Dr. rer. nat. med. habil. Silvia Capellino

silvia-capellino_neu-600x453-cut8 Group Leader

Neuroimmunology

Phone: +49 231 1084 420
Email:

Publications in Pubmed

Curriculum Vitae:

  • Since 2016: Leader of the Junior Research Group „Neuroimmunology“ at the Leibniz Research Centre for Working Environment and Human Factors, at the Technical University Dortmund (IfADo) and Marie Skłodowska-Curie scholarship holder.
  • 2015-2016: PostDoc (University of Giessen and Kerckhoff Clinic, Bad Nauheim, Germany).
  • 2014: Maternity leave
  • 2012-2013: PostDoc (The Johns Hopkins University, School of Medicine, Baltimore MD, USA).
  • 2012: Habilitation (University of Regensburg, Germany)
  • 2007-2012: PostDoc (University of Regensburg, Germany)
  • 2007: Ph.D. on Clinical and Experimental Immunology (University of Genoa, Italy and University of Regensburg, Germany)
  • 2003: Diploma in Biology (University of Genoa, Italy)

Research topics:

  • NeuroEndocrine Immunology
  • Rheumatology

Publications:

  • Böhm, M.; Apel, M.; Lowin, T.; Lorenz, J.; Jenei-Lanzl, Z.; Capellino, S.; Dosoki, H.; Grässel, S.: alpha-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients
    Biochem. Pharmacol. 116: 89-99 (2016)
    I am interested in this work
    http://dx.doi.org/10.1016/j.bcp.2016.07.003
  • Novaira, H. J.; Graceli, J. B.; Capellino, S.; Schoeffield, A.; Hoffman, G. E.; Wolfe, A.; Wondisford, F.; Radovick, S.: Development and characterization of novel rat anti-mERbeta sera
    Endocrinology 157: 2844-2852 (2016)
    I am interested in this work
    http://dx.doi.org/10.1210/en.2016-1122
  • Jenei-Lanzl, Z.; Capellino, S.; Kees, F.; Fleck, M.; Lowin, T.; Straub, R. H.: Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis
    Ann. Rheum. Dis. 74: 444-451 (2015)
    http://dx.doi.org/10.1136/annrheumdis-2013-203925
    I am interested in this work
  • Capellino, S.; Straub, R. H.; Cutolo, M.: Aromatase and regulation of the estrogen-to-androgen ratio in synovial tissue inflammation: common pathway in both sexes
    Ann. N. Y. Acad. Sci. 1317: 24-31 (2014)
    http://dx.doi.org/10.1111/nyas.12398
    I am interested in this work
  • Capellino, S.; Cosentino, M.; Luini, A.; Bombelli, R.; Lowin, T.; Cutolo, M.; Marino, F.; Straub, R. H.: Increased expression of dopamine receptors in synovial fibroblasts from patients with rheumatoid arthritis: inhibitory effects of dopamine on interleukin-8 and interleukin-6
    Arthritis Rheumatol. 66: 2685-2693 (2014)
    I am interested in this work
    http://dx.doi.org/10.1002/art.38746
  • Capellino, S.; Weber, K.; Gelder, M.; Härle, P.; Straub, R. H.: First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy
    Arthritis Rheumatol 64: 1110-1118 (2012)
    http://dx.doi.org/10.1002/art.33431
    I am interested in this work
  • Lowin, T.; Weidler, C.; Jenei-Lanzl, Z.; Capellino, S.; Baerwald, C. G.; Buttgereit, F.; Straub, R. H.: Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis
    Arthritis Rheumatol 64: 1799-1808 (2012)
    http://dx.doi.org/10.1002/art.34338
    I am interested in this work
  • Graf, N.; McLean, M.; Capellino, S.; Schölmerich, J.; Murray, G. I.; El-Omar, E. M.; Straub, R. H.: Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps: a putative role of semaphorins 3F and 3A
    Neurogastroenterol. Motil. 24: 120-128 (2012)
    I am interested in this work
    http://dx.doi.org/10.1111/j.1365-2982.2011.01818.x
  • van der Goes, M. C.; Straub, R. H.; Wenting, M. J.; Capellino, S.; Jacobs, J. W.; Jahangier, Z. N.; Rauch, L.; Lafeber, F. P.: Intra-articular glucocorticoid injections decrease the number of steroid hormone receptor positive cells in synovial tissue of patients with persistent knee arthritis
    Ann. Rheum. Dis. 71: 1552-1558 (2012)
    I am interested in this work
    http://dx.doi.org/10.1136/annrheumdis-2011-201019
  • Probst, C.; Pongratz, G.; Capellino, S.; Szeimies, R. M.; Schölmerich, J.; Fleck, M.; Salzberger, B.; Ehrenstein, B.: Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis : a case report
    BMC Infect. Dis. 10: article 239 (5 pp) (2010)
    I am interested in this work
    http://dx.doi.org/10.1186/1471-2334-10-239
  • Capellino, S.; Cosentino, M.; Wolff, C.; Schmidt, M.; Grifka, J.; Straub, R. H.: Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target
    Ann. Rheum. Dis. 69: 1853-1860 (2010)
    I am interested in this work
  • Haas, S.; Capellino, S.; Phan, N. Q.; Böhm, M.; Luger, T. A.; Straub, R. H.; Ständer, S.: Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis
    J. Derm. Sci. 58: 193-197 (2010)
    I am interested in this work
    http://dx.doi.org/10.1016/j.jdermsci.2010.03.020
  • Ferrero, S.; Haas, S.; Remorgida, V.; Camerini, G.; Fulcheri, E.; Ragni, N.; Straub, R. H.; Capellino, S.: Loss of sympathetic nerve fibers in intestinal endometriosis
    Fertil. Steril. 94: 2817-2819 (2010)
    I am interested in this work
    http://dx.doi.org/10.1016/j.fertnstert.2010.06.069
  • Cutolo, M.; Brizzolara, R.; Atzeni, F.; Capellino, S.; Straub, R. H.; Puttini, P. C.: The immunomodulatory effects of estrogens: clinical relevance in immune-mediated rheumatic diseases
    Ann. N. Y. Acad. Sci. 1193: 36-42 (2010)
    I am interested in this work
    http://dx.doi.org/10.1111/j.1749-6632.2009.05383.x
  • Schmidt, M.; Hartung, R.; Capellino, S.; Cutolo, M.; Pfeifer-Leeg, A.; Straub, R. H.: Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis
    Arthritis Rheumatol. 60: 2913-2922 (2009)
    I am interested in this work
    http://dx.doi.org/10.1002/art.24859
  • Dirmeier, M.; Capellino, S.; Schubert, T.; Angele, P.; Anders, S.; Straub, R. H.: Lower density of synovial nerve fibres positive for calcitonin gene-related peptide relative to substance P in rheumatoid arthritis but not in osteoarthritis
    Rheumatology 47: 36-40 (2008)
    http://dx.doi.org/10.1093/rheumatology/kem301
    I am interested in this work
  • Straub, R. H.; Grum, F.; Strauch, U.; Capellino, S.; Battaille, F.; Bleich, A.; Falk, W.; Obermeier, F.: Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation
    Gut. 57: 977-921 (2008)
    I am interested in this work
    http://dx.doi.org/10.1136/gut.2007.125401
  • Capellino, S.; Straub, R. H.: Neuroendocrine immune pathways in chronic arthritis
    Best. Pract. Res. Clin. Rheumatol. 22: 285-297 (2008)
    I am interested in this work
    http://dx.doi.org/10.1016/j.berh.2008.01.010
  • Cutolo, M.; Capellino, S.; Straub, R. H.: Oestrogens in rheumatic diseases: friend or foe?
    Rheumatology 47: Suppl. 3 :iii2-iii5 (2008)
    I am interested in this work
    http://dx.doi.org/10.1093/rheumatology/ken150
  • Capellino, S.; Montagna, P.; Villaggio, B.; Soldano, S.; Straub, R. H.; Cutolo, M.: Hydroxylated estrogen metabolites influence the proliferation of cultured human monocytes: possible role in synovial tissue hyperplasia
    Clin. Exp. Rheumatol. 26: 903-909 (2008)
    I am interested in this work
  • Lehner, B.; Koeck, F. X.; Capellino, S.; Schubert, T. E.; Hofbauer, R.; Straub, R. H.: Preponderance of sensory versus sympathetic nerve fibers and increased cellularity in the infrapatellar fat pad in anterior knee pain patients after primary arthroplasty
    J. Orthop. Res. 26: 342-350 (2008)
    I am interested in this work
    http://dx.doi.org/10.1002/jor.20498
  • Montagna, P.; Capellino, S.; Villaggio, B.; Remorgida, V.; Ragni, N.; Cutolo, M.; Ferrero, S.: Peritoneal fluid macrophages in endometriosis: correlation between the expression of estrogen receptors and inflammation
    Fertil. Steril. 90: 156-164 (2008)
    I am interested in this work
  • Capellino, S.; Lowin, T.; Angele, P.; Falk, W.; Grifka, J.; Straub, R. H.: Increased chromogranin A levels indicate sympathetic hyperactivity in patients with rheumatoid arthritis and systemic lupus erythematosus
    J. Rheumatol. 35: 91-99 (2008)
    I am interested in this work
  • Capellino, S.; Riepl, B.; Rauch, L.; Angele, P.; Cutolo, M.; Straub, R. H.: Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation?
    Ann. Rheum. Dis. 66: 53-58 (2007)
    I am interested in this work
    http://dx.doi.org/10.1136/ard.2006.055483
  • Cutolo, M.; Capellino, S.; Sulli, A.; Serioli, B.; Sechhi, M. E.; Villaggio, B.; Straub, R. H.: Estrogens and autoimmune diseases
    Ann. N. Y. Acad. Sci. 1089: 538-547 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1386.043
  • Cutolo, M.; Sulli, A.; Capellino, S.; Villaggio, B.; Montagna, P.; Pizzorni, C.; Paolino, S.; Seriolo, B.: Anti-TNF and sex hormones
    Ann. NY Acad. Sci. 1069: 391-400 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1351.0
  • Sulli, A.; Montecucco, C. M.; Caporali, R.; Cavagna, L.; Montagna, P.; Capellino, S.; Fazzuoli, L.; Cutolo, M.: Glucocorticoid effects on adrenal steroids and cytokine responsiveness in polymyalgia rheumatica and elderly onset rheumatoid arthritis
    Ann. NY Acad. Sci. 1069: 307-314 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1351.0
  • Capellino, S.; Montagna, P.; Villaggio, B.; Sulli, A.; Soldano, S.; Ferrero, S.; Remorgida, V.; Cutolo, M.: Role of estrogens in inflammatory response: expression of estrogen receptors in peritoneal fluid macrophages from endometriosis
    Ann. NY Acad. Sci. 1069: 263-267 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1351.0
  • Janele, D.; Lang, T.; Capellino, S.; Cutolo, M.; da Silva, J. A.; Straub, R. H.: Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol
    Ann. NY Acad. Sci. 1069: 168-182 (2006)
    I am interested in this work
    http://dx.doi.org/10.1196/annals.1351.0
  • Cutolo, M.; Montecucco, C. M.; Cavagna, L.; Caporali, R.; Capellino, S.; Montagna, P.; Fazzuoli, L.; Sulli, A.: Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis
    Ann. Rheum. Dis. 65: 1438-1443 (2006)
    I am interested in this work
    http://dx.doi.org/10.1136/ard.2006.051979
  • Cutolo, M.; Capellino, S.; Montagna, P.; Sulli, A.; Seriolo, B.; Villaggio, B.: Anti-inflammatory effects of leflunomide in combination with methotrexate on co-culture of T lymphocytes and synovial macrophages from rheumatoid arthritis patients
    Ann. Rheum. Dis. 65: 728-735 (2006)
    I am interested in this work
    http://dx.doi.org/10.1136/ard.2005.045641
  • Cutolo, M.; Maestroni, G. J.; Otsa, K.; Aakre, O.; Villaggio, B.; Capellino, S.; Montagna, P.; Sulli, A.: Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison
    Ann. Rheum. Dis. 64: 212-216 (2005)
    I am interested in this work
    http://dx.doi.org/10.1136/ard.2004.023416
  • Capellino, S.; Montagna, P.; Villaggio, B.; Cutolo, M.: [Effects of estrogen peripheral metabolism in rheumatoid arthritis]: [Article in Italian]
    Rheumatismo 57: 78-82 (2005)
    I am interested in this work
  • Capellino, S.; Villaggio, V.; Montagna, P.; Sulli, A.; Craviotto, C.; Cutolo, M.: 17beta-Estradiol and testosterone influence the mRNA expression and the time course of inflammatory cytokines in activated human monocytic cell line (THP-1)
    Reumatismo 57: 193-196 (2005)
    I am interested in this work
    http://dx.doi.org/10.4081/reumatismo.2005.193
  • Cutolo, M.; Capellino, S.; Montagna, P.; Ghiorzo, P.; Sulli, A.; Villaggio, B.: Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line
    Arthritis Res. Ther. 7: R1124-R1132 (2005)
    I am interested in this work
    http://dx.doi.org/10.1186/ar179
  • Cutolo, M.; Villaggio, B.; Seriolo, B.; Montagna, P.; Capellino, S.; Straub, R. H.; Sulli, A.: Synovial fluid estrogens in rheumatoid arthritis
    Autoimmun. Rev. 3: 193-198 (2004)
    I am interested in this work
    http://dx.doi.org/10.1016/j.autrev.2003.08.00
  • Cutolo, M.; Villaggio, B.; Seriolo, B.; Montagna, P.; Capellino, S.; Straub, R. H.; Sulli, A.: Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity
    Lupus 13: 635-638 (2004)
    I am interested in this work
    http://dx.doi.org/10.1191/0961203304lu1094oa
  • Cutolo, M.; Capellino, S.; Montagna, P.; Villaggio, B.; Sulli, A.; Seriolo, B.; Straub, R. H.: New roles for estrogens in rheumatoid arthritis
    Clin. Exp. Rheumatol. 21: 687-690 (2003)
    I am interested in this work