Environ. Health 80A: 423-429 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304736
  • Höhne, S.; Gerullis, H.; Blaszkewicz, M.; Selinski, S.; Hengstler, J. G.; Otto, T.; Golka, K.: N-acetyltransferase 1*10 genotype in bladder cancer patients
    J. Toxicol. Environ. Health 80A: 417-422 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304727
  • Isermann, J.; Prager, H.-M.; Ebbinghaus, R.; Janasik, B.; Widera, A.; Selinski, S.; Hengstler, J. G.; Golka, K.: Urinary cadmium levels in active and retired coal miners
    J. Toxicol. Environ. Health 80A: 405-410 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304710
  • Golka, K.; Ickstadt, K.; Selinski, S.; Hengstler, J. G.; Wilhelm, M.: Third Symposium on Interdisciplinary Activities in Environmental Toxicology in North Rhine-Westphalia, Germany
    J. Toxicol. Environ. Health 80A: 395 (2017)
    I am interested in this work
    http://dx.doi.org/10.1080/10937404.2017.1304744
  • Heimes, A.-S.; Madjar, K.; Edlund, K.; Battista, M. J.; Almstedt, K.; Rahnenführer, J.; Hengstler, J. G.; Schmidt, M.: Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer
    Breast Cancer Res. Treat. 165: 293-300 (2017)
    http://dx.doi.org/10.1007/s10549-017-4327-0
    I am interested in this work
  • Colaianna, M.; Ilmjärv, S.; Peterson, H.; Kern, I.; Julien, S.; Hengstler, J. G.; Leist, M.; Krause, K. H.: Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
    Arch. Toxicol. 91: 365-391 (2017)
    http://dx.doi.org/10.1007/s00204-016-1690-2
    I am interested in this work
  • Golka, K.; Ovsiannikov, D.; Blaszkewicz, M.; Moormann, O.; Haenel, M. W.; Hengstler, J. G.; Selinski, S.: Urinary bladder cancer in a former area of underground hard coal mining
    In: Progress in medical geology (S. 214-228) / ed. by Motomu Ibaraki and Hiroko Mori. Newcastle upon Tyne: Cambridge Scholars Publ., 2017.
    I am interested in this work
  • Waldmann, T.; Grinberg, M.; König, A.; Rempel, E.; Schildknecht, S.; Henry, M.; Hengstler, J. G.; Leist, M.: Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity
    Chem. Res. Toxicol. 30: 905-922 (2017)
    http://dx.doi.org/10.1021/acs.chemrestox.6b00259
    I am interested in this work
  • Hengstler, J. G.: Leber
    In: Das Toxikologiebuch: Grundlagen, Verfahren, Bewertung (S. 251-274) / herausgegeben von Helmut Greim. Weinheim: Wiley-VCH Verlag, 2017.
    I am interested in this work
  • Hengstler, J. G.; van Thriel, C.: Gesundheitsrisiken durch Aluminium
    Pädiatr. Praxis 87: 719-725 (2017)
    I am interested in this work
  • Shinde, V.; Hoelting, L.; Srinivasan, S. P.; Liebing, J.; Stöber, R.; Godoy, P.; van Thriel, C.; Hengstler, J. G.: Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests
    Arch. Toxicol. 91: 839-864 (2017)
    I am interested in this work
    http://dx.doi.org/10.1007/s00204-016-1741-8
  • Heimes, A.-S.; Madjar, K.; Edlund, K.; Battista, M. J.; Almstedt, K.; Gebhard, S.; Hengstler, J. G.; Schmidt, M.: Prognostic significance of interferon regulating factor 4 (IRF4) in node-negative breast cancer
    J. Cancer Res. Clin. Oncol. 143: 1123-1131 (2017)
    http://dx.doi.org/10.1007/s00432-017-2377-7
    I am interested in this work
  • Bucur, P. O.; Bekheit, M.; Audebert, C.; Othman, A.; Hammad, S.; Sebagh, M.; Hengstler, J. G.; Vibert, E.: Modulating portal hemodynamics with vascular ring allows efficient regeneration after partial hepatectomy in a porcine model
    Ann. Surg. XX: epub ahead of print (2017)
    http://dx.doi.org/10.1097/SLA.0000000000002146
  • Ehnert, S.; Sreekumar, V.; Aspera-Werz, R. H.; Sajadian, S. O.; Wintermeyer, E.; Hengstler, J. G.; Godoy, P.; Nussler, A. K.: TGF-ß1 impairs mechanosensation of human osteoblasts via HDAC6-mediated shortening and distortion of primary cilia
    J. Mol. Med. 95: 653-663 (2017)
    I am interested in this work
    http://dx.doi.org/10.1007/s00109-017-1526-4
  • Grinberg, M.; Djureinovic, D.; Brunnström, H. R.; Mattsson, J. S.; Edlund, K.; Hengstler, J. G.; la Fleur, L.; Micke, P.: Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters
    Mod. Pathol. 30: 964-977 (2017)
    I am interested in this work
    http://dx.doi.org/10.1038/modpathol.2017.14
  • Hoehme, S.; Friebel, A.; Hammad, S.; Drasdo, D.; Hengstler, J. G.: Creation of three-dimensional liver tissue models from experimental images for systems medicine
    Methods Mol. Biol. 1506: 319-362 (2017)
    I am interested in this work
    http://dx.doi.org/10.1007/978-1-4939-6506-9_22