Univ.-Prof. Dr. med. Jan G. Hengstler

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Werdegang

• November 11, 1998: Habilitation, venia legendi für Pharmakologie und Toxikologie
• June 04, 1997: Facharzt für Pharmakologie und Toxikologie
• August 05, 1992: Approbation als Arzt
• December 19, 1991: Promotion zum Dr. med.
• October 1984 – October 1990: Studium Humanmedizin, Universität Mainz

Aktuelle Position

• ab März 2007: Projektgruppe Systemtoxikologie (ehemals Gefahrstoffbelastungen und individuelle Suszeptibilität) am Leibniz-Institut für Arbeitsphysiologie

Frühere Stellen

• March 2006 - Feb 2007: Kommissarischer Leiter des Instituts für Rechtsmedizin und der Forensischen Toxikologie, Universität Leipzig
• April 2003 - Feb 2007: Professor für Molekulare Toxikologie, Universität Leipzig
• November 1990 - March 2002: Forschung am Institut für Toxikologie, Universität Mainz (Direktor: Prof. Dr. Franz Oesch)

Arbeitsgebiete

• Toxicogenomics
• Onkogene und Karzinogenese
• Leber und Hepatozyten

Aktuelle Forschung

• Leiter der Projektgruppe "Systemtoxikologie" (ehemals "Gefahrstoffbelastungen und Suszeptibilität") (seit 01.03.2007)

Lehre

• Toxikologie für Chemiker
• Postgradualausbildung für Fachtoxikologen

Ausgewählte Publikationen

Publications 2007 - 1990

2007, 2006, 2005, 2004, 2003, 2002, 2001, 2000, 1999, 1998, 1997, 1996, 1995, 1994-1990

2007

Original papers

Carmo H, Brulport M, Hermes M, Oesch F, de Boer D, Remiao F, Carvalho F, Schon MR, Krebsfaenger N, Doehmer J, Bastos Mde L, Hengstler JG. CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA). Toxicology. 2007 Jan 18;229(3):236-44. Epub 2006 Dec 5.

Aurich I, Mueller LP, Aurich H, Luetzkendorf J, Tisljar K, Dollinger M, Schormann W, Walldorf J, Hengstler J, Fleig WE, Christ B. Functional integration of human mesenchymal stem cell-derived hepatocytes into mouse livers. Gut. 2007;56(3):405-415.

Hohme S, Hengstler JG, Brulport M, Schafer M, Bauer A, Gebhardt R, Drasdo D. Mathematical modelling of liver regeneration after intoxication with CCl(4). Chem Biol Interact. 2007 Feb 2; [Epub ahead of print]

Ullrich A, Berg C, Hengstler JG, Runge D. Use of a standardised and validated long-term human hepatocyte culture system for repetitive analyses of drugs: Repeated administrations of acetaminophen reduces albumin and urea secretion. ALTEX. 2007;24(1):35-40.

Saussele T, Burk O, Blievernicht JK, Klein K, Nussler A, Nussler N, Hengstler JG, Eichelbaum M, Schwab M, Zanger UM. Selective Induction of Human Hepatic Cytochromes P450 2B6 and 3A4 by Metamizole. Clin Pharmacol Ther. 2007 Mar 7; [Epub ahead of print]

Schmidt M, Bremer E, Hasenclever D, Victor A, Gehrmann M, Steiner E, Schiffer IB, Gebhardt S, Lehr HA, Mahlke M, Hermes M, Mustea A, Tanner B, Koelbl H, Pilch H, Hengstler JG. Role of the progesterone receptor for paclitaxel resistance in primary breast cancer. Br J Cancer. 2007 Jan 29;96(2):241-7.

Reviews

Hewitt NJ, Lechon MJ, Houston JB, Hallifax D, Brown HS, Maurel P, Kenna JG, Gustavsson L, Lohmann C, Skonberg C, Guillouzo A, Tuschl G, Li AP, LeCluyse E, Groothuis GM, Hengstler JG. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev. 2007;39(1):159-234.

2006

Original papers

Weber M, Modemann S, Schipper P, Trauer H, Franke H, Illes P, Geiger KD, Hengstler JG, Kleemann WJ. Increased polysialic acid neural cell adhesion molecule expression in human hippocampus of heroin addicts. Neuroscience. 2006;138(4):1215-23.

Bauer M, Herbarth O, Aust G, Hengstler JG, Dotzauer A, Graebsch C, Schmuecking E. Expression patterns and novel splicing variants of glutathione-S-transferase isoenzymes of human lung and hepatocyte cell lines. Cell Tissue Res. 2006;324(3):423-32.

Kafert-Kasting S, Alexandrova K, Barthold M, Laube B, Friedrich G, Arseniev L, Hengstler JG. Enzyme induction in cryopreserved human hepatocyte cultures. Toxicology 220:117-25, 2006.

Meinl W, Pabel U, Osterloh-Quiroz M, Hengstler JG, Glatt H. Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue. Int J Cancer 118:1090-7, 2006.

Spangenberg C, Lausch EU, Trost TM, Prawitt D, May A, Keppler R, Fees SA, Reutzel D, Bell C, Schmitt S, Schiffer IB, Weber A, Brenner W, Hermes M, Sahin U, Tureci O, Koelbl H, Hengstler JG, Zabel BU. ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions. Cancer Res. 2006;66(7):3715-25.

Schupp T, Bolt HM, Jaeckh R, Hengstler JG. Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobiles. Toxicol Lett. 160:93-104, 2006.

Eberhardt M, Salmon P, von Mach MA, Hengstler JG, Brulport M, Linscheid P, Seboek D, Oberholzer J, Barbero A, Martin I, Muller B, Trono D, Zulewski H. Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets. Biochem Biophys Res Commun. 2006 Jul 7;345(3):1167-76.

Tanner B, Hasenclever D, Stern K, Schormann W, Bezler M, Hermes M, Brulport M, Bauer A, Schiffer IB, Gebhard S, Schmidt M, Steiner E, Sehouli J, Edelmann J, Lauter J, Lessig R, Krishnamurthi K, Ullrich A, Hengstler JG. ErbB-3 predicts survival in ovarian cancer. J Clin Oncol. 2006 Sep 10;24(26):4317-23.

Hausherr CK, Schiffer IB, Gebhard S, Banic A, Tanner B, Kolbl H, Thoenes E, Beckers T, Spangenberg C, Prawitt D, Trost T, Zabel B, Oesch F, Hermes M, Hengstler JG. Dephosphorylation of p-ERK1/2 in relation to tumor remission after HER-2 and Raf1 blocking therapy in a conditional mouse tumor model. Mol Carcinog. 2006;45(5):302-8.

Dorn DC, Alexenizer M, Hengstler JG, Dorn A. Tumor cell specific toxicity of Inula helenium. extracts. Phytother Res. Phytother Res. 2006 Nov;20(11):970-80.

Carmo H, Brulport M, Hermes M, Oesch F, Silva R, Ferreira LM, Branco PS, Boer DD, Remiao F, Carvalho F, Schon MR, Krebsfaenger N, Doehmer J, Bastos MD, Hengstler JG. Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity. Pharmacogenet Genomics. 2006 Nov;16(11):789-799.

Klingmuller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Gotschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Zeilinger K, Heinrich M, Zanger UM, Gebhardt R, Maiwald T, Heinrich R, Timmer J, von Weizsacker F, Hengstler JG. Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Syst Biol (Stevenage). 2006 Nov;153(6):433-47.

Reviews

Hengstler JG, Foth H, Kahl R, Kramer PJ, Lilienblum W, Schulz T, Schweinfurth H., The REACH concept and its impact on toxicological sciences. Toxicology. 2006 Mar 15;220(2-3):232-9.

Nussler A, Konig S, Ott M, Sokal E, Christ B, Thasler W, Brulport M, Gabelein G, Schormann W, Schulze M, Ellis E, Kraemer M, Nocken F, Fleig W, Manns M, Strom SC, Hengstler JG., Present status and perspectives of cell-based therapies for liver diseases. J Hepatol. 2006 Jul;45(1):144-59.

Hengstler JG, Bockamp EO, Hermes M, Brulport M, Bauer A, Schormann W, Schiffer IB, Hausherr C, Eshkind L, Antunes C, Franzen A, Krishnamurthi K, Lausch E, Lessig R, Chakrabarti T, Prawitt D, Zabel B, Spangenberg C. Oncogene-blocking therapies: new insights from conditional mouse tumor models. Curr Cancer Drug Targets. 2006 Nov;6(7):603-12.

Marc Brulport, Alexander Bauer, Jan G. Hengstler, Blei, P. 757-780, Handbuch der Lebensmitteltoxikologie, Dunkelberg H , Gebel T, Hartwig A (Hrsg.), ISBN-10 3-527-31166-1, Wiley-VCH, 2006.

2005

Original papers

Ringel M, von Mach MA, Santos R, Feilen PJ, Brulport M, Hermes M, Bauer AW, Schormann W, Tanner B, Schon MR, Oesch F, Hengstler JG. Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction. Toxicology, 206:153-67, 2005.

Carmo H, Hengstler JG, Boer D, Ringel M, Remiao F, Carvalho F, Fernandes E, Reys LA, Oesch F, Bastos Mde L. Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human. Toxicology, 206:75-89, 2005.

Schupp T, Bolt HM, Hengstler JG. Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars. Toxicology, 206:461-70, 2005.

Trost TM, Lausch EU, Fees SA, Schmitt S, Enklaar T, Reutzel D, Brixel LR, Schmidtke P, Maringer M, Schiffer IB, Heimerdinger CK, Hengstler JG, Fritz G, Bockamp EO, Prawitt D, Zabel BU, Spangenberg C. Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res. 65:840-9, 2005.

Ruhnke M, Ungefroren H, Nussler A, Martin F, Brulport M, Schormann W, Hengstler JG, Klapper W, Ulrichs K, Hutchinson JA, Soria B, Parwaresch RM, Heeckt P, Kremer B, Fändrich F, Reprogramming of Human Peripheral Blood Monocytes into Functional Hepatocyte and Pancreatic Islet-like Cells. Gastroenterology, 128:1774-86, 2005.

Weil T, Abdalla MA, Jatzke C, Hengstler J, Mullen K. Water-soluble rylene dyes as high-performance colorants for the staining of cells. Biomacromolecules. 2005; 6:68-79.

von Mach MA, Hermanns-Clausen M, Koch I, Hengstler JG, Lauterbach M, Kaes J, Weilemann LS. Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases. Clin Toxicol 43:31-7, 2005.

Ruhnke M, Nussler AK, Ungefroren H, Hengstler JG, Kremer B, Hoeckh W, Gottwald T, Heeckt P, Fandrich F. Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy. Transplantation. 79:1097-103, 2005.

Mohrmann G, Hengstler JG, Hofmann TG, Endele SU, Lee B, Stelzer C, Zabel B, Brieger J, Hasenclever D, Tanner B, Sagemueller J, Sehouli J, Will H, Winterpacht A. SPOC1, a novel PHD-finger protein: Association with residual disease and survival in ovarian cancer. Int J Cancer, 116:547-54, 2005.

Spannbauer MM, Oleszczuk A, Tannapfel A, Bluher M, Pietsch UC, Hengstler J, Donaubauer B, Madaj-Sterba P, Furll M, Schuhmacher A, Thiery J, Hauss JP, Schon MR. Micro- and macrovesicular steatotic liver model for transplantation induced by ethanol and protein-deficient diet. Transplant Proc. 37:210-211, 2005.

Guzman SJ, Gerevich Z, Hengstler JG, Illes P, Kleemann W. P2Y(1) receptors inhibit both strength and plasticity of glutamatergic synaptic neurotransmission in the rat prefrontal cortex. Synapse 57:235-238, 2005.

Review

Hengstler JG, Brulport M, Schormann W, Bauer A, Hermes M, Nussler AK, Fandrich F, Ruhnke M, Ungefroren H, Griffin L, Bockamp E, Oesch F, von Mach M.-A., Generation of human hepatocytes by stem cell technology: definition of the hepatocyte. Expert Opin. Drug Metab. Toxicol. 1:61-74, 2005.

2004

Original papers

102. Reder-Hilz B, Ullrich M, Ringel M, Hewitt N, Utesch D, Oesch F, Hengstler JG, Metabolism of propafenone and verapamil by cryopreserved human, rat mouse and dog hepatocytes: comparison with metabolism in vivo. Naunyn Schmiedebergs Arch Pharmacol 369, 408-17, 2004

103. Herrmann F, Lehr HA, Drexler I, Sutter G, Hengstler JG, Wollscheid U, Seliger B, HER-2/neu-Mediated Regulation of Components of the MHC Class I Antigen-Processing Pathway. Cancer Res. 64: 215-20, 2004.

104. Tanner B, Grimme S, Schiffer I, Heimerdinger C, Schmidt M, Dutkowski P, Neubert S, Oesch F, Franzen A, Kolbl H, Fritz G, Kaina B, Hengstler JG, Nuclear expression of apurinic/apyrimidinic endonuklease increases with progression of ovarian carcinomas. Gynecol Oncol 92, 568-77, 2004.

105. Carmo H, Hengstler JG, de Boer D, Ringel M, Carvalho F, Fernandes E, Remiao F, dos Reys LA, Oesch F, de Lourdes Bastos M, Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse. Naunyn Schmiedebergs Arch Pharmacol 369, 198-205, 2004.

106. von Mach MA, Hengstler JG, Brulport M, Eberhardt M, Schormann W, Hermes M, Prawitt D, Zabel B, Grosche J, Reichenbach A, Muller B, Weilemann LS, Zulewski H. In vitro cultured islet-derived progenitor cells of human origin express human albumin in severe combined immunodeficiency mouse liver in vivo. Stem Cells 22, 1134-41, 2004.

107. Eger K, Hermes M, Uhlemann K, Rodewald S, Ortwein J, Brulport M, Bauer A, Schormann W, Lupatsch F, Schiffer I, Heimerdinger C, Gebhard S, Spangenberg C, Pravitt D, Trost T, Zabel B, Tanner B, Krugel U, Franke H, Illes P, Madaj-Sterba P, Bockamp EO, Beckers T, Hengstler J.G. 4-Epidoxycycline: an alternative to doxycycline to control gene expression in conditional mouse models. Biochem Biophys Res Commun 323, 979-986, 2004.

108. Micke P, Hengstler JG, Albrecht H, Faldum A, Bittinger F, Becker K, Wiewrodt R, Fischer B, Buhl R. c-kit expression in adenocarcinomas of the lung. Tumour Biol. 25:235-42, 2004.

109. Brenner W, Benzing F, Gudejko-Thiel J, Fischer R, Farber G, Hengstler JG, Seliger B, Thuroff JW. Regulation of beta1 integrin expression by PKCepsilon in renal cancer cells. Int J Oncol. 25:1157-63, 2004.

Reviews

113. Oesch F und Hengstler, JG, Bedeutung des Metabolismus für die Risikoabschätzung. In: Regulatorische Toxikologie, Springer-Verlag, Eds.: Reichel, Schwenk, Heidelberg, S. 359-372, 2004.

114. Streffer C, Bolt H, Follesdahl D, Hall P, Hengstler JG, Jakob P, Oughton D, Prieß K, Rehbinder E, Swaton E, Low dose exposures in the environment. Springer-Verlag, editor: C. Streffer, 470 pages, ISBN 3-540-21083-0, Heidelberg, 2004.

115. Bolt HM, Foth H, Hengstler JG, Degen G, Carcinogenicity categorization of chemicals – new aspects to be considered in a European perspective. Toxicology Letters 151, 29-41, 2004.

116. Kaina B und Hengstler, JG, Haben Karzinogene eine Schwellendosis? Pro und Contra. In: Regulatorische Toxikologie, Springer-Verlag, Eds.: Reichel, Schwenk, Heidelberg, S. 254-261, 2004.

117. Oesch F, Hengstler JG. and Arand M. Detoxification strategy of epoxide hydrolase – the basis for a novel threshold for definable genotoxic carcinogens. Nonlinearity in Biology, Toxicology and Medicine, 2: 21-26, 2004.

2003

Original papers

82. Micke P, Basrai M, Faldum A, Bittinger F, Ronnstrand L, Blaukat A, Beeh KM, Oesch F, Fischer B, Buhl R, Hengstler JG. Characterization of c-kit Expression in Small Cell Lung Cancer: Prognostic and Therapeutic Implications. Clin Cancer Res 9, 188-94, 2003.

83. Hengstler JG, Bolm-Audorff U, Faldum A, Janssen K, Reifenrath M, Gotte W, Jung D, Mayer-Popken O, Fuchs J, Gebhard S, Bienfait Schlink K, Dietrich C, Faust D, Epe B, Oesch F. Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition HG, prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected. Carcinogenesis 24, 63-73, 2003.

84. Hengstler JG, Re: DNA damage induction and repair inhibition. Carcinogenesis 24, 1855-1857, 2003.

85. Arand M, Herrero Plana ME, Hengstler JG, Lohmann M, Cronin A, Oesch F. Detoxification strategy of epoxide hydrolase the basis for a threshold in chemical carcinogenesis. EXCLI J 22, 22-30, 2003.

86. Schiffer IB, Gebhard S, Heimerdinger CK, Heling A, Hast J, Wollscheid U, Seliger B, Tanner B, Gilbert S, Beckers T, Baasner S, Brenner W, Spangenberg C, Prawitt D, Trost T, Schreiber WG, Zabel B, Thelen M, Lehr HA, Oesch F, Hengstler JG. Switching off her-2/neu in a tetracycline-controlled mouse tumor model leads to apoptosis and tumor-size-dependent remission. Cancer Res. 63, 7221-31, 2003.

87. Jung D, Bolm-Audorff U, Faldum A, Hengstler JG, Attia DI, Janssen K, Reifenrath M, Bienfait HG, Mayer-Popken O, Konietzko J. Immunotoxicity of co-exposures to heavy metals: In vitro studies and results from occupational exposure to cadmium, cobalt and lead. EXCLI J 2, 31-44, 2003.

88. Steiner E, Eicher O, Sagemuller J, Schmidt M, Pilch H, Tanner B, Hengstler JG, Hofmann M, Knapstein PG. Multivariate independent prognostic factors in endometrial carcinoma: A clinicopathologic study in 181 patients: 10 years experience at the Department of Obstetrics and Gynecology of the Mainz University. Int J Gynecol Cancer 13, 197-203, 2003.

89. von Mach MA, Schlosser J, Weiland M, Feilen PJ, Ringel M, Hengstler JG, Weilemann LS, Beyer J, Kann P, Schneider St. Cryopreservation of islets of Langerhans: Optimization of protocols. EXCLI J 2, 6-21, 2003.

90. Efferth T, Sauerbrey A, Olbrich A, Gebhart E, Rauch P, Weber HO, Hengstler JG, Halatsch ME, Volm M, Tew KD, Ross DD, Funk JO, Molecular modes of action of artesunate in tumor cell lines, Mol Pharmacol. 64, 382-94, 2003.

91. Schiffer IB, Schreiber WG, Graf R, Schreiber EM, Jung D, Rose DM, Hehn M, Gebhard S, Sagemuller J, Spiess HW, Oesch F, Thelen M, Hengstler JG. No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI. Bioelectromagnetics 24, 241.50, 2003.

92. Tanner B, Beerheide W, Jensen O, von Mach MA, Ringel M, Fleckenstein C, Schumann S, Renzing N, Hildebrand A, Neubert S, Glawatz C, Hengstler JG. Isolation and transplantation of human mesenchymal stem cells from cord blood. Geburtsh. Frauenheilk. 63, 1040-1046, 2003.

93. Spangenberg C, Trost T, Lausch E, Fees S, Prawitt D, Hengstler JG, Sahin U, Tureci O, Zabel B, Molecular analyses examining the consequences of reversible ERBB2-expression in breast carcinoma cells. American Journal of Human Genetics 73 (5), 500, 2003.

94. Brenner W, Farber G, Herget T, Wiesner C, Hengstler JG, Thuroff JW. Protein kinase C eta is associated with progression of renal cell carcinoma (RCC). Anticancer Res. 23, 4001-6, 2003.

95. von Mach MA, Schlosser J, Weiland M, Feilen PJ, Ringel M, Hengstler JG, Weilemann LS, Beyer J, Kann P, Schneider S., Size of pancreatic islets of Langerhans: a key parameter for viability after cryopreservation. Acta Diabetol. 40, 123-9, 2003.

96. Brenner W, Wiesner C, Färber G, Herget T, Hengstler JG, Thüroff JW. Gender specific expression of tumor suppressor PKCd versus oncogenic PKCh in renal cell carcinoma. EXCLI J 2003;2:45-51.

Reviews

97. Hengstler JG, Bogdanffy MS, Bolt HM and Oesch F, Challenging Dogma: Thresholds for Genotoxic Carcinogens? The case of Vinyl Acetate, Annu Rev Pharmacol Toxicol, 43, 485-520, 2003.

98. Von Mach MA, Lauterbach M, Kaes J, Hengstler JG, Weilemann LS. Deliberate self-poisoning with paracetamol (acetaminophen), Dtsch Med Wochenschr 128, 15-9, 2003.

99. Gebhardt R, Hengstler JG, Müller D, Glöckner R, Buenning P, Laube B, Schmelzer E, Martina Ullrich, Utesch D, Hewitt N, Ringel M, Reder Hilz B, Bader A, Langsch A, Koose T, Burger HJ, Maas J, Oesch F, New hepatocyte in vitro systems for drug metabolism: Metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures, Drug Metabolism Reviews, 35, 145-213, 2003.

100. Hengstler JG, Heimerdinger C, Schiffer IB, Brulport M, Toxikologie und Kanzerogenität: Gibt es einen Schwellenmechanismus? Forum DKG 6, 26-30, 2003.

1012. Graefe A, Müller RK, Hengstler JG, 15 Jahre Postgradualstudium Toxikologie und Umweltschutz der Universität Leipzig von 1988 bis 2003. Eigenverlag, S. 1-497, 2003.

2002

Original papers

69. Ringel M, Oesch F, Bader A, Gerl M, Klebach M, Quint M, Tanner B, Dillenburg W, Böttger T, Hengstler JG, Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte cultures, Xenobiotica 32, 653-666, 2002.

70. Hast J, Schiffer IB, Neugebauer B, Teichman E, Schreiber W, Brieger J, Kim DW, Gebhard S, Born CJ, Strugala M, Sagemuller J, Brenner W, Mann WJ, Oesch F, Thelen M, Hengstler JG. Angiogenesis and fibroblast proliferation precede formation of recurrent tumors after radiation therapy in nude mice. Anticancer Res 22, 677-88, 2002.

71. Brenner W, Färber G, Herget T, Lehr H-A, Hengstler JG, Thüroff JW: Loss of the tumor suppressor protein PTEN during renal carcinogenesis. Int J Cancer 99, 53-57, 2002

72. Beerheide W, von Mach MA, Ringel M, Fleckenstein C, Schumann S, Renzing N, Hildebrandt A, Brenner W, Jensen O, Gebhard S, Reifenberg K, Bender J, Oesch F, Hengstler JG Downregulation of beta2-microglobulin in human cord blood somatic stem cells after transplantation into livers of SCID-mice: an escape mechanism of stem cells? Biochemical Biophysical Research Communications 294, 1052-1063, 2002.

73. Osterod M, Larsen E, Le Page F, Hengstler JG, Van Der Horst GT, Boiteux S, Klungland A, Epe B. A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage. Oncogene 28, 8232-8239, 2002.

74. Micke P, Faldum A, Metz T, Beeh KM, Bittinger F, Hengstler JG, Buhl R. Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer--what limits limited disease? Lung Cancer 37, 271-276, 2002.

75. Vlachtsis K, Brieger J, Kim DW, Gieringer R, Hast J, Hengstler JG, Mann W. Quantitative analysis of VEGF-isoforms in head and neck squamous cell carcinoma cell lines: relation to xenotransplantability and tumour progression in mice. Oncol Rep 9, 1133-1138, 2002.

76. Tanner B, Pilch H, Schaffer U, Franzen A, Seufert R, Hengstler JG. Expression of c-erbB-2 and topoisomerase II alpha in relation to chemoresistance in ovarian cancer. Zentralbl Gynakol 124, 176-83, 2002.

77. Blaum K, Geppert C, Schreiber WG, Hengstler JG, Muller P, Nortershauser W, Wendt K, Bushaw BA., Trace determination of gadolinium in biomedical samples by diode laser-based multi-step resonance ionization mass spectrometry. Anal Bioanal Chem 372, 759-65, 2002.

78. Tanner B, Pilch H, Bahlmann F, Kaina B, Hengstler JG. Activity of the DNA-repair enzyme O-6-methylguanine-DNA methytransferase in ovarian cancer. Geburtsh. Frauenheilk. 62, 560-565, 2002.

Reviews

79. Brenner W, Färber G, Pahernik S, Lehr HA, Herget T, Hengstler JG, Thüroff JW, Role of the tumorsuppressor PTEN in renal cell carcinomas, Act. Urol., in press, 2002.

80. Tanner B, Pilch H, Schmidt M, Hengstler JG, Expression of metallothionein and glutathione in ovarian carcinomas, German Journal of Obstetrics and Gynecology 62, 145-154, 2002.

81. Hengstler JG, Heimerdinger CK, Schiffer IB, Gebhard S, Sagemüller J, Tanner B, Bolt HM, Oesch F. Dietary topoisomerase II-poisons: contribution of soy products to infant leukemia? EXCLI J 1, 8-14, 2002.

2001

Original papers

60. Hengstler JG, Pilch H, Schmidt M, Dahlenburg H, Sagemüller J, Schiffer I, Oesch F, Knapstein PG, Kaina B and B Tanner, Metallothionein expression in ovarian cancer in relation to histopathologic parameters and molecular markers of prognosis, Int. J. Cancer, 95, 121-127, 2001.

61. Micke P, Hengstler JG, Ros R, Bittinger F, Metz T, Gebhard S, Beeh KM, Oesch F, Buhl R, C-erbB-2 expression in small cell lung cancer is associated with poor prognosis, Int. J. Cancer 92, 474-479, 2001.

62. Schreiber WG, Teichmann EM, Schiffer I, Hast J, Akbari W, Georgi H, Graf R, Hehn M, Spiebeta HW, Thelen M, Oesch F, Hengstler JG. Lack of mutagenic and co-mutagenic effects of magnetic fields during magnetic resonance imaging. J Magn Reson Imaging. 14, 779-88, 2001.

63. Oesch-Bartlomowicz B, Richter B, Becker R, Vogel S, Padma PR, Hengstler JG, Oesch F, cAMP-dependent phosphorylation of CYP2B1 as a functional switch for cyclophosphamide activation and its hormonal control in vitro and in vivo, Int. J. Cancer 94, 733-742, 2001.

64. Bottger T, Kirsch D, Hengstler JG, Bauer A, Wolf HK, Junginger T, Hereditary pancreatitis - A clinically relevant cause of pancreatic adenocarcinoma? Zbl Chir 126: 897-900, 2001.

65. Romaneehsen B, Anders M, Rohrl B, Hengstler JG, ThelenM, Cryotherapy of malignant tumors. MR imaging in comparison with pathological changes in mice Rofo Fortschr. Rontg. 173: 632-638, 2001.

66. Osterod M, Stephan Hollenbach, Jan G. Hengstler, Deborah E. Barnes, Tomas Lindahl and Bernd Epe, Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (ogg1) deficient mice, Carcinogenesis, 22, 1459-1463, 2001.

Reviews

67. Hengstler JG and Oesch F, The Ames Test, Encyclopedia of Genetics, edited by Sydney Brenner and Jeffrey H. Miller, Academic Press, New York, 51-54, 2001.

68. Oesch F, Herrero ME, Lohmann M, Hengstler JG, Arand M, Sequestration of biologically reactive intermediates by trapping as covalent enzyme-intermediate complex. In: Biological Reactive Intermediates VI, ed.: R. Snyder, Kluwer Academic / Plenum Publishers, New York, pp. 577-586, 2001.

2000

Original papers

50. Hengstler JG, Bockisch A, Fuchs J, Grimm W, Görges R, Oesch-Bartlomowicz B, Zapf AO, Lade K, Tanner B, Teichmann E, Thelen M, Gebhard S, Oesch F, Induction of DNA single strand breaks by 131I and 99Tcm in human mononuclear blood cells in vitro and extrapolation to the in vivo situation, Radiation Research, 153, 512-520, 2000.

51. Hengstler JG, Ringel M, Biefang K, Hammel S, Milbert U, Gerl M, Klebach M, Diener B, Platt KL, Böttger T., Steinberg P, Oesch F, Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction, Chemico Biological Interactions, 125, 51-73, 2000.

52. Kienast K., Kaes C., Drumm K., Buhl R, Oesch F., Hengstler J.G., Asbestos-exposed blood monocytes – deoxyribonucleic acid strand lesions in co-cultured bronchial epithelial cells, Scand. J. Work Environ. Health 26, 71-77, 2000.

53. Teichmann EM, Hengstler JG, Schreiber WG, Akbari W, Georgi H, Hehn M, Schiffer I, Oesch F, Spiess HW, Thelen M, Mutagenic or co-mutagenic effect of magnetic fields in the Ames test, Rofo Fortschr. Rontg. 172, 934-939, 2000.

54. Goodman JE, Lavigne JA, Hengstler JG, Tanner B, Helzlsouer KJ, Yager JD, Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk, Cancer Epidem Biomar 9, 1373-1376, 2000.

55. Karim N, Allmeling C, Hengstler JG, Haverich A, Bader A, Diazepam metabolism and albumin secretion of porcine hepatocytes in collagen-sandwich after cryopreservation, Biotechnology Letters 22, 1647-1652, 2000.

56. Hengstler JG, Bauer A, Wolf HK, Bulitta CJ, Tanner B, Oesch F, Boettger T, mutation analysis of the cationic trypsinogen gene in patients with pancreatic cancer, Anticancer Research, 20, 2967-2974, 2000.

57. Oesch F, Herrero ME, Hengstler JG, Lohmann M, Arand M, Metabolic detoxification: Implications for thresholds, Toxicologic Pathology, 28, 382-387, 2000.

Reviews

58. Hengstler JG, Utesch D, Steinberg P, Ringel M, Swales N, Biefang K, Platt KL, Diener B, Böttger T, Fischer T, Oesch F, Cryopreserved primary hepatocytes as an in vitro model for the evaluation of drug metabolism and enzyme induction. Drug Metabolism Reviews 32, 81-118, 2000.

59. Oesch F, Arand M and Hengstler JG, Enzympolymorphismen als Ursachen erhöhter Suszeptibilität in der chemischen Karzinogenese. In:  Strahlenbiologie und Strahlenschutz, Individuelle Strahlenempfindlichkeit und Strahlenschutz, Publikationsreihe: Fortschritte im Strahlenschutz, Band II, pp. 374-393, eds.: W.U. Müller, G. Heinemann and F. Fehringer, Bad Kissingen, 2000.

1999

Original papers

37. Hengstler JG, Lange J, Kett A, Dornhöfer N, Meinert R, Arand M, Knapstein PG, Becker R, Oesch F and Tanner B, Contribution of c-erbB-2 and topoisomerase IIa to chemoresistance in ovarian cancer, Cancer Res. 59, 3206-3214, 1999.

38. Hengstler JG, Tanner B, Möller L, Vydra M, Oesch F, Meinert R, Kaina B, Activity of O6-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer, Int. J. Cancer 84, 388-395, 1999.

39. Schlink K, Janßen K, Nitzsche S, Gebhard S, Hengstler JG, Klein S, Oesch F, Activity of O6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students, Arch. Toxicol. 73, 15-21, 1999.

40. Steinberg P, Fischer T, Kiulies S, Biefang K, Platt K-L, Oesch F, Böttger Th, Bulitta C, Kempf P, Hengstler JG, Drug metabolizing capacity of cryopreserved human, rat and mouse liver parenchymal cells in suspension, Drug Metabolism and Disposition, 27, 1415-1422, 1999.

41. Strolin-Benedetti M, Brogin G, Bani M, Oesch F, Hengstler JG, Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate, Xenobiotica, 29, 1171-1180, 1999.

42. Walgenbach S, Rosniatowski R, Bittinger F, Schicketanz KH, Hafner F, Hengstler J, Junginger T, Modified cryopreservation and xenotransplantation of human parathyroid tissue, Langenbeck´s Arch. Surg. 384, 277-283, 1999.

43. Schaeffer U, Strohschneider T, Pilch H, Hengstler JG, Tanner B, Stadtmüller A, Hannekum A, Influence of several solutions used in bypass surgery on the permeability of the endothelium of carotid arteries in New Zealand rabbits, Thorac. Cardiovasc. Surg. 47, 240-243, 1999.

Reviews

44. Hengstler J.G. and Oesch F., Interspecies differences in xenobiotic metabolizing enzymes and their importance for interspecies extrapolation of toxicity. In: General and Applied Toxicology, eds.: Ballantyne B., Marrs T., and Syversen T., Volume 1, 271-290, Macmillan Reference LTD, London, 1999.

45. Hengstler JG, Walz J, Kübel R, Truong T, Fuchs J, Seidel A, Arand M, and Oesch F, Enhancement of the mutagenicity of ethylene oxide and several directly acting mutagens by human erythrocytes and its reduction by xenobiotic interaction, In: Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes, Kluwer Academic Plenum Publishers, edited by Arinc et al., New York, pp. 221-246, 1999.

46. Hengstler JG, Van der Burg B, Steinberg P, Oesch F, Interspecies Differences in Cancer Susceptibility and Toxicity, Drug Metabolism Reviews 31, 917-970, 1999.

47. Oesch F, Reifenrath M, Janßen K, Götte W, Jung D, Fuchs J, Gebhard S, Bienfait HG, Schlink K, Dietrich C, Faust D, Epe B, Bolm-Audorff U, Hengstler JG, Berufliche Exposition gegenüber Kobalt und Cadmium: DNA-Schädigung und Hemmung der DNA-Reparatur, Symposium Medical 9, 30-31, 1999.

48. Tanner B, Pilch H, Schmidt M, Steuer M, Schäffer U, Knapstein PG, Oesch F, Hengstler JG, Correlation of c-erbB-2 and topoisomerase IIa mRNA expression in ovarian cancer. S. Pecorelli, G. Atlante, P. Benedetti, S. Mancuso, eds., International Gynecologic Cancer Society, pp. 303-310, Monduzzi Editore, Bologna, 1999.

49. Li AP, Gorycki PD, Hengstler JG, Kedderis GL, Koebe HG, Rahmani R, de Sousas G, Silva JM, Skett P, Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel, Chem. Biol. Interact. 121, 117-23, 1999.

1998

Original papers

31. Hengstler J.G., Kett A., Arand M., Oesch-Bartlomowicz B., Oesch F., Pilch H., Tanner B., Glutathione S-transferase T1 and M1 gene defects in ovarian carcinoma, Cancer Letters, 130, 43-48, 1998.

32. Tanner B., Hengstler J.G., Luch A., Meinert R., Kreutz E., Arand M., Wilkens C., Hofmann M., Oesch F. Knapstein P.G., Becker R., C-myc mRNA expression in epithelial ovarian carcinomas in relation to estrogen receptor status, metastatic spread, survival time, FIGO stage, and histologic grade and type, Int. J. Gynecol. Pathol. 17, 66-74, 1998.

33. Hengstler J.G., Böttger T., Tanner B., Dietrich B., Henrich M., Knapstein P.G., Junginger Th., Oesch F., Resistance factors in colon cancer tissue and the adjacent normal colon tissue: Glutathione S-transferase a and p, glutathione, and aldehyde dehydrogenase, Cancer Letters 128, 105-112, 1998.

34. Oesch-Bartlomowicz B, Padma PR, Becker R, Richter B, Hengstler JG, Freeman JE, Wolf R, Oesch F, Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement, Experimental Cell Research 242, 294-302, 1998.
 

Reviews

35. Kienast K., Drumm K., Hengstler J.G., Smolarski R., Daum T., Grammann N., Carter J., Becker S., Devlin R.B., Koren H., Induction of superoxide dismutase (SOD) transcription and DNA strand lesions in alveolar macrophages after exposure to indoor relevant particles and fibers, In: ILSI Monographs: Relationships Between Respiratory Disease and Exposure to Air Pollution, ed.: U. Mohr, p.p. 361-365, 1998.

36. Hengstler JG, Arand M, Herrero ME, and Oesch F, Polymorphisms of N-Acetyltransferases, Glutathione S-transferases, Microsomal Epoxide Hydrolase and Sulfotransferases: Influence on Cancer Susceptibility. Recent Results Cancer Res., 154, 47-85, in: Genes and Environment, ed.: Schwab M, Springer, New York, 1998.

1997

Original papers

21. Hengstler J.G., Hengst A., Fuchs J., Tanner B., Oesch F., Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after activation by cytochrome P450 2B1, Mutation Res. 372, 215-223, 1997.

22. Hengstler J.G., Bockisch A., Fuchs J., Grimm W., Zapf A.O., Lade K., Tanner B., Oesch F., Increase in DNA-single strand break rejoining by continuous exposure of human mononuclear blood cells to radioiodine (131I) in vitro, Int. J. Radiat. Biol. 72, 607-613, 1997.

23. Hengstler J.G., Fuchs J., Tanner B., Oesch-Bartlomowicz B., Hölz C., Oesch F., Analysis of DNA single strand breaks in human venous blood: A technique which does not require isolation of white blood cells, Environmental and Molecular Mutagenesis 29, 58-62, 1997.

24. Tanner B., Hengstler J.G., Laubscher S., Meinert R., Oesch F., Knapstein P.G., Becker R., MDM2 mRNA expression is associated with survival in ovarian cancer, Int. J. Cancer 74, 1-5, 1997.

25. Fritz G., Hengstler J.G., Kaina B., High-dose selection with mafosfamide results in sensitivity to DNA cross-linking agents: characterization of hypersensitive cell lines, Cancer Res. 57, 454-460, 1997.

26. Oesch-Bartlomowicz B., Arens H.J., Richter B., Hengstler J.G., Oesch F., Control of the mutagenicity of aromatic amines by protein kinases and phosphatases: I. The protein phosphatase inhibitors okadaic acid and ortho-vanadate drastically reduce the mutagenicity of aromatic amines, Arch. Toxicol., 71, 601-611, 1997.

27. Tanner B., Hengstler J.G., Dietrich B., Henrich M., Steinberg P., Weikel W., Meinert R., Kaina R., Oesch F., Knapstein P.G., Glutathione, 65, 54 Glutathione S-transferase a and p, and aldehyde dehydrogenase content in relationship to drug resistance in ovarian cancer., Gynecol. Oncol. 62, 1997.

28. Padma P.R., Oesch-Bartlomowicz B., Hengstler J.G., Oesch F., Control of the mutagenicity of arylamines by protein kinases and phosphatases: II. Lack of response of rat liver N-acetyl transferases to phosphorylation modulators, Arch. Toxicol., 71, 655-659, 1997.

29. Herrero M.E., Arand M., Hengstler J.G., Oesch F., Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide-induced but not from ethylene oxide-induced DNA strand breaks, Environmental and Molecular Mutagenesis, 30, 429-439, 1997.

Review

30. Oesch F., Fuchs J., Arand M., Gebhard S., Hallier A., Oesch-Bartlomowicz B., Jung D., Tanner B., Bolm-Audorff U., Hiltl G., Bienfait G., Konietzko J., Hengstler J.G., Möglichkeiten und Grenzen der alkalischen Filterelution zum Biomonitoring gentoxischer Belastungen, In: Molekulare Marker bei Beruflich Verursachten Tumoren, Hrsg.: Bundesanstalt für Arbeitsschutz und Arbeitsmedizin, S. 71-101, Berlin, 1997.

1996

Original papers

14. Fuchs J., Hengstler J.G., Hummrich F., Oesch F., Transient increase in DNA strand breaks in car refinishing spray painters, Scand. J. Work Environ. Health 22, 438-443, 1996.

15. Arand M, Mühlbauer R, Hengstler JG, Jäger E, Fuchs J, Winkler L, Oesch F, A multiplex polymerase chain reaction protocol for thesimultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms, Anal. Biochem. 236, 184-186, 1996.

16. Preuss I., Eberhagen I., Haas S., Eichhorn U., Kaufmann M., Beck T., Eibl R.H., Dall P., Bauknecht T., Dippold W., Hengstler J.G., Kaina B., Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and normal tissue, Cancer Det. & Prev. 20, 130-136, 1996.

17. Fuchs J., Hengstler J.G., Boettler G., Oesch F., Primary DNA damage in peripheral mononuclear blood cells of workers exposed to bitumen-based products, Int. Arch. Occup. Environ. Health 68, 141-146, 1996.

Reviews

18. Control Mechanisms of Carcinogenesis, eds. J.G. Hengstler and F. Oesch, Mainz, 1996 in the publishing house of the editors.

19. Oesch F, Hengstler JG, International symposium on control mechanisms of carcinogenesis: meeting report, J. Cancer Res. Clin. Oncol. 122, 374-378, 1996.

20. Jung D., Clark G., Hengstler J.G., Uhrig P., Edler L., Needham L., Lucier G., Patterson D., Oesch F., Konietzko J., Ah-Rezeptor, Enzymaktivität und Dioxinspiegel, Forum DKG 11, 108-110, 1996.

1995

Original papers

9. Hengstler J.G., Fuchs J., Bolm-Audorff U., Meyer S., Oesch F., DNA single strand breaks in fire fighters accidently exposed to o-nitroanisole and other chemicals, Scand. J. Work Environ. Health 21, 36-42, 1995.

10. Fuchs J., Burg J., Hengstler J.G., Bolm-Audorff U., Oesch F., DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in cutting fluids, Mutation Res. 342, 95-102, 1995

11. Oesch F., Hengstler J.G., Arand M., Fuchs J., Detection of primary DNA damage: applicability to biomonitoring of genotoxic occupational exposure and in clinical therapy, Pharmacogenetics 5, 118-122, 1995.

12. Fuchs J., Hengstler J.G., Jung D., Hiltl G., Konietzko J., Oesch F., DNA damage in nurses handling antineoplasitic agents, Mutation Res. 342, 17-23, 1995.

13. Oesch F., Fuchs J., Arand M., Vaupel J, Hengstler J.G., DNA single strand break analysis in mononuclear blood cells of gasoline station attendants, Int. Arch. Occup. Environ. Health 67, 35-39, 1995.

1990 - 1994

Original papers
 

1. Schäfer M, Hengstler JG, Löffler S, Flesh P, Isolation, identification and toxicological characterisation of TSS1, a new mycotoxin of the rosenane class., Mycotox. Res. 6, 21-30, 1990.

2. Hengstler J.G., Fuchs J., Oesch F., DNA strand breaks and cross-links in peripheral mononuclear blood cells of human ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin, Cancer Res. 52, 5622-5626, 1992.

3. Hengstler JG, Löffler S, Schaefer M, Glatt HR, Fuchs J, Flesh P, Oesch F, DNA strand break induction, mutagenicity, and cytotoxicity of the mycotoxins 11-ß-hydroxy-7-deoxy-rosenonolactone, rosenonolactone, and trichothecin, Mycotox. Res. 8, 77-83, 1992.

4. Hengstler J.G., Fuchs J., Gebhard S., Oesch F., Glycolaldehyde causes DNA-protein crosslinks: a new aspect of ethylene oxide genotoxicity, Mutation Res. 304, 229-234, 1994.

5. Fuchs J, Wullenweber U, Hengstler JG, Bienfait HG, Hiltl G, Oesch F, Genotoxic risk for humans due to a working place exposure to ethylene oxide: remarkable individual differences in susceptibility, Arch. Toxicol. 68, 343-348, 1994.

6. Oesch F, Hengstler JG, Fuchs J, Cigarette smoking protects mononuclear blood cells of carcinogen exposed workers from additional work-exposure induced DNA single strand breaks, Mutat. Res. 321, 175-185, 1994.

7. Dunkelberg H, Fuchs J, Hengstler JG, Klein E, Oesch F, Strüder K, Genotoxic effects of the herbicides alachlor, atrazine, pendimethaline, and simazine in mammalian cells, Bull. Environ. Contam. Toxicol. 52, 498-504, 1994.

Review

8. Schuler M, Hengstler JG, Oesch F, Huber Ch, Sekundäre Neoplasien des immunsupprimierten Patienten, Dtsch. Med. Wschr. 119, 1747-1754, 1994.

Gremientätigkeiten

• Beratungskommission der Gesellschaft für Toxikologie (GT)
• DFG-Senatskommission zur Beurteilung der gesundheitlichen Unbedenklichkeit von Lebensmitteln
• Projektkomitee des Forschungsnetzwerks HepatoSys

Schriftleitung wissenschaftlicher Zeitschriften

• Archives of Toxicology (editor)
• Experimental and Clinical Sciences, EXCLI J (editor)
• Toxicology (editorial board member)

Preisträger der EUROTOX 2009