Publications from the CancerSys work program
- A. Raue, V. Becker, U. Klingmüller, J. Timmer. Identifiability
and observability analysis for experimental design in nonlinear dynamical
models. Chaos 20 , 2010, 045105,
- A. Raue, C. Kreutz, T. Maiwald, U. Klingmüller, J. Timmer. Addressing
parameter identifiability by model-based experimentation. IET Systems
Biology 5, 2011, 120-130,
- A. Raue, C. Kreutz, T. Maiwald, J. Bachmann, M. Schilling, U. Klingmüller,
J. Timmer. Structural
and practical identifiability analysis of partially observed dynamical models
by exploiting the profile likelihood. Bioinformatics 25, 2009, 1923-1929,
- Stefan Höhme, Marc Brulport, Alexander Bauer, Essam Bedawy, Wiebke
Schormann, Matthias Hermes, Verena Puppe, Rolf Gebhardt, Sebastian Zellmer,
Michael Schwarz, Ernesto Bockamp, Tobias Timmel, Jan G. Hengstler, Dirk Drasdo.
Prediction and validation of cell alignment along micro-vessels as order
principle to restore tissue architecture in liver regeneration. PNAS,
107(23), 2010, 10371 -10376,
- Radszuweit M, Block M, Hengstler JG, Schöll E, Drasdo D., Comparing
the growth kinetics of cell populations in two and three dimensions. Phys
Rev E Stat Nonlin Soft Matter Phys. 2009 May;79(5 Pt 1):051907,
- Chafey P, Finzi L, Boisgard R, Caüzac M, Clary G, Broussard C, Pégorier
JP, Guillonneau F, Mayeux P, Camoin L, Tavitian B, Colnot S, Perret C. Proteomic
analysis of beta-catenin activation in mouse liver by DIGE analysis identifies
glucose metabolism as a new target of the Wnt pathway. Proteomics,
15, 2009, 3889-3900,
- Torre C., Perret C., Colnot S. Transcription
dynamics in a physiological process: beta-Catenin signaling directs liver
metabolic zonation. Int J Biochem Cell Biol, online 13 Nov 2009,
in press,
- Benhamouche S, Torre C, Mitchell C, Godard C, Veber P, Letourneur F, Cagnard
N, Jacques S, Finzi L, Perret C, Colnot S.. The transforming growth factor-alpha
and cyclin D1 genes are direct targets of ß-catenin signaling in hepatocyte
proliferation. Submitted,
- Braeuning, A. & Schwarz, M.. Zonation of heme synthesis enzymes
in mouse liver and their regulation by ß catenin and Ha-ras. Biol.Chem.,
2010 Nov;391(11):1305-13,
- Kielbasa SM., Klein H., Roider H., .Vingro M., Bluethgen N.. TransFind
- Predicting transcriptional regulators for gene sets. Nucleic Acids
Research, accepted 2010,
- Parikh J., Klinger B., Xia Y., Marto JA. Bluethgen N.. Discovering
causal signaling pathways through gene expression patterns using SPEED.
Nucleic Acids Research, accepted 2010.
- S. Hoehme and D. Drasdo. Biomechanical versus nutrient control: what
determines the growth dynamics of mammalian cell populations? Mathematical
Population Studies, accepted 2010
- D. Drasdo, N. Jagiella, I. Ramis-Conde, I. Vignon-Clementel, W. Weens.
Modeling steps from a benign tumor to an invasive cancer: examples of
intrinsically multi-scale problems in: From single scale-based models to multiscale
modelling eds. A. Chauviere, L. Preziosi, C. Verdier/ CRC Press Taylor
& Francis, eds. A. Chauviere, L. Preziosi, C. Verdier/ CRC Press Taylor
& Francis, 2010,
- Ramis-Conde I, Chaplain MA, Anderson AR Drasdo D. Multi-scale modelling
of cancer cell intravasation: the role of cadherins in metastasis. Phys
Biol. Mar 25;6(1) 200916008 - 16020,
Publications related to CancerSys
- Godoy P, Hengstler JG, Ilkavets I, Meyer C, Bachmann A, Müller A, Tuschl
G, Mueller SO, Dooley S. Extracellular matrix modulates sensitivity of
hepatocytes to fibroblastoid dedifferentiation and transforming growth factor
beta-induced apoptosis. Hepatology. 2009 Jun;49(6):2031-43.
- Schmidt M, Hengstler JG, von Törne C, Koelbl H, Gehrmann MC. Coordinates
in the universe of node-negative breast cancer revisited. Cancer Res.
2009 Apr 1;69(7):2695-8.
- Aurich H, Sgodda M, Kaltwasser P, Vetter M, Weise A, Liehr T, Brulport M,
Hengstler JG, Dollinger MM, Fleig WE, Christ B. Hepatocyte differentiation
of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic
integration in vivo. Gut. 2009 Apr;58(4):570-81.
- Schumann A, Bauer A, Hermes M, Gilbert M, Hengstler JG, Wilhelm C. A
rapid and easy to handle thermoluminescence based technique for evaluation
of carbon tetrachloride-induced oxidative stress on rat hepatocytes.
Arch Toxicol. 2009 Jul;83(7):709-20.
- Schmidt M, Böhm D, von Törne C, Steiner E, Puhl A, Pilch H, Lehr
HA, Hengstler JG, Kölbl H, Gehrmann M. The humoral immune system
has a key prognostic impact in node-negative breast cancer. Cancer Res.
2008 Jul 1;68(13):5405-13.
- Hermes M, Schormann W, Brulport M, Uhlemann K, Lupatsch F, Horn LC, Schumann
A, Allgaier C, Weishaupt M, Engeland K, Müller GA, Mössner J, Bauer
A, Schiffer IB, Gebhard S, Schmidt M, Lausch E, Prawitt D, Wilhelm C, Hengstler
JG. Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation:
influence on tumour development in an ERBB2-dependent mouse tumour model.
Br J Cancer. 2008 May 6;98(9):1525-1532.
- Schormann W, Hammersen FJ, Brulport M, Hermes M, Bauer A, Rudolph C, Schug
M, Lehmann T, Nussler A, Ungefroren H, Hutchinson J, Fändrich F, Petersen
J, Wursthorn K, Burda MR, Brüstle O, Krishnamurthi K, von Mach M, Hengstler
JG. Tracking of human cells in mice. Histochem Cell Biol. 2008 Apr
19. [Epub ahead of print]
- Steiner E, Pollow K, Hasenclever D, Schormann W, Hermes M, Schmidt M, Puhl
A, Brulport M, Bauer A, Petry IB, Koelbl H, Hengstler JG. Role of urokinase-type
plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1)
for prognosis in endometrial cancer. Gynecol Oncol. 2008 Mar;108(3):569-76.
- Schmidt M, Victor A, Bratzel D, Boehm D, Cotarelo C, Lebrecht A, Siggelkow
W, Hengstler JG, Elsäßer A, Gehrmann M, Lehr HA, Koelbl H, von
Minckwitz G, Harbeck N, Thomssen C. Long-term outcome prediction by clinicopathological
risk classification algorithms in node-negative breast cancer--comparison
between Adjuvant!, St Gallen, and a novel risk algorithm used in the prospective
randomized Node-Negative-Breast Cancer-3 (NNBC-3) trial. Ann Oncol. 2008
Sep 29. [Epub ahead of print]
- Schmidt M, Hasenclever D, Schaeffer M, Boehm D, Cotarelo C, Steiner E, Lebrecht
A, Siggelkow W, Weikel W, Schiffer-Petry I, Gebhard S, Pilch H, Gehrmann M,
Lehr HA, Koelbl H, Hengstler JG, Schuler M. Prognostic effect of epithelial
cell adhesion molecule overexpression in untreated node-negative breast cancer.
Clin Cancer Res. 2008 Sep 15;14(18):5849-55.
- Gehrmann M, Schmidt M, Brase JC, Roos P, Hengstler JG. Prediction of
paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?
Pharmacogenomics. 2008 Jul;9(7):969-74.
- Bockamp E, Sprengel R, Eshkind L, Lehmann T, Braun JM, Emmrich F, Hengstler
JG. Conditional transgenic mouse models: from the basics to genome-wide
sets of knockouts and current studies of tissue regeneration. Regen Med.
2008 Mar;3(2):217-35.
Awards granted to partners of the CancerSys work programm
