Priv.-Doz. Dr. rer. nat. Peter Roos

Academic background

• 2001 up to now: leader of the project group ‚Molecular Toxicology’ at the IfADo – Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
• 1999-2000: scientific assistant at the Neurological University Clinic, St. Josef-Hospital, Bochum, Germany
• 1997-1999: scientific assistant at the Institute of Hygiene and Environmental Medicine (Prof. Dott), RWTH Aachen, Germany
• 1996: professional dissertation, Priv.-Doz. Dr. rer. nat., Faculty of Medicine, Ruhr-University Bochum
• 1987-1996: scientific assistant at the Institute for Physiological Chemistry, Department of Bioenergetics (Prof. Hanstein), Ruhr-University Bochum, Germany
• 1982-1987: scientific assistant at the Institute for Biophysics and Electron microscopy (Prof. Vogell), University Düsseldorf, Germany
• 1982: PhD, Dipl. Biol. Dr. rer. nat.
• 1979-1982: Dept. of Plant Biochemistry, Faculty of Biology, Ruhr-University Bochum, Thesis
• 1978: Plant Biochemistry, Faculty of Biology, Ruhr-University Bochum, Diploma in biology
• 1973-1978: Ruhr-University Bochum, Course of studies in biology

Research interests

• molecular effects of toxic and carcinogenic compounds on urothelial cells
• chemically induced urinary bladder carcinogenesis
• primary processes indcued by carcinogens in urothelial cells
• expression and inducibility of cytochromes P450
• effects of carcinogens on components of cellular signal transduction pathways and cell cycle control
• biomarkers for bladder cancer
• post-translational protein modification under the influence of carcinogens
• development of methods for the analysis of post-translational protein modifications
• development of methods for the analysis of xenobiotic-dependent effects on the proteome and the phosphoproteome of urothelial cells

Current research

• research group "Molecular toxicology"

Teaching

• since 2005: lectures in toxicology for medical students and for graduate students of the International Graduate School in Biology (Ruhr-University Bochum, Faculties of Medicine and of Biology)
• since 2002: courses on ‘Xenobiotic Metabolism and Toxicokinetics’ for the German Society of Pharmacology, Clinical Pharmacology and Toxicology (DGPT) to purchase the degree ‘Expert in Toxicology – DGPT’ (organization, chair, lectures)
• since 1988 up to now: practical courses, seminars and lectures in basic biochemistry and molecular biology for medical students (Ruhr-University Bochum)
• 1986–1987: courses in electron microscopy and lectures in cell biology

Selected publications

• Roos PH, Golka K, Hengstler JG (2008) Predictive biomarkers and signatures in urinary bladder cancer. Curr Opin Mol Ther 10, 243-250.
• Roos PH, Venkatachalam A, Manz A, Wäntig L, Koehler CU, Jakubowski N (2008) Detection of electrophoretically separated cytochromes P450 by element labelled monoclonal antibodies via laser ablation inductively coupled plasma mass spectrometry. Anal Bioanal Chem 392, 1135–1147.
• Köhler CU, Roos PH (2008) Focus on the Intermediate State: Immature mRNA of Cytochromes P450 - Methods and Insights. Anal Bioanal Chem 392, 1109-1122.
• Jakubowski N, Messerschmidt J, Garijo Anorbe M, Wäntig L, Hayen H, Roos PH (2008) Labelling of proteins by use of iodination and detection by ICP-MS. J Anal At Spectrom 23, 1487-1496.
• Dörrenhaus A, Müller T, Roos PH (2007) Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers. Arch Toxicol 81, 19-25.
• Roos PH, Belik R, Föllmann W, Degen GH, Knopf HJ, Bolt HM, Golka K (2006) Expression of cytochrome P450 enzymes CYP1A1, CYP1B1, CYP2E1, and CYP4B1 in non-invasively obtained transitional cells of the human urinary tract. Arch Toxicol 80, 45–52.
• Roos PH, Bolt HM (2005) Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1. Expert Opinion Drug Metab Toxicol 1, 187–202.
• Roos PH, Tschirbs S, Hack A, Welge P, Wilhelm M (2004) Different mechanisms of mammalian species to handle ingested polycyclic aromatic hydrocarbons: Organ-specific response patterns of CYP1A1-induction upon oral intake of PAH-contaminated soils in mipigs and rats. Xenobiotica 34, 781–795.
• Lemm F, Wilhelm M, Roos PH (2004) Occupational exposure to polycyclic aromatic hydrocarbons suppresses constitutive expression of CYP1B1 on the transcript level in human leukocytes. Int J Hyg Environ Health 207, 325–335.