Model 1 of the regeneration of the liver without CCl4:
One of the gains of the model is the possibility to modify the model parameters and predict their influence on the process of regeneration. Here, we identified the model parameter "coordinated cell orientation" (CCO) as crucial for the regeneration process. When hepatocytes divide the orientation of daughter cells is initially random. Later, the daughter cells realign orienting themselves to the central vein. This process of realigning is termed CCO. In the present simulation we deleted the model parameter CCO. As a result the degree of disorder increases and the micro-architecture of the liver lobule is destroyed.