1st Bollendorf Academy Discussions, May 17-19, 2004

Scientists of two research institutions, IfADo, Dortmund, and BGFA (Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin der Ruhr-Universität), Bochum, met for three days in an informal atmosphere at the Academy of Burg Bollendorf, at the German/Luxemburg borderline river, the Sauer. These First Bollendorf Academy Discussions served to concentrate ongoing research lines on occupational and environmental cancer at both institutions, in order to tackle important contemporary public health issues.

In a first round, recent and unpublished data concerning gene-environment interactions leading to head-and-neck cancer were discussed, with a focus on DNA repair genes. This malignancy is a major topic of ongoing cooperation between IfADo, BGFA, and clinicians of the University of Bonn as well. The cancer type is preferentially caused by smoking and alcohol drinking, which leads to important interactions between genetic traits and the toxicants (1-4).

Another topic was discussions on current results of case studies of urothelial cancer in the industrial manufacture of explosives in the former German Democratic Republic, following earlier publications of the group (5-7). Publications of the group have been of high relevance for matters of workers' compensation, and it was considered important to continue further on this avenue.

Finally, new reports on the human renal carcinogenicity of trichloroethylene were reviewed. In 2003, a new consecutive epidemiological case-control study was published on persons with occupational trichloroethylene exposure diseased from renal cell cancer in the German area of Arnsberg (8). These new data are further supplemented by results of a study on pre-clinical nephrotoxicity in these cases (9). It therefore appears important to discuss these new data on the background of an earlier review (10) on human nephrotoxicity and nephrocarcinogenicity of trichloroethylene, with a view on ongoing regulatory discussions and activities of the group in this field (11-13).

It was very much felt that the meeting had been extremely successful for the ongoing and future work at both research institutions, also due to contributions of the local setting and the superb social atmosphere. It was therefore decided to establish a tradition and to continue with these activities in the future.

The picture shows (from left to right): H.M.Bolt, IfADo, T. Brüning, BGFA, and V. Harth, BGFA.

Cited publications related to the discussions

1. Ko Y, Abel J, Harth V, Brode P, Antony C, Donat S, Fischer HP, Ortiz-Pallardo ME, Thier R, Sachinidis A, Vetter H, Bolt HM, Herberhold C, Brüning T Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue. Cancer Res. 2001 Jun 1;61(11):4398-404
2. Fronhoffs S, Brüning T, Ortiz-Pallardo E, Bröde P, Koch B, Harth V, Sachinidis A, Bolt HM, Herberhold C, Vetter H, Ko Y. Real-time PCR analysis of the N-acetyltransferase NAT1 allele *3, *4, *10, *11, *14 and *17 polymorphism in squamous cell cancer of head and neck. Carcinogenesis. 2001 Sep;22(9):1405-12
3. Wenghoefer M, Pesch B, Harth V, Bröde P, Fronhoffs S, Landt O, Brüning T, Abel J, Bolt HM, Herberhold C, Vetter H, Ko YD. Association between head and neck cancer and microsomal epoxide hydrolase genotypes. Arch Toxicol. 2003 Jan;77(1):37-41. Epub 2002 Oct 26
4. Neuhaus T, Ko YD, Lorenzen K, Fronhoffs S, Harth V, Bröde P, Vetter H, Bolt HM, Pesch B, Brüning T. Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer. Toxicol Lett. 2004 Jun 15;151(1):273-82
5. Brüning T, Chronz C, Thier R, Havelka J, Ko Y, Bolt HM. Occurrence of urinary tract tumors in miners highly exposed to dinitrotoluene. J Occup Environ Med. 1999 Mar;41(3):144-9
6. Brüning T, Thier R, Mann H, Melzer H, Bröde P, Dallner G, Bolt HM. Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene. J Occup Environ Med. 2001 Jul;43(7):610-5.
7. Brüning T, Thier R, Bolt HM. Nephrotoxicity and nephrocarcinogenicity of dinitrotoluene: new aspects to be considered. Rev Environ Health. 2002 Jul-Sep;17(3):163-72.
8. Brüning T, Pesch B, Wiesenhütter B, Rabstein S, Lammert M, Baumuller A, Bolt HM. Renal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, Germany. Am J Ind Med. 2003 Mar;43(3):274-85.
9. Bolt HM, Lammert M, Selinski S, Brüning T. Urinary alpha1-microglobulin excretion as biomarker of renal toxicity in trichloroethylene-exposed persons. Int Arch Occup Environ Health. 2004 Apr;77(3):186-90. Epub 2004 Feb 25
10. Brüning T, Bolt HM. Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies. Crit Rev Toxicol. 2000 May;30(3):253-85.
11. Bolt HM. Genotoxicity--threshold or not? Introduction of cases of industrial chemicals. Toxicol Lett. 2003 Apr 11;140-141:43-51.
12. Bolt HM, Foth H, Hengstler JG, Degen GH. Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective. Toxicol Lett. 2004 Jun 15;151(1):29-41.
13. Bolt HM, Degen GH. How to Assess Human Carcinogenic Risk of Chemicals? Contributions of the EUROTOX Specialty Section Carcinogenesis. Toxicol Sci. 2004 May 24 [Epub ahead of print]

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