Date(s) - 09/07/2018
14:00 - 16:00
Prof. Leonardo Guzmán will give a talk entitled „Cellular Mechanism of Dendrimer Internalization and Effects in Neuronal Physiology“
Dr. Leonardo Guzmán is currently the Director of the Department of Physiology of the Faculty of Biological Sciences of the University of Concepcion, Chile. His area of primary specialty was neuronal signal transduction, to then study the interactions of these molecular systems with the function of ion channels and drug design.
His scientific contribution has focused on the design of small molecules that inhibit the potentiation of ethanol on the glycine receptor. Furthermore, Dr. Guzmán has developed a line of research in the study of drug nanocarriers and the molecular interactions that determine their functionality in biological systems. Drug nanocarriers are promising tools for the treatment of CNS diseases including neurodegenerative diseases like Parkinson and Alzheimer.
The safe use of such nanomaterial is one of the research topics of the Leibniz Research Alliance (LRA) “Nanosafety” of which the IfADo is a member. As part of our actives in this LRA Dr. Guzmáns PhD student Filipe Vidal spent six months at the IfADo to perform experiments with different dendrimers in neuronal cell cultures as well as biodistribution studies in mice. By inviting Dr. Guzmán to give a lecture and subsequently visit our lab we strengthen the collaboration between the University of Concepción and the IfADo.