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Preliminary program

 

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Thursday, 19 May 2011  
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Registration (10:00)
   
Welcome  
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Chair: Prof. Dr. J. G. Hengstler (12:00 - 12:15)
   
Prof. Dr. Roger S. Goody, Max Planck Institute of Molecular Physiology, Dortmund
Prof. Dr. Katja Ickstadt, Faculty of Statistics, TU Dortmund University
Prof. Dr. Jan G. Hengstler, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
   
Keynote Lecture  
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Chair: Prof. Dr. J. G. Hengstler (12:00 - 12:15)
   

Dr. Patricio Godoy, IfADo – Leibniz Research Centre for Working Environment and Human Factors, Dortmund      
Understanding and improving in vitro hepatocyte systems: Inflammation and cholestasis gene expression signatures as novel features of primary hepatocytes in culture

 
   
Coffee Break (12:45 - 13:00)
   
Session 1: PCB case Dortmund  
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Chair: Prof. Dr. M. Wilhelm, Prof. Dr. T. Kraus (13:00 - 14:30)
   

Prof. Dr. Thomas Kraus, RWTH Aachen University, Institute of Occupational and Social Medicine, Aachen
Development of a preventive surveillance program for active and former workers of a transformer and condenser recycling company, their family members and employees of surrounding companies

Knut Rauchfuss, North Rhine-Westphalia State Agency for Nature, Environment and Consumer Protection, Recklinghausen
Derivation of a health based guidance value for PCB in human blood samples

Dr. Thomas Schettgen, RWTH Aachen University, Institute of Occupational and Social Medicine, Aachen
Blood PCB levels of workers of a transformer recycling company, their family members and employees of surrounding companies

Dr. Jürgen Wittsiepe, Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum
Levels of PCDD/F in blood samples of occupationally exposed workers from a transformer recycling plant in Dortmund, Germany

   
Coffee Break (14:30 - 15:00)
   
Session 2: Guided Poster Session I (In vitro, methods and studies)
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Chair: Dr. W. Föllmann, Prof. Dr. G. Leng (15:00 - 16:15)
 
Session 3: Neurotoxicity and toxicogenomics - Bringing labs and rats to the chip
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Chair: PD Dr. C. van Thriel, Prof. Dr. E. Fritsche (16:15 - 18:15)
 

PD Dr. Christoph van Thriel, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
The Network Formation Assay (NFA) - a new tool for the assessment of neurotoxic effects of environmental chemicals

Prof. Dr. Ellen Fritsche, IUF - Leibniz Research Institute of Environmental Medicine, Düsseldorf and RWTH Aachen University
Human Neurospheres as three dimensional cellular systems for developmental neurotoxicity testing

Dr. Kathrin Gassmann, IUF - Leibniz Research Institute of Environmental Medicine, Düsseldorf
Developmental neurotoxicity of PAHs: Species-specific AHR-insufficiency protects human neural progenitor cells

Heike Hardelauf, Leibniz-Institut für Analytische Wissenschaften - ISAS, Dortmund
Micropatterned in vitro neuronal networks for toxicity screening

Julia Sisnaiske, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Embryonic stem cell-derived neurons are a suitable tool for neurotoxicology research

Markus Schug, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
New approaches in in vitro toxicogenomics

 

Talk at the Graduiertenkolleg 'Statistische Modellbildung' (for statisticians)

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Chair: Prof Dr. K. Ickstadt (14:00 - 16:00)
 
Frank Geller, Statens Serum Institut, Kopenhagen, Denmark
To be announced
 
Dinner at the restaurant "Kräutergarten" (19:30)
 
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Friday, 20 May 2011
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Registration (8:00)
 
Keynote Lecture
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Chair: Prof. Dr. K. Ickstadt (8:15 - 8:45)
 
Dr. Silvia Selinski, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
How many SNPs do we need to predict NAT2 phenotype?
 
Session 4: Statistical challenges in genome-wide studies
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Chair: Prof. Dr. K. Ickstadt, Dr. H. Schwender (08:45 - 10:00)
 

Frank Geller, Statens Serum Institut, Kopenhagen, Denmark
Detoxification genes in genome-wide association studies

Prof. Dr. Jörg Rahnenführer, Faculty of Statistics, TU Dortmund University
Prediction of progression and therapy response for cancer patients: Are high-dimensional genomic data a blessing or a curse?

Martin Schäfer, Faculty of Statistics, TU Dortmund University
Integrative Analyses for Omics Data

 
Coffee Break (10:00 - 10:20)
 
Session 5: Guided Poster Session II (Statistics, methods and studies)
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Chair: Prof. Dr. Dr. H. M. Bolt, Dr. H.-P. Rihs (10:20 - 11:40)
 
Session 6: Co-existence of newly detected and well-known environmental toxicants in NRW, biomarkers and polymorphisms I
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Chair: Prof. Dr. K. Golka, Dr. S. Selinski (11:40 - 13:15)
 

Prof. Dr. Dr. Hermann M. Bolt, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Environmental and occupational boron exposures in Bandirma, Turkey

Prof. Dr. Klaus Golka, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
N-acetyltransferase 2 and glutathione S-transferase M1 in colon and rectal cancer cases from an industrialized area

Dr. Monika Kasper-Sonnenberg, Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum
Determination of Bisphenol A in urine from mother-child pairs. Results from the Duisburg birth cohort

Dr. Jürgen Hölzer, Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum
PFOA-concentrations in blood samples of children, mothers and men of Arnsberg - 2 years follow up

 
Lunch (13:15 - 14:15)
 
Session 7: Co-existence of newly detected and well-known environmental toxicants in NRW, biomarkers and polymorphisms II
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Chair: Dr. S. Selinski, Prof. Dr. K. Golka (14:15 - 15:45)
 

Dr. Hans-Peter Rihs, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
Role of interleukin ((IL)-13 and IL-18 promoter polymorphisms in health care workers with natural rubber latex allergy

Sabine Hertel, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen
Effects of ultra-fine air pollution on systemic inflammation in a large German cohort

Prof. Dr. Ursula Krämer, IUF- Leibniz Research Institute of Environmental Medicine, Düsseldorf, and PD Dr. Barbara Hoffmann, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen
Cardiovascular and respiratory effects of fine particle exposure - results from studies in the Ruhr Area

 
Coffee Break (15:45 - 16:15)
 
Closing Session und Poster Award
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Chair: Prof. Dr. S. Kacew (16:15 - 17:00)
 

Prof. Dr. Dr. Hermann M. Bolt, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
News, views and highlights of the conference

Prof. Dr. Sam Kacew
Poster Award

 
IBS Tutorial 'Toxicology for Statisticians'
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  (17:30 - 18:15)
Prof. Dr. Klaus Golka, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund

Basic principles and the role of statistics in toxicology

 
 
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Preliminary Poster Program
 
Session 2: Guided Poster Session I (In vitro, methods and studies)
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Chair: Dr. W. Föllmann, Prof. Dr. G. Leng (15:00 - 16:15)
 

In vitro & methods
Simone Scheitza, Ökotoxikologie/ Toxikologie, Trier University
Influence of long term culture of the human keratinocyte cell line HaCaT

Dr. Wolfram Föllmann, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
N-Acetylation of p-aminobenzoic acid and p-phenylenediamine in primary porcine urinary bladder epithelial cells and in the human urothelial cell line 5357

Kathrin Herbst, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Synergistic effects of benzo[a]pyrene and aromatic amines on DNA and AhR- and NFkB- signaltransduction in urothelial cells

Dr. Sabine Plöttner, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
Effects of cigarette smoke condensate on primary urothelial cells in vitro

Ricarda Zdenka, Institut für Hygiene und Arbeitsmedizin, Essen University Hospital
Biotransformation and genotoxic effects of monomethylarsonous acid [MMA(III)] in methylating and non-methylating human cells

Dr. Claudia Behm, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Cytotoxic potency of mycotoxins in cultures of V79 lung fibroblast cells

Studies
Prof Dr. Klaus Golka, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Ochratoxin A blood concentrations in healthy subjects and bladder cancer cases from Pakistan

Katherine Muñoz, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Biological monitoring of ochratoxin A in mother-child pairs from Chile

Dr. Vera van Kampen, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
Symptoms, spirometry, and serum antibody concentrations among 190 compost workers exposed to organic dust

Britta Schulze Waltrup, Faculty of Statistics, TU Dortmund University
Multivariate analysis of biological parameters from a study on boron exposure

Benjamin Kendzia, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
Cross-shift variation in occupational epidemiology - support for a diurnal variation of biomarkers for inflammation and genotoxic effects from a study in German male construction workers

Dr. Frank Hoffmeyer, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
Biomarkers in EBC among 58 mild steel welders applying different techniques

Annette Rennert, Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum
DHEA-S levels in prepubertal children is positively associated with backround exposure to PCBs and PCDD/F - Results from the Duisburg birth cohort study

 
Session 5: Guided Poster Session II (Statistics, methods and studies)
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Chair: Prof. Dr. Dr. H. M. Bolt, Dr. H.-P. Rihs (10:20 - 11:40)
 
Statistics
Birte Hellwig, Faculty of Statistics, TU Dortmund University
Cancer classification from genome-wide gene expression data - how do we find the really important genes?

Miriam Lohr, Faculty of Statistics, TU Dortmund University
Clinical prognosis based on differential gene regulatory networks

Dr. Holger Schwender, Faculty of Statistics, TU Dortmund University
Imputing Missing Genotypes with Weighted k Nearest Neighbors

Studies
Dr. Hans-Peter Rihs, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
Modulation of oxidative DNA damage by repair enzymes XRCC1 and hOGG1

Torsten Klein, St. Vincenz Hospital, Menden
Indication for joint replacement and glutathione S-transferases M1 and T1 genotypes

Kristian Knoell, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Development of a strategy for biological monitoring in a chemical plant producing 3,3'-dichlorobenzidine dihydrochloride

Emanuel Roth, Department of Urology, Paul Gerhardt Foundation, Lutherstadt Wittenberg
Bladder cancer survival in a former industrial area in Saxony-Anhalt

Prof. Dr. Klaus Golka, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Bladder cancer in crack testers applying azo dye-based sprays to metal bodies

PD Peter H. Roos, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Is there an association between arylamine-metabolizing CYP4B1 and bladder cancer?

Daniel Ovsiannikov, Department of Urology, St.-Josefs-Hospital Dortmund-Hoerde
Polymorphic enzymes, urinary bladder cancer risk, and structural change in the local industry

Dr. Anna Zimmermann, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Miners compensated for pneumoconiosis and glutathione S-transferase M1 genotype

Prof. Dr. Dr. Hermann M. Bolt, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Occupational cancers related to 1,3-propane sultone

Methods
Dr. Verena Liebers, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
Assessment of airborne exposure to endotoxin and pyrogenic activity using electrostatic dust fall collectors (EDCs)

Dr. Ingrid Sander, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
Development and application of mould antigen specific Enzyme-linked Immuno Sorbent Assays (ELISA) to quantify airborne antigen exposure

Marie-Louise Lehmann, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
A new technique to gain urothelial cells from patients via micro-brushing